RNA duplexes with abasic substitutions are potent and allele-selective inhibitors of huntingtin and ataxin-3 expression

Nucleic Acids Research

Volumn 41, Issue 18, 2013, Pages 8788-8801

  Liu, Jing ^a   Pendergraff, Hannah ^a,b,c   Narayanannair, K Jayaprakash ^c   Lackey, Jeremy G ^c   Kuchimanchi, Satya ^c   Rajeev, Kallanthottathil G ^c   Manoharan, Muthiah ^c   Hu, Jiaxin ^a   Corey, David R ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c ALNYLAM PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 3; HUNTINGTIN; MESSENGER RNA;

ALLELE; ARTICLE; ATAXIN 3 GENE; BASE MISPAIRING; CAG REPEAT; CATALYSIS; CONTROLLED STUDY; GENE SILENCING; HUMAN; HUMAN CELL; HUNTINGTIN GENE; HUNTINGTON CHOREA; MACHADO JOSEPH DISEASE; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA INTERFERENCE; RNA SEQUENCE; RNA SYNTHESIS;

ALLELES; BASE PAIR MISMATCH; CELL LINE; HUMANS; HUNTINGTON DISEASE; MACHADO-JOSEPH DISEASE; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84885945709     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkt594     Document Type: Article

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