5,6-Dihydro-5-aza-2′-deoxycytidine potentiates the anti-HIV-1 activity of ribonucleotide reductase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 22, 2013, Pages 7222-7228

  Rawson, Jonathan M ^a,c   Heineman, Richard H ^a,b,e   Beach, Lauren B ^a,c   Martin, Jessica L ^a,c   Schnettler, Erica K ^a,c   Dapp, Michael J ^a,c   Patterson, Steven E ^a,c,d   Mansky, Louis M ^a,b,c,d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e Kurtztown University   (United States)

Author keywords

5,6 Dihydro 5 aza 2 deoxycytidine; Error catastrophe; KP 1212; Lethal mutagenesis; Resveratrol

Indexed keywords

DEFEROXAMINE; GEMCITABINE; GREEN FLUORESCENT PROTEIN; KP 1212; NUCLEOSIDE ANALOG; OXIDOREDUCTASE INHIBITOR; RESVERATROL; RIBONUCLEOTIDE REDUCTASE; RIBONUCLEOTIDE REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIVIRAL ACTIVITY; ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MUTATION RATE; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; VIRUS MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

2′,2′-DIFLUORO-2′-DEOXYCYTIDINE; 2′,2′-DIFLUORO-2′-DEOXYURIDINE; 5,6-DIHYDRO-5-AZA-2′-DEOXYCYTIDINE; 5-AZA-5,6,-DIHYDRO-2′-DEOXYCYTIDINE; 5-AZACYTIDINE; 5-AZC; DFDC; DFDU; DIMETHYLSULFOXIDE; DMSO; ERROR CATASTROPHE; KP-1212; LETHAL MUTAGENESIS; MOI; MULTIPLICITY OF INFECTION; NRTI; NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; RESVERATROL; RIBONUCLEOTIDE REDUCTASE INHIBITOR; RNRI; SD; STANDARD DEVIATION;

ANTI-HIV AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; DEOXYCYTIDINE; ENZYME INHIBITORS; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HIV-1; HUMANS; LUMINESCENT PROTEINS; MUTATION; RIBONUCLEOTIDE REDUCTASES; STILBENES; VIRAL PROTEINS;

EID: 84885836195     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.023     Document Type: Article

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