Neurotoxic hippocampal lesions have no effect on odor span and little effect on odor recognition memory but produce significant impairments on spatial span, recognition, and alternation

Journal of Neuroscience

Volumn 20, Issue 8, 2000, Pages 2964-2977

  Dudchenko, Paul A ^a   Wood, Emma R ^b   Eichenbaum, Howard ^c  

^a UNIVERSITY OF STIRLING   (United Kingdom)

^b UNIVERSITY OF EDINBURGH   (United Kingdom)

^c BOSTON UNIVERSITY   (United States)

Author keywords

Delayed alternation; Delayed nonmatching to sample; Hippocampus; Ibotenic acid; Olfactory memory; Span; Spatial memory; T maze

Indexed keywords

IBOTENIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HIPPOCAMPUS; MALE; MAZE TEST; MEMORY; NEUROTOXICITY; NONHUMAN; ODOR; PRIORITY JOURNAL; RAT; RECOGNITION; SPATIAL MEMORY;

EID: 0034655162     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-08-02964.2000     Document Type: Article

References (46)

1. Aggleton JP, Brown MW (1999) Episodic memory, amnesia, and the hippocampal-anterior thalamic axis. Behav Brain Sci 22:425-489.
2. Aggleton JP, Hunt PR, Rawlins JNP (1986) The effects of hippocampal lesions upon spatial and non-spatial tests of working memory. Behav Brain Res 19:133-146.
3. Aggleton JP, Keen S, Warburton EC, Bussey TJ (1997) Extensive cytotoxic lesions involving both the rhinal cortices and area TE impair recognition but spare spatial alternation in the rat. Brain Res Bull 43:279-287.
4. Alvarez P, Zola-Morgan S, Squire LR (1995) Damage limited to the hippocampal region produces long-lasting memory impairment in monkeys. J Neurosci 15:3796-3807.
5. Angeli SJ, Murray EA, Mishkin M (1993) Hippocampectomized monkeys can remember one place but not two. Neuropsychologia 31:1021-1030.
6. Beason-Held LL, Rosene DL, Killiany RJ, Moss MB (1999) Hippocampal formation lesions produce memory impairment in the rhesus monkey. Hippocampus 9:562-574.
7. Bunsey M, Eichenbaum H (1996) Conservation of hippocampal memory function in rats and humans. Nature 379:255-257.
8. Clark RE, Zola SM, Squire LR (1999) Delay-dependent impairments in recognition memory in rats with ibotenic acid lesions restricted to the hippocampus. Soc Neurosci Abstr 25:88.
9. Cohen NJ, Eichenbaum H (1993) Memory, amnesia, and the hippocampal system. Cambridge, MA: MIT.
10. Corkin S (1984) Lasting consequences of bilateral medial temporal lobectomy: clinical course and experimental findings in H.M. Semin Neurol 4:249-259.
11. Day LB, Weisand M, Sutherland RJ, Schauert T (1999) The hippocampus is not necessary for a place response but may be necessary for pliancy. Behav Neurosci 113:914-924.
12. Dudchenko P, Wood ER, Faherty J, Eichenbaum H (1998) Eight, plus or minus two: olfactory span in the rat, and the contribution of the hippocampus to olfactory working memory. Soc Neurosci Abstr 24:928.
13. Dusek JA, Eichenbaum H (1998) The hippocampus and transverse patterning guided by olfactory cues. Behav Neurosci 112:762-771.
14. Eichenbaum H, Fagan A, Mathews P, Cohen NJ (1988) Hippocampal system dysfunction and odor discrimination learning in rats: impairment or facilitation depending on representational demands. Behav Neurosci 102:331-339.
15. Eichenbaum H, Otto T, Cohen NJ (1994) Two functional components of the hippocampal memory system. Behav Brain Sci 17:449-518.
16. Ennaceur A, Neave N, Aggleton JP (1996) Neurotoxic lesions of the perirhinal cortex do not mimic the behavioural effects of fornix transection in the rat. Behav Brain Res 80:9-25.
17. Hampson RE, Jarrard LE, Deadwyler SA (1999) Effects of ibotenate hippocampal and extrahippocampal destruction on delayed-match and nonmatch-to-sample behavior in rats. J Neurosci 19:1492-1507.
18. Jarrard LE (1989) On the use of ibotenic acid to lesion selectively different components of the hippocampal formation. J Neurosci Methods 29:251-259.
19. Jarrard LE (1993) On the role of the hippocampus in learning and memory in the rat. Behav Neural Biol 60:9-26.
20. Kesner RP, Bolland BL, Dakis M (1993) Memory for spatial locations, motor responses, and objects: triple dissociation among the hippocampus, caudate nucleus, and extrastriate visual cortex. Exp Brain Res 93:462-470.
21. Maguire EA, Burgess N, O'Keefe J (1999) Human spatial navigation: cognitive maps, sexual dimorphism, and neural substrates. Curr Opin Neurobiol 9:171-177.
22. Meunier M, Bachevalier J, Mishkin M, Murray EA (1993) Effects on visual recognition of combined and separate ablations of the entorhinal and perirhinal cortex in rhesus monkeys. J Neurosci 13:5418-5432.
23. Miller GA (1956) The magical number seven, plus or minus two: some limits on our capacity for processing information. Psychol Rev 63:81-97.
24. Morris RGM, Schenk F, Tweedie F, Jarrard LE (1990) Ibotenate lesions of hippocampus and subiculum: dissociating components of allocentric spatial learning. Eur J Neurosci 2:1016-1028.
25. Mumby DG, Pinel JPJ (1994) Rhinal cortex lesions and object recognition in rats. Behav Neurosci 108:1-8.
26. Mumby DG, Wood ER, Pinel JPJ (1992) Object-recognition memory is only mildly impaired in rats with lesions of the hippocampus and amygdala. Psychobiology 23:26-36.
27. Murray EA (1996) What have ablation studies told us about the neural substrates of stimulus memory? Semin Neurosci 8:13-22.
28. Murray EA, Mishkin M (1998) Object recognition and location memory in monkeys with excitotoxic lesions of the amygdala and hippocampus. J Neurosci 18:6568-6582.
29. Neave N, Lloyd S, Sahgal A, Aggleton JP (1994) Lack of effect of lesions in the anterior cingulate cortex and retrosplenial cortex on certain tests of spatial memory in the rat. Behav Brain Res 65:89-101.
30. O'Keefe J, Nadel L (1978) The hippocampus as a cognitive map. Oxford: Oxford UP.
31. Olton DS, Feustle WA (1981) Hippocampal function required for nonspatial working memory. Exp Brain Res 41:380-389.
32. Otto T, Eichenbaum H (1992) Complementary roles of the orbital prefrontal and the perirhinal-entorhinal cortices in an odor-guided delayed-nonmatching-to-sample task. Behav Neurosci 106:762-775.
33. Rawlins JNP, Lyford GL, Seferiades A, Deacon RMJ, Cassaday HJ (1993) Critical determinants of nonspatial working memory deficits in rats with conventional lesions of the hippocampus or fornix. Behav Neurosci 107:420-433.
34. Rothblat LA, Kromer LF (1991) Object recognition memory in the rat: the role of the hippocampus. Behav Brain Res 42:25-32.
35. Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11-21.
36. Shaw C, Aggleton JP (1993) The effects of fornix and medial prefrontal lesions on delayed non-matching-to-sample by rats. Bchav Brain Res 54:91-102.
37. Standing L (1973) Learning 10,000 pictures. Q J Exp Psych 25:207-222.
38. Steele K, Rawlins JNP (1989) Rats remember long lists of nonspatial items. Psychobiology 17:450-452.
39. Steele K, Rawlins JNP (1993) The effects of hippocampectomy on performance by rats of a running recognition task using long lists of non-spatial items. Behav Brain Res 54:1-10.
40. Suzuki WA, Zola-Morgan S, Squire LR, Amaral DG (1993) Lesions of the perirhinal and parahippocampal cortices in the monkey produce long lasting memory impairment in the visual and tactile modalities. J Neurosci 13:2430-2451.
41. Swanson LW (1992) Brain maps: structure of the rat brain. Amsterdam: Elsevier Science BV.
42. Whishaw IQ, Jarrard LE (1996) Evidence for extrahippocampal involvement in place learning and hippocampal involvement in path integration. Hippocampus 6:513-524.
43. Whishaw IQ, Cassel J-C, Jarrard LE (1995) Rats with fimbria-fornix lesions display a place response in a swimming pool: a dissociation between getting there and knowing where. J Neurosci 15:5779-5788.
44. Zola SM, Squire LR, Teng E, Stefanacci L, Buffalo EA, Clark RE (2000) Impaired recognition memory in monkeys after damage limited to the hippocampal region. J Neurosci 20:451-463.
45. Zola-Morgan S, Squire LR, Amaral DG, Suzuki W (1989) Lesions of perirhinal and parahippocampal cortex that spare the amygdala and hippocampal formation produce severe memory impairment. J Neurosci 9:4355-4370.
46. Zola-Morgan S, Squire LR, Ramus SJ (1994) Severity of memory impairment in monkeys as a function of locus and extent of damage within the medial temporal lobe memory system. Hippocampus 4:483-495.