Patients with subclinical Cushing's syndrome due to adrenal adenoma have increased cardiovascular risk

Journal of Clinical Endocrinology and Metabolism

Volumn 87, Issue 11, 2002, Pages 4872-4878

  Tauchmanovà, Libuse ^a   Rossi, Riccardo ^a   Biondi, Bernadette ^a   Pulcrano, Melania ^a   Nuzzo, Vincenzo ^a   Palmieri, Emiliano Antonio ^a   Fazio, Serafino ^a   Lombardi, Gaetano ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL; GLUCOSE; HYDROCORTISONE; INSULIN; TRIACYLGLYCEROL;

ADRENAL CORTEX ADENOMA; ADULT; AGED; ARTICLE; ATHEROSCLEROTIC PLAQUE; BLOOD PRESSURE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CAROTID ARTERY; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CONTROLLED STUDY; CUSHING SYNDROME; DYSLIPIDEMIA; ECHOGRAPHY; ELECTROCARDIOGRAPHY; FEMALE; GLUCOSE BLOOD LEVEL; HEMOSTASIS; HUMAN; HYDROCORTISONE RELEASE; HYPERTENSION; IMPAIRED GLUCOSE TOLERANCE; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; RISK FACTOR; TRIACYLGLYCEROL BLOOD LEVEL;

ADENOMA; ADRENAL GLAND NEOPLASMS; ADULT; AGED; ARTERIOSCLEROSIS; BLOOD GLUCOSE; BLOOD PRESSURE; BODY CONSTITUTION; BODY MASS INDEX; CARDIOVASCULAR DISEASES; CAROTID ARTERIES; CHOLESTEROL; CUSHING SYNDROME; DIABETES MELLITUS, TYPE 2; DIASTOLE; FASTING; FEMALE; FIBRINOGEN; GLUCOSE INTOLERANCE; HUMANS; HYPERLIPIDEMIAS; HYPERTENSION; INSULIN; INSULIN RESISTANCE; MALE; MIDDLE AGED; RISK FACTORS; SYSTOLE; TRIGLYCERIDES;

EID: 0036847434     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.2001-011766     Document Type: Article

References (47)

1. Biondi B, Palmieri EA, Fazio S, Cosco C, Nocera M, Saccà L, Filetti S, Lombardi G, Perticone F 2000 Endogenous subclinical hyperthyroidism affects quality of life and cardiac morphology an function in young and middle-aged patients. J Clin Endocrinol Metab 85:4701-4705
2. Biondi B. Fazio S, Carella C, Amato G, Cittadini A, Lupoli G, Saccà L, Bellastella A, Lombardi G 1993 Cardiac effects of long-term thyrotropin suppressive therapy with levothyroxine. J Clin Endocrinol Metab 77:334-338
3. Ross NS 1994 Epidemiology of Cushing's syndrome and subclinical disease. Endocrinol Metab Clin North Am 23:539-546
4. Reincke M, Nieke J, Krestin GP, Saeger W, Allolio B, Winkelmann W 1992 Preclinical Cushing's syndrome in adrenal "incidentalomas:" comparison with adrenal Cushing's syndrome. J Clin Endocrinol Metab 75:826-832
5. Terzolo M, Osella G, Alì A, Borretta G, Cesario F, Paccotti P, Angeli A 1998 Subclinical Cushing's syndrome in adrenal incidentaloma. Clin Endocrinol (Oxf) 48:89-97
6. Mantero F, Terzolo M, Arnaldi G, Osella G, Masini AM, Alì A, Giovanetti M, Opocher G, Angeli A 2000 A survey on adrenal incidentaloma in Italy. J Clin Endocrinol Metab 85:637-644
7. Rossi R., Tauchmanovà L, Luciano A, Di Martino M, Battista C, del Viscovo L, Nuzzo V, Lombardi G 2000 Subclinical Cushing's syndrome in patients with adrenal incidentaloma. Clinical and biochemical features. J Clin Endocrinol Metab 85:1440-1448
8. Kaye TB, Crapo L 1990 The Cushing's syndrome: An update on diagnostic tests. Ann Intern Med 112:434-444
9. Goldstein LB, Adams R, Becker K, Furberg CD, Gorelick PB, Hademenos G, Hill M, Howard G, Howard VJ, Jacobs B, Levine SR, Mosca L, Sacco RL, Sherman DG, Wolf PA, del Zoppo GJ 2001 Primary prevention of ischemic stroke. A statement for healthcare professionals from the stroke council of the American Heart Association. Circulation 103:163-182
10. Fernández-Real JM, Ricart W, Simò R, Salinas I, Webb SM 1998 Study of glucose tolerance in consecutive patients harbouring incidental adrenal tumours. Clin Endocrinol (Oxf) 49:53-61
11. Rossi R, Tauchmanovà L 2001 Metabolic abnormalities in patients with adrenal incidentaloma [Letter]. J Clin Endocrinol Metab 86:951-952
12. Osella G, Terzolo M, Reimondo G, Piovesan A, Pia A, Termine A, Paccotti P, Angeli A 1997 Serum markers of bone and collagen turnover in patients with Cushing's syndrome and in subjects with adrenal incidentalomas. J Clin Endocrinol Metab 82:3303-3307
13. Sartorio A, Conti A, Ferrero S, Giambona S, Re T, Passini E, Ambrosi B 1998 Evaluation of markers of bone and collagen turnover in patients with active and preclinical Cushing's syndrome and in patients with adrenal incidentaloma. Eur J Endocrinol 138:146-152
14. Torlontano M, Chiodini I, Pileri M, Guglielmi G, Cammisa M, Modoni S, Carnevale V, Trischetta V, Scillitani A 1999 Altered bone mass and turnover in female patients with adrenal incidentaloma: The effect of subclinical hypercortisolism. J Clin Endocrinol Metab 84:2381-2385
15. Tauchmanovà L, Rossi R, Nuzzo V, dei Puente A, Esposito-del Puente A, Pizzi C, Fonderico F, Lupoli G, Lombardi G 2001 Bone loss determined by quantitative ultrasonometry correlates inversely with the disease activity in patients with different degree of endogenous glucocorticoid excess due to adrenal mass. Eur J Endocrinol 145:241-247
16. Osella G, Reimondo G, Peretti P, Alì A, Paccotti P, Angeli A, Terzolo M 2001 The patients with incidentally discovered adrenal adenoma (incidentaloma) are not at increased risk of osteoporosis. J Clin Endocrinol Metab 86:604-607
17. Royal College of Physicians 1983 Obesity. A report of the Royal College of Physicians. J R Coll Physicians Lond 17:5-65
18. Kirkendall WH, Burton HC, Epstein FH, Freis ED 1967 Recommendation for human blood pressure determination by sphygmomanometers. Circulation 36:980-988
19. Nieman L, Cutler Jr GB 1995 Cushing's syndrome. In: DeGroot JL, ed. Endocrinology, 3rd Ed. Philadelphia: Saunders; 1741-1762
20. Joint National Committee on High Blood Pressure 1993 Fifth report of the joint national committee on high blood pressure. Arch Intern Med 153:154-183
21. Expert Committee on the Diagnosis and Classification of Diabetes Mellitus 1997 Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Cate 20:1183-1197
22. International Task Force for Prevention of Coronary Heart Disease 1998 Coronary heart disease: Reducing the risk. Nutr Metab Cardiovasc 8:212-271
23. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC 2000 Homeostasis model assessment: Insulin resistance and β cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-419
24. Emoto M, Nishizawa Y, Maekawa K, Hiura Y, Kanda H, Kawagishi T, Shoji T, Okuno Y, Morii H 1999 Homeostasis model assessment as a clinical index of insulin resistance in type 2 diabetic patients treated with sulfonylureas. Diabetes Care 22:818-822
25. Ross EJ, Linch DC 1982 Cushing's syndrome-killing disease: Discriminatory value of signs an symptoms aiding early diagnosis. Lancet 2:646-649
26. Extabe J, Vazquez JA 1994 Morbidity and mortality in Cushing's disease: An epidemiological approach. Clin Endocrinol (Oxf) 40:479-484
27. Colao AM, Pivonello R, Spiezia S, Faggiano A, Ferone D, Filipella M, Marzullo P, Cerbone G, Siciliani M, Lombardi G 1999 Persistence of increased cardiovascular risk in patients with Cushing's disease after five years of successful cure. J Clin Endocrinol Metab 84:2664-2672
28. Plotz CM, Knowlton AI, Ragan I 1952 The natural history of Cushing's syndrome. Am J Med 3:597-614
29. Urbanic RC, George JM 1981 Cushing's disease: 18 Years experience. Medicine 60:14-24
30. Soffer LJ, Iannaccone A., Gabrilove JL 1961 Cushing's syndrome: A study of fifty patients. Am J Med 30:129-135
31. Sprague RG, Randall RV, Salassa RM 1956 Cushing's syndrome. A progressive and often fatal disease. Arch Intern Med 98:389-398
32. Hashimoto S, Midorikawa S, Sanada H, Watanabe T 2000 SSPG titer is a diagnostic marker for adrenocortical adenoma in patients with non-functioning adrenal incidentaloma. Biomed Pharmacother 54(Suppl 1):175-177
33. Garrapa GGM, Pantanetti P, Arnaldi G, Mantero F, Faloia E 2001 Body composition and metabolic features in women with adrenal incidentaloma or Cushing's syndrome. J Clin Endocrinol Metab 86:5301-5306
34. Lamarche B 1998 Abdominal obesity and its metabolic complications: Implications for the risk of ischaemic heart disease. Coron Artery Dis 9:473-481
35. Saruta T, Suzuki H, Handa M, Ogaroshi Y, Kondo K, Somba S 1986 Multiple factors contribute to the pathogenesis of hypertension in Cushing's syndrome. J Clin Endocrinol Metab 62:275-279
36. Leibowitz G, Tsur A, Chayen SD, Salameh M, Raz I, Cerasi E, Gross DJ 1996 Pre-clinical Cushing's syndrome: An unexpected frequent cause of poor glycemic control in obese diabetic patients. Clin Endocrinol (Oxf) 44:717-722
37. Ambrosi B, Sartorio A, Pizzocaro A, Passini E, Bottasso B, Federici A 2000 Evaluation of haemostatic and fibrinolytic markers in patients with Cushing's syndrome and in patients with adrenal incidentaloma, Exp Clin Endocrinol Diabetes 108:294-298
38. Sjöberg HE, BlombŠck M, Granberg PO 1976 Thromboembolic complications, heparin treatment and increase in coagulation factors in Cushing's syndrome. Acta Med Scand 199:95-98
39. Lorenzen I, Hansen LK 1967 Effect of glucocorticoids on human vascular connective tissue. Vasc Dis 4:335-341
40. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R 1986 Intimal plus medial thickness of the arterial wall: A direct measurement with ultrasound imaging. Circulation 74:1399-1406
41. Stamler J, Pick R, Katz LN 1954 Effects of cortisone, hydrocortisone and corticotropin on lipemia, glycemia and atherogenesis in cholesterol-fed chicks. Circulation 10:237-246
42. Rosenfeld S, Marmorston J, Sobel H, White AE 1960 Enhancement of experimental atherosclerosis by ACTH in the dog. Proc Soc Exp Biol Med 103:83-86
43. Katayama M, Nomura K, Ujihara M, Obara T, Demura H 1998 Age-dependent decline in cortisol levels and clinical manifestations in patients with ACTH-independent Cushing's syndrome. Clin Endocrinol (Oxf) 49:311-316
44. Midorikawa S, Sanada H, Hashimoto S, Suzuki T, Watanabe T 2001 The improvement of insulin resistance in patients with adrenal incidentaloma by surgical resection. Clin Endocrinol (Oxf) 54:797-804
45. Mirallie E, Jafari M, Pattou F, Erenst O, Huglo D, Carnaille B, Proye C 2001 Outcome of non-operated adrenal masses in 126 patients observed from 1986 to 1999. Ann Chir 126:212-220
46. Siren J, Tervahartiala P, Sivula A, Haapiainen R 2000 Natural course of adrenal incidentalomas: Seven-year follow-up-up study. World J Surg 245:579-582
47. Terzolo M, Pia A, Alì A, Osella G, Reimondo G, Bovio S, Daffara F, Procopio M, Paccotti P, Borretta G, Angeli A 2002 Adrenal incidentaloma: A new cause of the metabolic syndrome? J Clin Endocrinol Metab 87:998-1003