Relationship between the mutation of leptin receptor gene and tumorigenesis of breast cancer

Chinese Journal of Oncology

Volumn 33, Issue 3, 2011, Pages 207-211

  Han, Cun Zhi ^a   Du, Li Li ^b   Jing, Jie Xian ^b   Zhao, Xian Wen ^b   Tian, Fu Guo ^b   Tian, Bao Guo ^b   Wu, Haiming ^b  

^a SHANXI CANCER HOSPITAL   (China)

^b NONE

Author keywords

Breast neoplasms; Leptin receptor gene; Mutation; Obesity; Overweight

Indexed keywords

GENOMIC DNA; LEPTIN RECEPTOR;

ARTICLE; BENIGN TUMOR; BREAST CANCER; BREAST CARCINOGENESIS; CODON; CONTROLLED STUDY; DNA POLYMORPHISM; EXON; GENE MUTATION; GENE SEQUENCE; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALIGNANT NEOPLASTIC DISEASE; NUCLEIC ACID BASE SUBSTITUTION; OBESITY; POLYMERASE CHAIN REACTION;

ADENOMA; ADULT; AGED; BREAST; BREAST NEOPLASMS; CARCINOMA; EXONS; FEMALE; GENE FREQUENCY; HUMANS; HYPERPLASIA; MIDDLE AGED; OBESITY; POINT MUTATION; RECEPTORS, LEPTIN;

EID: 80053421007     PISSN: 02533766     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0253-3766.2011.03.012     Document Type: Article

References (10)

1. Ostrowska L, Czapska D, Karczewski J. Obesity as a risk factor of breast carcinoma in woman. Pol Merkur Lekaiski, 2003, 14:224-228. (Pubitemid 36511381)
2. Kuriyama S, Tsubono Y, Hozawa A, et al. Obesity and risk of cancer in Japan. Int J Cancer, 2005, 113:148-157. (Pubitemid 39507322)
3. Ishikawa M, Kitayama J, Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res, 2004, 10:4325-4331. (Pubitemid 38878870)
4. Ukkola O, Tremblay A, Després JP, et al. Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding. J Intern Med, 2000, 248:435-439.
5. Han C, Zhang HT, Du L, et al. Serum levels of leptin, insulin, and lipids in relation to breast cancer in China. Endocrine, 2005, 26:19-24. (Pubitemid 41271112)
6. Matsuoka N, Ogawa Y, Hosoda K, et al. Human leptin receptor gene in obese Japanese subjects; evidence against either obesity-causing mutations or association of sequence variants with obesity. Diabetologia, 1997, 40:1204-1210. (Pubitemid 27421893)
7. Buchberger JM, Schmidt I. Is the onset of obesity in suckling fa/fa rats linked to a potentially larger milk intake? Am J Physiol, 1997, 271:472-476.