ABT-594 (a nicotinic acetylcholine agonist): Anti-allodynia in a rat chemotherapy-induced pain model

European Journal of Pharmacology

Volumn 509, Issue 1, 2005, Pages 43-48

  Lynch III, James J ^a   Wade, Carrie L ^a   Mikusa, Joseph P ^a   Decker, Michael W ^a   Honore, Prisca ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Allodynia; Analgesia; Cancer pain; Neuropathic pain; Nicotinic acetylcholine receptor; Vincristine

Indexed keywords

5 (2 AZETIDINYLMETHOXY) 2 CHLOROPYRIDINE; CHLORISONDAMINE; MECAMYLAMINE; NALOXONE; NICOTINIC AGENT; VINCRISTINE;

ALLODYNIA; ANALGESIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 13844254492     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.12.034     Document Type: Article

References (31)

1. A.W. Bannon, M.W. Decker, P. Curzon, M.J. Buckley, D.J.B. Kim, R.J. Radek, J.K. Lynch, J.T. Wasicak, N.-H. Lin, W.H. Arnold, M.W. Holladay, M. Williams, and S.P. Arneric ABT-594 [(R)-5-2-azetidinylmethoxy)-2-chloropyridine] : a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization J. Pharmacol. Exp. Ther. 285 1998 787 794
2. A.W. Bannon, M.W. Decker, M.W. Holladay, P. Curzon, D. Donnelly-Roberts, P.S. Puttfarcken, R.S. Bitner, A. Diaz, A.H. Dickenson, R.D. Porsolt, M. Williams, and S.P. Arneric Broad-spectrum, non-opioid analgesic activity by selective modulation of neuronal nicotinic acetylcholine receptors Science 279 1998 77 81
3. A.W. Bannon, M.W. Decker, D.J.B. Kim, J.E. Campbell, and S.P. Arneric ABT-594, a novel cholinergic channel modulator, is efficacious in nerve ligation and diabetic neuropathy models of neuropathic pain Brain Res. 801 1998 158 163
4. L. Bardin, J.P. Tarayre, N. Malfetes, W. Koek, and F.C. Colpaert Profound, non-opioid analgesia produced by the high-efficacy 5-HT1A agonist F 13640 in the formalin model of tonic nociceptive pain Pharmacology 67 2003 182 194
5. D. Barlocco, G. Cignarella, D. Tondi, P. Vianello, S. Villa, A. Bartolini, C. Ghelardini, N. Galeotti, D.J. Anderson, T.A. Kuntzweiler, D. Colombo, and L. Toma Mono- and didubstituted-3-8-dizabicyclo[3.2.1]octane derivatives an analgesics structurally related to epibatidine: synthesis, activity and modeling J. Med. Chem. 41 1998 674 681
6. S. Bosnjak, S. Jelic, S. Susnjar, and V. Lukic Gabapentin for relief of neuropathic pain related to anticancer treatment: a preliminary study J. Chemother. 14 2002 214 219
7. S. Boyce, J.K. Webb, S.L. Shepheard, M.G.N. Russell, R.G. Hill, and N.M.J. Rupniak Analgesic and toxic effects of ABT-594 resemble epibatidine and nicotine in rats Pain 85 2000 443 450
8. R.T. Boyd, M.H. Jacob, A.E. McEachern, S. Caron, and D.K. Berg Nicotinic acetylcholine receptor mRNA in dorsal root ganglion neurons J. Neurobiol. 22 1991 1 14
9. S.R. Chaplan, F.W. Bach, J.W. Pogrel, J.M. Chung, and T.L. Yaksh Quantitative assessment of tactile allodynia in the rat paw J. Neurosci. Methods 53 1994 55 63
10. P.B.S. Clarke, I. Chaudieu, H. El-Bizri, P. Boksa, M. Quik, B.A. Esplin, and R. Capek The pharmacology of the nicotinic antagonist, chlorisondamine, investigated in rat brain and autonomic ganglion Br. J. Pharmacol. 111 1994 397 405
11. P. Curzon, A.L. Nikkel, A.W. Bannon, S.P. Arneric, and M.W. Decker Differences between the antinociceptive effects of the cholinergic channel activators A-85380 and (±)-epibatidine in rats J. Pharmacol. Exp. Ther. 287 1998 847 853
12. M.W. Decker, A.W. Bannon, M.J. Buckley, D.J.B. Kim, M.W. Holladay, K.B. Ryther, N.-H. Lin, J.T. Wasicak, M. Williams, and S.P. Arneric Antinociceptive effects of the novel neuronal nicotinic acetylchloline receptor agonist, ABT-594, in mice Eur. J. Pharmacol. 346 1988 23 33
13. D.L. Donnelly-Roberts, P.S. Puttfarcken, T.A. Kuntzweiler, C.A. Briggs, D.J. Anderson, J.E. Campbell, M. Piattoni-Kaplan, D.G. McKenna, J.T. Wasicak, M.W. Holladay, M. Williams, and S.P. Arneric ABT-594 [(R)-5-(2- azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective analgesic acting via neuronal nicotinic acetylcholine receptors: I. In vivo characterization J. Pharmacol. Exp. Ther. 285 1998 777 786
14. J.R. Genzen, W.V. Cleve, and D.S. McGehee Dorsal root ganglion neurons express multiple nicotinic acetylcholine receptor subtypes J. Neurophysiol. 86 2001 1773 1782
15. K. Hempenstall, and A.S.C. Rice Current treatment options in neuropathic pain Curr. Opin. Investig. Drugs 3 2002 441 448
16. A.C. Kesingland, C.T. Gentry, M.S. Panesar, M.A. Bowes, J.-M. Vernier, R. Cube, K. Walker, and L. Urban Analgesic profile of the nicotinic acetylcholine receptor agonists, (+)-epibatidine and ABT-594 in models of persistent inflammatory and neuropathic pain Pain 86 2000 113 118
17. Z.D. Luo, N.A. Calcutt, E.S. Higuera, C.R. Valder, Y.-H. Song, C.I. Svensson, and R.R. Myers Injury type-specific calcium channel alpha-2-delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin J. Pharmacol. Exp. Ther. 303 2002 1199 1205
18. J.J. Lynch III, C.L. Wade, C.M. Zhong, J.P. Mikusa, and P. Honore Attenuation of mechanical allodynia by clinically utilized drugs in a rat chemotherapy-induced neuropathic pain model Pain 110 2004 56 63
19. N. Nozaki-Taguchi, S.R. Chaplan, E.S. Higuera, R.C. Ajakwe, and T.L. Yaksh Vincristine-induced allodynia in the rat Pain 93 2001 69 76
20. R.K. Portenoy, and P. Lesage Management of cancer pain Lancet 353 1999 1695 1700
21. C. Qian, T. Li, and T.Y. Shen Epibatidine is a nicotinic analgesic Eur. J. Pharmacol. 250 1993 R13 R14
22. L.E. Rueter, K.L. Kohlhaas, P. Curzon, C.S. Surowy, and M.D. Meyer Peripheral and central sites of action for A-85380 in the spinal nerve ligation model of neuropathic pain Pain 103 2003 269 276
23. S.A. Schug, D. Zech, S. Grond, H. Jung, T. Meuser, and B. Stobbe A long-term survey of morphine in cancer pain patients J. Pain Symp. Manag. 7 1992 259 266
24. T.F. Spande, M. Garraffo, M.W. Edwards, J.C. Yeh, L. Pannell, and J.W. Daly Epibatidine: A novel (chloropyridyl)azabicycloheptane with potent analgesic activity from an Ecuadoran poison frog J. Am. Chem. Soc. 114 1992 3475 3478
25. P. Stute, J. Soukup, M. Menzel, R. Sabatowski, and S. Grond Analysis and treatment of different types of neuropathic cancer pain J. Pain Symp. Manag. 26 2003 1123 1131
26. J.P. Sullivan, D. Donnelly-Roberts, C.A. Briggs, D.J. Anderson, M. Gopalakrishnan, M. Piattoni-Kaplan, J.E. Campbell, D.G. McKenna, E. Molinari, A.-M. Hettinger, D.S. Garvey, J.T. Wasicak, M.W. Holladay, M. Williams, and S.P. Arneric A-85380 [3-(2(S)-azetidinylmethoxy) pyridine]: In vitro pharmacological properties of a novel, high affinity alpha4beta2 nicotinic acetylcholine receptor ligand Neuropharmacology 35 1996 725 734
27. J.H. Uhm, and W.K.A. Yung Neurologic complications of cancer therapy Curr. Treat. Options Neurol. 1 1999 428 437
28. M. Vincler, and J.C. Eisenach Plasticity of spinal nicotinic acetylcholine receptors following spinal nerve ligation Neurosci. Res. 48 2004 139 145
29. M. Winkelmuller, and W. Winkelmuller Long-term effects of continuous intrathecal opioid treatment in chronic pain of nonmalignant etiology J. Neurosurg. 85 1996 458 467
30. G.I. Wolfe, and R.J. Barohn Painful peripheral neuropathy Curr. Treat. Options Neurol. 4 2002 177 188
31. L. Yang, F.-X. Zhang, F. Huang, Y.-J. Lu, G.-D. Li, L. Bao, H.-S. Xiao, and X. Zhang Peripheral nerve injury induces trans-synaptic modification of channels, receptors and signal pathways in rat dorsal spinal cord Eur. J. Neurosci. 19 2004 871 883