Association of LEP G2548A and LEPR Q223R Polymorphisms with Cancer Susceptibility: Evidence from a Meta-Analysis

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  He, Jing ^a,b   Xi, Bo ^c   Ruiter, Rikje ^d   Shi, Ting Yan ^a,b   Zhu, Mei Ling ^a,b   Wang, Meng Yun ^a,b   Li, Qiao Xin ^a,b   Zhou, Xiao Yan ^a,b   Qiu, Li Xin ^a,b   Wei, Qing Yi ^a,e  

^a FUDAN UNIVERSITY SHANGHAI CANCER CENTER   (China)

^b FUDAN UNIVERSITY   (China)

^c SHANDONG UNIVERSITY   (China)

^d ERASMUS MEDICAL CENTER   (Netherlands)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

AFRICAN; ARTICLE; ASIAN; CANCER SUSCEPTIBILITY; CAUCASIAN; CONTROLLED STUDY; DNA POLYMORPHISM; ENERGY EXPENDITURE; ETHNICITY; EXON; FOOD INTAKE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE METABOLISM; HAPLOTYPE MAP; HUMAN; LATIN AMERICAN; LEP G2548A GENE; LEPR Q223R GENE; META ANALYSIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; PROSTATE CANCER; PROTEIN EXPRESSION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMATIC REVIEW; TUMOR GENE;

CASE-CONTROL STUDIES; CONTINENTAL POPULATION GROUPS; DATABASES, BIBLIOGRAPHIC; GENETIC PREDISPOSITION TO DISEASE; HAPMAP PROJECT; HUMANS; LEPTIN; MALE; MODELS, GENETIC; NEOPLASMS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSTATIC NEOPLASMS; RECEPTORS, LEPTIN; RNA, MESSENGER;

EID: 84885811504     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0075135     Document Type: Article

References (53)

1. Jemal A, Bray F, Center MM, Ferlay J, Ward E, et al. (2011) Global cancer statistics. CA Cancer J Clin 61: 69-90. doi:10.3322/caac.20107. PubMed: 21296855.
2. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, et al. (2000) Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland. N Engl J Med 343: 78-85. doi:10.1056/NEJM200007133430201. PubMed: 10891514.
3. Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, (2000) Environmental and heritable factors in the causation of cancer: analyses of cohorts of twins from Sweden, Denmark, and Finland, N Engl J Med 343: 78-84.
4. Friedman JM, Halaas JL, (1998) Leptin and the regulation of body weight in mammals. Nature 395: 763-770. doi:10.1038/27376. PubMed: 9796811.
5. Unger RH, Zhou YT, Orci L, (1999) Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A 96: 2327-2332. doi:10.1073/pnas.96.5.2327. PubMed: 10051641.
6. Lakka HM, Oksanen L, Tuomainen TP, Kontula K, Salonen JT, (2000) The common pentanucleotide polymorphism of the 3'-untranslated region of the leptin receptor gene is associated with serum insulin levels and the risk of type 2 diabetes in non-diabetic men: a prospective case-control study. J Intern Med 248: 77-83. doi:10.1046/j.1365-2796.2000.00696.x. PubMed: 10947884.
7. Lönnqvist F, Arner P, Nordfors L, Schalling M, (1995) Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1: 950-953. doi:10.1038/nm0995-950. PubMed: 7585223.
8. Yiannakouris N, Yannakoulia M, Melistas L, Chan JL, Klimis-Zacas D, et al. (2001) The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 86: 4434-4439. doi:10.1210/jc.86.9.4434. PubMed: 11549688.
9. Snoussi K, Strosberg AD, Bouaouina N, Ben Ahmed S, Helal AN, et al. (2006) Leptin and leptin receptor polymorphisms are associated with increased risk and poor prognosis of breast carcinoma. BMC Cancer 6: 38. doi:10.1186/1471-2407-6-38. PubMed: 16504019.
10. Liu CL, Chang YC, Cheng SP, Chern SR, Yang TL, et al. (2007) The roles of serum leptin concentration and polymorphism in leptin receptor gene at codon 109 in breast cancer. Oncology 72: 75-81. doi:10.1159/000111097. PubMed: 18004080.
11. Han CZ, Du LL, Jing JX, Zhao XW, Tian FG, et al. (2008) Associations among lipids, leptin, and leptin receptor gene Gin223Arg polymorphisms and breast cancer in China. Biol Trace Elem Res 126: 38-48. doi:10.1007/s12011-008-8182-z. PubMed: 18668212.
12. Ribeiro R, Vasconcelos A, Costa S, Pinto D, Morais A, et al. (2004) Overexpressing leptin genetic polymorphism (-2548 G/A) is associated with susceptibility to prostate cancer and risk of advanced disease. Prostate 59: 268-274. doi:10.1002/pros.20004. PubMed: 15042602.
13. Ribeiro R, Araújo AP, Coelho A, Catarino R, Pinto D, et al. (2006) A functional polymorphism in the promoter region of leptin gene increases susceptibility for non-small cell lung cancer. Eur J Cancer 42: 1188-1193. doi:10.1016/j.ejca.2006.02.004. PubMed: 16630717.
14. Chia VM, Newcomb PA, Lampe JW, White E, Mandelson MT, et al. (2007) Leptin concentrations, leptin receptor polymorphisms, and colorectal adenoma risk. Cancer Epidemiol Biomarkers Prev 16: 2697-2703. doi:10.1158/1055-9965.EPI-07-0467. PubMed: 18086776.
15. Mantzoros CS, Moschos SJ, (1998) Leptin: in search of role(s) in human physiology and pathophysiology. Clin Endocrinol (Oxf) 49: 551-567. doi:10.1046/j.1365-2265.1998.00571.x. PubMed: 10197068.
16. Woo HY, Park H, Ki CS, Park YL, Bae WG, (2006) Relationships among serum leptin, leptin receptor gene polymorphisms, and breast cancer in Korea. Cancer Lett 237: 137-142. doi:10.1016/j.canlet.2005.05.041. PubMed: 16011872.
17. Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P, (2002) A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res 34: 355-359. doi:10.1055/s-2002-33466. PubMed: 12189581.
18. Chovanec J, Bienertová-Vasků JA, Dostálová Z, (2009) Leptin--2548 g/A polymorphism in endometrial cancer. Klin Onkol 22: 223-227. PubMed: 19886360.
19. Kote-Jarai Z, Singh R, Durocher F, Easton D, Edwards SM, et al. (2003) Association between leptin receptor gene polymorphisms and early-onset prostate cancer. BJU Int 92: 109-112. doi:10.1046/j.1464-410X.2003.04272.x. PubMed: 12823393.
20. Skibola CF, Holly EA, Forrest MS, Hubbard A, Bracci PM, et al. (2004) Body mass index, leptin and leptin receptor polymorphisms, and non-hodgkin lymphoma. Cancer Epidemiol Biomarkers Prev 13: 779-786. PubMed: 15159310.
21. Willett EV, Skibola CF, Adamson P, Skibola DR, Morgan GJ, et al. (2005) Non-Hodgkin's lymphoma, obesity and energy homeostasis polymorphisms. Br J Cancer 93: 811-816. doi:10.1038/sj.bjc.6602762. PubMed: 16160698.
22. Gallicchio L, McSorley MA, Newschaffer CJ, Huang HY, Thuita LW, et al. (2007) Body mass, polymorphisms in obesity-related genes, and the risk of developing breast cancer among women with benign breast disease. Cancer Detect Prev 31: 95-101. doi:10.1016/j.cdp.2007.02.004. PubMed: 17428620.
23. Doecke JD, Zhao ZZ, Stark MS, Green AC, Hayward NK, et al. (2008) Single nucleotide polymorphisms in obesity-related genes and the risk of esophageal cancers. Cancer Epidemiol Biomarkers Prev 17: 1007-1012. doi:10.1158/1055-9965.EPI-08-0023. PubMed: 18398047.
24. Okobia MN, Bunker CH, Garte SJ, Zmuda JM, Ezeome ER, et al. (2008) Leptin receptor Gln223Arg polymorphism and breast cancer risk in Nigerian women: a case control study. BMC Cancer 8: 338. doi:10.1186/1471-2407-8-338. PubMed: 19017403.
25. Slattery ML, Wolff RK, Herrick J, Caan BJ, Potter JD, (2008) Leptin and leptin receptor genotypes and colon cancer: gene-gene and gene-lifestyle interactions. Int J Cancer 122: 1611-1617. PubMed: 18059035.
26. Ulybina IuM, Imianitov EN, Vasil'ev DA, Bershtein LM, (2008) [Polymorphism of glucose intolerance and insulin resistance susceptibility genes in oncological patients]. Mol Biol (Mosk) 42: 947-956.
27. Moore SC, Leitzmann MF, Albanes D, Weinstein SJ, Snyder K, et al. (2009) Adipokine genes and prostate cancer risk. Int J Cancer 124: 869-876. doi:10.1002/ijc.24043. PubMed: 19035456.
28. Pechlivanis S, Bermejo JL, Pardini B, Naccarati A, Vodickova L, et al. (2009) Genetic variation in adipokine genes and risk of colorectal cancer. Eur J Endocrinol 160: 933-940. doi:10.1530/EJE-09-0039. PubMed: 19273568.
29. Teras LR, Goodman M, Patel AV, Bouzyk M, Tang W, et al. (2009) No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev 18: 2553-2557. doi:10.1158/1055-9965.EPI-09-0542. PubMed: 19723917.
30. Tsilidis KK, Helzlsouer KJ, Smith MW, Grinberg V, Hoffman-Bolton J, et al. (2009) Association of common polymorphisms in IL10, and in other genes related to inflammatory response and obesity with colorectal cancer. Cancer Causes Control 20: 1739-1751. doi:10.1007/s10552-009-9427-7. PubMed: 19760027.
31. Vasků A, Vokurka J, Bienertová-Vasků J, (2009) Obesity-related genes variability in Czech patients with sporadic colorectal cancer: preliminary results. Int J Colorectal Dis 24: 289-294. doi:10.1007/s00384-008-0553-6. PubMed: 18704460.
32. Wang MH, Helzlsouer KJ, Smith MW, Hoffman-Bolton JA, Clipp SL, et al. (2009) Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate 69: 874-885. doi:10.1002/pros.20933. PubMed: 19267370.
33. Yapijakis C, Kechagiadakis M, Nkenke E, Serefoglou Z, Avgoustidis D, et al. (2009) Association of leptin-2548G/A and leptin receptor Q223R polymorphisms with increased risk for oral cancer. J Cancer Res Clin Oncol 135: 603-612. doi:10.1007/s00432-008-0494-z. PubMed: 18855010.
34. Cleveland RJ, Gammon MD, Long CM, Gaudet MM, Eng SM, et al. (2010) Common genetic variations in the LEP and LEPR genes, obesity and breast cancer incidence and survival. Breast Cancer Res Treat 120: 745-752. doi:10.1007/s10549-009-0503-1. PubMed: 19697123.
35. Partida-Pérez M, de la Luz Ayala-Madrigal M, Peregrina-Sandoval J, Macías-Gómez N, Moreno-Ortiz J, et al. (2010) Association of LEP and ADIPOQ common variants with colorectal cancer in Mexican patients. Cancer Biomark 7: 117-121. PubMed: 21263187.
36. Nyante SJ, Gammon MD, Kaufman JS, Bensen JT, Lin DY, et al. (2011) Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes. Breast Cancer Res Treat 129: 593-606. doi:10.1007/s10549-011-1517-z. PubMed: 21516303.
37. Kim EY, Chin HM, Park SM, Jeon HM, Chung WC, et al. (2012) Susceptibility of gastric cancer according to leptin and leptin receptor gene polymorphisms in Korea. J Korean Surg Soc 83: 7-13. doi:10.4174/jkss.2012.83.1.7. PubMed: 22792528.
38. Kim KZ, Shin A, Lee YS, Kim SY, Kim Y, et al. (2012) Polymorphisms in adiposity-related genes are associated with age at menarche and menopause in breast cancer patients and healthy women. Hum Reprod 27: 2193-2200. doi:10.1093/humrep/des147. PubMed: 22537818.
39. Li Y, Geng J, Wang Y, Lu Q, Du Y, et al. (2012) The role of leptin receptor gene polymorphisms in determining the susceptibility and prognosis of NSCLC in Chinese patients. J Cancer Res Clin Oncol 138: 311-316. doi:10.1007/s00432-011-1098-6. PubMed: 22127368.
40. Dai K, Chen J, Yang L, Gong Z, (2010) The relationship of serum leptin and leptin receptor polymorphisms with primary hepatocellular carcinoma. Chin J Gastroenterol Hepatol 19: 722-724.
41. Holm K, Melum E, Franke A, Karlsen TH, (2010) SNPexp- A web tool for calculating and visualizing correlation between HapMap genotypes and gene expression levels. BMC Bioinformatics 11: 600. doi:10.1186/1471-2105-11-600. PubMed: 21167019.
42. International HapMap Consortium (2003) The International HapMap Project. Nature 426: 789-796. doi:10.1038/nature02168. PubMed: 14685227.
43. He J, Qiu LX, Wang MY, Hua RX, Zhang RX, et al. (2012) Polymorphisms in the XPG gene and risk of gastric cancer in Chinese populations. Hum Genet 131: 1235-1244. doi:10.1007/s00439-012-1152-8. PubMed: 22371296.
44. Stranger BE, Forrest MS, Dunning M, Ingle CE, Beazley C, et al. (2007) Relative impact of nucleotide and copy number variation on gene expression phenotypes. Science 315: 848-853. doi:10.1126/science.1136678. PubMed: 17289997.
45. He J, Shi TY, Zhu ML, Wang MY, Li QX, et al. (2013) Associations of Lys939Gln and Ala499Val polymorphisms of the XPC gene with cancer susceptibility: A meta-analysis. Int J Cancer, 133: 1765-75. doi:10.1002/ijc.28089. PubMed: 23400628.
46. Mantel N, Haenszel W, (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719-748. PubMed: 13655060.
47. DerSimonian R, Laird N, (1986) Meta-analysis in clinical trials. Control Clin Trials 7: 177-188. doi:10.1016/0197-2456(86)90046-2. PubMed: 3802833.
48. Egger M, Davey Smith G, Schneider M, Minder C, (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315: 629-634. doi:10.1136/bmj.315.7109.629. PubMed: 9310563.
49. Han CZ, Shi J, Du LL, Jing JX, Zhao XW, et al. (2007) [Association among lipids, leptin and leptin receptor polymorphisms with risk of breast cancer]. Zhonghua Liu Xing Bing Xue Za Zhi 28: 136-140. PubMed: 17649682.
50. Han CZ, Du LL, Jing JX, Zhao XW, Tian FG, et al. (2011) [Relationship between the mutation of leptin receptor gene and tumorigenesis of breast cancer]. Zhonghua Zhong Liu Za Zhi 33: 207-211. PubMed: 21575521.
51. Bianchini F, Kaaks R, Vainio H, (2002) Overweight, obesity, and cancer risk. Lancet Oncol 3: 565-574. doi:10.1016/S1470-2045(02)00849-5. PubMed: 12217794.
52. Cohen SS, Fowke JH, Cai Q, Buchowski MS, Signorello LB, et al. (2012) Differences in the Association between Serum Leptin Levels and Body Mass Index in Black and White Women: A Report from the Southern Community Cohort Study. Ann Nutr Metab 60: 90-97. doi:10.1159/000336180. PubMed: 22353927.
53. He BS, Pan YQ, Zhang Y, Xu YQ, Wang SK, (2012) Effect of LEPR Gln223Arg polymorphism on breast cancer risk in different ethnic populations: a meta-analysis. Mol Biol Rep 39: 3117-3122. doi:10.1007/s11033-011-1076-8. PubMed: 21698367.