메뉴 건너뛰기




Volumn 86, Issue 8, 2013, Pages 1208-1214

Neuronal nicotinic receptors as analgesic targets: It's a winding road

Author keywords

Analgesia; Nicotinic; Nociception; Pain

Indexed keywords


EID: 84885640206     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.08.001     Document Type: Review
Times cited : (91)

References (93)
  • 1
    • 49649099082 scopus 로고    scopus 로고
    • Efficacy of opioids for chronic pain: A review of the evidence
    • Ballantyne JC, Shin NS. Efficacy of opioids for chronic pain: a review of the evidence. Clinical Journal of Pain 2008;24:469-78.
    • (2008) Clinical Journal of Pain , vol.24 , pp. 469-478
    • Ballantyne, J.C.1    Shin, N.S.2
  • 3
    • 0037375098 scopus 로고    scopus 로고
    • College on Problems of Drug Dependence taskforce on prescription opioid non-medical use and abuse: Position statement
    • DOI 10.1016/S0376-8716(03)00003-6
    • Zacny J, Bigelow G, Compton P, Foley K, Iguchi M, Sannerud C. College on problems of drug dependence taskforce on prescription opioid non-medical use and abuse: position statement. Drug and Alcohol Dependence 2003;69:215-32. (Pubitemid 36293934)
    • (2003) Drug and Alcohol Dependence , vol.69 , Issue.3 , pp. 215-232
    • Zacny, J.1    Bigelow, G.2    Compton, P.3    Foley, K.4    Iguchi, M.5    Sannerud, C.6
  • 4
    • 29244473555 scopus 로고    scopus 로고
    • Major increases in opioid analgesic abuse in the united states: Concerns and strategies
    • Compton WM, Volkow ND. Major increases in opioid analgesic abuse in the United States: concerns and strategies. Drug and Alcohol Dependence 2006;81:103-8.
    • (2006) Drug and Alcohol Dependence , vol.81 , pp. 103-108
    • Compton, W.M.1    Volkow, N.D.2
  • 8
    • 0018642954 scopus 로고
    • Antinociceptive effects of central and systemic administrations of nicotine in the rat
    • DOI 10.1007/BF00492216
    • Sahley TL, Berntson GG. Antinociceptive effects of central and systemic administrations of nicotine in the rat. Psychopharmacology 1979;65:279-83. (Pubitemid 10194755)
    • (1979) Psychopharmacology , vol.65 , Issue.3 , pp. 279-283
    • Sahley, T.L.1    Berntson, G.G.2
  • 9
    • 0022541740 scopus 로고
    • Nicotine-produced antinociception in minimally deprived smokers and ex-smokers
    • DOI 10.1016/0306-4603(86)90052-3
    • Fertig JB, Pomerleau OF, Sanders B. Nicotine-produced antinociception in minimally deprived smokers and ex-smokers. Addictive Behaviors 1986;11:239-48. (Pubitemid 16058028)
    • (1986) Addictive Behaviors , vol.11 , Issue.3 , pp. 239-248
    • Fertig, J.B.1    Pomerleau, O.F.2
  • 11
    • 0024584311 scopus 로고
    • A randomized trial to increase smoking intervention by physicians. Doctors helping smokers, round I
    • DOI 10.1001/jama.261.14.2101
    • Kottke TE, Brekke ML, Solberg LI, Hughes JR. A randomized trial to increase smoking intervention by physicians. Doctors helping smokers, Round I. JAMA 1989;261:2101-6. (Pubitemid 19097972)
    • (1989) Journal of the American Medical Association , vol.261 , Issue.14 , pp. 2101-2106
    • Kottke, T.E.1    Brekke, M.L.2    Solberg, L.I.3    Hughes, J.R.4
  • 12
    • 0031852541 scopus 로고    scopus 로고
    • Associative tolerance to nicotine analgesia in the rat: Tail-flick and hot-plate tests
    • DOI 10.1037//1064-1297.6.3.248
    • Cepeda-Benito A, Reynoso J, McDaniel EH. Associative tolerance to nicotine analgesia in the rat: tail-flick and hot-plate tests. Experimental and Clinical Psychopharmacology 1998;6:248-54. (Pubitemid 28393942)
    • (1998) Experimental and Clinical Psychopharmacology , vol.6 , Issue.3 , pp. 248-254
    • Cepeda-Benito, A.1    Reynoso, J.2    McDaniel, E.H.3
  • 13
    • 67651149831 scopus 로고    scopus 로고
    • Epibatidine: From frog alkaloid to analgesic clinical candidates. A testimonial to true grit!
    • Garraffo HMS, Thomas F, Williams Michael. Epibatidine: from frog alkaloid to analgesic clinical candidates. A Testimonial to true grit! Heterocycles 2009;79:207-17.
    • (2009) Heterocycles , vol.79 , pp. 207-217
    • Garraffo, H.M.S.1    Thomas, F.2    Michael, W.3
  • 14
    • 0034058306 scopus 로고    scopus 로고
    • Alkaloids from frog skin: The discovery of epibatidine and the potential for developing novel non-opioid analgesics
    • DOI 10.1039/a900728h
    • Daly JW, Garraffo HM, Spande TF, Decker MW, Sullivan JP, Williams M. Alkaloids from frog skin: the discovery of epibatidine and the potential for developing novel non-opioid analgesics. Natural Products Reports 2000;17:131-5. (Pubitemid 30218016)
    • (2000) Natural Product Reports , vol.17 , Issue.2 , pp. 131-135
    • Daly, J.W.1    Garraffo, H.M.2    Spande, T.F.3    Decker, M.W.4    Sullivan, J.P.5    Williams, M.6
  • 18
    • 0000727741 scopus 로고
    • (+/-)-Epibatidine can differentially evoke responses mediated by putative subtypes of nicotinic acetylcholine receptors (nAChRs)
    • Sullivan J, Briggs C, Donnelly-Roberts D, Brioni J, Radek R, McKenna D, et al. (+/-)-Epibatidine can differentially evoke responses mediated by putative subtypes of nicotinic acetylcholine receptors (nAChRs). Medicinal Chemistry Research 1994;4:502-16.
    • (1994) Medicinal Chemistry Research , vol.4 , pp. 502-516
    • Sullivan, J.1    Briggs, C.2    Donnelly-Roberts, D.3    Brioni, J.4    Radek, R.5    McKenna, D.6
  • 20
    • 13844254492 scopus 로고    scopus 로고
    • ABT-594 (a nicotinic acetylcholine agonist): Anti-allodynia in a rat chemotherapy-induced pain model
    • DOI 10.1016/j.ejphar.2004.12.034
    • Lynch JJ3rd, Wade CL, Mikusa JP, Decker MW, Honore P. ABT-594 (a nicotinic acetylcholine agonist): anti-allodynia in a rat chemotherapy-induced pain model. European Journal of Pharmacology 2005;509:43-8. (Pubitemid 40248784)
    • (2005) European Journal of Pharmacology , vol.509 , Issue.1 , pp. 43-48
    • Lynch III, J.J.1    Wade, C.L.2    Mikusa, J.P.3    Decker, M.W.4    Honore, P.5
  • 21
    • 0034193948 scopus 로고    scopus 로고
    • Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain
    • DOI 10.1016/S0304-3959(00)00233-5, PII S0304395900002335
    • Kesingland AC, Gentry CT, Panesar MS, Bowes MA, Vernier JM, Cube R, et al. Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain. Pain 2000;86:113-8. (Pubitemid 30211710)
    • (2000) Pain , vol.86 , Issue.1-2 , pp. 113-118
    • Kesingland, A.C.1    Gentry, C.T.2    Panesar, M.S.3    Bowes, M.A.4    Vernier, J.-M.5    Cube, R.6    Walker, K.7    Urban, L.8
  • 23
    • 70350617803 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of abt-594 in patients with diabetic peripheral neuropathic pain
    • Rowbotham MC, Duan WR, Thomas J, Nothaft W, Backonja MM. A randomized, double-blind, placebo-controlled trial evaluating the efficacy and safety of ABT-594 in patients with diabetic peripheral neuropathic pain. Pain 2009;146:245-52.
    • (2009) Pain , vol.146 , pp. 245-252
    • Rowbotham, M.C.1    Duan, W.R.2    Thomas, J.3    Nothaft, W.4    Backonja, M.M.5
  • 24
    • 77949416116 scopus 로고    scopus 로고
    • Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects
    • Ueda M, Iida Y, Tominaga A, Yoneyama T, Ogawa M, Magata Y, et al. Nicotinic acetylcholine receptors expressed in the ventralposterolateral thalamic nucleus play an important role in anti-allodynic effects. British Journal of Pharmacology 2010;159:1201-10.
    • (2010) British Journal of Pharmacology , vol.159 , pp. 1201-1210
    • Ueda, M.1    Iida, Y.2    Tominaga, A.3    Yoneyama, T.4    Ogawa, M.5    Magata, Y.6
  • 26
    • 0029670191 scopus 로고    scopus 로고
    • Functional contributions of a5 subunit to neuronal acetylcholine receptor channels
    • Ramirez-Latorre J, Yu CR, Qu X, Perin F, Karlin A, Role L. Functional contributions of a5 subunit to neuronal acetylcholine receptor channels. Nature 1996;380:347-51.
    • (1996) Nature , vol.380 , pp. 347-351
    • Ramirez-Latorre, J.1    Yu, C.R.2    Qu, X.3    Perin, F.4    Karlin, A.5    Role, L.6
  • 30
    • 84876963838 scopus 로고    scopus 로고
    • A3b4.*nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the a5 subunit in the mouse
    • Jackson KJ, Sanjakdar SS, Muldoon PP, McIntosh JM, The Damaj MI. a3b4.*nicotinic acetylcholine receptor subtype mediates nicotine reward and physical nicotine withdrawal signs independently of the a5 subunit in the mouse. Neuropharmacology 2013;70:228-35.
    • (2013) Neuropharmacology , vol.70 , pp. 228-235
    • Jackson, K.J.1    Sanjakdar, S.S.2    Muldoon, P.P.3    McIntosh, J.M.4    Damaj, M.I.5
  • 32
    • 84877822730 scopus 로고    scopus 로고
    • In vivo pharmacological interactions between a type ii positive allosteric modulator of α7 nicotinic ach receptors and nicotinic agonists in a murine tonic pain model
    • Freitas K, Negus SS, Carroll FI, Damaj MI. In vivo pharmacological interactions between a type II positive allosteric modulator of α7 nicotinic ACh receptors and nicotinic agonists in a murine tonic pain model. British Journal of Pharmacology 2013;169:567-79.
    • (2013) British Journal of Pharmacology , vol.169 , pp. 567-579
    • Freitas, K.1    Negus, S.S.2    Carroll, F.I.3    Damaj, M.I.4
  • 33
    • 15044360252 scopus 로고    scopus 로고
    • Antinociceptive effects of choline against acute and inflammatory pain
    • DOI 10.1016/j.neuroscience.2004.12.026
    • Wang Y, Su DM, Wang RH, Liu Y, Wang H. Antinociceptive effects of choline against acute and inflammatory pain. Neuroscience 2005;132:49-56. (Pubitemid 40380713)
    • (2005) Neuroscience , vol.132 , Issue.1 , pp. 49-56
    • Wang, Y.1    Su, D.-M.2    Wang, R.-H.3    Liu, Y.4    Wang, H.5
  • 34
    • 80051925529 scopus 로고    scopus 로고
    • The antihyperalgesic effect of cytidine-50-diphosphate-choline in neuropathic and inflammatory pain models
    • Bagdas D, Sonat FA, Hamurtekin E, Sonal S, Gurun MS. The antihyperalgesic effect of cytidine-50-diphosphate-choline in neuropathic and inflammatory pain models. Behavioural Pharmacology 2011;22:589-98.
    • (2011) Behavioural Pharmacology , vol.22 , pp. 589-5898
    • Bagdas, D.1    Sonat, F.A.2    Hamurtekin, E.3    Sonal, S.4    Gurun, M.S.5
  • 35
    • 33750002031 scopus 로고    scopus 로고
    • The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: The involvement of cholinergic system
    • DOI 10.1016/j.brainres.2006.07.118, PII S0006899306023481
    • Hamurtekin E, Gurun MS. The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: the involvement of cholinergic system. Brain Research 2006;1117:92-100. (Pubitemid 44573100)
    • (2006) Brain Research , vol.1117 , Issue.1 , pp. 92-100
    • Hamurtekin, E.1    Sibel Gurun, M.2
  • 36
    • 77349114869 scopus 로고    scopus 로고
    • Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain
    • Gao B, Hierl M, Clarkin K, Juan T, Nguyen H, Valk M, et al. Pharmacological effects of nonselective and subtype-selective nicotinic acetylcholine receptor agonists in animal models of persistent pain. Pain 2010;149:33-49.
    • (2010) Pain , vol.149 , pp. 33-49
    • Gao, B.1    Hierl, M.2    Clarkin, K.3    Juan, T.4    Nguyen, H.5    Valk, M.6
  • 39
    • 3242682547 scopus 로고    scopus 로고
    • 3 receptor facilitates at-level mechanical allodynia following spinal cord injury
    • DOI 10.1016/j.pain.2004.03.040, PII S0304395904001824
    • Oatway MA, Chen Y, Weaver LC. The 5-HT3 receptor facilitates atlevel mechanical allodynia following spinal cord injury. Pain 2004;110:259-68. (Pubitemid 38953291)
    • (2004) Pain , vol.110 , Issue.1-2 , pp. 259-268
    • Oatway, M.A.1    Chen, Y.2    Weaver, L.C.3
  • 40
    • 0036899904 scopus 로고    scopus 로고
    • Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways
    • DOI 10.1038/nn966
    • Suzuki R, Morcuende S, Webber M, Hunt SP, Dickenson AH. Superficial NK1-expressing neurons control spinal excitability through activation of descending pathways. Nature Neuroscience 2002;5:1319-26. (Pubitemid 35417767)
    • (2002) Nature Neuroscience , vol.5 , Issue.12 , pp. 1319-1326
    • Suzuki, R.1    Morcuende, S.2    Webber, M.3    Hunt, S.P.4    Dickenson, A.H.5
  • 41
    • 0034534187 scopus 로고    scopus 로고
    • Efficacy and tolerability of tropisetron in primary fibromyalgia-A highly selective and competitive 5-ht3 receptor antagonist
    • Farber L, Stratz T, Bruckle W, Spath M, Pongratz D, Lautenschlager J, et al. Efficacy and tolerability of tropisetron in primary fibromyalgia-A highly selective and competitive 5-HT3 receptor antagonist. Scandinavian Journal of Rheumatology 2000;113(Suppl.):49-54.
    • (2000) Scandinavian Journal of Rheumatology , vol.113 , Issue.SUPPL. , pp. 49-54
    • Farber, L.1    Stratz, T.2    Bruckle, W.3    Spath, M.4    Pongratz, D.5    Lautenschlager, J.6
  • 43
    • 0033555286 scopus 로고    scopus 로고
    • Transmitters involved in antinociception in the spinal cord
    • DOI 10.1016/S0361-9230(98)00159-2, PII S0361923098001592
    • Furst S. Transmitters involved in antinociception in the spinal cord. Brain Research Bulletin 1999;48:129-41. (Pubitemid 29177388)
    • (1999) Brain Research Bulletin , vol.48 , Issue.2 , pp. 129-141
    • Furst, S.1
  • 44
    • 34548677767 scopus 로고    scopus 로고
    • Allosteric modulation of nicotinic acetylcholine receptors
    • DOI 10.1016/j.bcp.2007.07.011, PII S0006295207004637
    • Bertrand D, Gopalakrishnan M. Allosteric modulation of nicotinic acetylcholine receptors. Biochemical Pharmacology 2007;74:1155-63. (Pubitemid 47417931)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.8 , pp. 1155-1163
    • Bertrand, D.1    Gopalakrishnan, M.2
  • 45
    • 84870895846 scopus 로고    scopus 로고
    • Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models
    • Freitas K, Ghosh S. Ivy Carroll F, Lichtman AH, Imad Damaj M. Effects of alpha 7 positive allosteric modulators in murine inflammatory and chronic neuropathic pain models. Neuropharmacology 2013;65:156-64.
    • (2013) Neuropharmacology , vol.65 , pp. 156-164
    • Freitas, K.1    Ghosh, S.2    Ivy Carroll, F.3    Lichtman, A.H.4    Imad Damaj, M.5
  • 46
    • 80052063236 scopus 로고    scopus 로고
    • Antinociceptive activity of a4b2.*neuronal nicotinic receptor agonist a-366833 in experimental models of neuropathic and inflammatory pain
    • Nirogi R, Jabaris SL, Jayarajan P, Abraham R, Shanmuganathan D, Rasheed MA, et al. Antinociceptive activity of a4b2.*neuronal nicotinic receptor agonist A-366833 in experimental models of neuropathic and inflammatory pain. European Journal of Pharmacology 2011;668:155-62.
    • (2011) European Journal of Pharmacology , vol.668 , pp. 155-162
    • Nirogi, R.1    Jabaris, S.L.2    Jayarajan, P.3    Abraham, R.4    Shanmuganathan, D.5    Rasheed, M.A.6
  • 47
    • 34548674477 scopus 로고    scopus 로고
    • A-366833: A novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]- heptane α4β2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models
    • DOI 10.1016/j.bcp.2007.08.010, PII S0006295207005515
    • Ji J, Bunnelle WH, Anderson DJ, Faltynek C, Dyhring T, Ahring PK, et al. A-366833: a novel nicotinonitrile-substituted 3,6-diazabicyclo[3.2.0]-heptane a4b2 nicotinic acetylcholine receptor selective agonist: Synthesis, analgesic efficacy and tolerability profile in animal models. Biochem. Pharmacology 2007;74:1253-62. (Pubitemid 47417939)
    • (2007) Biochemical Pharmacology , vol.74 , Issue.8 , pp. 1253-1262
    • Ji, J.1    Bunnelle, W.H.2    Anderson, D.J.3    Faltynek, C.4    Dyhring, T.5    Ahring, P.K.6    Rueter, L.E.7    Curzon, P.8    Buckley, M.J.9    Marsh, K.C.10    Kempf-Grote, A.11    Meyer, M.D.12
  • 48
    • 80052027395 scopus 로고    scopus 로고
    • A4b2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of a4b2 nachr agonists in pain
    • Lee CH, Zhu C, Malysz J, Campbell T, Shaughnessy T, Honore P, et al. a4b2 neuronal nicotinic receptor positive allosteric modulation: an approach for improving the therapeutic index of a4b2 nAChR agonists in pain. Biochemical Pharmacology 2011;82:959-66.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 959-966
    • Lee, C.H.1    Zhu, C.2    Malysz, J.3    Campbell, T.4    Shaughnessy, T.5    Honore, P.6
  • 49
    • 84875466730 scopus 로고    scopus 로고
    • Unravelling the mechanism of action of ns9283, a positive allosteric modulator of (alpha4)3(-beta2)2 nicotinic ach receptors
    • Grupe M, Jensen AA, Ahring PK, Christensen JK, Grunnet M. Unravelling the mechanism of action of NS9283, a positive allosteric modulator of (alpha4)3(-beta2)2 nicotinic ACh receptors. British Journal of Pharmacology 2013;168:2000-10.
    • (2013) British Journal of Pharmacology , vol.168 , pp. 2000-2010
    • Grupe, M.1    Jensen, A.A.2    Ahring, P.K.3    Christensen, J.K.4    Grunnet, M.5
  • 50
    • 80052030619 scopus 로고    scopus 로고
    • Potentiation of analgesic efficacy but not side effects: Co-administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats
    • Zhu CZ, Chin CL, Rustay NR, Zhong C, Mikusa J, Chandran P, et al. Potentiation of analgesic efficacy but not side effects: co-administration of an alpha4beta2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats. Biochemical Pharmacology 2011;82:967-76.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 967-976
    • Zhu, C.Z.1    Chin, C.L.2    Rustay, N.R.3    Zhong, C.4    Mikusa, J.5    Chandran, P.6
  • 51
    • 13444249910 scopus 로고    scopus 로고
    • Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain
    • DOI 10.1016/j.neulet.2004.11.020
    • Dube GR, Kohlhaas KL, Rueter LE, Surowy CS, Meyer MD, Briggs CA. Loss of functional neuronal nicotinic receptors in dorsal root ganglion neurons in a rat model of neuropathic pain. Neuroscience Letters 2005;376:29-34. (Pubitemid 40202932)
    • (2005) Neuroscience Letters , vol.376 , Issue.1 , pp. 29-34
    • Dube, G.R.1    Kohlhaas, K.L.2    Rueter, L.E.3    Surowy, C.S.4    Meyer, M.D.5    Briggs, C.A.6
  • 52
    • 0034795753 scopus 로고    scopus 로고
    • Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes
    • Genzen JR, Van Cleve W, McGehee DS. Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes. Journal of Neurophysiology 2001;86:1773-82. (Pubitemid 32953226)
    • (2001) Journal of Neurophysiology , vol.86 , Issue.4 , pp. 1773-1782
    • Genzen, J.R.1    Van Cleve, W.2    Mcgehee, D.S.3
  • 53
    • 0038312028 scopus 로고    scopus 로고
    • Short- and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors
    • DOI 10.1073/pnas.1131709100
    • Genzen JR, McGehee DS. Short-and long-term enhancement of excitatory transmission in the spinal cord dorsal horn by nicotinic acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America 2003;100:6807-12. (Pubitemid 36666661)
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.11 , pp. 6807-6812
    • Genzen, J.R.1    McGehee, D.S.2
  • 54
    • 14144254799 scopus 로고    scopus 로고
    • Nicotinic AChR in subclassified capsaicin-sensitive and -insensitive nociceptors of the rat DRG
    • DOI 10.1152/jn.00591.2004
    • Rau KK, Johnson RD, Cooper BY. Nicotinic AChR in subclassified capsaicinsensitive and -insensitive nociceptors of the rat DRG. Journal of Neurophysiology 2005;93:1358-71. (Pubitemid 40283725)
    • (2005) Journal of Neurophysiology , vol.93 , Issue.3 , pp. 1358-1371
    • Rau, K.K.1    Johnson, R.D.2    Cooper, B.Y.3
  • 55
    • 0242677114 scopus 로고    scopus 로고
    • Characterization of Neuronal Nicotinic Acetylcholine Receptors in the Membrane of Unmyelinated Human C-Fiber Axons by In Vitro Studies
    • DOI 10.1152/jn.00512.2003
    • Lang PM, Burgstahler R, Sippel W, Irnich D, Schlotter-Weigel B, Grafe P. Characterization of neuronal nicotinic acetylcholine receptors in the membrane of unmyelinated human C-fiber axons by in vitro studies. Journal of Neurophysiology 2003;90:3295-303. (Pubitemid 37430024)
    • (2003) Journal of Neurophysiology , vol.90 , Issue.5 , pp. 3295-3303
    • Lang, P.M.1    Burgstahler, R.2    Sippel, W.3    Irnich, D.4    Schlotter-Weigel, B.5    Grafe, P.6
  • 57
    • 12344297870 scopus 로고    scopus 로고
    • Knock down of the α5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia
    • DOI 10.1016/j.pbb.2004.10.011, PII S0091305704003363
    • Vincler MA, Eisenach JC. Knock down of thea5 nicotinic acetylcholine receptor in spinal nerve-ligated rats alleviates mechanical allodynia. Pharmacology Biochemistry and Behavior 2005;80:135-43. (Pubitemid 40126211)
    • (2005) Pharmacology Biochemistry and Behavior , vol.80 , Issue.1 , pp. 135-143
    • Vincler, M.A.1    Eisenach, J.C.2
  • 58
    • 0037849869 scopus 로고    scopus 로고
    • Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain
    • DOI 10.1016/s0304-3959(02)00455-4
    • Rueter LE, Kohlhaas KL, Curzon P, Surowy CS, Meyer MD. Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain. Pain 2003;103:269-76. (Pubitemid 36638816)
    • (2003) Pain , vol.103 , Issue.3 , pp. 269-276
    • Rueter, L.E.1    Kohlhaas, K.L.2    Curzon, P.3    Surowy, C.S.4    Meyer, M.D.5
  • 59
    • 65349139499 scopus 로고    scopus 로고
    • The effect of peripherally administered cdp-choline in an acute inflammatory pain model: The role of α7 nicotinic acetylcholine receptor
    • Gurun MS, Parker R, Eisenach JC, Vincler M. The effect of peripherally administered CDP-choline in an acute inflammatory pain model: the role of α7 nicotinic acetylcholine receptor. Anesthesia and Analgesia 2009;108:1680-7.
    • (2009) Anesthesia and Analgesia , vol.108 , pp. 1680-1167
    • Gurun, M.S.1    Parker, R.2    Eisenach, J.C.3    Vincler, M.4
  • 60
    • 77954414716 scopus 로고    scopus 로고
    • Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation
    • Gahring LC, Osborne AV, Reed M, Rogers SW. Neuronal nicotinic alpha7 receptors modulate early neutrophil infiltration to sites of skin inflammation. Journal of Neuroinflammation 2010;7:38.
    • (2010) Journal of Neuroinflammation , vol.7 , pp. 38
    • Gahring, L.C.1    Osborne, A.V.2    Reed, M.3    Rogers, S.W.4
  • 61
    • 37749038270 scopus 로고    scopus 로고
    • Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation
    • Osborne-Hereford AV, Rogers SW, Gahring LC. Neuronal nicotinic alpha7 receptors modulate inflammatory cytokine production in the skin following ultraviolet radiation. Journal of Neuroimmunology 2008;193:130-9.
    • (2008) Journal of Neuroimmunology , vol.193 , pp. 130-139
    • Osborne-Hereford, A.V.1    Rogers, S.W.2    Gahring, L.C.3
  • 62
  • 64
    • 33747125503 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells
    • Gahring LC, Rogers SW. Neuronal nicotinic acetylcholine receptor expression and function on nonneuronal cells. AAPS Journals 2005;7:E885-94.
    • (2005) AAPS Journals , vol.7
    • Gahring, L.C.1    Rogers, S.W.2
  • 65
    • 0037110652 scopus 로고    scopus 로고
    • Coexpression of α9 and α10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons
    • DOI 10.1016/S0306-4522(02)00274-9, PII S0306452202002749
    • Lips KS, Pfeil U, KummerW. Coexpression of a9 and a10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons. Neuroscience 2002;115:1-5. (Pubitemid 35232683)
    • (2002) Neuroscience , vol.115 , Issue.1 , pp. 1-5
    • Lips, K.S.1    Pfeil, U.2    Kummer, W.3
  • 66
    • 7544225904 scopus 로고    scopus 로고
    • Characterization of the human nicotinic acetylcholine receptor subunit alpha (α) 9 (CHRNA9) and alpha (α) 10 (CHRNA10) in lymphocytes
    • DOI 10.1016/j.lfs.2004.05.031, PII S0024320504006630
    • Peng H, Ferris RL, Matthews T, Hiel H, Lopez-Albaitero A, Lustig LR. Characterization of the human nicotinic acetylcholine receptor subunit alpha (a) 9 (CHRNA9) and alpha (a) 10 (CHRNA10) in lymphocytes. Life Sciences 2004;76:263-80. (Pubitemid 39452910)
    • (2004) Life Sciences , vol.76 , Issue.3 , pp. 263-280
    • Peng, H.1    Ferris, R.L.2    Matthews, T.3    Hiel, H.4    Lopez-Albaitero, A.5    Lustig, L.R.6
  • 67
    • 58149172098 scopus 로고    scopus 로고
    • Analgesic adams dj. A-conotoxins vc1.1 and rg1a inhibit n-type calcium channels in rat sensory neurons via gabab receptor activation
    • Callaghan B, Haythornthwaite A, Berecki G, Clark RJ, Craik DJ, Analgesic Adams DJ. a-conotoxins Vc1.1 and Rg1A inhibit N-type calcium channels in rat sensory neurons via GABAB receptor activation. J. Neuroscience 2008;28:10943-51.
    • (2008) J. Neuroscience , vol.28 , pp. 10943-10951
    • Callaghan, B.1    Haythornthwaite, A.2    Berecki, G.3    Clark, R.J.4    Craik, D.J.5
  • 68
    • 84865750751 scopus 로고    scopus 로고
    • Molecular basis for the differential sensitivity of rat and human a9a10 nachrs to a-conotoxin rgia
    • Azam L, McIntosh JM. Molecular basis for the differential sensitivity of rat and human a9a10 nAChRs to a-conotoxin RgIA. Journal of Neurochemistry 2012;122:1137-44.
    • (2012) Journal of Neurochemistry , vol.122 , pp. 1137-1144
    • Azam, L.1    McIntosh, J.M.2
  • 70
    • 0027135197 scopus 로고
    • Depression by nicotine of pain-related nociceptive activity in the rat thalamus and spinal cord
    • Jurna I, Krauss P, Baldauf J. Depression by nicotine of pain-related nociceptive activity inthe rat thalamus and spinal cord. Clinical Investigator1993;72:65-73. (Pubitemid 24002254)
    • (1993) Clinical Investigator , vol.72 , Issue.1 , pp. 65-73
    • Jurna, I.1    Krauss, P.2    Baldauf, J.3
  • 71
    • 0035059685 scopus 로고    scopus 로고
    • The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats
    • DOI 10.1016/S0304-3959(00)00425-5, PII S0304395900004255
    • Hama AT, Lloyd GK, Menzaghi F. The antinociceptive effect of intrathecal administration of epibatidine with clonidine or neostigmine in the formalin test in rats. Pain 2001;91:131-8. (Pubitemid 32279618)
    • (2001) Pain , vol.91 , Issue.1-2 , pp. 131-138
    • Hama, A.T.1    Lloyd G.Kenneth2    Menzaghi, F.3
  • 73
    • 0032403103 scopus 로고    scopus 로고
    • Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists
    • DOI 10.1016/S0028-3908(98)00143-9, PII S0028390898001439
    • Khan IM, Buerkle H, Taylor P, Yaksh TL. Nociceptive and antinociceptive responses to intrathecally administered nicotinic agonists. Neuropharmacology 1998;37:1515-25. (Pubitemid 28550425)
    • (1998) Neuropharmacology , vol.37 , Issue.12 , pp. 1515-1525
    • Khan, I.M.1    Buerkle, H.2    Taylor, P.3    Yaksh, T.L.4
  • 74
    • 0037145712 scopus 로고    scopus 로고
    • Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism
    • DOI 10.1016/S0006-8993(02)03270-5, PII S0006899302032705
    • Rashid MH, Ueda H. Neuropathy-specific analgesic action of intrathecal nicotinic agonists and its spinal GABA-mediated mechanism. Brain Research 2002;953:53-62. (Pubitemid 35217807)
    • (2002) Brain Research , vol.953 , Issue.1-2 , pp. 53-62
    • Rashid Md.Harunor1    Ueda, H.2
  • 75
    • 2442432828 scopus 로고    scopus 로고
    • Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord
    • Cordero-Erausquin M, Pons S, Faure P, Changeux JP. Nicotine differentially activates inhibitory and excitatory neurons in the dorsal spinal cord. Pain 2004;109:308-18.
    • (2004) Pain , vol.109 , pp. 308-3018
    • Cordero-Erausquin, M.1    Pons, S.2    Faure, P.3    Changeux, J.P.4
  • 76
    • 0033626562 scopus 로고    scopus 로고
    • The antinociceptive effects α7 nicotinic agonists in an acute pain model
    • Damaj MI, Meyer EM, Martin BR. The antinociceptive effects α7 nicotinic agonists in an acute pain model. Neuropharmacology 2000;39:2785-91.
    • (2000) Neuropharmacology , vol.39 , pp. 2785-2791
    • Damaj, M.I.1    Meyer, E.M.2    Martin, B.R.3
  • 78
    • 11844291367 scopus 로고    scopus 로고
    • Nicotinic modulation of GABAergic synaptic transmission in the spinal cord dorsal horn
    • DOI 10.1016/j.brainres.2004.10.042, PII S000689930401772X
    • Genzen JR, McGehee DS. Nicotinic modulation of GABAergic synaptic transmission in the spinal cord dorsal horn. Brain Research 2005;1031:229-37. (Pubitemid 40093075)
    • (2005) Brain Research , vol.1031 , Issue.2 , pp. 229-237
    • Genzen, J.R.1    McGehee, D.S.2
  • 79
    • 0035476224 scopus 로고    scopus 로고
    • Nicotine facilitates glycine release in the rat spinal dorsal horn
    • DOI 10.1111/j.1469-7793.2001.t01-1-00101.x
    • Kiyosawa A, Katsurabayashi S, Akaike N, Pang ZP, Akaike N. Nicotine facilitates glycine release in the rat spinal dorsal horn. Journal of Physiology 2001;536:101-10. (Pubitemid 32952221)
    • (2001) Journal of Physiology , vol.536 , Issue.1 , pp. 101-110
    • Kiyosawa, A.1    Katsurabayashi, S.2    Akaike, N.3    Pang, Z.P.4    Akaike, N.5
  • 80
    • 33749324999 scopus 로고    scopus 로고
    • Tonic inhibitory role of α4β2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice
    • DOI 10.1016/j.pain.2006.05.011, PII S0304395906002624
    • Rashid MH, Furue H, Yoshimura M, Ueda H. Tonic inhibitory role of a4b2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice. Pain 2006;125:125-35. (Pubitemid 44498970)
    • (2006) Pain , vol.125 , Issue.1-2 , pp. 125-135
    • Rashid, M.H.1    Furue, H.2    Yoshimura, M.3    Ueda, H.4
  • 81
    • 80051791452 scopus 로고    scopus 로고
    • Nociceptive thresholds are controlled through spinal b2-subunit- containing nicotinic acetylcholine receptors
    • Yalcin I, Charlet A, Cordero-Erausquin M, Tessier LH, Picciotto MR, Schlichter R, et al. Nociceptive thresholds are controlled through spinal b2-subunit-containing nicotinic acetylcholine receptors. Pain 2011;152:2131-7.
    • (2011) Pain , vol.152 , pp. 2131-2137
    • Yalcin, I.1    Charlet, A.2    Cordero-Erausquin, M.3    Tessier, L.H.4    Picciotto, M.R.5    Schlichter, R.6
  • 82
    • 0037223117 scopus 로고    scopus 로고
    • Modulation of inhibitory synaptic activity by a non-α4β2, non-α7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord
    • DOI 10.1016/S0304-3959(02)00074-X
    • Takeda D, Nakatsuka T, Papke R, Gu JG. Modulation of inhibitory synaptic activity by a non-a4b2, non-a7 subtype of nicotinic receptors in the substantia gelatinosa of adult rat spinal cord. Pain 2003;101:13-23. (Pubitemid 36044650)
    • (2003) Pain , vol.101 , Issue.1-2 , pp. 13-23
    • Takeda, D.1    Nakatsuka, T.2    Papke, R.3    Gu, J.G.4
  • 83
    • 0032527594 scopus 로고    scopus 로고
    • Role of the nucleus raphe magnus in antinociception produced by ABT- 594: Immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons
    • Bitner RS, Nikkel AL, Curzon P, Arneric SP, Bannon AW, Decker MW. Role of the nucleus raphe magnus in antinociception produced by ABT-594: immediate early gene responses possibly linked to neuronal nicotinic acetylcholine receptors on serotonergic neurons. Journal of Neuroscience 1998;18:5426-32. (Pubitemid 28311958)
    • (1998) Journal of Neuroscience , vol.18 , Issue.14 , pp. 5426-5432
    • Bitner, R.S.1    Nikkel, A.L.2    Curzon, P.3    Arneric, S.P.4    Bannon, A.W.5    Decker, M.W.6
  • 84
    • 0038503327 scopus 로고    scopus 로고
    • Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission
    • DOI 10.1002/syn.10218
    • Cucchiaro G, Commons KG. a4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission. Synapse 2003;49:195-205. (Pubitemid 36870557)
    • (2003) Synapse , vol.49 , Issue.3 , pp. 195-205
    • Cucchiaro, G.1    Commons, K.G.2
  • 85
    • 39049147096 scopus 로고    scopus 로고
    • Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents
    • Matsumoto M, Xie W, Inoue M, Ueda H. Evidence for the tonic inhibition of spinal pain by nicotinic cholinergic transmission through primary afferents. Molecular Pain 2007;3:41.
    • (2007) Molecular Pain , vol.3 , pp. 41
    • Matsumoto, M.1    Xie, W.2    Inoue, M.3    Ueda, H.4
  • 86
    • 36448975257 scopus 로고    scopus 로고
    • Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons
    • DOI 10.1016/j.brainres.2007.09.027, PII S0006899307021592
    • Dehkordi O, Millis RM, Dennis GC, Jazini E, Williams C, Hussain D, et al. Expression of alpha-7 and alpha-4 nicotinic acetylcholine receptors by GABAergic neurons of rostral ventral medulla and caudal pons. Brain Research 2007;1185:95-102. (Pubitemid 350166304)
    • (2007) Brain Research , vol.1185 , Issue.1 , pp. 95-102
    • Dehkordi, O.1    Millis, R.M.2    Dennis, G.C.3    Jazini, E.4    Williams, C.5    Hussain, D.6    Jayam-Trouth, A.7
  • 87
    • 84865637361 scopus 로고    scopus 로고
    • Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-ht(4), 5-ht(6) and 5-ht(7) receptors
    • Godinez-Chaparro B, Lopez-Santillan FJ, Orduna P, Granados-Soto V. Secondary mechanical allodynia and hyperalgesia depend on descending facilitation mediated by spinal 5-HT(4), 5-HT(6) and 5-HT(7) receptors. Neuroscience 2012;222:379-91.
    • (2012) Neuroscience , vol.222 , pp. 379-391
    • Godinez-Chaparro, B.1    Lopez-Santillan, F.J.2    Orduna, P.3    Granados-Soto, V.4
  • 89
    • 34249330701 scopus 로고    scopus 로고
    • Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats
    • DOI 10.1016/j.neulet.2007.04.058, PII S0304394007005095
    • Hamurtekin E, Bagdas D, Gurun MS. Possible involvement of supraspinal opioid and GABA receptors in CDP-choline-induced antinociception in acute pain models in rats. Neuroscience Letters 2007;420:116-21. (Pubitemid 46818674)
    • (2007) Neuroscience Letters , vol.420 , Issue.2 , pp. 116-121
    • Hamurtekin, E.1    Bagdas, D.2    Gurun, M.S.3
  • 90
    • 80052031263 scopus 로고    scopus 로고
    • An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants
    • Baddick CG, Marks MJ. An autoradiographic survey of mouse brain nicotinic acetylcholine receptors defined by null mutants. Biochemical Pharmacology 2011;82:828-41.
    • (2011) Biochemical Pharmacology , vol.82 , pp. 828-841
    • Baddick, C.G.1    Marks, M.J.2
  • 91
    • 0028364095 scopus 로고
    • Antinociceptive effects of carbachol microinjected into different portions of the mesencephalic periaqueductal gray matter of the rat
    • DOI 10.1016/0006-8993(94)91321-8
    • Guimaraes AP, Prado WA. Antinociceptive effects of carbachol microinjected into different portions of the mesencephalic periaqueductal gray matter of the rat. Brain Research 1994;647:220-30. (Pubitemid 24176084)
    • (1994) Brain Research , vol.647 , Issue.2 , pp. 220-230
    • Guimaraes, A.P.C.1    Prado, W.A.2
  • 92
    • 77953811632 scopus 로고    scopus 로고
    • Presynaptic nicotinic acetylcholine receptors enhance gabaergic synaptic transmission in rat periaqueductal gray neurons
    • Nakamura M, Jang IS. Presynaptic nicotinic acetylcholine receptors enhance GABAergic synaptic transmission in rat periaqueductal gray neurons. European Journal of Pharmacology 2010;640:178-84.
    • (2010) European Journal of Pharmacology , vol.640 , pp. 178-184
    • Nakamura, M.1    Jang, I.S.2
  • 93
    • 27944489507 scopus 로고    scopus 로고
    • Comparison of α2 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice
    • DOI 10.1002/cne.20762
    • Ishii K, Wong JK, Sumikawa K. Comparison of a2 nicotinic acetylcholine receptor subunit mRNA expression in the central nervous system of rats and mice. Journal of Comparative Neurology 2005;493:241-60. (Pubitemid 41677479)
    • (2005) Journal of Comparative Neurology , vol.493 , Issue.2 , pp. 241-260
    • Ishii, K.1    Wong, J.K.2    Sumikawa, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.