Adequately Adapted Insulin Secretion and Decreased Hepatic Insulin Extraction Cause Elevated Insulin Concentrations in Insulin Resistant Non-Diabetic Adrenal Incidentaloma Patients

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Anderwald, Christian Heinz ^a,b,c,d   Tura, Andrea ^b   Gessl, Alois ^a   Luger, Anton ^a   Pacini, Giovanni ^b   Krebs, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b CNR   (Italy)

^c Mariahilf Community Pharmacy   (Austria)

^d Specialized Hospital Complex Agathenhof   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN;

ADRENAL INCIDENTALOMA; ADULT; ARTICLE; BODY MASS; CELL FUNCTION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; MAJOR CLINICAL STUDY; MALE; ORAL GLUCOSE TOLERANCE TEST; OUTCOME ASSESSMENT; PANCREAS ISLET BETA CELL; PROTEIN BLOOD LEVEL; RETROSPECTIVE STUDY;

ADRENAL GLAND NEOPLASMS; BLOOD GLUCOSE; C-PEPTIDE; CASE-CONTROL STUDIES; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LIVER; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 84885788708     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0077326     Document Type: Article

References (38)

1. Young WF Jr., (2007) Clinical practice. The incidentally discovered adrenal mass. N Engl J Med 356: 601-610. doi:10.1056/NEJMcp065470. PubMed: 17287480.
2. Mansmann G, Lau J, Balk E, Rothberg M, Miyachi Y, et al. (2004) The clinically inapparent adrenal mass: update in diagnosis and management. Endocr Rev 25: 309-340. doi:10.1210/er.2002-0031. PubMed: 15082524.
3. Terzolo M, Pia A, Alì A, Osella G, Reimondo G, et al. (2002) Adrenal incidentaloma: a new cause of the metabolic syndrome? J Clin Endocrinol Metab 87: 998-1003. doi:10.1210/jc.87.3.998. PubMed: 11889151.
4. Tauchmanovà L, Rossi R, Biondi B, Pulcrano M, Nuzzo V, et al. (2002) Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk. J Clin Endocrinol Metab 87: 4872-4878. doi:10.1210/jc.2001-011766. PubMed: 12414841.
5. Chiodini I, Torlontano M, Scillitani A, Arosio M, Bacci S, et al. (2005) Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol 153: 837-844. doi:10.1530/eje.1.02045. PubMed: 16322389.
6. Garrapa GG, Pantanetti P, Arnaldi G, Mantero F, Faloia E, (2001) Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome. J Clin Endocrinol Metab 86: 5301-5306. doi:10.1210/jc.86.11.5301. PubMed: 11701696.
7. Fernandez-Real JM, Engel WR, Simo R, Salinas I, Webb SM, (1998) Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours. Study Group of Incidental Adrenal Adenoma. Clin Endocrinol (Oxf) 49: 53-61. doi:10.1046/j.1365-2265.1998.00437.x.
8. Ivović M, Marina LV, Vujović S, Tančić-Gajić M, Stojanović M, et al. (2013) Nondiabetic patients with either subclinical Cushing's or nonfunctional adrenal incidentalomas have lower insulin sensitivity than healthy controls: Clinical implications. Metabolism, 62: 786-92. PubMed: 23332445.
9. Muscogiuri G, Sorice GP, Prioletta A, Mezza T, Cipolla C, et al. (2011) The size of adrenal incidentalomas correlates with insulin resistance. Is there a cause-effect relationship? Clin Endocrinol (Oxf) 74: 300-305. doi:10.1111/j.1365-2265.2010.03928.x.
10. Chiodini I, (2011) Clinical review: Diagnosis and treatment of subclinical hypercortisolism. J Clin Endocrinol Metab 96: 1223-1236. doi:10.1210/jc.2010-2722. PubMed: 21367932.
11. Chiodini I, Morelli V, Salcuni AS, Eller-Vainicher C, Torlontano M, et al. (2010) Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism. J Clin Endocrinol Metab 95: 2736-2745. doi:10.1210/jc.2009-2387. PubMed: 20375210.
12. Stadler M, Pacini G, Petrie J, Luger A, Anderwald C, (2009) Beta cell (dys)function in non-diabetic offspring of diabetic patients. Diabetologia 52: 2435-2444. doi:10.1007/s00125-009-1520-7. PubMed: 19756484.
13. Bonadonna RC, Stumvoll M, Fritsche A, Muggeo M, Häring H, et al. (2003) Altered homeostatic adaptation of first- and second-phase beta-cell secretion in the offspring of patients with type 2 diabetes: studies with a minimal model to assess beta-cell function. Diabetes 52: 470-480. doi:10.2337/diabetes.52.2.470. PubMed: 12540623.
14. Elbein SC, Wegner K, Kahn SE, (2000) Reduced beta-cell compensation to the insulin resistance associated with obesity in members of caucasian familial type 2 diabetic kindreds. Diabetes Care 23: 221-227. doi:10.2337/diacare.23.2.221. PubMed: 10868835.
15. Kautzky-Willer A, Thomaseth K, Clodi M, Ludvik B, Waldhäusl W, et al. (1996) Beta-cell activity and hepatic insulin extraction following dexamethasone administration in healthy subjects. Metabolism 45: 486-491. doi:10.1016/S0026-0495(96)90224-3. PubMed: 8609836.
16. Vila G, Krebs M, Riedl M, Baumgartner-Parzer SM, Clodi M, et al. (2010) Acute effects of hydrocortisone on the metabolic response to a glucose load: increase in the first-phase insulin secretion. Eur J Endocrinol 163: 225-231. doi:10.1530/EJE-10-0282. PubMed: 20484150.
17. Anderwald C, (2009) Novel Aspects on Insulin Resistance. A Quick Overview. Endocrinologist 19: 302-305. doi:10.1097/TEN.0b013e3181c0479d.
18. Faerch K, Brøns C, Alibegovic AC, Vaag A, (2010) The disposition index: adjustment for peripheral vs. hepatic insulin sensitivity? J Physiol 588: 759-764. doi:10.1113/jphysiol.2009.184028. PubMed: 20100741.
19. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, et al. (2008) The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93: 1526-1540. doi:10.1210/jc.2008-0125. PubMed: 18334580.
20. Anderwald C, Gastaldelli A, Tura A, Krebs M, Promintzer-Schifferl M, et al. (2011) Mechanism and effects of glucose absorption during an oral glucose tolerance test among females and males. J Clin Endocrinol Metab 96: 515-524. doi:10.1210/jc.2010-1398. PubMed: 21147888.
21. Anderwald C, Tura A, Winhofer Y, Krebs M, Winzer C, et al. (2011) Glucose absorption in gestational diabetes mellitus during an oral glucose tolerance test. Diabetes Care 34: 1475-1480. doi:10.2337/dc10-2266. PubMed: 21602425.
22. Anderwald C, Anderwald-Stadler M, Promintzer M, Prager G, Mandl M, et al. (2007) The Clamp-Like Index: a novel and highly sensitive insulin sensitivity index to calculate hyperinsulinemic clamp glucose infusion rates from oral glucose tolerance tests in nondiabetic subjects. Diabetes Care 30: 2374-2380. doi:10.2337/dc07-0422. PubMed: 17595351.
23. Tura A, Kautzky-Willer A, Pacini G, (2006) Insulinogenic indices from insulin and C-peptide: comparison of beta-cell function from OGTT and IVGTT. Diabetes Res Clin Pract 72: 298-301. doi:10.1016/j.diabres.2005.10.005. PubMed: 16325298.
24. Tura A, Ludvik B, Nolan JJ, Pacini G, Thomaseth K, (2001) Insulin and C-peptide secretion and kinetics in humans: direct and model-based measurements during OGTT. Am J Physiol Endocrinol Metab 281: E966-E974. PubMed: 11595652.
25. Stadler M, Anderwald C, Karer T, Tura A, Kästenbauer T, et al. (2006) Increased plasma amylin in type 1 diabetic patients after kidney and pancreas transplantation: A sign of impaired beta-cell function? Diabetes Care 29: 1031-1038. doi:10.2337/dc05-1247. PubMed: 16644633.
26. Matsuda M, DeFronzo RA, (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22: 1462-1470. doi:10.2337/diacare.22.9.1462. PubMed: 10480510.
27. Anderwald CH, Tura A, Promintzer-Schifferl M, Prager G, Stadler M, et al. (2012) Alterations in gastrointestinal, endocrine, and metabolic processes after bariatric Roux-en-Y gastric bypass surgery. Diabetes Care 35: 2580-2587. doi:10.2337/dc12-0197. PubMed: 22923664.
28. Tura A, Morbiducci U, Sbrignadello S, Winhofer Y, Pacini G, et al. (2011) Shape of glucose, insulin, C-peptide curves during a 3-h oral glucose tolerance test: any relationship with the degree of glucose tolerance? Am J Physiol Regul Integr Comp Physiol 300: R941-R948. doi:10.1152/ajpregu.00650.2010. PubMed: 21248305.
29. Abdul-Ghani MA, Jenkinson CP, Richardson DK, Tripathy D, DeFronzo RA, (2006) Insulin secretion and action in subjects with impaired fasting glucose and impaired glucose tolerance: results from the Veterans Administration Genetic Epidemiology Study. Diabetes 55: 1430-1435. doi:10.2337/db05-1200. PubMed: 16644701.
30. Anderwald C, Bernroider E, Krššák M, Stingl H, Brehm A, et al. (2002) Effects of insulin treatment in type 2 diabetic patients on intracellular lipid content in liver and skeletal muscles. Diabetes 51: 3025-3032. doi:10.2337/diabetes.51.10.3025. PubMed: 12351443.
31. Anderwald C, Brunmair B, Stadlbauer K, Krebs M, Fürnsinn C, et al. (2007) Effects of free fatty acids on carbohydrate metabolism and insulin signalling in perfused rat liver. Eur J Clin Invest 37: 774-782. doi:10.1111/j.1365-2362.2007.01858.x. PubMed: 17888088.
32. Anderwald C, Tura A, Grassi A, Krebs M, Szendroedi J, et al. (2011) Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity. Diabetes Care 34: 437-441. doi:10.2337/dc10-1137. PubMed: 21216852.
33. Goran MI, Bergman RN, Cruz ML, Watanabe R, (2002) Insulin resistance and associated compensatory responses in african-american and Hispanic children. Diabetes Care 25: 2184-2190. doi:10.2337/diacare.25.12.2184. PubMed: 12453958.
34. Cerutti F, Sacchetti C, Bessone A, Rabbone I, Cavallo-Perin P, et al. (1998) Insulin secretion and hepatic insulin clearance as determinants of hyperinsulinaemia in normotolerant grossly obese adolescents. Acta Paediatr 87: 1045-1050. doi:10.1111/j.1651-2227.1998.tb01411.x. PubMed: 9825970.
35. Chap Z, Jones RH, Chou J, Hartley CJ, Entman ML, et al. (1986) Effect of dexamethasone on hepatic glucose and insulin metabolism after oral glucose in conscious dogs. J Clin Invest 78: 1355-1361. doi:10.1172/JCI112722. PubMed: 3534000.
36. Beaudry JL, Riddell MC, (2012) Effects of glucocorticoids and exercise on pancreatic beta-cell function and diabetes development. Diabetes/Metab Res Rev 28: 560-573. doi:10.1002/dmrr.2310.
37. Wiesner TD, Blüher M, Windgassen M, Paschke R, (2003) Improvement of insulin sensitivity after adrenalectomy in patients with pheochromocytoma. J Clin Endocrinol Metab 88: 3632-3636. doi:10.1210/jc.2003-030000. PubMed: 12915647.
38. Isles CG, Johnson JK, (1983) Phaeochromocytoma and diabetes mellitus: further evidence that alpha 2 receptors inhibit insulin release in man. Clin Endocrinol (Oxf) 18: 37-41. doi:10.1111/j.1365-2265.1983.tb03184.x. PubMed: 6303636.