Morphological characterization of the retina of the CNGA3-/- Rho-/- mutant mouse lacking functional cones and rods

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 6, 2004, Pages 2039-2048

  Claes, Ellen ^a   Seeliger, Mathias ^b   Michalakis, Stylianos ^c   Biel, Martin ^c   Humphries, Peter ^d   Haverkamp, Silke ^a  

^a MAX PLANCK INSTITUTE FOR BRAIN RESEARCH   (Germany)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITY OF MUNICH   (Germany)

^d TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; CATION CHANNEL; CYCLIC NUCLEOTIDE; GLUTAMATE RECEPTOR; BIOLOGICAL MARKER; CYCLIC AMP; CYCLIC NUCLEOTIDE GATED ION CHANNELS; CYCLIC-NUCLEOTIDE GATED ION CHANNELS; ION CHANNEL; NERVE PROTEIN; RHODOPSIN;

ANIMAL TISSUE; ARTICLE; CELL TYPE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CROSS BREEDING; ELECTRON MICROSCOPY; ELECTRORETINOGRAM; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PHOTORECEPTOR; PRIORITY JOURNAL; RETINA AMACRINE CELL; RETINA BIPOLAR GANGLION CELL; RETINA CONE; RETINA DEGENERATION; RETINA ROD; SYNAPTIC TRANSMISSION; ANIMAL; C57BL MOUSE; ELECTRORETINOGRAPHY; FLUORESCENCE MICROSCOPY; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOUSE MUTANT; NERVE ENDING; PATHOLOGY; PHYSIOLOGY; RETINA; SYNAPSE;

ANIMALS; BIOLOGICAL MARKERS; CYCLIC AMP; ELECTRORETINOGRAPHY; ION CHANNELS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, FLUORESCENCE; NERVE ENDINGS; NERVE TISSUE PROTEINS; PHOTORECEPTORS, VERTEBRATE; RETINA; RETINAL DEGENERATION; RHODOPSIN; SYNAPSES;

EID: 3042536025     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0741     Document Type: Article

References (40)

1. Bowes C, Li T, Danciger M, Baxter LC, Applebury ML, Farber DB. Retinal degeneration in the rd mouse is caused by a defect in the beta subunit of rod cGMP-phosphodiesterase. Nature. 1990;347: 677-680.
2. Carter-Dawson LD, LaVail MM, Sidman RL. Differential effect of the rd mutation on rods and cones in the mouse retina. Invest Ophthalmol Vis Sci. 1978;17:489-498.
3. Strettoi E, Pignatelli V. Modifications of retinal neurons in a mouse model of retinitis pigmentosa. Proc Natl Acad Sci USA. 2000;97: 11020-11025.
4. Strettoi E, Porciatti V, Falsini B, Pignatelli V, Rossi C. Morphological and functional abnormalities in the inner retina of the rd/rd mouse. J Neurosci. 2002;22:5492-5504.
5. Humphries MM, Rancourt D, Farrar GJ, et al. Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet. 1997;15:216-219.
6. Lem J, Krasnoperova NV, Calvert PD, et al. Morphological, physiological, and biochemical changes in rhodopsin knockout mice. Proc Natl Acad Sci USA. 1999;96:736-741.
7. Jaissle GB, May CA, Reinhard J, et al. Evaluation of the rhodopsin knockout mouse as a model of pure cone function. Invest Ophthalmol Vis Sci. 2001;42:506-513.
8. Kaupp UB, Seifert R. Cyclic nucleotide-gated ion channels (review). Physiol Rev. 2002;82:769-824.
9. Biel M, Seeliger M, Pfeifer A, et al. Selective loss of cone function in mice lacking the cyclic nucleotide-gated channel CNG3. Proc Natl Acad Sci USA. 1999;96:7553-7557.
10. Seeliger MW, Grimm C, Ståhlberg F, et al. New views on RPE65 deficiency: the rod system is the source of vision in a mouse model of Leber congenital amaurosis. Nat Genet. 2001;29:70-74.
11. Brandstätter JH, Fletcher EL, Garner CC, Gundelfinger ED, Wässle H. Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina. Eur J Neurosci. 1999;11:3683-3693.
12. Hack I, Frech M, Dick O, Peichl L, Brandstätter JH. Heterogeneous distribution of AMPA glutamate receptor subunits at the photoreceptor synapses of rodent retina. Eur J Neurosci. 2001;13:15-24.
13. Nomura A, Shigemoto R, Nakamura Y, Okamoto N, Mizuno N, Nakanishi S. Developmentally regulated postsynaptic localization of a metabotropic glutamate receptor in rat rod bipolar cells. Cell. 1994;77:361-369.
14. Vardi N, Morigiwa K. ON cone bipolar cells in rat express the metabotropic receptor mGluR6. Vis Neurosci. 1997;14:789-794.
15. Morgans CW. Localization of the alpha(1F) calcium channel subunit in the rat retina. Invest Ophthalmol Vis Sci. 2001;42:2414-2418.
16. Krizaj D, Demarco SJ, Johnson J, Strehler EE, Copenhagen DR. Cell-specific expression of plasma membrane calcium ATPase isoforms in retinal neurons. J Comp Neurol. 2002;451:1-21.
17. Haverkamp S, Wässle H. Immunocytochemical analysis of the mouse retina. J Comp Neurol. 2000;424:1-23.
18. Muresan V, Lyass A, Schnapp BJ. The kinesin motor KIF3A is a component of the presynaptic ribbon in vertebrate photoreceptors. J Neurosci. 1999;19:1027-1037.
19. Rice DS, Curran T. Disabled-1 is expressed in type AII amacrine cells in the mouse retina. J Comp Neurol. 2000;424:327-338.
20. Haeseleer F, Sokal I, Verlinde CL, et al. Five members of a novel Ca(2+)-binding protein (CABP) subfamily with similarity to calmodulin. J Biol Chem. 2000;275:1247-1260.
21. Haverkamp S, Ghosh KK, Hirano AA, Wässle H. Immunocytochemical description of five bipolar cell types of the mouse retina. J Comp Neurol. 2003;455:463-476.
22. Cueva JG, Haverkamp S, Reimer RJ, Edwards R, Wässle H, Brecha NC. Vesicular gamma-aminobutyric acid transporter expression in amacrine and horizontal cells. J Comp Neurol. 2002;445:227-237.
23. Sosula L, Glow PH. Increase in number of synapses in the inner plexiform layer of light deprived rat retinae: quantitative electron microscopy. J Comp Neurol. 1971;141:427-451.
24. Fisher LJ. Development of retinal synaptic arrays in the inner plexiform layer of dark-reared mice. J Embryol Exp Morphol. 1979;54:219-227.
25. Kirsch J, Betz H. Glycine-receptor activation is required for receptor clustering in spinal neurons. Nature. 1998;392:717-720.
26. Craig AM. Activity and synaptic receptor targeting: the long view. Neuron. 1998;21:459-462.
27. Haverkamp S, Müller U, Harvey K, Harvey RJ, Betz H, Wässle H. Diversity of glycine receptors in the mouse retina: localization of the alpha3 subunit. J Comp Neurol. 2003;465:524-539.
28. Jones BW, Watt CB, Frederick JM, et al. Retinal remodeling triggered by photoreceptor degenerations. J Comp Neurol. 2003;464: 1-16.
29. Jansen HG, Sanyal S. Development and degeneration of retina in rds mutant mice: electron microscopy. J Comp Neurol. 1984;224: 71-84.
30. Jansen HG, Sanyal S. Synaptic changes in the terminals of rod photoreceptors of albino mice after partial visual cell loss induced by brief exposure to constant light. Cell Tissue Res. 1987;250:43-52.
31. Dick O, tom Dieck S, Altrock WD, et al. The presynaptic active zone protein bassoon is essential for photoreceptor ribbon synapse formation in the retina. Neuron. 2003;37:775-786.
32. Lewis GP, Linberg KA, Fisher SK. Neurite outgrowth from bipolar and horizontal cells after experimental retinal detachment. Invest Ophthalmol Vis Sci. 1998;39:424-434.
33. Marc RE, Jones BW, Watt CB, Strettoi E. Neural remodeling in retinal degeneration. Prog Retin Eye Res. 2003;22:607-655.
34. Bennett J. Gene therapy for retinitis pigmentosa (review). Curr Opin Mol Ther. 2000;2:420-425.
35. Lund RD, Kwan AS, Keegan DJ, Sauve Y, Coffey PJ, Lawrence JM. Cell transplantation as a treatment for retinal disease. Prog Retin Eye Res. 2001;20:415-449.
36. Gouras P, Tanabe T. Survival and integration of neural retinal transplants in rd mice. Graefes Arch Clin Exp Ophthalmol. 2003; 241:403-409.
37. Peng YW, Hao Y, Petters RM, Wong F. Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. Nat Neurosci. 2000;3:1121-1127.
38. Filoteo AG, Elwess NL, Enyedi A, Caride A, Aung HH, Penniston JT. Plasma membrane Ca2+ pump in rat brain: patterns of alternative splices seen by isoform-specific antibodies. J Biol Chem. 1997;272: 23741-23747.
39. Howell BW, Gertler FB, Cooper JA. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J. 1997;16:121-132.
40. Marksitzer R, Benke D, Fritschy JM, Trzeciak A, Bannwarth W, Möhler H. GABAA-receptors: drug binding profile and distribution of receptors containing the alpha 2-subunit in situ. J Recept Res. 1993;13:467-477.