Gene replacement therapy for retinal CNG channelopathies

Molecular Genetics and Genomics

Volumn 288, Issue 10, 2013, Pages 459-467

  Schön, Christian ^a   Biel, Martin ^a   Michalakis, Stylianos ^a  

^a UNIVERSITY OF MUNICH   (Germany)

Author keywords

Adeno associated virus; Channelopathies; CNG channel; Cyclic nucleotide gated channel; Gene therapy; Retina

Indexed keywords

CYCLIC GMP; CYCLIC NUCLEOTIDE GATED A3 CHANNEL SUBUNIT; CYCLIC NUCLEOTIDE GATED B1 CHANNEL SUBUNIT; CYCLIC NUCLEOTIDE GATED B1A CHANNEL SUBUNIT; CYCLIC NUCLEOTIDE GATED CHANNEL; GENE THERAPY AGENT; MESSENGER RNA; PARVOVIRUS VECTOR; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; BLINDNESS; CHANNELOPATHY; COLOR BLINDNESS; CYCLIC NUCLEOTIDE GATED A1 CHANNEL SUBUNIT GENE; CYCLIC NUCLEOTIDE GATED A3 CHANNEL SUBUNIT GENE; CYCLIC NUCLEOTIDE GATED B1 CHANNEL SUBUNIT GENE; CYCLIC NUCLEOTIDE GATED B3 CHANNEL SUBUNIT GENE; DISEASE MODEL; GENE; GENE CASSETTE; GENE DELETION; GENE INACTIVATION; GENE OVEREXPRESSION; GENE REPLACEMENT THERAPY; HUMAN; LOSS OF FUNCTION MUTATION; MISSENSE MUTATION; MOLECULAR DYNAMICS; MUTATIONAL ANALYSIS; NONHUMAN; PHOTOTRANSDUCTION; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RETINA CONE; RETINA DEGENERATION; RETINA DISEASE; RETINA ROD; RETINAL CYCLIC NUCLEOTIDE GATED CHANNELOPATHY; RETINITIS PIGMENTOSA; REVIEW; RNA TRANSLATION; VIRAL GENE DELIVERY SYSTEM; VISION;

ANIMALS; CHANNELOPATHIES; COLOR VISION DEFECTS; CYCLIC NUCLEOTIDE-GATED CATION CHANNELS; DEPENDOVIRUS; GENETIC THERAPY; GENETIC VECTORS; HUMANS; MODELS, ANIMAL; MODELS, MOLECULAR; MUTATION; PHOTORECEPTOR CELLS, VERTEBRATE; PHYLOGENY; RETINITIS PIGMENTOSA;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 84885575214     PISSN: 16174615     EISSN: 16174623     Source Type: Journal    
DOI: 10.1007/s00438-013-0766-4     Document Type: Review

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