MicroRNA-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5

BMC Cancer

Volumn 12, Issue , 2012, Pages

  Liu, Xiang hua ^a   Lu, Kai hua ^a,b   Wang, Ke ming ^c   Sun, Ming ^a   Zhang, Er bao ^a   Yang, Jin song ^a   Yin, Dan dan ^a   Liu, Zhi li ^c   Zhou, Jing ^c   Liu, Zhi jun ^a   De, Wei ^a   Wang, Zhao xia ^c  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

^c THE SECOND AFFILIATED HOSPITAL OF NANJING MEDICAL UNIVERSITY   (China)

Author keywords

HOXA5; Invasion; miR 196a; Non small cell lung cancer; Proliferation

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; DNA; LUCIFERASE; MICRORNA; MICRORNA 196A; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR HOXA5; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ARTICLE; CANCER CELL CULTURE; CANCER STAGING; CANCER TISSUE; CELL ASSAY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA METHYLATION; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; LYMPH NODE METASTASIS; PLASMID; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SEQUENCE ANALYSIS; STUDENT T TEST; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; CARCINOMA, NON-SMALL-CELL LUNG; CELL GROWTH PROCESSES; CELL LINE, TUMOR; CELL MOVEMENT; DNA METHYLATION; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HUMANS; LUNG NEOPLASMS; MICRORNAS; NEOPLASM INVASIVENESS; UP-REGULATION;

EID: 84864716794     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-12-348     Document Type: Article

References (35)

1. Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010, 60(5):277-300. 10.3322/caac.20073, 20610543.
2. Verdecchia A, Francisci S, Brenner H, Gatta G, Micheli A, Mangone L, Kunkler I. Recent cancer survival in Europe: a 2000-02 period analysis of EUROCARE-4 data. Lancet Oncol 2007, 8(9):784-796. 10.1016/S1470-2045(07)70246-2, 17714993.
3. Farazi TA, Spitzer JI, Morozov P, Tuschl T. miRNAs in human cancer. J Pathol 2011, 223(2):102-115. 10.1002/path.2806, 3069496, 21125669.
4. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2):281-297. 10.1016/S0092-8674(04)00045-5, 14744438.
5. Chitwood DH, Timmermans MC. Small RNAs are on the move. Nature 2010, 467(7314):415-419. 10.1038/nature09351, 20864994.
6. Kosik KS. MicroRNAs and cellular phenotypy. Cell 2010, 143(1):21-26. 10.1016/j.cell.2010.09.008, 20887887.
7. Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006, 6(11):857-866. 10.1038/nrc1997, 17060945.
8. Ding J, Huang S, Wu S, Zhao Y, Liang L, Yan M, Ge C, Yao J, Chen T, Wan D, et al. Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA. Nat Cell Biol 2010, 12(4):390-399. 10.1038/ncb2039, 20305651.
9. Hui AB, Shi W, Boutros PC, Miller N, Pintilie M, Fyles T, McCready D, Wong D, Gerster K, Waldron L, et al. Robust global micro-RNA profiling with formalin-fixed paraffin-embedded breast cancer tissues. Lab Invest 2009, 89(5):597-606. 10.1038/labinvest.2009.12, 19290006.
10. Wang YX, Zhang XY, Zhang BF, Yang CQ, Chen XM, Gao HJ. Initial study of microRNA expression profiles of colonic cancer without lymph node metastasis. J Dig Dis 2010, 11(1):50-54. 10.1111/j.1751-2980.2009.00413.x, 20132431.
11. Sun M, Liu XH, Li JH, Yang JS, Zhang EB, Yin DD, Liu ZL, Zhou J, Ding Y, Li SQ, et al. MiR-196a Is Upregulated in Gastric Cancer and Promotes Cell Proliferation by Downregulating p27kip1. Mol Cancer Ther 2012, 11(4):842-852. 10.1158/1535-7163.MCT-11-1015, 22343731.
12. Wang R, Wang ZX, Yang JS, Pan X, De W, Chen LB. MicroRNA-451 functions as a tumor suppressor in human non-small cell lung cancer by targeting ras-related protein 14 (RAB14). Oncogene 2011, 30(23):2644-2658. 10.1038/onc.2010.642, 21358675.
13. Braig S, Mueller DW, Rothhammer T, Bosserhoff A-K. MicroRNA miR-196a is a central regulator of HOX-B7 and BMP4 expression in malignant melanoma. Cellular and Molecular Life Sciences 2010, 67(20):3535-3548. 10.1007/s00018-010-0394-7, 20480203.
14. Mueller DW, Bosserhoff AK. MicroRNA miR-196a controls melanoma-associated genes by regulating HOX-C8 expression. Int J Cancer 2011, 129(5):1064-1074. 10.1002/ijc.25768, 21077158.
15. Guan Y, Mizoguchi M, Yoshimoto K, Hata N, Shono T, Suzuki SO, Araki Y, Kuga D, Nakamizo A, Amano T, et al. MiRNA-196 Is Upregulated in Glioblastoma But Not in Anaplastic Astrocytoma and Has Prognostic Significance. Clinical Cancer Research 2010, 16(16):4289-4297. 10.1158/1078-0432.CCR-10-0207, 20601442.
16. Luthra R, Singh RR, Luthra MG, Li YX, Hannah C, Romans AM, Barkoh BA, Chen SS, Ensor J, Maru DM, et al. MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. Oncogene 2008, 27(52):6667-6678. 10.1038/onc.2008.256, 18663355.
17. Schimanski CC, Frerichs K, Rahman F, Berger M, Lang H, Galle PR, Moehler M, Gockel I. High miR-196a levels promote the oncogenic phenotype of colorectal cancer cells. World J Gastroenterol 2009, 15(17):2089-2096. 10.3748/wjg.15.2089, 2678579, 19418581.
18. Zhang SZ. Knockdown of c-Met by adenovirus-delivered small interfering RNA inhibits hepatocellular carcinoma growth in vitro and in vivo. Molecular Cancer Therapeutics 2005, 4(10):1577-1584. 10.1158/1535-7163.MCT-05-0106, 16227408.
19. Abramovich C, Humphries RK. Hox regulation of normal and leukemic hematopoietic stem cells. Curr Opin Hematol 2005, 12(3):210-216. 10.1097/01.moh.0000160737.52349.aa, 15867577.
20. Iimura T, Pourquie O. Hox genes in time and space during vertebrate body formation. Dev Growth Differ 2007, 49(4):265-275. 10.1111/j.1440-169X.2007.00928.x, 17501904.
21. Moens CB, Selleri L. Hox cofactors in vertebrate development. Dev Biol 2006, 291(2):193-206. 10.1016/j.ydbio.2005.10.032, 16515781.
22. Magli MC, Barba P, Celetti A, De Vita G, Cillo C, Boncinelli E. Coordinate regulation of HOX genes in human hematopoietic cells. Proc Natl Acad Sci U S A 1991, 88(14):6348-6352. 10.1073/pnas.88.14.6348, 52080, 1712489.
23. Daniels TR, Neacato II, Rodriguez JA, Pandha HS, Morgan R, Penichet ML. Disruption of HOX activity leads to cell death that can be enhanced by the interference of iron uptake in malignant B cells. Leukemia 2010, 24(9):1555-1565. 10.1038/leu.2010.142, 20574452.
24. Morgan R, Pirard PM, Shears L, Sohal J, Pettengell R, Pandha HS. Antagonism of HOX/PBX dimer formation blocks the in vivo proliferation of melanoma. Cancer Res 2007, 67(12):5806-5813. 10.1158/0008-5472.CAN-06-4231, 17575148.
25. Morgan R, Plowright L, Harrington KJ, Michael A, Pandha HS. Targeting HOX and PBX transcription factors in ovarian cancer. BMC Cancer 2010, 10:89. 10.1186/1471-2407-10-89, 2846885, 20219106.
26. Plowright L, Harrington KJ, Pandha HS, Morgan R. HOX transcription factors are potential therapeutic targets in non-small-cell lung cancer (targeting HOX genes in lung cancer). Br J Cancer 2009, 100(3):470-475. 10.1038/sj.bjc.6604857, 2658540, 19156136.
27. Shears L, Plowright L, Harrington K, Pandha HS, Morgan R. Disrupting the interaction between HOX and PBX causes necrotic and apoptotic cell death in the renal cancer lines CaKi-2 and 769-P. J Urol 2008, 180(5):2196-2201. 10.1016/j.juro.2008.07.018, 18804814.
28. Aulisa L, Forraz N, McGuckin C, Hartgerink JD. Inhibition of cancer cell proliferation by designed peptide amphiphiles. Acta Biomater 2009, 5(3):842-853. 10.1016/j.actbio.2008.11.002, 19249722.
29. Mandeville I, Aubin J, LeBlanc M, Lalancette-Hebert M, Janelle MF, Tremblay GM, Jeannotte L. Impact of the loss of Hoxa5 function on lung alveogenesis. Am J Pathol 2006, 169(4):1312-1327. 10.2353/ajpath.2006.051333, 1698857, 17003488.
30. Packer AI, Mailutha KG, Ambrozewicz LA, Wolgemuth DJ. Regulation of the Hoxa4 and Hoxa5 genes in the embryonic mouse lung by retinoic acid and TGFbeta1: implications for lung development and patterning. Dev Dyn 2000, 217(1):62-74. 10.1002/(SICI)1097-0177(200001)217:1<62::AID-DVDY6>3.0.CO;2-U, 10679930.
31. Golpon HA, Geraci MW, Moore MD, Miller HL, Miller GJ, Tuder RM, Voelkel NF. HOX genes in human lung: altered expression in primary pulmonary hypertension and emphysema. Am J Pathol 2001, 158(3):955-966. 10.1016/S0002-9440(10)64042-4, 1850338, 11238043.
32. Raman V, Martensen SA, Reisman D, Evron E, Odenwald WF, Jaffee E, Marks J, Sukumar S. Compromised HOXA5 function can limit p53 expression in human breast tumours. Nature 2000, 405(6789):974-978. 10.1038/35016125, 10879542.
33. Gendronneau G, Lemieux M, Morneau M, Paradis J, Tetu B, Frenette N, Aubin J, Jeannotte L. Influence of Hoxa5 on p53 tumorigenic outcome in mice. Am J Pathol 2010, 176(2):995-1005. 10.2353/ajpath.2010.090499, 2808102, 20042682.
34. Raman V, Tamori A, Vali M, Zeller K, Korz D, Sukumar S. HOXA5 regulates expression of the progesterone receptor. J Biol Chem 2000, 275(34):26551-26555. 10.1074/jbc.C000324200, 10875927.
35. Chen H, Zhang H, Lee J, Liang X, Wu X, Zhu T, Lo PK, Zhang X, Sukumar S. HOXA5 acts directly downstream of retinoic acid receptor beta and contributes to retinoic acid-induced apoptosis and growth inhibition. Cancer Res 2007, 67(17):8007-8013. 10.1158/0008-5472.CAN-07-1405, 17804711.