A single conformational transglutaminase 2 epitope contributed by three domains is critical for celiac antibody binding and effects

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 2, 2012, Pages 431-436

  Simon Vecsei, Zsófia ^a   Király, Róbert ^a,b   Bagossi, Péter ^a   Tóth, Boglárka ^a   Dahlbom, Ingrid ^c   Caja, Sergio ^d   Csosz, Éva ^a   Lindfors, Katri ^d   Sblattero, Daniele ^e   Nemes, Éva ^a   Mäki, Markku ^d   Fésüs, László ^a,b   Korponay Szabó, Ilma R ^a,f  

^a UNIVERSITY OF DEBRECEN   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c UPPSALA UNIVERSITY   (Sweden)

^d TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

^e UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^f HEIM PÁL CHILDREN S HOSPITAL   (Hungary)

Author keywords

Conformational epitope; Endomysial antibodies; Immunotherapy

Indexed keywords

ANTIBODY; CALCIUM; EPITOPE; GLUTAMIC ACID; PROTEIN GLUTAMINE GAMMA GLUTAMYLTRANSFERASE 2;

ALPHA HELIX; ANTIBODY COMBINING SITE; ANTIBODY PRODUCTION; ANTIGEN BINDING; ARTICLE; CALCIUM BINDING; CARBOXY TERMINAL SEQUENCE; CELIAC DISEASE; CONTROLLED STUDY; HUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN CROSS LINKING; PROTEIN DOMAIN; PROTEIN STRUCTURE; T LYMPHOCYTE ACTIVATION;

ANALYSIS OF VARIANCE; ANIMALS; AUTOANTIBODIES; AUTOANTIGENS; CELIAC DISEASE; CELLS, CULTURED; CRYSTALLOGRAPHY; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FLUORESCENT ANTIBODY TECHNIQUE; GLIADIN; GTP-BINDING PROTEINS; HUMANS; IMMUNOTHERAPY; LYMPHOCYTE ACTIVATION; MICE; MODELS, MOLECULAR; T-LYMPHOCYTES; TRANSGLUTAMINASES;

EID: 84855990625     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1107811108     Document Type: Article

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