-
2
-
-
33745370633
-
Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. Transcellular transport in Caco-2 cells
-
Bourdet DL, Pollack GM, and Thakker DR (2006) Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells. Pharm Res 23:1178-1187.
-
(2006)
Pharm Res
, vol.23
, pp. 1178-1187
-
-
Bourdet, D.L.1
Pollack, G.M.2
Thakker, D.R.3
-
3
-
-
68249092793
-
The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe
-
Chang JH, Yoo P, Lee T, Klopf W, and Takao D (2009) The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe. Mol Pharm 6:1216-1227.
-
(2009)
Mol Pharm
, vol.6
, pp. 1216-1227
-
-
Chang, J.H.1
Yoo, P.2
Lee, T.3
Klopf, W.4
Takao, D.5
-
4
-
-
0033984905
-
A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism
-
Cong D, Doherty M, and Pang KS (2000) A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism. Drug Metab Dispos 28:224-235.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 224-235
-
-
Cong, D.1
Doherty, M.2
Pang, K.S.3
-
5
-
-
0032793959
-
OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
-
Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, and Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866-871.
-
(1999)
Drug Metab Dispos
, vol.27
, pp. 866-871
-
-
Cvetkovic, M.1
Leake, B.2
Fromm, M.F.3
Wilkinson, G.R.4
Kim, R.B.5
-
6
-
-
40049110714
-
Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
-
Dobson PD and Kell DB (2008) Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7:205-220.
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 205-220
-
-
Dobson, P.D.1
Kell, D.B.2
-
7
-
-
0036159433
-
Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
-
Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, and Kim RB (2002) Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 71:11-20.
-
(2002)
Clin Pharmacol Ther
, vol.71
, pp. 11-20
-
-
Dresser, G.K.1
Bailey, D.G.2
Leake, B.F.3
Schwarz, U.I.4
Dawson, P.A.5
Freeman, D.J.6
Kim, R.B.7
-
8
-
-
0022070123
-
Absorption potential: estimating the fraction absorbed for orally administered compounds
-
Dressman JB, Amidon GL, and Fleisher D (1985) Absorption potential: estimating the fraction absorbed for orally administered compounds. J Pharm Sci 74:588-589.
-
(1985)
J Pharm Sci
, vol.74
, pp. 588-589
-
-
Dressman, J.B.1
Amidon, G.L.2
Fleisher, D.3
-
9
-
-
0034009448
-
In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin
-
Fisher MB, Campanale K, Ackermann BL, VandenBranden M, and Wrighton SA (2000) In vitro glucuronidation using human liver microsomes and the pore-forming peptide alamethicin. Drug Metab Dispos 28:560-566.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 560-566
-
-
Fisher, M.B.1
Campanale, K.2
Ackermann, B.L.3
VandenBranden, M.4
Wrighton, S.A.5
-
10
-
-
39449086202
-
Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug
-
Fujioka Y, Metsugi Y, Ogawara K, Higaki K, and Kimura T (2008) Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug. Int J Pharm 352:36-43.
-
(2008)
Int J Pharm
, vol.352
, pp. 36-43
-
-
Fujioka, Y.1
Metsugi, Y.2
Ogawara, K.3
Higaki, K.4
Kimura, T.5
-
12
-
-
29144436223
-
-
Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.)Membrane transporters and drug response, in: Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.), pp. 41-70, McGraw-Hill, New York
-
Giacomini KM and Sugiyama Y (2006) Membrane transporters and drug response, in: Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.), pp. 41-70, McGraw-Hill, New York.
-
(2006)
Membrane transporters and drug response
-
-
Giacomini, K.M.1
Sugiyama, Y.2
-
13
-
-
0037427972
-
The superfamily of organic anion transporting polypeptides
-
Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
-
(2003)
Biochim Biophys Acta
, vol.1609
, pp. 1-18
-
-
Hagenbuch, B.1
Meier, P.J.2
-
14
-
-
1242340323
-
The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins
-
Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, and Bruford EA (2004) The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction. Pflugers Arch 447:465-468.
-
(2004)
Introduction. Pflugers Arch
, vol.447
, pp. 465-468
-
-
Hediger, M.A.1
Romero, M.F.2
Peng, J.B.3
Rolfs, A.4
Takanaga, H.5
Bruford, E.A.6
-
15
-
-
84885782322
-
-
Modern Pharmaceutics (Banker GS and Rhodes CT, eds.), Marcel Dekker, New York
-
Hoener B-A and Benet LZ (2002) Factors influencing drug absorption and drug availability, in: Modern Pharmaceutics (Banker GS and Rhodes CT, eds.), pp. 145-186, Marcel Dekker, New York.
-
(2002)
Factors influencing drug absorption and drug availability
, pp. 145-186
-
-
Hoener, B.-A.1
Benet, L.Z.2
-
16
-
-
25144450046
-
Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
-
Ito K, Suzuki H, Horie T, and Sugiyama Y (2005) Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res 22:1559-1577.
-
(2005)
Pharm Res
, vol.22
, pp. 1559-1577
-
-
Ito, K.1
Suzuki, H.2
Horie, T.3
Sugiyama, Y.4
-
17
-
-
0032872193
-
Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux
-
Karlsson J, Ungell A, Grasjo J, and Artursson P (1999) Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. Eur J Pharm Sci 9:47-56.
-
(1999)
Eur J Pharm Sci
, vol.9
, pp. 47-56
-
-
Karlsson, J.1
Ungell, A.2
Grasjo, J.3
Artursson, P.4
-
18
-
-
33745889935
-
Nucleoside transporters: from scavengers to novel therapeutic targets
-
King AE, Ackley MA, Cass CE, Young JD, and Baldwin SA (2006) Nucleoside transporters: from scavengers to novel therapeutic targets. Trends Pharmacol Sci 27:416-425.
-
(2006)
Trends Pharmacol Sci
, vol.27
, pp. 416-425
-
-
King, A.E.1
Ackley, M.A.2
Cass, C.E.3
Young, J.D.4
Baldwin, S.A.5
-
19
-
-
84885754581
-
Theory and applications of diffusion and dissolution
-
Theory and Practices of Contemporary Pharmaceutics (Ghosh TK and Jasti BR, eds.), CRC Press, Boca Rotan, FL
-
Li X and Jasti B (2005) Theory and applications of diffusion and dissolution, in: Theory and Practices of Contemporary Pharmaceutics (Ghosh TK and Jasti BR, eds.), pp 197-216, CRC Press, Boca Rotan, FL.
-
(2005)
, pp. 197-216
-
-
Li, X.1
Jasti, B.2
-
20
-
-
0035289779
-
Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
-
Lipinski CA, Lombardo F, Dominy BW, and Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26.
-
(2001)
Adv Drug Deliv Rev
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
21
-
-
0033255551
-
Overview of membrane transport
-
Oh DM and Amidon GL (1999) Overview of membrane transport. Pharm Biotechnol 12:1-27.
-
(1999)
Pharm Biotechnol
, vol.12
, pp. 1-27
-
-
Oh, D.M.1
Amidon, G.L.2
-
23
-
-
0002954795
-
Drug transport and targeting
-
(Amidon GL and Sadee W, eds.), Kluwer Academic/Plenum Publishers, New York
-
Oh D-M, Han H-K, and Amidon GL (1999b) Drug transport and targeting, in: Membrane Transporters as Drug Targets (Amidon GL and Sadee W, eds.), Kluwer Academic/Plenum Publishers, New York.
-
(1999)
Membrane Transporters as Drug Targets
-
-
Oh, D.-M.1
Han, H.-K.2
Amidon, G.L.3
-
24
-
-
0033980917
-
Cimetidine absorption and elimination in rat small intestine
-
Piyapolrungroj N, Zhou YS, Li C, Liu G, Zimmermann E, and Fleisher D (2000) Cimetidine absorption and elimination in rat small intestine. Drug Metab Dispos 28:65-72.
-
(2000)
Drug Metab Dispos
, vol.28
, pp. 65-72
-
-
Piyapolrungroj, N.1
Zhou, Y.S.2
Li, C.3
Liu, G.4
Zimmermann, E.5
Fleisher, D.6
-
25
-
-
4344559467
-
The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
-
Scheepers A, Joost HG, and Schurmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 28:364-371.
-
(2004)
JPEN J Parenter Enteral Nutr
, vol.28
, pp. 364-371
-
-
Scheepers, A.1
Joost, H.G.2
Schurmann, A.3
-
26
-
-
0033257052
-
The mammalian facilitative glucose transporter (GLUT) family
-
Seatter MJ and Gould GW (1999) The mammalian facilitative glucose transporter (GLUT) family. Pharm Biotechnol 12:201-228.
-
(1999)
Pharm Biotechnol
, vol.12
, pp. 201-228
-
-
Seatter, M.J.1
Gould, G.W.2
-
27
-
-
84885732678
-
The role of permeability studies in preclinical evaluation
-
(Dressman JB and Lennernas H, eds.), Marcel Dekker, New York, NY
-
Smith PL (2000) The role of permeability studies in preclinical evaluation, in: Oral Drug Absorption (Dressman JB and Lennernas H, eds.), Marcel Dekker, New York, NY.
-
(2000)
Oral Drug Absorption
-
-
Smith, P.L.1
-
29
-
-
0033812228
-
Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
-
Sugawara M, Huang W, Fei YJ, Leibach FH, Ganapathy V, and Ganapathy ME (2000) Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci 89:781-789.
-
(2000)
J Pharm Sci
, vol.89
, pp. 781-789
-
-
Sugawara, M.1
Huang, W.2
Fei, Y.J.3
Leibach, F.H.4
Ganapathy, V.5
Ganapathy, M.E.6
-
30
-
-
0037378726
-
Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption
-
Tam D, Tirona RG, and Pang KS (2003) Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption. Drug Metab Dispos 31:373-383.
-
(2003)
Drug Metab Dispos
, vol.31
, pp. 373-383
-
-
Tam, D.1
Tirona, R.G.2
Pang, K.S.3
-
31
-
-
33747862996
-
The road map to oral bioavailability: an industrial perspective
-
Thomas VH, Bhattachar S, Hitchingham L, Zocharski P, Naath M, Surendran N, Stoner CL, and El-Kattan A (2006) The road map to oral bioavailability: an industrial perspective. Expert Opin Drug Metab Toxicol 2:591-608.
-
(2006)
Expert Opin Drug Metab Toxicol
, vol.2
, pp. 591-608
-
-
Thomas, V.H.1
Bhattachar, S.2
Hitchingham, L.3
Zocharski, P.4
Naath, M.5
Surendran, N.6
Stoner, C.L.7
El-Kattan, A.8
-
33
-
-
39149108776
-
Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update
-
Trevaskis NL, Charman WN, and Porter CJ (2008) Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv Drug Deliv Rev 60:702-716.
-
(2008)
Adv Drug Deliv Rev
, vol.60
, pp. 702-716
-
-
Trevaskis, N.L.1
Charman, W.N.2
Porter, C.J.3
-
34
-
-
0031946994
-
Membrane transport of drugs in different regions of the intestinal tract of the rat
-
Ungell AL, Nylander S, Bergstrand S, Sjoberg A, and Lennernas H (1998) Membrane transport of drugs in different regions of the intestinal tract of the rat. J Pharm Sci 87:360-366.
-
(1998)
J Pharm Sci
, vol.87
, pp. 360-366
-
-
Ungell, A.L.1
Nylander, S.2
Bergstrand, S.3
Sjoberg, A.4
Lennernas, H.5
-
35
-
-
17644380257
-
Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
-
Wu CY and Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23.
-
(2005)
Pharm Res
, vol.22
, pp. 11-23
-
-
Wu, C.Y.1
Benet, L.Z.2
-
36
-
-
34548155549
-
Biopharmaceutics classification of selected betablockers: solubility and permeability class membership
-
Yang Y, Faustino PJ, Volpe DA, Ellison CD, Lyon RC, and Yu LX (2007) Biopharmaceutics classification of selected betablockers: solubility and permeability class membership. Mol Pharm 4:608-614.
-
(2007)
Mol Pharm
, vol.4
, pp. 608-614
-
-
Yang, Y.1
Faustino, P.J.2
Volpe, D.A.3
Ellison, C.D.4
Lyon, R.C.5
Yu, L.X.6
-
37
-
-
85016967291
-
Analytical solutions to mass transfer
-
(Amidon GL, Lee PI, and Topp EM, eds.), Marcel Dekker, New York
-
Yu LX and Amidon GL (2000) Analytical solutions to mass transfer, in: Transport Processes in Pharmaceutical Systems (Amidon GL, Lee PI, and Topp EM, eds.), pp 23-54, Marcel Dekker, New York.
-
(2000)
Transport Processes in Pharmaceutical Systems
, pp. 23-54
-
-
Yu, L.X.1
Amidon, G.L.2
-
38
-
-
0034992583
-
Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors
-
Zhao YH, Le J, Abraham MH, Hersey A, Eddershaw PJ, Luscombe CN, Butina D, Beck G, Sherborne B, Cooper I, and Platts JA (2001) Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure-activity relationship (QSAR) with the Abraham descriptors. J Pharm Sci 90:749-784.
-
(2001)
J Pharm Sci
, vol.90
, pp. 749-784
-
-
Zhao, Y.H.1
Le, J.2
Abraham, M.H.3
Hersey, A.4
Eddershaw, P.J.5
Luscombe, C.N.6
Butina, D.7
Beck, G.8
Sherborne, B.9
Cooper, I.10
Platts, J.A.11
|