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Volumn 1, Issue 1, 2013, Pages 43-52

MicroRNA and Epigenetics: Diagnostic and Therapeutic Opportunities

Author keywords

Biomarkers; Cancer; Diagnosis; Epigenetics; MicroRNA; Pathobiology; Therapy

Indexed keywords


EID: 84885860212     PISSN: None     EISSN: 2167485X     Source Type: Journal    
DOI: 10.1007/s40139-013-0008-9     Document Type: Article
Times cited : (33)

References (72)
  • 1
    • 77955902024 scopus 로고    scopus 로고
    • The widespread regulation of microRNA biogenesis function and decay
    • COI: 1:CAS:528:DC%2BC3cXhtVCnurzF
    • Krol J, Loedige I, Filipowicz W (2010) The widespread regulation of microRNA biogenesis function and decay. Nat Rev 11:597–610
    • (2010) Nat Rev , vol.11 , pp. 597-610
    • Krol, J.1    Loedige, I.2    Filipowicz, W.3
  • 2
    • 60149095444 scopus 로고    scopus 로고
    • Most mammalian mRNAs are conserved targets of microRNAs
    • PID: 18955434, COI: 1:CAS:528:DC%2BD1MXptFWjuw%3D%3D
    • Friedman RC, Farh KK, Burge CB et al (2009) Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19(1):92–105
    • (2009) Genome Res , vol.19 , Issue.1 , pp. 92-105
    • Friedman, R.C.1    Farh, K.K.2    Burge, C.B.3
  • 3
    • 9144224451 scopus 로고    scopus 로고
    • Processing of primary microRNAs by the Microprocessor complex
    • COI: 1:CAS:528:DC%2BD2cXpsF2gtrY%3D
    • Denli AM, Tops BB, Plasterk RH et al (2004) Processing of primary microRNAs by the Microprocessor complex. Nat Rev 432:231–235
    • (2004) Nat Rev , vol.432 , pp. 231-235
    • Denli, A.M.1    Tops, B.B.2    Plasterk, R.H.3
  • 4
    • 77953183812 scopus 로고    scopus 로고
    • A dicer-independent miRNA biogenesis pathway that requires Ago catalysis
    • PID: 20424607, COI: 1:CAS:528:DC%2BC3cXmvFWksbY%3D
    • Cheloufi S, Dos Santos CO, Chong MM et al (2010) A dicer-independent miRNA biogenesis pathway that requires Ago catalysis. Nature 465:584–589
    • (2010) Nature , vol.465 , pp. 584-589
    • Cheloufi, S.1    Dos Santos, C.O.2    Chong, M.M.3
  • 5
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: small RNAs with a big role in gene regulation
    • PID: 15211354, COI: 1:CAS:528:DC%2BD2cXltVSmsbw%3D
    • He L, Hannon GJ (2004) MicroRNAs: small RNAs with a big role in gene regulation. Nat Rev Genet 5(7):522–531
    • (2004) Nat Rev Genet , vol.5 , Issue.7 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 6
    • 77949875682 scopus 로고    scopus 로고
    • MicroRNA control of signal transduction
    • PID: 20216554, COI: 1:CAS:528:DC%2BC3cXivFKnsbg%3D
    • Inui M, Martello G, Piccolo S (2010) MicroRNA control of signal transduction. Nat Rev Mol Cell Biol 11(4):252–263
    • (2010) Nat Rev Mol Cell Biol , vol.11 , Issue.4 , pp. 252-263
    • Inui, M.1    Martello, G.2    Piccolo, S.3
  • 7
    • 58649107855 scopus 로고    scopus 로고
    • MicroRNA and cancer—focus on apoptosis
    • PID: 19175697
    • Wang Y, Lee CG (2009) MicroRNA and cancer—focus on apoptosis. J Cell Mol Med 13(1):12–23
    • (2009) J Cell Mol Med , vol.13 , Issue.1 , pp. 12-23
    • Wang, Y.1    Lee, C.G.2
  • 8
    • 81855224576 scopus 로고    scopus 로고
    • Epigenetics and genetics. MicroRNAs en route to the clinic: Progress in validating and targeting microRNAs for cancer therapy
    • This study discusses the progress using mouse models to understand the roles of miRNAs in cancer and the potential for manipulating miRNAs for cancer therapy
    • •• Kasinski AL, Slack FJ (2011) Epigenetics and genetics. MicroRNAs en route to the clinic: progress in validating and targeting microRNAs for cancer therapy. Nat Rev 11:849–864. This study discusses the progress using mouse models to understand the roles of miRNAs in cancer and the potential for manipulating miRNAs for cancer therapy.
    • (2011) Nat Rev , vol.11 , pp. 849-864
    • Kasinski, A.L.1    Slack, F.J.2
  • 9
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • This report presents evidence for the involvement of miRNA genes in human tumors, and provides further evidence of the significance of this growing family of regulatory genes
    • • Calin GA, Dumitru CD, Shimizu M et al (2002) Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 99(24):15524–15529. This report presents evidence for the involvement of miRNA genes in human tumors, and provides further evidence of the significance of this growing family of regulatory genes.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.24 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 10
    • 12144290519 scopus 로고    scopus 로고
    • Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers
    • PID: 14973191, COI: 1:CAS:528:DC%2BD2cXitlWhtr8%3D
    • Calin GA, Sevignani C, Dumitru CD et al (2004) Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancers. Proc Natl Acad Sci USA 101(9):2999–3004
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.9 , pp. 2999-3004
    • Calin, G.A.1    Sevignani, C.2    Dumitru, C.D.3
  • 11
    • 66049130038 scopus 로고    scopus 로고
    • MicroRNAs and cancer—new paradigms in molecular oncology
    • PID: 19411171, COI: 1:CAS:528:DC%2BD1MXmvFGns78%3D
    • Negrini M, Nicoloso MS, Calin GA (2009) MicroRNAs and cancer—new paradigms in molecular oncology. Curr Opin Cell Biol 21(3):470–479
    • (2009) Curr Opin Cell Biol , vol.21 , Issue.3 , pp. 470-479
    • Negrini, M.1    Nicoloso, M.S.2    Calin, G.A.3
  • 12
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • PID: 21874049, COI: 1:CAS:528:DC%2BC3MXhtV2gsb7L
    • Davalos V, Moutinho C, Villanueva A et al (2012) Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 31(16):2062–2074
    • (2012) Oncogene , vol.31 , Issue.16 , pp. 2062-2074
    • Davalos, V.1    Moutinho, C.2    Villanueva, A.3
  • 13
    • 77958050722 scopus 로고    scopus 로고
    • Mechanisms of control of microRNA biogenesis
    • PID: 20833630, COI: 1:CAS:528:DC%2BC3cXht1Ogsb3N
    • Davis-Dusenbery BN, Hata A (2010) Mechanisms of control of microRNA biogenesis. J Biochem 148(4):381–392
    • (2010) J Biochem , vol.148 , Issue.4 , pp. 381-392
    • Davis-Dusenbery, B.N.1    Hata, A.2
  • 14
    • 84862182826 scopus 로고    scopus 로고
    • The duality of oncomiR addiction in the maintenance and treatment of cancer
    • PID: 22647359
    • Cheng CJ, Slack FJ (2012) The duality of oncomiR addiction in the maintenance and treatment of cancer. Cancer J 18(3):232–237
    • (2012) Cancer J , vol.18 , Issue.3 , pp. 232-237
    • Cheng, C.J.1    Slack, F.J.2
  • 15
    • 72849120988 scopus 로고    scopus 로고
    • miR-19 is a key oncogenic component of mir-17-92
    • PID: 20008935, COI: 1:CAS:528:DC%2BC3cXntFKn
    • Olive V, Bennett MJ, Walker JC et al (2009) miR-19 is a key oncogenic component of mir-17-92. Genes Dev 23(24):2839–2849
    • (2009) Genes Dev , vol.23 , Issue.24 , pp. 2839-2849
    • Olive, V.1    Bennett, M.J.2    Walker, J.C.3
  • 16
    • 72849125619 scopus 로고    scopus 로고
    • Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas
    • PID: 20008931, COI: 1:CAS:528:DC%2BC3cXntFKj
    • Mu P, Han YC, Betel D et al (2009) Genetic dissection of the miR-17~92 cluster of microRNAs in Myc-induced B-cell lymphomas. Genes Dev 23(24):2806–2811
    • (2009) Genes Dev , vol.23 , Issue.24 , pp. 2806-2811
    • Mu, P.1    Han, Y.C.2    Betel, D.3
  • 17
    • 42249093319 scopus 로고    scopus 로고
    • LNA-mediated microRNA silencing in non-human primates
    • PID: 18368051
    • Elmén J, Lindow M, Schütz S et al (2008) LNA-mediated microRNA silencing in non-human primates. Nature 452(7189):896–899
    • (2008) Nature , vol.452 , Issue.7189 , pp. 896-899
    • Elmén, J.1    Lindow, M.2    Schütz, S.3
  • 18
    • 37349113774 scopus 로고    scopus 로고
    • Inhibition of microRNA with antisense oligonucleotides
    • The focus of this review was the use of antisense oligonucleotides (antimiRs) in miRNA inhibition for loss-of-function studies. It summarizes the employed antisense chemistries and their utility in designing antimiR oligonucleotides, and describes in vivo delivery strategies and approaches for assessment of miRNA inhibition and potential off-target effects
    • • Esau C (2008) Inhibition of microRNA with antisense oligonucleotides. Methods Mol Biol 41(1):55–60. The focus of this review was the use of antisense oligonucleotides (antimiRs) in miRNA inhibition for loss-of-function studies. It summarizes the employed antisense chemistries and their utility in designing antimiR oligonucleotides, and describes in vivo delivery strategies and approaches for assessment of miRNA inhibition and potential off-target effects.
    • (2008) Methods Mol Biol , vol.41 , Issue.1 , pp. 55-60
    • Esau, C.1
  • 19
    • 28444469246 scopus 로고    scopus 로고
    • Silencing of microRNAs in vivo with ‘antagomirs’
    • The findings of this article show that antagomirs are powerful tools to silence specific miRNAs in vivo and may represent a therapeutic strategy for silencing miRNAs in disease
    • •• Krützfeldt J, Rajewsky N, Braich R et al (2005) Silencing of microRNAs in vivo with ‘antagomirs’. Nature 438(7068):685–689. The findings of this article show that antagomirs are powerful tools to silence specific miRNAs in vivo and may represent a therapeutic strategy for silencing miRNAs in disease.
    • (2005) Nature , vol.438 , Issue.7068 , pp. 685-689
    • Krützfeldt, J.1    Rajewsky, N.2    Braich, R.3
  • 20
    • 48249098902 scopus 로고    scopus 로고
    • Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM
    • PID: 18493594
    • Fontana L, Fiori ME, Albini S et al (2008) Antagomir-17-5p abolishes the growth of therapy-resistant neuroblastoma through p21 and BIM. PLoS ONE 3(5):e2236
    • (2008) PLoS ONE , vol.3 , Issue.5
    • Fontana, L.1    Fiori, M.E.2    Albini, S.3
  • 21
    • 77950665077 scopus 로고    scopus 로고
    • Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model
    • PID: 20351690, COI: 1:CAS:528:DC%2BC3cXjvFars74%3D
    • Ma L, Reinhardt F, Pan E et al (2010) Therapeutic silencing of miR-10b inhibits metastasis in a mouse mammary tumor model. Nat Biotechnol 28(4):341–347
    • (2010) Nat Biotechnol , vol.28 , Issue.4 , pp. 341-347
    • Ma, L.1    Reinhardt, F.2    Pan, E.3
  • 22
    • 84255192032 scopus 로고    scopus 로고
    • MiR-221 silencing blocks hepatocellular carcinoma and promotes survival
    • These findings proved the preclinical efficacy of chol-anti-miR-221 in a valid orthotopic mouse model of hepatocellular carcinoma. Results suggest that targeting this miRNA serves a therapeutic benefit for patients with advanced disease
    • •• Park JK, Kogure T, Nuovo GJ et al (2011) miR-221 silencing blocks hepatocellular carcinoma and promotes survival. Cancer Res 71(24):7608–7616. These findings proved the preclinical efficacy of chol-anti-miR-221 in a valid orthotopic mouse model of hepatocellular carcinoma. Results suggest that targeting this miRNA serves a therapeutic benefit for patients with advanced disease.
    • (2011) Cancer Res , vol.71 , Issue.24 , pp. 7608-7616
    • Park, J.K.1    Kogure, T.2    Nuovo, G.J.3
  • 23
    • 77949563626 scopus 로고    scopus 로고
    • Down-modulation of survivin expression and inhibition of tumor growth in vivo by EZN-3042, a locked nucleic acid antisense oligonucleotide
    • PID: 20391197, COI: 1:CAS:528:DC%2BC3cXkslKrtbs%3D
    • Sapra P, Wang M, Bandaru R et al (2010) Down-modulation of survivin expression and inhibition of tumor growth in vivo by EZN-3042, a locked nucleic acid antisense oligonucleotide. Nucleosides Nucleotides Nucleic Acids 29(2):97–112
    • (2010) Nucleosides Nucleotides Nucleic Acids , vol.29 , Issue.2 , pp. 97-112
    • Sapra, P.1    Wang, M.2    Bandaru, R.3
  • 24
    • 63349085394 scopus 로고    scopus 로고
    • A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference
    • PID: 19136465
    • Lu Y, Xiao J, Lin H et al (2009) A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res 37(3):e24
    • (2009) Nucleic Acids Res , vol.37 , Issue.3
    • Lu, Y.1    Xiao, J.2    Lin, H.3
  • 25
    • 81355142141 scopus 로고    scopus 로고
    • Non-coding RNAs in human disease
    • PID: 22094949, COI: 1:CAS:528:DC%2BC3MXhsVyktrfL
    • Esteller M (2011) Non-coding RNAs in human disease. Nat Rev Genet 12(12):861–874
    • (2011) Nat Rev Genet , vol.12 , Issue.12 , pp. 861-874
    • Esteller, M.1
  • 26
    • 38949133928 scopus 로고    scopus 로고
    • MicroRNAs as targets for antisense-based therapeutics
    • PID: 18081537, COI: 1:CAS:528:DC%2BD2sXhsVegurvO
    • Stenvang J, Kauppinen S (2008) MicroRNAs as targets for antisense-based therapeutics. Expert Opin Biol Ther 8(1):59–81
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.1 , pp. 59-81
    • Stenvang, J.1    Kauppinen, S.2
  • 27
    • 77649275464 scopus 로고    scopus 로고
    • miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis
    • PID: 20173740, COI: 1:CAS:528:DC%2BC3cXisFems7g%3D
    • Ma L, Young J, Prabhala H et al (2010) miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasis. Nat Cell Biol 12(3):247–256
    • (2010) Nat Cell Biol , vol.12 , Issue.3 , pp. 247-256
    • Ma, L.1    Young, J.2    Prabhala, H.3
  • 29
    • 34047270440 scopus 로고    scopus 로고
    • Characterization of microRNA expression levels and their biological correlates in human cancer cell lines
    • PID: 17363563, COI: 1:CAS:528:DC%2BD2sXivV2gu78%3D
    • Gaur A, Jewell DA, Liang Y et al (2007) Characterization of microRNA expression levels and their biological correlates in human cancer cell lines. Cancer Res 67(6):2456–2468
    • (2007) Cancer Res , vol.67 , Issue.6 , pp. 2456-2468
    • Gaur, A.1    Jewell, D.A.2    Liang, Y.3
  • 30
    • 34247593034 scopus 로고    scopus 로고
    • Impaired microRNA processing enhances cellular transformation and tumorigenesis
    • PID: 17401365, COI: 1:CAS:528:DC%2BD2sXksFersLo%3D
    • Kumar MS, Lu J, Mercer KL et al (2007) Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nat Genet 39(5):673–677
    • (2007) Nat Genet , vol.39 , Issue.5 , pp. 673-677
    • Kumar, M.S.1    Lu, J.2    Mercer, K.L.3
  • 31
    • 58049213696 scopus 로고    scopus 로고
    • Dicer, Drosha, and outcomes in patients with ovarian cancer
    • PID: 19092150, COI: 1:CAS:528:DC%2BD1cXhsFaltL3O
    • Merritt WM, Lin YG, Han LY et al (2008) Dicer, Drosha, and outcomes in patients with ovarian cancer. N Engl J Med 359(25):2641–2650
    • (2008) N Engl J Med , vol.359 , Issue.25 , pp. 2641-2650
    • Merritt, W.M.1    Lin, Y.G.2    Han, L.Y.3
  • 32
    • 38849209304 scopus 로고    scopus 로고
    • Not miR-ly small RNAs: big potential for microRNAs in therapy
    • PID: 18269923, COI: 1:CAS:528:DC%2BD1cXhsl2gsro%3D
    • Love TM, Moffett HF, Novina CD (2008) Not miR-ly small RNAs: big potential for microRNAs in therapy. J Allergy Clin Immunol 121(2):309–319
    • (2008) J Allergy Clin Immunol , vol.121 , Issue.2 , pp. 309-319
    • Love, T.M.1    Moffett, H.F.2    Novina, C.D.3
  • 33
    • 79960963683 scopus 로고    scopus 로고
    • MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma
    • PID: 21690566, COI: 1:CAS:528:DC%2BC3MXpsVOhu7o%3D
    • Ibrahim AF, Weirauch U, Thomas M et al (2011) MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma. Cancer Res 71(15):5214–5224
    • (2011) Cancer Res , vol.71 , Issue.15 , pp. 5214-5224
    • Ibrahim, A.F.1    Weirauch, U.2    Thomas, M.3
  • 34
    • 66449136951 scopus 로고    scopus 로고
    • Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model
    • PID: 19524505, COI: 1:CAS:528:DC%2BD1MXps1eiurg%3D
    • Kota J, Chivukula RR, O’Donnell KA et al (2009) Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell 137(6):1005–1017
    • (2009) Cell , vol.137 , Issue.6 , pp. 1005-1017
    • Kota, J.1    Chivukula, R.R.2    O’Donnell, K.A.3
  • 35
    • 84869219338 scopus 로고    scopus 로고
    • MiR-34—a microRNA replacement therapy is headed to the clinic
    • This review focuses on the molecular mechanisms of miR-34-mediated tumor suppression, pharmacologies in animal models of cancer, and a status update of a miR-34 therapy that may be among the first miRNA mimics to reach the clinic
    • • Bader AG (2012) miR-34—a microRNA replacement therapy is headed to the clinic. Front Genet 3:120. This review focuses on the molecular mechanisms of miR-34-mediated tumor suppression, pharmacologies in animal models of cancer, and a status update of a miR-34 therapy that may be among the first miRNA mimics to reach the clinic.
    • (2012) Front Genet , vol.3 , pp. 120
    • Bader, A.G.1
  • 36
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • PID: 16766263, COI: 1:CAS:528:DC%2BD28Xmt1eksLY%3D
    • Saito Y, Liang G, Egger G et al (2006) Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 9(6):435–443
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3
  • 37
    • 71549121035 scopus 로고    scopus 로고
    • Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer
    • PID: 19887623, COI: 1:CAS:528:DC%2BD1MXhsV2itLjF
    • Huang YW, Liu JC, Deatherage DE et al (2009) Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res 69(23):9038–9046
    • (2009) Cancer Res , vol.69 , Issue.23 , pp. 9038-9046
    • Huang, Y.W.1    Liu, J.C.2    Deatherage, D.E.3
  • 38
    • 79952717616 scopus 로고    scopus 로고
    • Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing
    • PID: 21368194, COI: 1:CAS:528:DC%2BC3MXjvV2jsLk%3D
    • Melo S, Villanueva A, Moutinho C et al (2011) Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci USA 108(11):4394–4399
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.11 , pp. 4394-4399
    • Melo, S.1    Villanueva, A.2    Moutinho, C.3
  • 39
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: rationale, strategies and challenges
    • COI: 1:CAS:528:DC%2BC3cXht1akur7L
    • Garzon R, Marcucci G, Croce CM (2010) Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discovery 9:775–789
    • (2010) Nat Rev Drug Discovery , vol.9 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 40
    • 83255192141 scopus 로고    scopus 로고
    • Developing therapeutic microRNAs for cancer
    • PID: 21633392, COI: 1:CAS:528:DC%2BC3MXmvVegtbw%3D
    • Bader AG, Brown D, Stoudemire J et al (2011) Developing therapeutic microRNAs for cancer. Gene Ther 18:1121–1126
    • (2011) Gene Ther , vol.18 , pp. 1121-1126
    • Bader, A.G.1    Brown, D.2    Stoudemire, J.3
  • 42
    • 55549114664 scopus 로고    scopus 로고
    • The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    • This article proposed that miR-15a and miR-16 act as tumor suppressor genes prostate cancer through the control of cell survival, proliferation and invasion. Moreover, they suggest that the therapeutic implications found may be exploited for future treatment of prostate cancer
    • • Bonci D, Coppola V, Musumeci M et al (2008) The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities. Nat Med 14(11):1271–1277. This article proposed that miR-15a and miR-16 act as tumor suppressor genes in prostate cancer through the control of cell survival, proliferation and invasion. Moreover, they suggest that the therapeutic implications found may be exploited for future treatment of prostate cancer.
    • (2008) Nat Med , vol.14 , Issue.11 , pp. 1271-1277
    • Bonci, D.1    Coppola, V.2    Musumeci, M.3
  • 43
    • 84859125688 scopus 로고    scopus 로고
    • MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth
    • PID: 22479342, COI: 1:CAS:528:DC%2BC38XlsFyksrc%3D
    • Nadiminty N, Tummala R, Lou W et al (2012) MicroRNA let-7c is downregulated in prostate cancer and suppresses prostate cancer growth. PLoS ONE 7(3):e32832
    • (2012) PLoS ONE , vol.7 , Issue.3
    • Nadiminty, N.1    Tummala, R.2    Lou, W.3
  • 44
    • 77952550515 scopus 로고    scopus 로고
    • Role of anti-oncomirs miR-143 and -145 in human colorectal tumors
    • PID: 20094072, COI: 1:CAS:528:DC%2BC3cXps1GksA%3D%3D
    • Akao Y, Nakagawa Y, Hirata I et al (2010) Role of anti-oncomirs miR-143 and -145 in human colorectal tumors. Cancer Gene Ther 17(6):398–408
    • (2010) Cancer Gene Ther , vol.17 , Issue.6 , pp. 398-408
    • Akao, Y.1    Nakagawa, Y.2    Hirata, I.3
  • 45
    • 80051590849 scopus 로고    scopus 로고
    • Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice
    • PID: 21622730, COI: 1:CAS:528:DC%2BC3MXhtFSqtLbK
    • Pramanik D, Campbell NR, Karikari C et al (2011) Restitution of tumor suppressor microRNAs using a systemic nanovector inhibits pancreatic cancer growth in mice. Mol Cancer Ther 10(8):1470–1480
    • (2011) Mol Cancer Ther , vol.10 , Issue.8 , pp. 1470-1480
    • Pramanik, D.1    Campbell, N.R.2    Karikari, C.3
  • 46
    • 80052698948 scopus 로고    scopus 로고
    • Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells
    • PID: 21712475, COI: 1:CAS:528:DC%2BC3MXhtFCjurnE
    • Rai K, Takigawa N, Ito S et al (2011) Liposomal delivery of MicroRNA-7-expressing plasmid overcomes epidermal growth factor receptor tyrosine kinase inhibitor-resistance in lung cancer cells. Mol Cancer Ther 10(9):1720–1727
    • (2011) Mol Cancer Ther , vol.10 , Issue.9 , pp. 1720-1727
    • Rai, K.1    Takigawa, N.2    Ito, S.3
  • 47
    • 78650624101 scopus 로고    scopus 로고
    • RNA interference in the clinic: challenges and future directions
    • PID: 21160526, COI: 1:CAS:528:DC%2BC3cXhsFKlsr%2FI
    • Pecot CV, Calin GA, Coleman RL et al (2011) RNA interference in the clinic: challenges and future directions. Nat Rev Cancer 11(1):59–67
    • (2011) Nat Rev Cancer , vol.11 , Issue.1 , pp. 59-67
    • Pecot, C.V.1    Calin, G.A.2    Coleman, R.L.3
  • 48
    • 0242719919 scopus 로고    scopus 로고
    • Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line
    • PID: 14738153
    • Gutiérrez-Puente Y, Tari AM, Ford RJ et al (2003) Cellular pharmacology of P-ethoxy antisense oligonucleotides targeted to Bcl-2 in a follicular lymphoma cell line. Leuk Lymphoma 44(11):1979–1985
    • (2003) Leuk Lymphoma , vol.44 , Issue.11 , pp. 1979-1985
    • Gutiérrez-Puente, Y.1    Tari, A.M.2    Ford, R.J.3
  • 49
    • 23044506285 scopus 로고    scopus 로고
    • Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery
    • PID: 16061675, COI: 1:CAS:528:DC%2BD2MXmvFSlur0%3D
    • Landen CN Jr, Chavez-Reyes A, Bucana C et al (2005) Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery. Cancer Res 65(15):6910–6918
    • (2005) Cancer Res , vol.65 , Issue.15 , pp. 6910-6918
    • Landen, C.N.1    Chavez-Reyes, A.2    Bucana, C.3
  • 50
    • 79957900919 scopus 로고    scopus 로고
    • Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice
    • PID: 21427705, COI: 1:CAS:528:DC%2BC3MXjsF2itb8%3D
    • Trang P, Wiggins JF, Daige CL et al (2011) Systemic delivery of tumor suppressor microRNA mimics using a neutral lipid emulsion inhibits lung tumors in mice. Mol Ther 19(6):1116–1122
    • (2011) Mol Ther , vol.19 , Issue.6 , pp. 1116-1122
    • Trang, P.1    Wiggins, J.F.2    Daige, C.L.3
  • 51
    • 80052632447 scopus 로고    scopus 로고
    • MiR-34a targeting of notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma
    • PID: 21931765
    • de Antonellis P, Medaglia C, Cusanelli E et al (2011) MiR-34a targeting of notch ligand delta-like 1 impairs CD15+/CD133+ tumor-propagating cells and supports neural differentiation in medulloblastoma. PLoS ONE 6(9):e24584
    • (2011) PLoS ONE , vol.6 , Issue.9
    • de Antonellis, P.1    Medaglia, C.2    Cusanelli, E.3
  • 52
    • 84864342160 scopus 로고    scopus 로고
    • The role of miRNAs as key regulators in the neoplastic microenvironment
    • Wentz-Hunter KK, Potashkin JA (2011) The role of miRNAs as key regulators in the neoplastic microenvironment. Mol Biol Int. doi: 10.4061/2011/839872
    • (2011) Mol Biol Int
    • Wentz-Hunter, K.K.1    Potashkin, J.A.2
  • 53
    • 48749122914 scopus 로고    scopus 로고
    • Circulating microRNAs as stable blood-based markers for cancer detection
    • PID: 18663219, COI: 1:CAS:528:DC%2BD1cXpsVCltL0%3D
    • Mitchell PS, Parkin RK, Kroh EM et al (2008) Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci USA 105(30):10513–10518
    • (2008) Proc Natl Acad Sci USA , vol.105 , Issue.30 , pp. 10513-10518
    • Mitchell, P.S.1    Parkin, R.K.2    Kroh, E.M.3
  • 54
    • 53349177819 scopus 로고    scopus 로고
    • Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases
    • PID: 18766170, COI: 1:CAS:528:DC%2BD1cXhtF2hsbbE
    • Chen X, Ba Y, Ma L et al (2008) Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res 18(10):997–1006
    • (2008) Cell Res , vol.18 , Issue.10 , pp. 997-1006
    • Chen, X.1    Ba, Y.2    Ma, L.3
  • 55
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • PID: 14508493, COI: 1:CAS:528:DC%2BD3sXnsV2kt7s%3D
    • Lee Y, Ahn C, Han J et al (2003) The nuclear RNase III Drosha initiates microRNA processing. Nature 425(6956):415–419
    • (2003) Nature , vol.425 , Issue.6956 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 56
    • 84869741959 scopus 로고    scopus 로고
    • Circulating microRNAs: New biomarkers in diagnosis, prognosis and treatment of cancer (review)
    • This manuscript emphasizes that miRNA profiling could improve the diagnosis of cancer and could predict patient outcome. Alterations in circulating miRNA may signal a predisposition to cancer, exalting the importance of these profiles as therapeutic targets in cancer patients
    • •• Allegra A, Alonci A, Campo S et al (2012) Circulating microRNAs: new biomarkers in diagnosis, prognosis and treatment of cancer (review). Int J Oncol 41(6):1897–1912. This manuscript emphasizes that miRNA profiling could improve the diagnosis of cancer and could predict patient outcome. Alterations in circulating miRNA may signal a predisposition to cancer, exalting the importance of these profiles as therapeutic targets in cancer patients.
    • (2012) Int J Oncol , vol.41 , Issue.6 , pp. 1897-1912
    • Allegra, A.1    Alonci, A.2    Campo, S.3
  • 57
    • 78149358386 scopus 로고    scopus 로고
    • Accessed December 2012
    • National Cancer Institute (2012) Cancer statistics. Available at http://www.cancer.gov/statistics/find. Accessed December 2012
    • (2012) Cancer Statistics
  • 58
    • 84977478146 scopus 로고    scopus 로고
    • MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer
    • PID: 21300873, COI: 1:CAS:528:DC%2BC3MXivFOgsLs%3D
    • Boeri M, Verri C, Conte D et al (2011) MicroRNA signatures in tissues and plasma predict development and prognosis of computed tomography detected lung cancer. Proc Natl Acad Sci USA 108(9):3713–3718
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.9 , pp. 3713-3718
    • Boeri, M.1    Verri, C.2    Conte, D.3
  • 59
    • 80052027132 scopus 로고    scopus 로고
    • Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers
    • Shen J, Liu Z, Todd NW et al (2011) Diagnosis of lung cancer in individuals with solitary pulmonary nodules by plasma microRNA biomarkers. BMC Cancer. doi: 10.1186/1471-2407-11-374
    • (2011) BMC Cancer
    • Shen, J.1    Liu, Z.2    Todd, N.W.3
  • 60
    • 79959298372 scopus 로고    scopus 로고
    • Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer
    • PID: 21627863, COI: 1:CAS:528:DC%2BC3MXhtVCktLjL
    • Wei J, Gao W, Zhu CJ et al (2011) Identification of plasma microRNA-21 as a biomarker for early detection and chemosensitivity of non-small cell lung cancer. Chin J Cancer 30(6):407–414
    • (2011) Chin J Cancer , vol.30 , Issue.6 , pp. 407-414
    • Wei, J.1    Gao, W.2    Zhu, C.J.3
  • 61
    • 80055051965 scopus 로고    scopus 로고
    • Plasma microRNAs as novel biomarkers for early detection of lung cancer
    • PID: 21904633, COI: 1:CAS:528:DC%2BC3MXhtFGkt73I
    • Zheng D, Haddadin S, Wang Y et al (2011) Plasma microRNAs as novel biomarkers for early detection of lung cancer. Int J Clin Exp Pathol 4(6):575–586
    • (2011) Int J Clin Exp Pathol , vol.4 , Issue.6 , pp. 575-586
    • Zheng, D.1    Haddadin, S.2    Wang, Y.3
  • 62
    • 70349168446 scopus 로고    scopus 로고
    • Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation
    • PID: 19782034, COI: 1:CAS:528:DC%2BD1MXhsVChsrzI
    • Huang X, Ding L, Bennewith KL et al (2009) Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell 35(6):856–867
    • (2009) Mol Cell , vol.35 , Issue.6 , pp. 856-867
    • Huang, X.1    Ding, L.2    Bennewith, K.L.3
  • 63
    • 46049089154 scopus 로고    scopus 로고
    • Accessed December 2012
    • Center for Disease Control and Prevention (2012) Breast cancer. Available at http://www.cdc.gov/cancer/breast/. Accessed December 2012
    • (2012) Breast Cancer
  • 64
    • 78049339462 scopus 로고    scopus 로고
    • Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
    • PID: 21047409, COI: 1:CAS:528:DC%2BC3cXhsVeqtLfK
    • Roth C, Rack B, Müller V et al (2010) Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer. Breast Cancer Res 12(6):R90
    • (2010) Breast Cancer Res , vol.12 , Issue.6 , pp. R90
    • Roth, C.1    Rack, B.2    Müller, V.3
  • 65
    • 84860390095 scopus 로고    scopus 로고
    • Circulating microRNAs: promising breast cancer biomarkers
    • PID: 21345257
    • Heneghan HM, Miller N, Kerin MJ (2011) Circulating microRNAs: promising breast cancer biomarkers. Breast Cancer Res 13(1):402
    • (2011) Breast Cancer Res , vol.13 , Issue.1 , pp. 402
    • Heneghan, H.M.1    Miller, N.2    Kerin, M.J.3
  • 66
    • 84877016115 scopus 로고    scopus 로고
    • Accessed December 2012
    • Center for Disease Control and Prevention (2012) Colorectal cancer. Available at http://www.cdc.gov/cancer/colorectal/. Accessed December 2012
    • (2012) Colorectal Cancer
  • 67
    • 79952752337 scopus 로고    scopus 로고
    • Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis
    • PID: 21445232, COI: 1:CAS:528:DC%2BC3MXktVWhsb0%3D
    • Cheng H, Zhang L, Cogdell DE et al (2011) Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS ONE 6(3):e17745
    • (2011) PLoS ONE , vol.6 , Issue.3
    • Cheng, H.1    Zhang, L.2    Cogdell, D.E.3
  • 68
    • 66049112674 scopus 로고    scopus 로고
    • Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening
    • PID: 19201770, COI: 1:CAS:528:DC%2BD1MXhtlSks7nE
    • Ng EK, Chong WW, Jin H et al (2009) Differential expression of microRNAs in plasma of patients with colorectal cancer: a potential marker for colorectal cancer screening. Gut 58(10):1375–1381
    • (2009) Gut , vol.58 , Issue.10 , pp. 1375-1381
    • Ng, E.K.1    Chong, W.W.2    Jin, H.3
  • 69
    • 79952945610 scopus 로고    scopus 로고
    • Accessed December 2012
    • National Cancer Institute (2012) SEER stat fact sheets: leukemia. Available at http://seer.cancer.gov/statfacts/html/leuks.html. Accessed December 2012
    • (2012) SEER stat fact sheets: Leukemia
  • 70
    • 79955582317 scopus 로고    scopus 로고
    • MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia
    • PID: 21460253, COI: 1:CAS:528:DC%2BC3MXlt1emurw%3D
    • Moussay E, Wang K, Cho JH et al (2011) MicroRNA as biomarkers and regulators in B-cell chronic lymphocytic leukemia. Proc Natl Acad Sci USA 108(16):6573–6578
    • (2011) Proc Natl Acad Sci USA , vol.108 , Issue.16 , pp. 6573-6578
    • Moussay, E.1    Wang, K.2    Cho, J.H.3
  • 71
    • 43449102192 scopus 로고    scopus 로고
    • Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma
    • PID: 18318758
    • Lawrie CH, Gal S, Dunlop HM et al (2008) Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphoma. Br J Haematol 141(5):672–675
    • (2008) Br J Haematol , vol.141 , Issue.5 , pp. 672-675
    • Lawrie, C.H.1    Gal, S.2    Dunlop, H.M.3
  • 72
    • 65849322883 scopus 로고    scopus 로고
    • Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients
    • PID: 19440243
    • Tanaka M, Oikawa K, Takanashi M et al (2009) Down-regulation of miR-92 in human plasma is a novel marker for acute leukemia patients. PLoS ONE 4(5):e5532
    • (2009) PLoS ONE , vol.4 , Issue.5
    • Tanaka, M.1    Oikawa, K.2    Takanashi, M.3


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