Identification of a specific one amino acid change in recombinant human transglutaminase 2 that regulates its activity and calcium sensitivity

Biochemical Journal

Volumn 455, Issue 3, 2013, Pages 261-272

  Kanchan, Kajal ^a   Ergülen, Elvan ^b   Király, Robert ^a   Simon Vecsei, Zsófia ^a   Fuxreiter, Mónika ^c   Fésüs, László ^d  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b UD GenoMed Medical Genome Technologies   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d Apoptosis and Genomics Research Group   (Hungary)

Author keywords

Calcium ionophore; Cross linking activity; Isopeptidase; Structure and function; SYPRO Orange; Transglutaminase

Indexed keywords

ANTIBODY; CALCIUM; ENZYME VARIANT; FIBRONECTIN; GLYCINE; GUANOSINE TRIPHOSPHATE; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2; RECOMBINANT PROTEIN; VALINE;

AMIDATION; AMINO ACID SUBSTITUTION; ANTIGENICITY; ARTICLE; BINDING AFFINITY; BINDING KINETICS; CALCIUM BINDING; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME INACTIVATION; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; GENETIC DATABASE; HUMAN; HUMAN CELL; ISOTHERMAL TITRATION CALORIMETRY; METAL BINDING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REGULATORY MECHANISM; SEQUENCE ALIGNMENT; STRUCTURE ANALYSIS;

BINDING SITES; CALCIUM; CARBON-NITROGEN LYASES; GLYCINE; GTP-BINDING PROTEINS; HEK293 CELLS; HUMANS; RECOMBINANT PROTEINS; TRANSGLUTAMINASES; VALINE;

EID: 84885636319     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20130696     Document Type: Article

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