메뉴 건너뛰기




Volumn 37, Issue 11, 2013, Pages 1190-1196

Kaempferol inhibits cancer cell growth by antagonizing estrogen-related receptor α and γ activities

Author keywords

Cancer cell; Estrogen related receptor; Kaempferol; Mitochondrial function

Indexed keywords

ERR GAMMA; ESTROGEN RELATED RECEPTOR ALPHA; KAEMPFEROL; ORPHAN NUCLEAR RECEPTOR; UNCLASSIFIED DRUG;

EID: 84885852628     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1002/cbin.10152     Document Type: Article
Times cited : (20)

References (30)
  • 1
    • 0141829776 scopus 로고    scopus 로고
    • Phytoestrogens:a review of the present state of research
    • Andreana L, Ososki EJK. (2003) Phytoestrogens:a review of the present state of research. Phytother Res 17:845-69.
    • (2003) Phytother Res , vol.17 , pp. 845-869
    • Andreana, L.1    Ososki, E.J.K.2
  • 2
    • 0037112441 scopus 로고    scopus 로고
    • Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer
    • Ariazi EA, Clark GM,Mertz JE (2002) Estrogen-related receptor α and estrogen-related receptor γ associate with unfavorable and favorable biomarkers, respectively, in human breast cancer. Cancer Res 62:6510-8.
    • (2002) Cancer Res , vol.62 , pp. 6510-6518
    • Ariazi, E.A.1    Clark, G.M.2    Mertz, J.E.3
  • 3
    • 43549102633 scopus 로고    scopus 로고
    • Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells
    • Bandyopadhyay S, Romero JR, Chattopadhyay N (2008) Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells. Mol Cell Endocrinol 287:57-64.
    • (2008) Mol Cell Endocrinol , vol.287 , pp. 57-64
    • Bandyopadhyay, S.1    Romero, J.R.2    Chattopadhyay, N.3
  • 5
    • 20444500826 scopus 로고    scopus 로고
    • Oestrogen receptor-related receptor alpha (ERRα) and oestrogen receptors (ERα and ERβ) exhibit different gene expression in human colorectal tumour progression
    • Cavallini A, Notarnicola M, Giannini R, Montemurro S, Lorusso D, Visconti A, Minervini F, Caruso MG (2005) Oestrogen receptor-related receptor alpha (ERRα) and oestrogen receptors (ERα and ERβ) exhibit different gene expression in human colorectal tumour progression. Eur J Cancer 41:1487-94.
    • (2005) Eur J Cancer , vol.41 , pp. 1487-1494
    • Cavallini, A.1    Notarnicola, M.2    Giannini, R.3    Montemurro, S.4    Lorusso, D.5    Visconti, A.6    Minervini, F.7    Caruso, M.G.8
  • 6
    • 80054716866 scopus 로고    scopus 로고
    • The metabolic regulator ERRalpha downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer
    • Chang C-Y, Kazmin D, Jasper JS, Kunder R, Zuercher WJ, McDonnell DP (2011) The metabolic regulator ERRalpha downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer. Cancer Cell 20:500-10.
    • (2011) Cancer Cell , vol.20 , pp. 500-510
    • Chang, C.-Y.1    Kazmin, D.2    Jasper, J.S.3    Kunder, R.4    Zuercher, W.J.5    McDonnell, D.P.6
  • 8
    • 0038810035 scopus 로고    scopus 로고
    • An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle
    • Handschin C, Rhee J, Lin J, Tarr PT, Spiegelman BM (2003) An autoregulatory loop controls peroxisome proliferator-activated receptor γ coactivator 1α expression in muscle. Proc Natl Acad Sci 100:7111-6.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 7111-7116
    • Handschin, C.1    Rhee, J.2    Lin, J.3    Tarr, P.T.4    Spiegelman, B.M.5
  • 10
    • 0037174798 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucinerich interaction motif within PGC-1alpha
    • Huss JM, Kopp RP, Kelly DP (2002) Peroxisome proliferatoractivated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucinerich interaction motif within PGC-1alpha. J Biol Chem 277: 40265-74.
    • (2002) J Biol Chem , vol.277 , pp. 40265-74
    • Huss, J.M.1    Kopp, R.P.2    Kelly, D.P.3
  • 11
    • 4744371376 scopus 로고    scopus 로고
    • Estrogenrelated receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle
    • Huss JM, Torra IP, Staels B, Giguere V, Kelly DP (2004) Estrogenrelated receptor α directs peroxisome proliferator-activated receptor α signaling in the transcriptional control of energy metabolism in cardiac and skeletal muscle. Mol Cell Biol 24:9079-91.
    • (2004) Mol Cell Biol , vol.24 , pp. 9079-9091
    • Huss, J.M.1    Torra, I.P.2    Staels, B.3    Giguere, V.4    Kelly, D.P.5
  • 12
    • 0031044228 scopus 로고    scopus 로고
    • Estrogen-related receptor α1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements
    • Johnston SD, Liu X, Zuo F, Eisenbraun TL, Wiley SR, Kraus RJ, Mertz JE (1997) Estrogen-related receptor α1 functionally binds as a monomer to extended half-site sequences including ones contained within estrogen-response elements. Mol Endocrinol 11:342-52.
    • (1997) Mol Endocrinol , vol.11 , pp. 342-352
    • Johnston, S.D.1    Liu, X.2    Zuo, F.3    Eisenbraun, T.L.4    Wiley, S.R.5    Kraus, R.J.6    Mertz, J.E.7
  • 14
    • 0034466972 scopus 로고    scopus 로고
    • Estrogen receptor transcription and transactivation:estrogen receptor alpha and estrogen receptor beta-regulation by selective estrogen receptor modulators and importance in breast cancer
    • Katzenellenbogen BS, Katzenellenbogen JA (2000) Estrogen receptor transcription and transactivation:estrogen receptor alpha and estrogen receptor beta-regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2:335-44.
    • (2000) Breast Cancer Res , vol.2 , pp. 335-344
    • Katzenellenbogen, B.S.1    Katzenellenbogen, J.A.2
  • 16
    • 33744922639 scopus 로고    scopus 로고
    • Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells
    • Oh SM, Kim YP, Chung KH (2006) Biphasic effects of kaempferol on the estrogenicity in human breast cancer cells. Arch Pharm Res 29:354-62.
    • (2006) Arch Pharm Res , vol.29 , pp. 354-362
    • Oh, S.M.1    Kim, Y.P.2    Chung, K.H.3
  • 17
    • 53049102012 scopus 로고    scopus 로고
    • Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species
    • Olszewska M (2008) Separation of quercetin, sexangularetin, kaempferol and isorhamnetin for simultaneous HPLC determination of flavonoid aglycones in inflorescences, leaves and fruits of three Sorbus species. J Pharm Biomed Anal 48:629-35.
    • (2008) J Pharm Biomed Anal , vol.48 , pp. 629-635
    • Olszewska, M.1
  • 18
    • 33846876099 scopus 로고    scopus 로고
    • Estrogen-related receptor as a therapeutic target in cancer
    • Stein RA, McDonnell DP (2006) Estrogen-related receptor as a therapeutic target in cancer. Endocr Relat Cancer 13:S25-32.
    • (2006) Endocr Relat Cancer , vol.13
    • Stein, R.A.1    McDonnell, D.P.2
  • 19
    • 0028068478 scopus 로고
    • Kaempferol-induced nuclear DNA damage and lipid peroxidation
    • Sahu SC, Gray GC (1994) Kaempferol-induced nuclear DNA damage and lipid peroxidation. Cancer Lett 85:159-64.
    • (1994) Cancer Lett , vol.85 , pp. 159-164
    • Sahu, S.C.1    Gray, G.C.2
  • 20
    • 0028280245 scopus 로고
    • Stimulation of pS2 expression by diet-derived compounds
    • Sathyamoorthy N,Wang TTY, Phang JM (1994) Stimulation of pS2 expression by diet-derived compounds. Cancer Res 54:957-61.
    • (1994) Cancer Res , vol.54 , pp. 957-961
    • Sathyamoorthy, N.1    Wang, T.T.Y.2    Phang, J.M.3
  • 22
    • 0038660688 scopus 로고    scopus 로고
    • The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha)
    • Schreiber SN, Knutti D, Brogli K, Uhlmann T, Kralli A (2003) The transcriptional coactivator PGC-1 regulates the expression and activity of the orphan nuclear receptor estrogen-related receptor alpha (ERRalpha). J Biol Chem 278:9013-8.
    • (2003) J Biol Chem , vol.278 , pp. 9013-9018
    • Schreiber, S.N.1    Knutti, D.2    Brogli, K.3    Uhlmann, T.4    Kralli, A.5
  • 24
    • 21544454405 scopus 로고    scopus 로고
    • Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells
    • Sun P SJ, Denkert C, Mustea A, Könsgen D, Koch I, Wei L, Lichtenegger W (2005) Expression of estrogen receptor-related receptors, a subfamily of orphan nuclear receptors, as new tumor biomarkers in ovarian cancer cells JMol Med 83:457-67.
    • (2005) J Mol Med , vol.83 , pp. 457-467
    • Sun, P.S.J.1    Denkert, C.2    Mustea, A.3    Könsgen, D.4    Koch, I.5    Wei, L.6    Lichtenegger, W.7
  • 26
    • 59849083230 scopus 로고    scopus 로고
    • Kaempferol is an estrogen-related receptor α and γ inverse agonist
    • Wang J, Fang F,Huang Z,Wang Y,Wong C (2009) Kaempferol is an estrogen-related receptor α and γ inverse agonist. FEBS Lett 583:643-7.
    • (2009) FEBS Lett , vol.583 , pp. 643-647
    • Wang, J.1    Fang, F.2    Huang, Z.3    Wang, Y.4    Wong, C.5
  • 27
    • 68849108383 scopus 로고    scopus 로고
    • Estrogen-related receptor α (ERRα) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells
    • Wu F, Wang J, Wang Y, Kwok T.-T, Kong S.-K, Wong C (2009) Estrogen-related receptor α (ERRα) inverse agonist XCT-790 induces cell death in chemotherapeutic resistant cancer cells. Chem Biol Interact 181:236-42.
    • (2009) Chem Biol Interact , vol.181 , pp. 236-242
    • Wu, F.1    Wang, J.2    Wang, Y.3    Kwok, T.-T.4    Kong, S.-K.5    Wong, C.6
  • 30
    • 45049088538 scopus 로고    scopus 로고
    • Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells
    • Zhang Y, Chen AY, Li M, Chen C, Yao Q (2008) Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res 148:17-23.
    • (2008) J Surg Res , vol.148 , pp. 17-23
    • Zhang, Y.1    Chen, A.Y.2    Li, M.3    Chen, C.4    Yao, Q.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.