Beneficial metabolic effects of prompt surgical treatment in patients with an adrenal incidentaloma causing biochemical hypercortisolism

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 6, 2010, Pages 2736-2745

  Chiodini, Iacopo ^a   Morelli, Valentina ^a   Salcuni, Antonio Stefano ^a   Eller Vainicher, Cristina ^a   Torlontano, Massimo ^d   Coletti, Francesca ^e   Iorio, Laura ^a,c   Cuttitta, Antonello ^d   Ambrosio, Angelo ^d   Vicentini, Leonardo ^b   Pellegrini, Fabio ^d,f   Copetti, Massimiliano ^d   Beck Peccoz, Paolo ^a   Arosio, Maura ^a,e   Ambrosi, Bruno ^a,c   Trischitta, Vincenzo ^d,g   Scillitani, Alfredo ^d  

^a UNIVERSITY OF MILAN   (Italy)

^b MAGGIORE HOSPITAL   (Italy)

^c San Donato Institute   (Italy)

^d CASA SOLLIEVO DELLA SOFFERENZA HOSPITAL   (Italy)

^e San Giuseppe Hospital   (Italy)

^f Santa Maria Imbaro   (Italy)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; CORTICOTROPIN; DEXAMETHASONE; GLUCOSE; HYDROCORTISONE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; DIAGNOSTIC AGENT; THYROTROPIN;

ADRENAL INCIDENTALOMA; ADRENALECTOMY; ADULT; AGED; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; CHOLESTEROL BLOOD LEVEL; CONSERVATIVE TREATMENT; CORTICOTROPIN BLOOD LEVEL; DEXAMETHASONE SUPPRESSION TEST; EARLY DIAGNOSIS; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYDROCORTISONE BLOOD LEVEL; HYDROCORTISONE URINE LEVEL; HYPERCORTISOLISM; LONGITUDINAL STUDY; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RETROSPECTIVE STUDY; ADRENAL TUMOR; BLOOD; CUSHING SYNDROME; FOLLOW UP; METABOLISM; MIDDLE AGED; PHYSIOLOGY; TREATMENT OUTCOME; URINE;

ADRENAL GLAND NEOPLASMS; ADRENOCORTICOTROPIC HORMONE; ADULT; AGED; BLOOD GLUCOSE; BLOOD PRESSURE; BODY WEIGHT; CHOLESTEROL; CHOLESTEROL, LDL; CUSHING SYNDROME; DEXAMETHASONE; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYDROCORTISONE; LONGITUDINAL STUDIES; MALE; METABOLIC SYNDROME X; MIDDLE AGED; THYROTROPIN; TREATMENT OUTCOME;

EID: 77954476416     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2009-2387     Document Type: Article

References (41)

1. Reincke M 2000 Subclinical Cushing's syndrome. Endocrinol Metab Clin North Am 29:47-56
2. Terzolo M, Reimondo G, Bovio S, Angeli A 2004 Subclinical Cushing's syndrome. Pituitary 7:217-223
3. Sippel RS, Chen H 2004 Subclinical Cushing's syndrome in adrenal incidentalomas. Surg Clin North Am 84:875-885
4. Terzolo M, Bovio S, Reimondo G, Pia A, Osella G, Borretta G, Angeli A 2005 Subclinical Cushing's syndrome in adrenal incidentalomas. Endocrinol Metab Clin North Am 34:423-439, x
5. Glazer HS, Weyman PJ, Sagel SS, Levitt RG, McClennan BL 1982 Nonfunctioning adrenal masses: incidental discovery on computed tomography. Am J Roengtenol 139:81-85
6. Griffing GT 1994 Editorial: A-I-D-S: the new endocrine epidemic. J Clin Endocrinol Metab 79:1530-1531
7. Chidiac RM, Aron DC 1997 Incidentaloma. A disease of modern technology. Endocrinol Metab Clin North Am 26:233-253
8. Bovio S, Cataldi A, Reimondo G, Sperone P, Novello S, Berruti A, Borasio P, Fava C, Dogliotti L, Scagliotti GV, Angeli A, Terzolo M 2006 Prevalence of adrenal incidentaloma in a contemporary computerized tomography series. J Endocrinol Invest 29:298-302
9. Mantero F, Terzolo M, Arnaldi G, Osella G, Masini AM, Alì A, Giovagnetti M, Opocher G, Angeli A 2000 A survey on adrenal incidentaloma in Italy. J Clin Endocrinol Metab 85:637-644
10. Leibowitz G, Tsur A, Chayen SD, Salameh M, Raz I, Cerasi E, Gross DJ 1996 Pre-clinical Cushing's syndrome: an unexpected frequent cause of poor glycaemic control in obese diabetic patients. Clin Endocrinol (Oxf) 44:717-722 (Pubitemid 26225189)
11. Rossi R, Tauchmanova L, Lucaio A, Di Martino M, Battista C, Del Viscovo L, Nuzzo V, Lombardi G 2000 Subclinical Cushing's syndrome in patients with adrenal incidentaloma: clinical and biochemical features. J Clin Endocrinol Metab 85:1440-1448
12. Garrapa GG, Pantanetti P, Arnaldi G, Mantero F, Faloia E 2001 Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome. J Clin Endocrinol Metab 86:5301-5306
13. Terzolo M, Pia A, Alì A, Osella G, Reimondo G, Bovio S, Daffara F, Procopio M, Paccotti P, Borretta G, Angeli A 2002 Adrenal incidentaloma: a new cause of the metabolic syndrome? J Clin Endocrinol Metab 87:998-1003
14. Angeli A, Terzolo M 2002 Editorial: adrenal incidentaloma-a modern disease with old complications. J Clin Endocrinol Metab 87:4869-4871 (Pubitemid 35316317)
15. Tauchmanovà L, Rossi R, Biondi B, Pulcrano M, Nuzzo V, Palmieri EA, Fazio S, Lombardi G 2002 Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk. J Clin Endocrinol Metab 87:4872-4878
16. Catargi B, Rigalleau V, Poussin A, Ronci-Chaix N, Bex V, Vergnot V, Gin H, Roger P, Tabarin A 2003 Occult Cushing's syndrome in type 2 diabetes. J Clin Endocrinol Metab 88:5808-5813
17. Terzolo M, Bovio S, Pia A, Conton PA, Reimondo G, Dall'Asta C, Bemporad D, Angeli A, Opocher G, Mannelli M, Ambrosi B, Mantero F 2005 Midnight serum cortisol as a marker of increased cardiovascular risk in patients with a clinically inapparent adrenal adenoma. Eur J Endocrinol 53:307-315
18. Chiodini I, Torlontano M, Scillitani A, Arosio M, Bacci S, Di Lembo S, Epaminonda P, Augello G, Enrini R, Ambrosi B, Adda G, Trischitta V 2005 Association of subclinical hypercortisolism with type 2 diabetes mellitus: a case-control study in hospitalized patients. Eur J Endocrinol 153:837-844
19. Chiodini I, Mascia ML, Muscarella S, Battista C, Minisola S, Arosio M, Santini SA, Guglielmi G, Carnevale V, Scillitani A 2007 Subclinical hypercortisolism among outpatients referred for "Osteoporosis." Ann Intern Med 147:541-548
20. Chiodini I, Morelli V, Masserini B, Salcuni AS, Eller-Vainicher C, Viti R, Coletti F, Guglielmi G, Battista C, Carnevale V, Iorio L, Beck-Peccoz P, Arosio M, Ambrosi B, Scillitani A 2009 Bone mineral density, prevalence of vertebral fractures and bone quality in patients with adrenal incidentalomas with and without subclinical hypercortisolism: an Italian Multicenter Study. J Clin Endocrinol Metab 94:3207-3214
21. Osella G, Reimondo G, Peretti P, Alì A, Paccotti P, Angeli A, Terzolo M2001 The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis. J Clin Endocrinol Metab 86:604-607
22. Francucci CM, Pantanetti P, Garrapa GG, Massi F, Arnaldi G, Mantero F2002Bonemetabolismandmass inwomenwith Cushing's syndrome and adrenal incidentaloma. Clin Endocrinol (Oxf) 57:587-593
23. Midorikawa S, Sanada H, Hashimoto S, Suzuki T, Watanabe T 2001 The improvement of insulin resistance in patients with adrenal incidentalomas by surgical resection. Clin Endocrinol (Oxf) 54: 797-804
24. Emral R, Uysal AR, Asik M, Gullu S, Corapcioglu D, Tonyukuk V, Erdogan G 2003 Prevalence of subclinical Cushing's syndrome in 70 patients with adrenal incidentaloma: clinical, biochemical and surgical outcomes. Endocr J 50:399-408
25. Bernini G, Moretti A, Iacconi P, Miccoli P, Nami R, Lucani B, Salvetti A 2003 Anthropometric, haemodynamic, humoral and hormonal evaluation in patients with incidental adrenocortical adenomas before and after surgery. Eur J Endocrinol 148:213-219
26. Erbil Y, Ademoǧlu E, Ozbey N, Barbaros U, Yanik BT, Salmaslioǧlu A, Bozbora A, Ozarmaǧan S 2006 Evaluation of the cardiovascular risk in patients with subclinical Cushing syndrome before and after surgery. World J Surg 30:1665-1671
27. Mitchell IC, Auchus RJ, Juneja K, Chang AY, Holt SA, Snyder 3rd WH, Nwariaku FE 2007 "Subclinical Cushing's syndrome" is not so subclinical: improvement after adrenalectomy in 9 patients. Surgery 142:900-905; discussion 905.e1
28. Tsuiki M, Tanabe A, Takagi S, Naruse M, Takano K 2008 Cardiovascular risks and their long-term clinical outcome in patients with subclinical Cushing's syndrome. Endocr J 55:737-745
29. Toniato A, Merante-Boschin I, Opocher G, Pelizzo MR, Schiavi F, Ballotta E 2009 Surgical versus conservative management for subclinical Cushing syndrome in adrenal incidentalomas: a prospective randomized study. Ann Surg 249:388-391
30. 2002 NIH State-of-the-Science statement on management of the clinically inapparent adrenal mass ("incidentaloma"). NIH Consens State Sci Statements 19:1-25 (Review)
31. Grumbach MM, Biller BM, Braunstein GD, Campbell KK, Carney JA, Godley PA, Harris EL, Lee JK, Oertel YC, Posner MC, Schlechte JA, Wieand HS 2003 Management of the clinically inapparent adrenal mass ("incidentalomas" ). Ann Intern Med 138:424-429
32. Tsagarakis S, Vassiliadi D, Thalassinos N 2006 Endogenous subclinical hypercortisolism: diagnostic uncertainties and clinical implications. J Endocrinol Invest 29:471-482 (Pubitemid 44043366)
33. Nieman LK, Biller BM, Findling JW, Newell-Price J, Savage MO, Stewart PM, Montori VM 2008 The diagnosis of Cushing's syndrome: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 93:1526-1540
34. Kratz A, Ferraro M, Sluss PM, Lewandrowski KB 2004 Laboratory reference values. N Engl J Med 351:1548-1563
35. The Expert Committee on the Diagnosis and Classification of Diabetes Mellitus 2003 Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus. Diabetes Care 26(Suppl 1):S5-S20
36. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults 2001 Executive Summary of the Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). JAMA 285:2486-2497
37. Vidal J 2002 Updated review on the benefits of weight loss. Int J Obes Relat Metab Disord 25(Suppl 4):S25-S28
38. Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, Grassi G, Heagerty AM, Kjeldsen SE, Laurent S, Narkiewicz K, Ruilope L, Rynkiewicz A, Schmieder RE, Boudier HA, Zanchetti A, Vahanai A, Camm J, De Caterina R, Dean V, Dickstein K, Filippatos G, Funck-Brentano C, Hellemans I, Kristensen SD, et al. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens 25:1105-1187
39. Masserini B, Morelli V, Bergamaschi S, Ermetici F, Eller-Vainicher C, Barbieri AM, Maffini MA, Scillitani A, Ambrosi B, Beck-Peccoz P, Chiodini I 2009 The limited role of midnight salivary cortisol in the diagnosis of subclinical hypercortisolism in patients with adrenal incidentalomas. Eur J Endocrinol 160:87-92
40. Eller-Vainicher C, Morelli V, Salcuni AS, Torlontano M, Coletti F, Iorio L, Cuttitta A, Ambrosio A, Vicentini L, Carnevale V, Beck- Peccoz P, Arosio M, Ambrosi B, Scillitani A, Chiodini I 2010 Postsurgical hypocortisolism after removal of an adrenal incidentaloma: is it predictable by an accurate endocrinological work-up before surgery? Eur J Endocrinol 162:91-99
41. Morelli V, Masserini B, Salcuni AS, Eller-Vainicher C, Savoca C, Viti R, Coletti F, Guglielmi G, Battista C, Iorio L, Beck-Peccoz P, Ambrosi B, Arosio M, Scillitani A, Chiodini I 3 May 2010 Subclinical Hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects. Clin Endocrinol (Oxf) doi: 10.1111/ j.1365-2265. 2010.03794x