Touching on translation

Cell and Tissue Research

Volumn 354, Issue 1, 2013, Pages 297-308

  Talpos, John ^a   Steckler, Thomas ^a  

^a JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

Automated cognition batteries; Clinical level; Drug development; Pre clinical level; Touch screen test; Translation

Indexed keywords

ANIMAL BEHAVIOR; BEHAVIORAL RESEARCH; DATA ANALYSIS; EXPERIMENTAL ANIMAL; GENERAL DEVICE; MAZE TEST; MENTAL TASK; NEUROSCIENCE; NONHUMAN; PREDICTIVE VALUE; PRIORITY JOURNAL; QUALITY CONTROL; REVIEW; RODENT; SPATIAL MEMORY; TASK PERFORMANCE; TOUCH SCREEN DEVICE; TRANSLATIONAL RESEARCH; VISUAL DISCRIMINATION; ANIMAL; ANIMAL MODEL; COGNITIVE DEFECT; COMPUTER INTERFACE; HUMAN; INSTRUMENTAL CONDITIONING; PROCEDURES; PSYCHOLOGY; RAT; SPRAGUE DAWLEY RAT; TOUCH;

RODENTIA;

ANIMALS; COGNITION DISORDERS; CONDITIONING, OPERANT; HUMANS; MODELS, ANIMAL; RATS; RATS, SPRAGUE-DAWLEY; TOUCH; TRANSLATIONAL MEDICAL RESEARCH; USER-COMPUTER INTERFACE;

EID: 84885664430     PISSN: 0302766X     EISSN: 14320878     Source Type: Journal    
DOI: 10.1007/s00441-013-1694-7     Document Type: Review

References (77)

1. Aimone JB, Deng W, Gage FH (2011) Resolving new memories: a critical look at the dentate gyrus, adult neurogenesis, and pattern separation. Neuron 70:589-596
2. Antonova E, Parslow D, Brammer M, Simmons A, Williams S, Dawson GR, Morris R (2011) Scopolamine disrupts hippocampal activity during allocentric spatial memory in humans: an fMRI study using a virtual reality analogue of the Morris water maze. J Psychopharmacol 25:1256-1265
3. Bakker A, Krauss GL, Albert MS, Speck CL, Jones LR, Stark CE, Yassa MA, Bassett SS, Shelton AL, Gallagher M (2012) Reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment. Neuron 74:467-474
4. Barnett JH, Sahakian BJ, Werners U, Hill KE, Brazil R, Gallagher O, Bullmore ET, Jones PB (2005) Visuospatial learning and executive function are independently impaired in first-episode psychosis. Psychol Med 35:1031-1041 (Pubitemid 41015701)
5. Bartko SJ, Vendrell I, Saksida LM, Bussey TJ (2011) A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.Psychopharmacology (Berl) 214:537-548
6. Belger A, Puce A, Krystal JH, Gore JC, Goldman-Rakic P, McCarthy G (1998) Dissociation of mnemonic and perceptual processes during spatial and nonspatial working memory using fMRI. Hum Brain Mapp 6:14-32 (Pubitemid 28080008)
7. Birrell JM, Brown VJ (2000) Medial frontal cortex mediates perceptual attentional set shifting in the rat. J Neurosci 20:4320-4324 (Pubitemid 30365702)
8. Blackwell AD, Sahakian BJ, Vesey R, Semple JM, Robbins TW, Hodges JR (2004) Detecting dementia: novel neuropsychological markers of preclinical Alzheimer's disease. Dement Geriatr Cogn Disord 17:42-48 (Pubitemid 37499966)
9. Brigman JL, Bussey TJ, Saksida LM, Rothblat LA (2005) Discrimination of multidimensional visual stimuli by mice: intra- and extradimensional shifts. Behav Neurosci 119:839-842 (Pubitemid 40934376)
10. Brigman JL, Mathur P, Harvey-White J, Izquierdo A, Saksida LM, Bussey TJ, Fox S, Deneris E, Murphy DL, Holmes A (2010) Pharmacological or genetic inactivation of the serotonin transporter improves reversal learning in mice. Cereb Cortex 20:1955-1963
11. Bussey TJ, Padain TL, Skillings EA, Winters BD, Morton AJ, Saksida LM (2008) The touchscreen cognitive testing method for rodents: how to get the best out of your rat. Learn Mem 15:516-523 (Pubitemid 352008674)
12. Bussey TJ, Holmes A, Lyon L, Mar AC, McAllister KA, Nithianantharajah J, Oomen CA, Saksida LM (2012) New translational assays for preclinical modelling of cognition in schizophrenia: the touchscreen testing method for mice and rats. Neuropharmacology 62:1191-1203
13. Castren E, Hen R (2013) Neuronal plasticity and antidepressant actions. Trends Neurosci 36:259-267
14. Chudasama Y, Muir JL (1997) A behavioural analysis of the delayed non-matching to position task: the effects of scopolamine, lesions of the fornix and of the prelimbic region on mediating behaviours by rats. Psychopharmacology (Berl) 134:73-82 (Pubitemid 27485551)
15. Clelland CD, Choi M, Romberg C, Clemenson GD Jr, Fragniere A, Tyers P, Jessberger S, Saksida LM, Barker RA, Gage FH, Bussey TJ (2009) A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science 325:210-213
16. Collins FS (2011) Reengineering translational science: the time is right. Sci Transl Med 3:90cm17
17. Cronbach LJ, Meehl PE (1955) Construct validity in psychological tests. Psychol Bull 52:281-302
18. Curry SH (2008) Translational science: past, present, and future. Biotechniques 44:ii-viii
19. de Rover M, Pironti VA, McCabe JA, Acosta-Cabronero J, Arana FS, Morein-Zamir S, Hodges JR, Robbins TW, Fletcher PC, Nestor PJ, Sahakian BJ (2011)Hippocampal dysfunction in patients with mild cognitive impairment: a functional neuroimaging study of a visuospatial paired associates learning task. Neuropsychologia 49:2060-2070
20. Dudchenko PA, Wood ER, Eichenbaum H (2000) Neurotoxic hippocampal lesions have no effect on odor span and little effect on odor recognition memory but produce significant impairments on spatial span, recognition, and alternation. J Neurosci 20:2964-2977 (Pubitemid 30220322)
21. Dudchenko PA, Talpos J, Young J, Baxter MG (2012) Animal models of working memory: a review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia. Neurosci Biobehav Rev [Epub ahead of print]
22. Fellini L (2012) How can a touch-screen based visual discrimination help to better characterize rodent models of schizophrenia. In: Spink AJ, Grieco F, Krips OE, Loijens LWS, Noldus LPJJ, Zimmerman PH (eds) Proceedings of measuring behavior, August 28-31, 2012, Utrecht, The Netherlands. Noldus Information Technology, Wageningen, pp 192-195
23. Finkelstein R, Miller T, Baughman R (2002) The challenge of translational research-a perspective from the NINDS. Nat Neurosci 5 (Suppl):1029-1030 (Pubitemid 35247191)
24. Geyer MA, Markou A (1995) Animal models of psychiatric disorders. In: Bloom FE, Kupfer D (eds) Psychopharmacology: the fourth generation of progress. Raven, New York, pp 787-798
25. Green MF, Nuechterlein KH, Gold JM, Barch DM, Cohen J, Essock S, Fenton WS, Frese F, Goldberg TE, Heaton RK, Keefe RS, Kern RS, Kraemer H, Stover E, Weinberger DR, Zalcman S, Marder SR (2004) Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria. Biol Psychiatry 56:301-307 (Pubitemid 39164514)
26. Green MF, Butler PD, Chen Y, Geyer MA, Silverstein S, Wynn JK, Yoon JH, Zemon V (2009) Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS. Schizophr Bull 35:163-181
27. Hampton RR, Hampstead BM, Murray EA (2004) Selective hippocampal damage in rhesus monkeys impairs spatial memory in an open-field test. Hippocampus 14:808-818 (Pubitemid 39517458)
28. Heishman SJ, Kleykamp BA, Singleton EG (2010) Meta-analysis of the acute effects of nicotine and smoking on human performance. Psychopharmacology (Berl) 210:453-469
29. Honey GD, Honey RA, Sharar SR, Turner DC, Pomarol-Clotet E, Kumaran D, Simons JS, Hu X, Rugg MD, Bullmore ET, Fletcher PC (2005) Impairment of specific episodic memory processes by sub-psychotic doses of ketamine: the effects of levels of processing at encoding and of the subsequent retrieval task. Psychopharmacology (Berl) 181:445-457 (Pubitemid 41480893)
30. Johansen JP, Cain CK, Ostroff LE, LeDoux JE (2011)Molecular mechanisms of fear learning and memory. Cell 147:509-524
31. Jones CA, Talpos JC, Pemberton DJ, Steckler T (2011) A strain comparison of acquisition, reversal learning and pharmacological manipulation of recall in a touchscreen-based visual discrimination in the mouse. Society for Neuroscience, Washington DC
32. Karlsson RM, Tanaka K, Saksida LM, Bussey TJ, Heilig M, Holmes A (2009) Assessment of glutamate transporter GLAST (EAAT1)-deficient mice for phenotypes relevant to the negative and executive/cognitive symptoms of schizophrenia. Neuropsychopharmacology 34:1578-1589
33. Keeler JF, Robbins TW (2011) Translating cognition from animals to humans. Biochem Pharmacol 81:1356-1366
34. Kheirbek MA, Klemenhagen KC, Sahay A, Hen R (2012) Neurogenesis and generalization: a new approach to stratify and treat anxiety disorders. Nat Neurosci 15:1613-1620
35. Kozak R, Mulryan L, Eastwood BJ, Chapin DS, Ballard T, Gilmour G, Gastambide F, Dix S, Janhunen SK, Plath P, Talpos J, Fellini L, Lerdrup L, Billa S, Ahokas L, Saksida LM, Mohler EG, Rueter LE, Malik N, Wyler R (2013) Multi-site validation of touch screen-base translational assays of cognition and their pharmacological sensitivity. American College of Neuropsychopharmacology, Hollywood
36. Krystal JH, Bennett A, Abi-Saab D, Belger A, Karper LP, D'Souza DC, Lipschitz D, Abi-Dargham A, Charney DS (2000) Dissociation of ketamine effects on rule acquisition and rule implementation: possible relevance to NMDA receptor contributions to executive cognitive functions. Biol Psychiatry 47:137-143 (Pubitemid 30069737)
37. Lemos R, Figueiredo P, Santana I, Simoes MR, Castelo-Branco M (2012) Temporal integration of 3D coherent motion cues defining visual objects of unknown orientation is impaired in amnestic mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis 28:885-896
38. McArthur RA, Borsini F (2008) Animal and translational models for CNS drug discovery, vol 1. Psychiatric disorders. Academic Press, Amsterdam
39. Malberg JE, Eisch AJ, Nestler EJ, Duman RS (2000) Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus. J Neurosci 20:9104-9110 (Pubitemid 32042912)
40. McAllister KA, Saksida LM, Bussey TJ (2013) Dissociation between memory retention across a delay and pattern separation following medial prefrontal cortex lesions in the touchscreen TUNL task. Neurobiol Learn Mem 101:120-126
41. McCarthy G, Puce A, Constable RT, Krystal JH, Gore JC, Goldman-Rakic P (1996) Activation of human prefrontal cortex during spatial and nonspatial working memory tasks measured by functional MRI. Cereb Cortex 6:600-611 (Pubitemid 26278184)
42. McTighe SM, Mar AC, Romberg C, Bussey TJ, Saksida LM (2009) A new touchscreen test of pattern separation: effect of hippocampal lesions. Neuroreport 20:881-885
43. Monk CS, Zhuang J, Curtis WJ, Ofenloch IT, Tottenham N, Nelson CA, Hu X (2002) Human hippocampal activation in the delayed matching- and nonmatching-to-sample memory tasks: an event-related functional MRI approach. Behav Neurosci 116:716-721 (Pubitemid 34793392)
44. Morgan CJ, Curran HV (2006) Acute and chronic effects of ketamine upon human memory: a review. Psychopharmacology (Berl) 188:408-424 (Pubitemid 46758974)
45. Mulshine JL, Jett M, Cuttitta F, Treston AM, Quinn K, Scott F, Iwai N, Avis I, Linnoila RI, Shaw GL (1993) Scientific basis for cancer prevention. Intermediate cancer markers. Cancer 72:978-983 (Pubitemid 23218013)
46. Newmark RE, Schon K, Ross RS, Stern CE (2013) Contributions of the hippocampal subfields and entorhinal cortex to disambiguation during working memory. Hippocampus 23:467-475
47. Nithianantharajah J, Komiyama NH, McKechanie A, Johnstone M, Blackwood DH, St Clair D, Emes RD, van de Lagemaat LN, Saksida LM, Bussey TJ, Grant SG (2013) Synaptic scaffold evolution generated components of vertebrate cognitive complexity. Nat Neurosci 16:16-24
48. O'Connel D, Roblin D (2006) Translational research in the pharmaceutical industry: from bench to bedside. Drug Discov Today 11:833-838 (Pubitemid 44280025)
49. Oomen CA, Bussey TJ, Saksida LM (2012) The retrosplenial cortex is involved in object-place paired-associates learning in the rat touchreen operant chamber. Society for Neuroscience, New Orleans
50. Owen AM, Morris RG, Sahakian BJ, Polkey CE, Robbins TW (1996) Double dissociations of memory and executive functions in working memory tasks following frontal lobe excisions, temporal lobe excisions or amygdalo-hippocampectomy in man. Brain 119:1597-1615 (Pubitemid 26375730)
51. Prusky GT, Alam NM, Beekman S, Douglas RM (2004) Rapid quantification of adult and developing mouse spatial vision using a virtual optomotor system. Invest Ophthalmol Vis Sci 45:4611-4616 (Pubitemid 39564690)
52. Rajendran G, Mitchell P (2006)Text chat as a tool for referential questioning in Asperger syndrome.J Speech Lang Hear Res 49:102-112 (Pubitemid 46940116)
53. Repantis D, Laisney O, Heuser I (2010a) Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review. Pharmacol Res 61:473-481
54. Repantis D, Schlattmann P, Laisney O, Heuser I (2010b) Modafinil and methylphenidate for neuroenhancement in healthy individuals: a systematic review. Pharmacol Res 62:187-206
55. Rolls ET, Kesner RP (2006) A computational theory of hippocampal function, and empirical tests of the theory. Prog Neurobiol 79:1-48
56. Romberg C, Horner AE, Bussey TJ, Saksida LM (2013) A touch screen-automated cognitive test battery reveals impaired attention, memory abnormalities, and increased response inhibition in the TgCRND8 mouse model of Alzheimer's disease. Neurobiol Aging 34:731-744
57. Rossier J, Schenk F (2003) Olfactory and/or visual cues for spatial navigation through ontogeny: olfactory cues enable the use of visual cues. Behav Neurosci 117:412-425 (Pubitemid 36686960)
58. Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R (2011) Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation. Nature 472:466-470
59. Sahgal A, McKeith IG, Galloway PH, Tasker N, Steckler T (1995) Do differences in visuospatial ability between senile dementias of the Alzheimer and Lewy body types reflect differences solely in mnemonic function? J Clin Exp Neuropsychol 17:35-43
60. Sanchez PE, Zhu L, Verret L, Vossel KA, Orr AG, Cirrito JR, Devidze N, Ho K, Yu GQ, Palop JJ, Mucke L (2012) Levetiracetam suppresses neuronal network dysfunction and reverses synaptic and cognitive deficits in an Alzheimer's disease model. Proc Natl Acad Sci U S A 109:E2895-E2903
61. Sehlmeyer C, Schoning S, Zwitserlood P, Pfleiderer B, Kircher T, Arolt V, Konrad C (2009) Human fear conditioning and extinction in neuroimaging: a systematic review. PLoS One 4:e5865
62. Steckler T (2010) Translational research. In: Stolerman I (ed) Encyclopedia of psychopharmacology, vol 2. Springer, Heidelberg, pp 1331-1334
63. Steckler T, Drinkenburg WH, Sahgal A, Aggleton JP (1998) Recognition memory in rats-I. Concepts and classification. Prog Neurobiol 54:289-311 (Pubitemid 28112648)
64. Steele SJ (2010) Working with the CTSA Consortium: what we bring to the table. Sci Transl Med 2:63mr5
65. Taffe MA, Weed MR, Gutierrez T, Davis SA, Gold LH (2002a) Differential muscarinic and NMDA contributions to visuo-spatial paired-associate learning in rhesus monkeys. Psychopharmacology (Berl) 160:253-262 (Pubitemid 34230677)
66. Taffe MA, Davis SA, Gutierrez T, Gold LH (2002b) Ketamine impairs multiple cognitive domains in rhesus monkeys. Drug Alcohol Depend 68:175-187 (Pubitemid 35247789)
67. Taffe MA, Weed MR, Gutierrez T, Davis SA, Gold LH (2004) Modeling a task that is sensitive to dementia of the Alzheimer's type: individual differences in acquisition of a visuo-spatial paired-associate learning task in rhesus monkeys. Behav Brain Res 149:123-133 (Pubitemid 38199928)
68. Talpos JC, Dias R, Bussey TJ, Saksida LM (2008) Hippocampal lesions in rats impair learning and memory for locations on a touch-sensitive computer screen: the ASAT task. Behav Brain Res 192:216-225
69. Talpos JC, Winters BD, Dias R, Saksida LM, Bussey TJ (2009) A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive impairments in neurodegenerative disease. Psychopharmacology (Berl) 205:157-168
70. Talpos JC, McTighe SM, Dias R, Saksida LM, Bussey TJ (2010) Trial-unique, delayed nonmatching-to-location (TUNL): a novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation. Neurobiol Learn Mem 94:341-352
71. Talpos JC, Aerts N, Fellini L, Steckler T (2012a) Evaluation of acute pharmacological models of disease in a rodent paired associates learning task utilizing touchscreen equipped operant boxes. Society for Neuroscience, New Orleans
72. Talpos JC, Fletcher AC, Circelli C, Tricklebank MD, Dix SL (2012b) The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli. Psychopharmacology (Berl) 221:437-449
73. Wehling M (2006) Translational medicine: can it really facilitate the transition of research from bench to bedside? Eur J Clin Pharmacol 62:91-95
74. Weniger G, Irle E (2008) Allocentric memory impaired and egocentric memory intact as assessed by virtual reality in recent-onset schizophrenia. Schizophr Res 101:201-209
75. Winters BD, Reid JM (2010) A distributed cortical representation underlies crossmodal object recognition in rats. J Neurosci 30:6253-6261
76. Woolf SH (2008) The meaning of translational research and why it matters. JAMA 299:211-213
77. Young JC, Baughman BC, Roper BL (2012) Validation of the repeatable battery for the assessment of neuropsychological status-effort index in a veteran sample.Clin Neuropsychol 26:688-699