메뉴 건너뛰기




Volumn , Issue , 2011, Pages 63-75

Absorption of Drugs via Passive Diffusion and Carrier-Mediated Pathways

Author keywords

Drug absorption via carrier mediated process drug drug interaction, dose dependent pharmacokinetics; Drug absorption via passive diffusion, carrier mediated pathways oral route, convenient and economical; Passive diffusion, solute molecules passing through random molecular motion

Indexed keywords


EID: 84885825119     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781118067598.ch6     Document Type: Chapter
Times cited : (2)

References (38)
  • 2
    • 33745370633 scopus 로고    scopus 로고
    • Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. Transcellular transport in Caco-2 cells
    • Bourdet DL, Pollack GM, and Thakker DR (2006) Intestinal absorptive transport of the hydrophilic cation ranitidine: a kinetic modeling approach to elucidate the role of uptake and efflux transporters and paracellular vs. transcellular transport in Caco-2 cells. Pharm Res 23:1178-1187.
    • (2006) Pharm Res , vol.23 , pp. 1178-1187
    • Bourdet, D.L.1    Pollack, G.M.2    Thakker, D.R.3
  • 3
    • 68249092793 scopus 로고    scopus 로고
    • The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe
    • Chang JH, Yoo P, Lee T, Klopf W, and Takao D (2009) The role of pH in the glucuronidation of raloxifene, mycophenolic acid and ezetimibe. Mol Pharm 6:1216-1227.
    • (2009) Mol Pharm , vol.6 , pp. 1216-1227
    • Chang, J.H.1    Yoo, P.2    Lee, T.3    Klopf, W.4    Takao, D.5
  • 4
    • 0033984905 scopus 로고    scopus 로고
    • A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism
    • Cong D, Doherty M, and Pang KS (2000) A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism. Drug Metab Dispos 28:224-235.
    • (2000) Drug Metab Dispos , vol.28 , pp. 224-235
    • Cong, D.1    Doherty, M.2    Pang, K.S.3
  • 5
    • 0032793959 scopus 로고    scopus 로고
    • OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine
    • Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, and Kim RB (1999) OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 27:866-871.
    • (1999) Drug Metab Dispos , vol.27 , pp. 866-871
    • Cvetkovic, M.1    Leake, B.2    Fromm, M.F.3    Wilkinson, G.R.4    Kim, R.B.5
  • 6
    • 40049110714 scopus 로고    scopus 로고
    • Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule?
    • Dobson PD and Kell DB (2008) Carrier-mediated cellular uptake of pharmaceutical drugs: an exception or the rule? Nat Rev Drug Discov 7:205-220.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 205-220
    • Dobson, P.D.1    Kell, D.B.2
  • 7
    • 0036159433 scopus 로고    scopus 로고
    • Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine
    • Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ, and Kim RB (2002) Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharmacol Ther 71:11-20.
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 11-20
    • Dresser, G.K.1    Bailey, D.G.2    Leake, B.F.3    Schwarz, U.I.4    Dawson, P.A.5    Freeman, D.J.6    Kim, R.B.7
  • 8
    • 0022070123 scopus 로고
    • Absorption potential: estimating the fraction absorbed for orally administered compounds
    • Dressman JB, Amidon GL, and Fleisher D (1985) Absorption potential: estimating the fraction absorbed for orally administered compounds. J Pharm Sci 74:588-589.
    • (1985) J Pharm Sci , vol.74 , pp. 588-589
    • Dressman, J.B.1    Amidon, G.L.2    Fleisher, D.3
  • 10
    • 39449086202 scopus 로고    scopus 로고
    • Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug
    • Fujioka Y, Metsugi Y, Ogawara K, Higaki K, and Kimura T (2008) Evaluation of in vivo dissolution behavior and GI transit of griseofulvin, a BCS class II drug. Int J Pharm 352:36-43.
    • (2008) Int J Pharm , vol.352 , pp. 36-43
    • Fujioka, Y.1    Metsugi, Y.2    Ogawara, K.3    Higaki, K.4    Kimura, T.5
  • 12
    • 29144436223 scopus 로고    scopus 로고
    • Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.)Membrane transporters and drug response, in: Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.), pp. 41-70, McGraw-Hill, New York
    • Giacomini KM and Sugiyama Y (2006) Membrane transporters and drug response, in: Goodman & Gilman's the Pharmacological Basis of Therapeutics (Goodman LS, Gilman A, Brunton LL, Lazo JS, and Parker KL, eds.), pp. 41-70, McGraw-Hill, New York.
    • (2006) Membrane transporters and drug response
    • Giacomini, K.M.1    Sugiyama, Y.2
  • 13
    • 0037427972 scopus 로고    scopus 로고
    • The superfamily of organic anion transporting polypeptides
    • Hagenbuch B and Meier PJ (2003) The superfamily of organic anion transporting polypeptides. Biochim Biophys Acta 1609:1-18.
    • (2003) Biochim Biophys Acta , vol.1609 , pp. 1-18
    • Hagenbuch, B.1    Meier, P.J.2
  • 14
    • 1242340323 scopus 로고    scopus 로고
    • The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins
    • Hediger MA, Romero MF, Peng JB, Rolfs A, Takanaga H, and Bruford EA (2004) The ABCs of solute carriers: physiological, pathological and therapeutic implications of human membrane transport proteins. Introduction. Pflugers Arch 447:465-468.
    • (2004) Introduction. Pflugers Arch , vol.447 , pp. 465-468
    • Hediger, M.A.1    Romero, M.F.2    Peng, J.B.3    Rolfs, A.4    Takanaga, H.5    Bruford, E.A.6
  • 16
    • 25144450046 scopus 로고    scopus 로고
    • Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport
    • Ito K, Suzuki H, Horie T, and Sugiyama Y (2005) Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res 22:1559-1577.
    • (2005) Pharm Res , vol.22 , pp. 1559-1577
    • Ito, K.1    Suzuki, H.2    Horie, T.3    Sugiyama, Y.4
  • 17
    • 0032872193 scopus 로고    scopus 로고
    • Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux
    • Karlsson J, Ungell A, Grasjo J, and Artursson P (1999) Paracellular drug transport across intestinal epithelia: influence of charge and induced water flux. Eur J Pharm Sci 9:47-56.
    • (1999) Eur J Pharm Sci , vol.9 , pp. 47-56
    • Karlsson, J.1    Ungell, A.2    Grasjo, J.3    Artursson, P.4
  • 19
    • 84885754581 scopus 로고    scopus 로고
    • Theory and applications of diffusion and dissolution
    • Theory and Practices of Contemporary Pharmaceutics (Ghosh TK and Jasti BR, eds.), CRC Press, Boca Rotan, FL
    • Li X and Jasti B (2005) Theory and applications of diffusion and dissolution, in: Theory and Practices of Contemporary Pharmaceutics (Ghosh TK and Jasti BR, eds.), pp 197-216, CRC Press, Boca Rotan, FL.
    • (2005) , pp. 197-216
    • Li, X.1    Jasti, B.2
  • 20
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings
    • Lipinski CA, Lombardo F, Dominy BW, and Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv Drug Deliv Rev 46:3-26.
    • (2001) Adv Drug Deliv Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 21
    • 0033255551 scopus 로고    scopus 로고
    • Overview of membrane transport
    • Oh DM and Amidon GL (1999) Overview of membrane transport. Pharm Biotechnol 12:1-27.
    • (1999) Pharm Biotechnol , vol.12 , pp. 1-27
    • Oh, D.M.1    Amidon, G.L.2
  • 23
    • 0002954795 scopus 로고    scopus 로고
    • Drug transport and targeting
    • (Amidon GL and Sadee W, eds.), Kluwer Academic/Plenum Publishers, New York
    • Oh D-M, Han H-K, and Amidon GL (1999b) Drug transport and targeting, in: Membrane Transporters as Drug Targets (Amidon GL and Sadee W, eds.), Kluwer Academic/Plenum Publishers, New York.
    • (1999) Membrane Transporters as Drug Targets
    • Oh, D.-M.1    Han, H.-K.2    Amidon, G.L.3
  • 25
    • 4344559467 scopus 로고    scopus 로고
    • The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
    • Scheepers A, Joost HG, and Schurmann A (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. JPEN J Parenter Enteral Nutr 28:364-371.
    • (2004) JPEN J Parenter Enteral Nutr , vol.28 , pp. 364-371
    • Scheepers, A.1    Joost, H.G.2    Schurmann, A.3
  • 26
    • 0033257052 scopus 로고    scopus 로고
    • The mammalian facilitative glucose transporter (GLUT) family
    • Seatter MJ and Gould GW (1999) The mammalian facilitative glucose transporter (GLUT) family. Pharm Biotechnol 12:201-228.
    • (1999) Pharm Biotechnol , vol.12 , pp. 201-228
    • Seatter, M.J.1    Gould, G.W.2
  • 27
    • 84885732678 scopus 로고    scopus 로고
    • The role of permeability studies in preclinical evaluation
    • (Dressman JB and Lennernas H, eds.), Marcel Dekker, New York, NY
    • Smith PL (2000) The role of permeability studies in preclinical evaluation, in: Oral Drug Absorption (Dressman JB and Lennernas H, eds.), Marcel Dekker, New York, NY.
    • (2000) Oral Drug Absorption
    • Smith, P.L.1
  • 28
    • 0036380244 scopus 로고    scopus 로고
    • Theoretical predictions of drug absorption in drug discovery and development
    • Stenberg P, Bergstrom CA, Luthman K, and Artursson P (2002) Theoretical predictions of drug absorption in drug discovery and development. Clin Pharmacokinet 41:877-899.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 877-899
    • Stenberg, P.1    Bergstrom, C.A.2    Luthman, K.3    Artursson, P.4
  • 29
    • 0033812228 scopus 로고    scopus 로고
    • Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2
    • Sugawara M, Huang W, Fei YJ, Leibach FH, Ganapathy V, and Ganapathy ME (2000) Transport of valganciclovir, a ganciclovir prodrug, via peptide transporters PEPT1 and PEPT2. J Pharm Sci 89:781-789.
    • (2000) J Pharm Sci , vol.89 , pp. 781-789
    • Sugawara, M.1    Huang, W.2    Fei, Y.J.3    Leibach, F.H.4    Ganapathy, V.5    Ganapathy, M.E.6
  • 30
    • 0037378726 scopus 로고    scopus 로고
    • Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption
    • Tam D, Tirona RG, and Pang KS (2003) Segmental intestinal transporters and metabolic enzymes on intestinal drug absorption. Drug Metab Dispos 31:373-383.
    • (2003) Drug Metab Dispos , vol.31 , pp. 373-383
    • Tam, D.1    Tirona, R.G.2    Pang, K.S.3
  • 33
    • 39149108776 scopus 로고    scopus 로고
    • Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update
    • Trevaskis NL, Charman WN, and Porter CJ (2008) Lipid-based delivery systems and intestinal lymphatic drug transport: a mechanistic update. Adv Drug Deliv Rev 60:702-716.
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 702-716
    • Trevaskis, N.L.1    Charman, W.N.2    Porter, C.J.3
  • 34
    • 0031946994 scopus 로고    scopus 로고
    • Membrane transport of drugs in different regions of the intestinal tract of the rat
    • Ungell AL, Nylander S, Bergstrand S, Sjoberg A, and Lennernas H (1998) Membrane transport of drugs in different regions of the intestinal tract of the rat. J Pharm Sci 87:360-366.
    • (1998) J Pharm Sci , vol.87 , pp. 360-366
    • Ungell, A.L.1    Nylander, S.2    Bergstrand, S.3    Sjoberg, A.4    Lennernas, H.5
  • 35
    • 17644380257 scopus 로고    scopus 로고
    • Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system
    • Wu CY and Benet LZ (2005) Predicting drug disposition via application of BCS: transport/absorption/elimination interplay and development of a biopharmaceutics drug disposition classification system. Pharm Res 22:11-23.
    • (2005) Pharm Res , vol.22 , pp. 11-23
    • Wu, C.Y.1    Benet, L.Z.2
  • 36
    • 34548155549 scopus 로고    scopus 로고
    • Biopharmaceutics classification of selected betablockers: solubility and permeability class membership
    • Yang Y, Faustino PJ, Volpe DA, Ellison CD, Lyon RC, and Yu LX (2007) Biopharmaceutics classification of selected betablockers: solubility and permeability class membership. Mol Pharm 4:608-614.
    • (2007) Mol Pharm , vol.4 , pp. 608-614
    • Yang, Y.1    Faustino, P.J.2    Volpe, D.A.3    Ellison, C.D.4    Lyon, R.C.5    Yu, L.X.6
  • 37
    • 85016967291 scopus 로고    scopus 로고
    • Analytical solutions to mass transfer
    • (Amidon GL, Lee PI, and Topp EM, eds.), Marcel Dekker, New York
    • Yu LX and Amidon GL (2000) Analytical solutions to mass transfer, in: Transport Processes in Pharmaceutical Systems (Amidon GL, Lee PI, and Topp EM, eds.), pp 23-54, Marcel Dekker, New York.
    • (2000) Transport Processes in Pharmaceutical Systems , pp. 23-54
    • Yu, L.X.1    Amidon, G.L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.