Histologic and apoptotic changes induced by titanium dioxide nanoparticles in the livers of rats

International Journal of Nanomedicine

Volumn 8, Issue , 2013, Pages 3937-3943

  Alarifi, Saud ^a   Ali, Daoud ^a   Al Doaiss, Amin A ^a,b   Ali, Bahy A ^a,c   Ahmed, Mukhtar ^a   Al Khedhairy, Abdulaziz A ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

^b SANA A UNIVERSITY   (Yemen)

^c Universities and Research centers District   (Egypt)

Author keywords

Alkaline phosphatase; Apoptosis; Histology; Liver; Rats; TiO2 nanoparticles; TUNEL assay

Indexed keywords

ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE; NANOPARTICLE; TITANIUM DIOXIDE;

ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; ATROPHY; CELL DEATH; CELL SIZE; CELL STRESS; CELL ULTRASTRUCTURE; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; LIVER; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN INTERACTION; RAT;

ALKALINE PHOSPHATASE; APOPTOSIS; HISTOLOGY; LIVER; RATS; TIO2 NANOPARTICLES; TUNEL ASSAY;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; LIVER; MALE; METAL NANOPARTICLES; RATS; RATS, WISTAR; TITANIUM;

EID: 84885728931     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S47174     Document Type: Article

References (34)

1. Peralta-Videa JR, Zhao L, Lopez-Moreno ML, de la Rosa G, Hong J, Gardea-Torresdey JL. Nanomaterials and the environment: a review for the biennium 2008-2010. J Hazard Mater. 2011;186:1-15.
2. Singh N, Manshian B, Jenkins GJS, et al. NanoGenotoxicology: the DNA damaging potential of engineered nanomaterials. Biomaterials. 2009;30:3891-3914.
3. Skocaj M, Filipic M, Petkovic J, Novak S. Titanium dioxide in our everyday life: is it safe? Radiol Oncol. 2011;45:227-247.
4. Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science. 2006;311:622-627.
5. Project of the Emerging Nanotechnologies 2009. Available from: http://www.nanotechproject.org. Accessed June 14, 2013.
6. Li JJ, Muralikrishnan S, Ng CT, Yung LY, Bay BH. Nanoparticle-induced pulmonary toxicity. Exp Biol Med (Maywood). 2012;235:1025-1033.
7. Madl AK, Pinkerton KE. Health effects of inhaled engineered and incidental nanoparticles. Crit Rev Toxicol. 2009;39:629-658.
8. Hirakawa K, Mori M, Yoshida M, Oikawa S, Kawanishi S. Photo-irradiated titanium dioxide catalyzes site specific DNA damage via generation of hydrogen peroxide. Free Radic Res. 2004;38:439-447.
9. 2 nanoparticles during zebra fish embryogenesis development. Mol Cell Toxicol. 2012;8:317-326.
10. Oberdorster G, Oberdorster E, Oberdorster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005;113:823-839.
11. Pan Z, Lee W, Slutsky L, Clark RA, Pernodet N, Rafailovich MH. Adverse effects of titanium dioxide nanoparticles on human dermal fibroblasts and how to protect cells. Small. 2009;5:511-520.
12. Barnard AS. One-to-one comparison of sun screen efficacy, aesthetics and potential nanotoxicity. Nat Nanotechnol. 2012;5:271-274.
13. Driscoll KE, Maurer JK. Cytokine and growth factor release by alveolar macrophages: potential biomarkers of pulmonary toxicity. Toxicol Pathol. 1991;19:398-405.
14. Baggs RB, Fern J, Oberdorster G. Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet Pathol. 1997;34: 592-597.
15. Bermudez E, Mangum JB, Wong BA, et al. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol Sci. 2004;77:347-357.
16. Thomas T, Thomas K, Sadrieh N, Savage N, Adair P, Bronaugh R. Research strategies for safety evaluation of nanomaterials, part VII: evaluating consumer exposure to nanoscale materials. Toxicol Sci. 2006;91:14-19.
17. Wang J, Zhou G, Chen C, et al. Acute toxicity and bio distribution of different sized titanium dioxide particles in mice after oral administration. Toxicol Lett. 2007;168:176-185.
18. 2 particles: differential responses related to surface properties. Toxicology. 2007;230: 90-104.
19. Li YF, Chen C. Fate and toxicity of metallic and metal-containing nanoparticles for biomedical applications. Small. 2011;7:2965-2980.
20. Ostrovsky S, Kazimirsky G, Gedanken A, Brodie C. Selective cytotoxic effect of ZnO nanoparticles on glioma cells. Nano Res. 2009;2: 882-890.
21. Park EJ, Yoon J, Choi K, Yi J, Park K. Induction of chronic inflammation in mice treated with titanium dioxide nanoparticles by intratracheal instillation. Toxicology. 2009;260(1-3):37-46.
22. Zhang XD, Wu HY, Wu D, et al. Toxicologic effects of gold nanoparticles in vivo by different administration routes. Int J Nanomedicine. 2010;5:771-781.
23. Bancroft JD, Stevens A. Theory and Practice of Histological Techniques, 4th ed. London, UK: Churchill-Livingstone; 1999.
24. King EJ, Armstrong AR. In vitro determination of alkaline phosphatase. Can Med Assoc J. 1934;31:376-379.
25. Giray B, Gurbay A, Hineal F. Cypermethrin induced oxidative stress in rat brain and liver is prevented by vit-E or allopurinol. Toxicol Lett. 2011;118:139-146.
26. Tietz NW. Fundamentals of Clinical Chemistry, 4th ed. Philadelphia, PA: WB Saunders Company; 1996.
27. Johar D, Roth JC, Bay GH, Walker JN, Kroczak TJ, Los M. Inflammatory response, reactive oxygen species, programmed (necrotic-like and apoptotic) cell death and cancer. Rocz Akad Med Bialymst. 2004;49:31-39.
28. Johnson CE. Effects of fluid imbalances. In: Conn PM, editor. Neurosciences in Medicine. New York, NY: JB Lippincott Company; 1995.
29. Gerlyng P, Åbyholm A, Grotmol T, et al. Binucleation and polyploidization patterns in developmental and regenerative rat liver growth. Cell Prolif. 2008;26:557-565.
30. Del Monte U. Swelling of hepatocytes injured by oxidative stress suggests pathological changes related to macromolecular crowding. Med Hypotheses. 2005;64:818-825.
31. Schrand AM, Rahman MF, Hussain SM. Metal-based nanoparticles and their toxicity assessment. Nanomed Nanobiotechnol. 2010;2: 544-568.
32. Park EJ, Yi J, Chung KH, Ryu DY, Choi J, Park K. Oxidative stress and apoptosis induced by titanium dioxide nanoparticles in cultured BEAS-2B cells. Toxicol Lett. 2008;180:222-229.
33. 2 particulates: the contribution of physicochemical characteristics. Part Fibre Toxicol. 2009;6:33.
34. World Health Organization. International Programme on Chemical Safety. Environmental Health Criteria 24-Titanium. Geneva, Switzerland: World Health Organization; 1982. Available from: http://www.inchem.org/documents/ehc/ehc/ehc24.htm. Accessed June 13, 2013.