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Volumn 18, Issue 3, 2013, Pages 570-578

Pharmacogenomics: Current applications and future prospects towards personalized therapeutics

Author keywords

Cancer; Epigenetics; Personalized medicine; Pharmacogenomics; Polymorphisms

Indexed keywords

ANTILEUKEMIC AGENT; ATAZANAVIR; BETA LACTAM ANTIBIOTIC; CETUXIMAB; CLOPIDOGREL; CODEINE; CYTOCHROME P450; CYTOCHROME P450 2D6; DRUG METABOLIZING ENZYME; ERLOTINIB; FLAVOPIRIDOL; GEFITINIB; GLUTATHIONE TRANSFERASE; IMATINIB; INDINAVIR; MERCAPTOPURINE; METHOTREXATE; PANITUMUMAB; SIMVASTATIN; TAMOXIFEN; TRASTUZUMAB; WARFARIN;

EID: 84885753871     PISSN: 11070625     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (76)
  • 1
    • 0344091561 scopus 로고    scopus 로고
    • Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans
    • DOI 10.1038/ng1128
    • Carlson CS, Eberle MA, Rieder MJ et al. Additional SNPs and linkage-disequilibrium analyses are necessary for whole-genome association studies in humans. Nat Genet 2003; 33: 518-521. (Pubitemid 36390016)
    • (2003) Nature Genetics , vol.33 , Issue.4 , pp. 518-521
    • Carlson, C.S.1    Eberle, M.A.2    Rieder, M.J.3    Smith, J.D.4    Kruglyak, L.5    Nickerson, D.A.6
  • 4
    • 70350044048 scopus 로고    scopus 로고
    • Towards targeted epigenetic therapy of cancer
    • Magic Z, Supic G, Brankovic-Magic M. Towards targeted epigenetic therapy of cancer. J BUON 2009;14(Suppl 1):S79-88.
    • (2009) J BUON , vol.14 , Issue.SUPPL. 1
    • Magic, Z.1    Supic, G.2    Brankovic-Magic, M.3
  • 5
    • 57649124311 scopus 로고    scopus 로고
    • Pharmacogenetics in acute lymphoblastic leukemia
    • Cheok MH, Pottier N, Kager L et al. Pharmacogenetics in acute lymphoblastic leukemia. Semin Hematol 2009; 46: 39-51.
    • (2009) Semin Hematol , vol.46 , pp. 39-51
    • Cheok, M.H.1    Pottier, N.2    Kager, L.3
  • 6
    • 84865705877 scopus 로고    scopus 로고
    • Personalized medicine: Potential, barriers and contemporary issues
    • Sorich MJ, McKinnon RA. Personalized medicine: potential, barriers and contemporary issues. Curr Drug Metab 2012;13:1000-1006.
    • (2012) Curr Drug Metab , vol.13 , pp. 1000-1006
    • Sorich, M.J.1    McKinnon, R.A.2
  • 7
    • 23044474063 scopus 로고    scopus 로고
    • Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes
    • DOI 10.1038/ng1612
    • Cheng Q, Yang W, Raimondi SC et al. Karyotypic abnormalities create discordance of germline genotype and cancer cell phenotypes. Nat Genet 2005; 37: 878-882. (Pubitemid 41077115)
    • (2005) Nature Genetics , vol.37 , Issue.8 , pp. 878-882
    • Cheng, Q.1    Yang, W.2    Raimondi, S.C.3    Pui, C.-H.4    Railing, M.V.5    Evans, W.E.6
  • 9
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DOI 10.1016/S0167-6296(02)00126-1
    • DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ 2003; 22: 151-185. (Pubitemid 36279392)
    • (2003) Journal of Health Economics , vol.22 , Issue.2 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 10
    • 0036441844 scopus 로고    scopus 로고
    • The value of improving the productivity of the drug development process: Faster Times and Better Decisions
    • DiMasi JA. The value of improving the productivity of the drug development process: faster times and better decisions. Pharmacoeconomics 2002; 20: 1-10. (Pubitemid 35397394)
    • (2002) PharmacoEconomics , vol.20 , Issue.SUPPL. 3 , pp. 1-10
    • DiMasi, J.A.1
  • 11
    • 0035775486 scopus 로고    scopus 로고
    • Pharmacogenomics: The inherited basis for interindividual differences in drug response
    • DOI 10.1146/annurev.genom.2.1.9
    • Evans W, Johnson JA. Pharmacogenomics: The Inherited Basis for Interindividual Differences in Drug Response. Annu Rev Genomics Hum Genet 2001; 2: 9-39. (Pubitemid 35264999)
    • (2001) Annual Review of Genomics and Human Genetics , vol.2 , pp. 9-39
    • Evans, W.E.1    Johnson, J.A.2
  • 15
    • 0034973773 scopus 로고    scopus 로고
    • Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity
    • Guengerich FP. Common and uncommon cytochrome P450 reactions related to metabolism and chemical toxicity. Chem Res Toxicol 2001; 14: 611-650. (Pubitemid 32565712)
    • (2001) Chemical Research in Toxicology , vol.14 , Issue.6 , pp. 611-650
    • Guengerich, F.P.1
  • 17
    • 57049177786 scopus 로고    scopus 로고
    • Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: Scale-up of a biomimetic reaction for metabolite production of drug candidates
    • Akagah B, Lormier AT, Fournet A, Figadère B. Oxidation of antiparasitic 2-substituted quinolines using metalloporphyrin catalysts: scale-up of a biomimetic reaction for metabolite production of drug candidates. Org Biomol Chem 2008; 6: 4494-4497.
    • (2008) Org Biomol Chem , vol.6 , pp. 4494-4497
    • Akagah, B.1    Lormier, A.T.2    Fournet, A.3    Figadère, B.4
  • 18
    • 0036119713 scopus 로고    scopus 로고
    • Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance
    • DOI 10.1046/j.0306-5251.2001.01556.x
    • Brazell C, Freeman A, Mosteller M. Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance. Br J Clin Pharmacol 2002; 53: 224-231. (Pubitemid 34226964)
    • (2002) British Journal of Clinical Pharmacology , vol.53 , Issue.3 , pp. 224-231
    • Brazell, C.1    Freeman, A.2    Mosteller, M.3
  • 19
    • 70350044042 scopus 로고    scopus 로고
    • Genomic strategies to improve outcome and individualize therapy in cancer: The paradigm of childhood acute lymphoblastic leukemia
    • Kager L. Genomic strategies to improve outcome and individualize therapy in cancer: the paradigm of childhood acute lymphoblastic leukemia. J BUON 2009; 14(Suppl 1):S181-186.
    • (2009) J BUON , vol.14 , Issue.SUPPL. 1
    • Kager, L.1
  • 20
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans W, Relling M. Pharmacogenomics: translating functional genomics into rational therapeutics. Science 1999; 286: 487-491.
    • (1999) Science , vol.286 , pp. 487-491
    • Evans, W.1    Relling, M.2
  • 21
    • 30444451921 scopus 로고    scopus 로고
    • Thiopurine methyltransferase in acute lymphoblastic leukemia [4]
    • DOI 10.1182/blood-2005-08-3379
    • Relling MV, Pui CH, Cheng C et al. Thiopurine methyltransferase in acute lymphoblastic leukemia. Blood 2006; 107: 843-844. (Pubitemid 43076417)
    • (2006) Blood , vol.107 , Issue.2 , pp. 843-844
    • Relling, M.V.1    Pui, C.-H.2    Cheng, C.3    Evans, W.E.4
  • 24
    • 0025837127 scopus 로고
    • Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia
    • Evans WE, Horner M, Chu YQ et al. Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase- deficient child with acute lymphocytic leukemia. J Pediatr 1991; 119: 985-989.
    • (1991) J Pediatr , vol.119 , pp. 985-989
    • Evans, W.E.1    Horner, M.2    Chu, Y.Q.3
  • 25
    • 0027524983 scopus 로고
    • Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia
    • Lennard L, Gibson BE, Nicole T et al. Congenital thiopurine methyltransferase deficiency and 6-mercaptopurine toxicity during treatment for acute lymphoblastic leukaemia. Arch Dis Child 1993; 69: 577-579. (Pubitemid 23355853)
    • (1993) Archives of Disease in Childhood , vol.69 , Issue.5 , pp. 577-579
    • Lennard, L.1    Gibson, B.E.S.2    Nicole, T.3    Lilleyman, J.S.4
  • 26
    • 0027285234 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient [8]
    • McLeod HL, Miller DR, Evans WE. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient Lancet 1993; 341: 1151. (Pubitemid 23125884)
    • (1993) Lancet , vol.341 , Issue.8853 , pp. 1151
    • McLeod, H.L.1    Miller, D.R.2    Evans, W.E.3
  • 27
    • 0031933720 scopus 로고    scopus 로고
    • Pharmacokinetics, dose adjustments, and 6-mercaptopurine/ methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency
    • DOI 10.1080/08035259850158001
    • Andersen JB, Szumlanski C, Weinshilboum RM et al. Pharmacokinetics, dose adjustments, and 6-mercaptopurine/methotrexate drug interactions in two patients with thiopurine methyltransferase deficiency. Acta Paediatr 1998; 87: 108-111. (Pubitemid 28086619)
    • (1998) Acta Paediatrica, International Journal of Paediatrics , vol.87 , Issue.1 , pp. 108-111
    • Brandt, A.J.1    Szumlanski, C.2    Weinshilboum, R.M.3    Schmiegelow, K.4
  • 28
    • 0027401302 scopus 로고
    • Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient [8]
    • Schutz E, Gummert J, Mohr F et al. Azathioprine-induced myelosuppression in thiopurine methyltransferase deficient heart transplant recipient. Lancet 1993; 341: 436. (Pubitemid 23048173)
    • (1993) Lancet , vol.341 , Issue.8842 , pp. 436
    • Schutz, E.1    Gummert, J.2    Mohr, F.3    Oellerich, M.4
  • 29
    • 0025331198 scopus 로고
    • Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia
    • DOI 10.1016/0140-6736(90)91745-V
    • Lennard L, Lilleyman JS, Van Loon J et al. Genetic variation in response to 6-mercaptopurine for childhood acute lymphoblastic leukaemia. Lancet 1990; 336: 225-229. (Pubitemid 20229068)
    • (1990) Lancet , vol.336 , Issue.8709 , pp. 225-229
    • Lennard, L.1    Lilleyman, J.S.2    Van Loon, J.3    Weinshilboum, R.M.4
  • 30
    • 36448987850 scopus 로고    scopus 로고
    • Pharmacogenomics of Analgesic Agents
    • DOI 10.1016/j.cpem.2007.08.001, PII S1522840107000547
    • Drendel A. Pharmacogenomics of Analgesic Agents. Clin Ped Emerg Med 2007; 8: 262-267. (Pubitemid 350163027)
    • (2007) Clinical Pediatric Emergency Medicine , vol.8 , Issue.4 , pp. 262-267
    • Drendel, A.1
  • 31
    • 35549000170 scopus 로고    scopus 로고
    • The pharmacogenetics of analgesia
    • DOI 10.1517/14656566.8.14.2235
    • Stamer UM, Stüber F. The pharmacogenetics of analgesia. Expert Opin Pharmacother 2007;8:2235-2245. (Pubitemid 350001587)
    • (2007) Expert Opinion on Pharmacotherapy , vol.8 , Issue.14 , pp. 2235-2245
    • Stamer, U.M.1    Stuber, F.2
  • 32
    • 67349235560 scopus 로고    scopus 로고
    • Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation?
    • Lötsch J, Rohrbacher M, Schmidt H et al. Can extremely low or high morphine formation from codeine be predicted prior to therapy initiation? Pain 2009; 144: 119-124.
    • (2009) Pain , vol.144 , pp. 119-124
    • Lötsch, J.1    Rohrbacher, M.2    Schmidt, H.3
  • 37
    • 49949104757 scopus 로고    scopus 로고
    • SLCO1B1 variants and statin-induced myopathy-a genomewide study
    • Link E, Parish S, Armitage J et al. SLCO1B1 variants and statin-induced myopathy-a genomewide study. N Engl J Med 2008; 359: 789-799.
    • (2008) N Engl J Med , vol.359 , pp. 789-799
    • Link, E.1    Parish, S.2    Armitage, J.3
  • 38
    • 73349098768 scopus 로고    scopus 로고
    • Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects
    • Treviño LR, Shimasaki N, Yang W et al. Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects. J Clin Oncol 2009; 27: 5972-5978.
    • (2009) J Clin Oncol , vol.27 , pp. 5972-5978
    • Treviño, L.R.1    Shimasaki, N.2    Yang, W.3
  • 39
    • 78249236222 scopus 로고    scopus 로고
    • Flavopiridol pharmacogenetics: Clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition
    • Ni W, Ji J, Dai Z et al. Flavopiridol pharmacogenetics: clinical and functional evidence for the role of SLCO1B1/OATP1B1 in flavopiridol disposition. PLoS ONE 2010; 5: e13792.
    • (2010) PLoS ONE , vol.5
    • Ni, W.1    Ji, J.2    Dai, Z.3
  • 40
    • 69249219296 scopus 로고    scopus 로고
    • Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy
    • Shuldiner AR, O'Connell JR, Bliden KP et al. Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy. JAMA 2009; 302: 849-857.
    • (2009) JAMA , vol.302 , pp. 849-857
    • Shuldiner, A.R.1    O'Connell, J.R.2    Bliden, K.P.3
  • 41
    • 51649110496 scopus 로고    scopus 로고
    • A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose
    • Cooper GM, Johnson JA, Langaee TY et al. A genome-wide scan for common genetic variants with a large influence on warfarin maintenance dose. Blood 2008; 112: 1022-1027.
    • (2008) Blood , vol.112 , pp. 1022-1027
    • Cooper, G.M.1    Johnson, J.A.2    Langaee, T.Y.3
  • 42
    • 59249100224 scopus 로고    scopus 로고
    • Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia
    • Yang JJ, Cheng C, Yang W et al. Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia. JAMA 2009; 301: 393-403.
    • (2009) JAMA , vol.301 , pp. 393-403
    • Yang, J.J.1    Cheng, C.2    Yang, W.3
  • 43
    • 70649093023 scopus 로고    scopus 로고
    • Pharmacogenomics of CYP3A: Considerations for HIV treatment
    • Lakhman SS, Ma Q, Morse GD. Pharmacogenomics of CYP3A: considerations for HIV treatment. Pharmacogenomics 2009; 10: 1323-1339.
    • (2009) Pharmacogenomics , vol.10 , pp. 1323-1339
    • Lakhman, S.S.1    Ma, Q.2    Morse, G.D.3
  • 45
    • 41049117206 scopus 로고    scopus 로고
    • Association of tumor necrosis factor-alpha -308G < A polymorphism with IgE-mediated allergy to betalactams in an Italian population
    • DOI 10.1038/sj.tpj.6500456, PII 6500456
    • Guéant-Rodriguez RM, Guéant JL, Viola M et al. Association of tumor necrosis factor-alpha -308G>A polymorphism with IgE-mediated allergy to beta lactams in an Italian population. Pharmacogenomics J 2008; 8: 162-168. (Pubitemid 351418952)
    • (2008) Pharmacogenomics Journal , vol.8 , Issue.2 , pp. 162-168
    • Gueant-Rodriguez, R.-M.1    Gueant, J.-L.2    Viola, M.3    Tramoy, D.4    Gaeta, F.5    Romano, A.6
  • 46
    • 33644518439 scopus 로고    scopus 로고
    • The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy
    • Trosko JE. The role of stem cells and gap junctions as targets for cancer chemoprevention and chemotherapy. Biomed Pharmacother 2005; 59: 326-331.
    • (2005) Biomed Pharmacother , vol.59 , pp. 326-331
    • Trosko, J.E.1
  • 47
    • 78651400336 scopus 로고    scopus 로고
    • Anticancer and chemopreventing natural products: Some biochemical and therapeutic aspects
    • Karikas GA. Anticancer and chemopreventing natural products: some biochemical and therapeutic aspects. J BUON 2010; 15: 627-638.
    • (2010) J BUON , vol.15 , pp. 627-638
    • Karikas, G.A.1
  • 48
    • 79957476232 scopus 로고    scopus 로고
    • Chemoprevention molecular and biochemical mechanisms involved in cancer control and management
    • Karikas GA. Chemoprevention molecular and biochemical mechanisms involved in cancer control and management. Health Sci J 2011; 5: 149-156.
    • (2011) Health Sci J , vol.5 , pp. 149-156
    • Karikas, G.A.1
  • 49
    • 84874825575 scopus 로고    scopus 로고
    • Natural and synthetic agents in cancer chemoprevention
    • Karikas GA. Natural and synthetic agents in cancer chemoprevention. Pharmakeftiki 2012; 24:79-88.
    • (2012) Pharmakeftiki , vol.24 , pp. 79-88
    • Karikas, G.A.1
  • 50
    • 67649305191 scopus 로고    scopus 로고
    • Epigenetics in cancer: Targeting chromatin modifications
    • Ellis L, Atadja PW, Johnstone RW. Epigenetics in cancer: targeting chromatin modifications. Mol Cancer Ther 2009; 8: 1409-1420.
    • (2009) Mol Cancer Ther , vol.8 , pp. 1409-1420
    • Ellis, L.1    Atadja, P.W.2    Johnstone, R.W.3
  • 51
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • DOI 10.1038/nrg2005, PII NRG2005
    • Esteller M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat Rev Genet 2007; 8: 286-298. (Pubitemid 46439286)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.4 , pp. 286-298
    • Esteller, M.1
  • 52
    • 20144388146 scopus 로고    scopus 로고
    • Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer
    • Fraga MF, Ballestar E, Villar-Garea A et al. Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer. Nat Genet 2005; 37: 391-400.
    • (2005) Nat Genet , vol.37 , pp. 391-400
    • Fraga, M.F.1    Ballestar, E.2    Villar-Garea, A.3
  • 53
    • 67149099680 scopus 로고    scopus 로고
    • Histone H4 lysine16 acetylation regulates cellular lifespan
    • Dang W, Steffen KK, Perry R et al. Histone H4 lysine16 acetylation regulates cellular lifespan. Nature 2009; 459: 802-807.
    • (2009) Nature , vol.459 , pp. 802-807
    • Dang, W.1    Steffen, K.K.2    Perry, R.3
  • 54
    • 33744805399 scopus 로고    scopus 로고
    • Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells
    • DOI 10.1016/j.ccr.2006.04.020, PII S1535610806001437
    • Saito Y, Liang G, Egger G et al. Specific activation of microRNA-127 with down regulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells. Cancer Cell 2006; 9: 435-443. (Pubitemid 43832188)
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 435-443
    • Saito, Y.1    Liang, G.2    Egger, G.3    Friedman, J.M.4    Chuang, J.C.5    Coetzee, G.A.6    Jones, P.A.7
  • 56
    • 33646228635 scopus 로고    scopus 로고
    • KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer
    • Lièvre A, Bachet JB, Le Corre D et al. KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer. Cancer Res 2006; 66:3992-3995.
    • (2006) Cancer Res , vol.66 , pp. 3992-3995
    • Lièvre, A.1    Bachet, J.B.2    Le Corre, D.3
  • 57
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado RG, Wolf M, Peeters M et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 2008; 26: 1626-1634.
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 60
    • 22144455380 scopus 로고    scopus 로고
    • Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412
    • DOI 10.1182/blood-2004-12-4617
    • Growney JD, Clark JJ, Adelsperger J et al. Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412. Blood 2005; 106:721-724. (Pubitemid 40981272)
    • (2005) Blood , vol.106 , Issue.2 , pp. 721-724
    • Growney, J.D.1    Clark, J.J.2    Adelsperger, J.3    Stone, R.4    Fabbro, D.5    Griffin, J.D.6    Gilliland, D.G.7
  • 62
    • 33745057881 scopus 로고    scopus 로고
    • HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer [15]
    • DOI 10.1056/NEJMc060020
    • Cappuzzo F, Bemis L, Varella-Garcia M. HER2 Mutation and Response to Trastuzumab Therapy in Non-Small-Cell Lung Cancer. N Engl J Med 2006; 354: 2619-2621. (Pubitemid 43882374)
    • (2006) New England Journal of Medicine , vol.354 , Issue.24 , pp. 2619-2621
    • Cappuzzo, F.1    Bemis, L.2    Varella-Garcia, M.3
  • 63
    • 84872290114 scopus 로고    scopus 로고
    • Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer
    • doi: 10.1155/2012/415170. Epub 2012, May 9
    • Wong ALA, Lee SC. Mechanisms of Resistance to Trastuzumab and Novel Therapeutic Strategies in HER2-Positive Breast Cancer. Int J Breast Cancer 2012; 415170. doi: 10.1155/2012/415170. Epub 2012, May 9.
    • (2012) Int J Breast Cancer , pp. 415170
    • Wong, A.L.A.1    Lee, S.C.2
  • 66
    • 36749025111 scopus 로고    scopus 로고
    • Recent advances in clinical oncoproteomics
    • Jain KK. Recent advances in clinical oncoproteomics. J BUON 2007;12(Suppl 1):S31-38. (Pubitemid 350200859)
    • (2007) Journal of B.U.ON. , vol.12 , Issue.SUPPL. 1
    • Jain, K.K.1
  • 67
    • 0036635332 scopus 로고    scopus 로고
    • Pharmacogenetic Challenges For The Health Care system
    • Robertson JA, Brody B, Buchanan A et al. Pharmacogenetic Challenges For The Health Care system. Health Affairs 2002; 21: 155-167.
    • (2002) Health Affairs , vol.21 , pp. 155-167
    • Robertson, J.A.1    Brody, B.2    Buchanan, A.3
  • 68
    • 84857237867 scopus 로고    scopus 로고
    • Adoption of pharmacogenomic testing by US physicians: Results of a nationwide survey
    • Stanek EJ, Sanders CL, Taber KA et al. Adoption of pharmacogenomic testing by US physicians: results of a nationwide survey. Clin Pharmacol Ther 2012; 91: 450-458.
    • (2012) Clin Pharmacol Ther , vol.91 , pp. 450-458
    • Stanek, E.J.1    Sanders, C.L.2    Taber, K.A.3
  • 69
    • 40949124834 scopus 로고    scopus 로고
    • Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: Are primary care physicians ready?
    • DOI 10.1038/clpt.2008.4, PII CLPT20084
    • Shields AE, Lerman C. Anticipating clinical integration of pharmacogenetic treatment strategies for addiction: are primary care physicians ready? Clin Pharmacol Ther 2008; 83: 635-639. (Pubitemid 351417077)
    • (2008) Clinical Pharmacology and Therapeutics , vol.83 , Issue.4 , pp. 635-639
    • Shields, A.E.1    Lerman, C.2
  • 70
    • 79955407298 scopus 로고    scopus 로고
    • Assessment of the pharmacogenomics educational needs of pharmacists
    • McCullough KB, Formea CM, Berg KD et al. Assessment of the pharmacogenomics educational needs of pharmacists. Am J Pharm Educ 2011; 75: 51.
    • (2011) Am J Pharm Educ , vol.75 , pp. 51
    • McCullough, K.B.1    Formea, C.M.2    Berg, K.D.3
  • 71
    • 79951809825 scopus 로고    scopus 로고
    • CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network
    • Relling MV, Klein TE. CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network. Clin Pharmacol Ther 2011; 89: 464-467.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 464-467
    • Relling, M.V.1    Klein, T.E.2
  • 72
    • 0032522873 scopus 로고    scopus 로고
    • Incidence of adverse drug reactions in hospitalized patients: A meta- analysis of prospective studies
    • DOI 10.1001/jama.279.15.1200
    • Lazarou J, Pomeranz BH, Corey PN. Incidence of adverse drug reactions in hospitalized patients: a meta-analysis of prospective studies. JAMA 1998; 279: 1200-1205. (Pubitemid 28193431)
    • (1998) Journal of the American Medical Association , vol.279 , Issue.15 , pp. 1200-1205
    • Lazarou, J.1    Pomeranz, B.H.2    Corey, P.N.3
  • 73
    • 77957995461 scopus 로고    scopus 로고
    • Cost effectiveness of pharmacogenomics: A critical and systematic review
    • Wong WB, Carlson JJ, Thariani R et al. Cost effectiveness of pharmacogenomics: a critical and systematic review. Pharmacoeconomics 2010; 28: 1001-1013.
    • (2010) Pharmacoeconomics , vol.28 , pp. 1001-1013
    • Wong, W.B.1    Carlson, J.J.2    Thariani, R.3
  • 74
    • 33747168764 scopus 로고    scopus 로고
    • Cost-effectiveness of pharmacogenomics in clinical practice: A case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe
    • DOI 10.2217/14622416.7.5.783
    • van den Akker-van Marle ME, Gurwitz D, Detmar SB et al. Cost-effectiveness of pharmacogenomics in clinical practice: a case study of thiopurine methyltransferase genotyping in acute lymphoblastic leukemia in Europe. Pharmacogenomics 2006; 7: 783-792. (Pubitemid 44225913)
    • (2006) Pharmacogenomics , vol.7 , Issue.5 , pp. 783-792
    • Van Den A-Van, M.M.E.1    Gurwitz, D.2    Detmar, S.B.3    Enzing, C.M.4    Hopkins, M.M.5    Gutierrez, D.M.E.6    Ibarreta, D.7
  • 75
    • 52149112915 scopus 로고    scopus 로고
    • Pharmacogenetics of hypersensitivity to abacavir: From PGx hypothesis to confirmation to clinical utility
    • Hughes AR, Spreen WR, Mosteller M et al. Pharmacogenetics of hypersensitivity to abacavir: from PGx hypothesis to confirmation to clinical utility. Pharmacogenomics J 2008; 8: 365-374.
    • (2008) Pharmacogenomics J , vol.8 , pp. 365-374
    • Hughes, A.R.1    Spreen, W.R.2    Mosteller, M.3
  • 76
    • 77953304931 scopus 로고    scopus 로고
    • Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study)
    • Epstein RS, Moyer TP, Aubert RE et al. Warfarin genotyping reduces hospitalization rates results from the MM-WES (Medco-Mayo Warfarin Effectiveness study). J Am Coll Cardiol 2010; 55: 2804-2812.
    • (2010) J Am Coll Cardiol , vol.55 , pp. 2804-2812
    • Epstein, R.S.1    Moyer, T.P.2    Aubert, R.E.3


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