Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification

International Journal of Cardiology

Volumn 168, Issue 3, 2013, Pages 2242-2247

  Wen, Chaoyang ^a,b   Yang, Xiaoli ^b,c   Yan, Zhifeng ^d   Zhao, Man ^b   Yue, Xiang ^b   Cheng, Xiaozhong ^b   Zheng, Zirui ^b   Guan, Kai ^b   Dou, Jianping ^a   Xu, Tao ^a   Zhang, Yanhong ^b   Song, Ting ^b   Wei, Congwen ^b   Zhong, Hui ^b  

^a Hainan Branch of Chinese PLA General Hospital Sanya City   (China)

^b BEIJING INSTITUTE OF BIOTECHNOLOGY   (China)

^c Third Hospital of the General Brigade of Armed Police   (China)

^d CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

IL 1 secretion; Nalp3 inflammasomes; VSMC calcification

Indexed keywords

ADAPTOR PROTEIN; CRYOPYRIN; GLYCEROL 2 PHOSPHATE; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MESSENGER RNA; PROTEIN ASC; UNCLASSIFIED DRUG; CELL RECEPTOR; INTERLEUKIN 6; NOD-LIKE RECEPTOR 3, RAT; RNA;

ADULT; ANIMAL EXPERIMENT; ARTICLE; BLOOD VESSEL CALCIFICATION; CELL CULTURE; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN TISSUE; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; WESTERN BLOTTING; ANIMAL; ATHEROSCLEROSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; GENETICS; IMMUNOBLOTTING; METABOLISM; MIDDLE AGED; PATHOLOGY; RETROSPECTIVE STUDY; SPRAGUE DAWLEY RAT; THORACIC AORTA;

ANIMALS; AORTA, THORACIC; ATHEROSCLEROSIS; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; INFLAMMASOMES; INTERLEUKIN-6; MALE; MIDDLE AGED; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RETROSPECTIVE STUDIES; RNA; VASCULAR CALCIFICATION;

EID: 84885598216     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2013.01.211     Document Type: Article

References (25)

1. M.A. Allison, M.H. Criqui, and C.M. Wright Patterns and risk factors for systemic calcified atherosclerosis Arterioscler Thromb Vasc Biol 24 2004 331 336
2. R. Wayhs, A. Zelinger, and P. Raggi High coronary artery calcium scores pose an extremely elevated risk for hard events J Am Coll Cardiol 39 2002 225 230
3. Y. Tintut, J. Patel, and F. Parhami Tumor necrosis factor-alpha promotes in vitro calcification of vascular cells via the cAMP pathway Circulation 102 2000 2636 2642
4. N. Inohara, M. Chamaillard, and C. McDonald NOD-LRR proteins: role in host-microbial interactions and inflammatory disease Annu Rev Biochem 74 2005 355 383
5. A. Dunne Inflammasome activation: from inflammatory disease to infection Biochem Soc Trans 39 2011 669 673
6. F. Martinon, K. Burns, and J. Tschopp The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of pro IL-beta Mol Cell 10 2002 417 426
7. V. Petrilli, C. Dostert, and D.A. Muruve The inflammasome: a danger sensing complex triggering innate immunity Curr Opin Immunol 19 2007 615 622
8. S. Mariathasan, and D.M. Monack Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation Nat Rev Immunol 7 2007 31 40
9. B.J. DeYoung, and R.W. Innes Plant NBS-LRR proteins in pathogen sensing and host defense Nat Immunol 7 2006 1243 1249
10. J. Tschopp, F. Martinon, and K. Burns NALPs: a novel protein family involved in inflammation Nat Rev Mol Cell Biol 4 2003 95 104
11. Christian R. McIntire, Garabet Yeretssian, and Maya Saleh Inflammasomes in infection and inflammation Apoptosis 14 2009 522 535
12. C. Dostort, V. Potrilli, and R. Van Bruggen Innate immune activation through NALP3 inflammasome sensing of asbestos and silica Science 320 2008 674 677
13. F. Martinon, V. Petrilli, and A. Mayor Gout-associated uric acid crystals activate the NALP3 inflammasome Nature 440 2006 237 241
14. A. Halle, V. Hornung, and G.C. Petzold The NALP3 inflammasome is involved in the innate immune response to amyloid-β Nat Immunol 9 2008 857 865
15. V. Hornung, F. Bauernfeind, and A. Halle Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization Nat Immunol 9 2008 847 856
16. P. Duewell, H. Kono, and K.J. Rayner NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals Nature 464 2010 1357 1361
17. G.D. Collett, A.P. Sage, and J.P. Kirton Axl/phosphatidylinositol 3-kinase signaling inhibits mineral deposition by vascular smooth muscle cells Circ Res 100 2007 502 509
18. A. Lomri, P.J. Marie, and P.V. Tran Characterization of endosteal osteoblastic cells isolated from mouse caudal vertebrae Bone 9 1988 165 175
19. V.E. Macrae, M.G. Davey, and L. McTeir Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick Bone 46 2010 1146 1155
20. P. Olesen, K. Nguyen, and L. Wogensen Calcification of human vascular smooth muscle cells: associations with osteoprotegerin expression and acceleration by high-dose insulin Am J Physiol Heart Circ Physiol 292 2007 1058 1064
21. S. Panizo, A. Cardus, and M. Encinas RANKL increases vascular smooth muscle cell calcification through a RANK-BMP4-dependent pathway Circ Res 104 2009 1041 1048
22. B.T. Mossman, and A. Churg Mechanisms in the pathogenesis of asbestosis and silicosis Am J Respir Crit Care Med 157 1998 1666 1680
23. Y. Tintut, J. Patel, and M. Territo Monocyte/macrophage regulation of vascular calcification in vitro Circulation 105 2002 650 655
24. A.E. Ewence, M. Bootman, and H.L. Roderick Calcium phosphate crystals induce cell death in human vascular smooth muscle cells: a potential mechanism in atherosclerotic plaque destabilization Circ Res 103 2008 28 34
25. F. Martinon, A. Mayor, and J. Tschopp The inflammasomes: guardians of the body Annu Rev Immunol 27 2009 229 265