Caloric Restriction, Longevity, and Adiposity

Adipose Tissue in Health and Disease

Volumn , Issue , 2010, Pages 423-439

  Redman, Leanne M ^a   Ravussin, Eric ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Adiposity; Aging; Caloric restriction; Chronic disease; Longevity; Obesity

Indexed keywords

EID: 84885540151     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527629527.ch22     Document Type: Chapter

References (96)

1. Flegal, K.M. et al. (2002) Prevalence and trends in obesity among US adults, 1999-2000. JAMA, 288, 1723-1727.
2. Allison, D.B. et al. (1999) Annual deaths attributable to obesity in the United States. JAMA, 282, 1530-1538.
3. Fontaine, K.R. et al. (2003) Years of life lost due to obesity. JAMA, 289, 187-193.
4. Olshansky, S.J. et al. (2005) A potential decline in life expectancy in the United States in the 21st century. N. Engl. J. Med., 352, 1138-1145.
5. Calle, E.E., Teras, L.R., and Thun, M.J. (2005) Adiposity and physical activity as predictors of mortality. N. Engl. J. Med., 352, 1381-1384; author reply 1381-1384.
6. Zamboni, M. et al. (2003) Body composition changes in stable-weight elderly subjects: the effect of sex. Aging Clin. Exp. Res., 15, 321-327.
7. Hughes, V.A. et al. (2001) Longitudinal muscle strength changes in older adults: influence of muscle mass, physical activity, and health. J. Gerontol. A. Biol. Sci. Med. Sci., 56, B209-B217.
8. Stanforth, P.R. et al. (2004) Generalized abdominal visceral fat prediction models for black and white adults aged 17-65 y: the HERITAGE Family Study. Int. J. Obes. Relat. Metab. Disord., 28, 925-932.
9. Cree, M.G. et al. (2004) Intramuscular and liver triglycerides are increased in the elderly. J. Clin. Endocrinol. Metab., 89, 3864-3871.
10. Folsom, A.R. et al. (2000) Associations of general and abdominal obesity with multiple health outcomes in older women: the Iowa Women's Health Study. Arch. Intern. Med., 160, 2117-2128.
11. Reaven, G.M. (1988) Banting Lecture 1988. Role of insulin resistance in human disease. Diabetes, 37, 1595-1607.
12. McCay, C.M., Crowell, M.F., and Maynard, L.A. (1935) The effect of retarded growth upon the length of life span and upon the ultimate body size. Nutrition, 1989, 5, 155-171; discussion 172.
13. Walford, R.L., Harris, S.B., and Weindruch, R. (1987) Dietary restriction and aging: historical phases, mechanisms and current directions. J. Nutr., 117, 1650-1654.
14. Heilbronn, L.K. and Ravussin, E. (2003) Calorie restriction and aging: review of the literature and implications for studies in humans. Am. J. Clin. Nutr., 78, 361-369.
15. Furuyama, T. et al. (2002) Effects of aging and caloric restriction on the gene expression of Foxo1, 3, and 4 (FKHR, FKHRL1, and AFX) in the rat skeletal muscles. Microsc. Res. Tech., 59, 331-334.
16. Motta, M.C. et al. (2004) Mammalian SIRT1 represses forkhead transcription factors. Cell, 116, 551-563.
17. Kapahi, P. et al. (2004) Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr. Biol., 14, 885-890.
18. Yamaza, H. et al. (2004) Atransgenic dwarf rat model as a tool for the study of calorie restriction and aging. Exp. Gerontol., 39, 269-272.
19. Shimokawa, I. et al. (2003) Life span extension by reduction of the growth hormone-insulin-like growth factor-1 axis: relation to caloric restriction. FASEB J., 17, 1108-1109.
20. Pugh, T.D., Klopp, R.G., and Weindruch, R. (1999) Controlling caloric consumption: protocols for rodents and rhesus monkeys. Neurobiol. Aging, 20, 157-165.
21. Lane, M.A. et al. (1996) Calorie restriction lowers body temperature in rhesus monkeys, consistent with a postulated anti-aging mechanism in rodents. Proc. Natl. Acad. Sci. USA, 93, 4159-4164.
22. Roth, G.S. et al. (2002) Biomarkers of caloric restriction may predict longevity in humans. Science, 297, 811.
23. Blanc, S. et al. (2003) Energy expenditure of rhesus monkeys subjected to 11 years of dietary restriction. J. Clin. Endocrinol. Metab., 88, 16-23.
24. Sacher, G.A. and Duffy, P.H. (1979) Genetic relation of life span to metabolic rate for inbred mouse strains and their hybrids. Fed. Proc., 38, 184-188.
25. FAO/WHO/UNU (1985) Energy and protein requirements. Report of a joint FAO/WHO/UNU Expert Consultation. WHO Tech. Rep. Ser., 724, 1-206.
26. Weyer, C. et al. (2000) Energy expenditure, fat oxidation, and body weight regulation: a study of metabolic adaptation to longterm weight change. J. Clin. Endocrinol. Metab., 85, 1087-1094.
27. McCarter, R.J. and Palmer, J. (1992) Energy metabolism and aging: a lifelong study of Fischer 344 rats. Am. J. Physiol. Endocrinol. Metab., 263, E448-E452.
28. Ballor, D.L. (1991) Effect of dietary restriction and/or exercise on 23-h metabolic rate and body composition in female rats. J. Appl. Physiol., 71, 801-806.
29. Gonzales-Pacheco, D.M. et al. (1993) Energy restriction reduces metabolic rate in adult male Fisher-344 rats. J. Nutr., 123, 90-97.
30. Lane, M.A. et al. (1995) Energy balance in rhesus monkeys (Macaca mulatta) subjected to long-term dietary restriction. J. Gerontol. A Biol. Sci. Med. Sci., 50, B295-B302.
31. DeLany, J.P. et al. (1999) Long-term calorie restriction reduces energy expenditure in aging monkeys. J. Gerontol. A Biol. Sci. Med. Sci., 54, B5-B11; discussion B12-B13.
32. Ravussin, E. and Bogardus, C. (1989) Relationship of genetics, age, and physical fitness to daily energy expenditure and fuel utilization. Am. J. Clin. Nutr., 49 (5 Suppl.), 968-975.
33. Selman, C. et al. (2005) Energy expenditure of calorically restricted rats is higher than predicted from their altered body composition. Mech. Ageing. Dev., 126, 783-793.
34. Sohal, R.S. and Allen, R.G. (1985) Relationship between metabolic rate, free radicals, differentiation and aging: a unified theory. Basic Life Sci., 35, 75-104.
35. Alexeyev, M.F., LeDoux, S.P., and Wilson, G.L. (2004) Mitochondrial DNA and aging. Clin. Sci., 107, 355-364.
36. Barger, J.L., Walford, R.L., and Weindruch, R. (2003) The retardation of aging by caloric restriction: its significance in the transgenic era. Exp. Gerontol., 38, 1343-1351.
37. Jung, K.J. et al. (2004) Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process. Exp. Gerontol., 39, 1169-1177.
38. Weindruch, R. et al. (1986) The retardation of aging in mice by dietary restriction: longevity, cancer, immunity and lifetime energy intake. J. Nutr., 116, 641-654.
39. Sohal, R.S. and Weindruch, R. (1996) Oxidative stress, caloric restriction, and aging. Science, 273, 59-63.
40. Lee, D.W. and Yu, B.P. (1990) Modulation of free radicals and superoxide dismutases by age and dietary restriction. Aging, 2, 357-362.
41. Dandona, P. et al. (2001) The suppressive effect of dietary restriction and weight loss in the obese on the generation of reactive oxygen species by leukocytes, lipid peroxidation, and protein carbonylation. J. Clin. Endocrinol. Metab., 86, 355-362.
42. Navarro, A. and Boveris, A. (2004) Rat brain and liver mitochondria develop oxidative stress and loose enzymatic activities upon aging. Am. J. Physiol. Regul. Integr. Comp. Physiol., 287, R1244-R1249.
43. Bevilacqua, L. et al. (2004) Effects of shortand medium-term calorie restriction on muscle mitochondrial proton leak and reactive oxygen species production. Am. J. Physiol. Endocrinol. Metab., 286, E852-E861.
44. Fulle, S. et al. (2004) The contribution of reactive oxygen species to sarcopenia and muscle ageing. Exp. Gerontol., 39, 17-24.
45. Banerjee, A.K. et al. (2003) Oxidant, antioxidant and physical exercise. Mol. Cell. Biochem., 253 (1-2), 307-312.
46. Powers, S.K. et al. (2004) Dietary antioxidants and exercise. J. Sports Sci., 22, 81-94.
47. Ravi, K.T., Subramanyam, M., and Asha, D.S. (2004) Swim exercise training and adaptations in the antioxidant defense system of myocardium of old rats: relationship to swim intensity and duration. Comp. Biochem. Physiol. B. Biochem. Mol. Biol., 137, 187-196.
48. Goto, S. et al. (2004) Regular exercise: an effective means to reduce oxidative stress in old rats. Ann. NY Acad. Sci., 1019, 471-474.
49. Ji, L.L. (2002) Exercise-induced modulation of antioxidant defense. Ann. NY Acad. Sci., 959, 82-92.
50. Higashi, Y. and Yoshizumi, M. (2004) Exercise and endothelial function: role of endothelium-derived nitric oxide and oxidative stress in healthy subjects and hypertensive patients. Pharmacol. Ther., 102, 87-96.
51. Goto, C. et al. (2003) Effect of different intensities of exercise on endotheliumdependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation, 108, 530-535.
52. Knowler, W.C. et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N. Engl. J. Med., 346, 393-403.
53. Velthuis-te Wierik, E.J. et al. (1994) Energy restriction, a useful intervention to retard human ageing? Results of a feasibility study. Eur. J. Clin. Nutr., 48, 138-148.
54. Walford, R.L. et al. (2002) Calorie restriction in biosphere 2: alterations in physiologic, hematologic, hormonal, and biochemical parameters in humans restricted for a 2-year period. J. Gerontol. A Biol. Sci. Med. Sci., 57, B211-B224.
55. Verdery, R.B. and Walford, R.L. (1998) Changes in plasma lipids and lipoproteins in humans during a 2-year period of dietary restriction in Biosphere 2. Arch. Intern. Med., 158, 900-906.
56. Heilbronn, L.K., Noakes, M., and Clifton, P.M. (2001) Energy restriction and weight loss on very-low-fat diets reduce C-reactive protein concentrations in obese, healthy women. Arterioscler. Thromb. Vasc. Biol., 21, 968-970.
57. Bastard, J.P. et al. (2000) Elevated levels of interleukin 6 are reduced in serum and subcutaneous adipose tissue of obese women after weight loss. J. Clin. Endocrinol. Metab., 85, 3338-3342.
58. Mavri, A. et al. (2001) Subcutaneous abdominal, but not femoral fat expression of plasminogen activator inhibitor-1 (PAI-1) is related to plasma PAI-1 levels and insulin resistance and decreases after weight loss. Diabetologia, 44, 2025-2031.
59. Velthuis-te Wierik, E.J. et al. (1995) Beneficial effect of a moderately energyrestricted diet on fibrinolytic factors in non-obese men. Metabolism, 44, 1548-1552.
60. Fontana, L. et al. (2004) Long-term calorie restriction is highly effective in reducing the risk for atherosclerosis in humans. Proc. Natl. Acad. Sci. USA, 101, 6659-6663.
61. Bodkin, N.L., Ortmeyer, H.K., and Hansen, B.C. (1995) Long-term dietary restriction in older-aged rhesus monkeys: effects on insulin resistance. J. Gerontol. A Biol. Sci. Med. Sci., 50, B142-B147.
62. Cefalu, W.T. et al. (1999) Influence of caloric restriction on the development of atherosclerosis in nonhuman primates: progress to date. Toxicol. Sci., 52 (2 Suppl.), 49-55.
63. Gazdag, A.C. et al. (2000) Effect of long-term caloric restriction on GLUT4, phosphatidylinositol-3 kinase p85 subunit, and insulin receptor substrate-1 protein levels in rhesus monkey skeletal muscle. J. Gerontol. A Biol. Sci. Med. Sci., 55, B44-B46; discussion B47-B48.
64. Lane, M.A. et al. (2001) Caloric restriction in primates. Ann. NY Acad. Sci., 928, 287-295.
65. Walford, R.L. et al. (1999) Physiologic changes in humans subjected to severe, selective calorie restriction for two years in biosphere 2: health, aging, and toxicological perspectives. Toxicol. Sci., 52 (2 Suppl.), 61-65.
66. Robertson, R.P. (2004) Chronic oxidative stress as a central mechanism for glucose toxicity in pancreatic islet beta cells in diabetes. J. Biol. Chem., 279, 42351-42354.
67. Stenkula, K.G. et al. (2004) Expression of a mutant IRS inhibits metabolic and mitogenic signalling of insulin in human adipocytes. Mol. Cell. Endocrinol., 221, 1-8.
68. Kagawa, Y. (1978) Impact of Westernization on the nutrition of Japanese: changes in physique, cancer, longevity and centenarians. Prev. Med., 7, 205-217.
69. Japan Ministry ofHealth, Law and Welfare (2005) Journal of Health and Welfare Statistics, Health and Welfare Statistics Association, Tokyo.
70. Willcox, D.C. et al. (2006) Caloric restriction and human longevity: what can we learn from the Okinawans? Biogerontology, 7, 173-177.
71. Suzuki, M., Wilcox, B.J., and Wilcox, C.D. (2001) Implications from and for food cultures for cardiovascular disease: longevity. Asia Pac. J. Clin. Nutr., 10, 165-171.
72. Vallejo, E.A. (1957) Hunger diet on alternate days in the nutrition of the aged. Prensa Med. Argent., 44, 119-120.
73. Stunkard, A.J. (1976) Nutrition, longevity and obesity, in Nutrition, Aging and Obesity (eds Rockstein, M., and Sussman, M.L.), Academic Press, New York, pp. 253-284.
74. Walford, R.L., Harris, S.B., and Gunion, M.W. (1992) The calorically restricted low-fat nutrient-dense diet in Biosphere 2 significantly lowers blood glucose, total leukocyte count, cholesterol, and blood pressure in humans. Proc. Natl. Acad. Sci. USA, 89, 11533-11537.
75. Weyer, C. et al. (2000) Energy metabolism after 2 y of energy restriction: the biosphere 2 experiment. Am. J. Clin. Nutr., 72, 946-953.
76. Heilbronn, L.K. et al. (2006) Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial. JAMA, 295, 1539-1548.
77. Larson-Meyer, D.E. et al. (2006) Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care, 29, 1337-1344.
78. Redman, L.M. et al. (2007) Effect of calorie restriction with or without exercise on body composition and fat distribution. J. Clin. Endocrinol. Metab., 92, 865-872.
79. Civitarese, A.E. et al. (2007) Calorie restriction increases muscle mitochondrial biogenesis in healthy humans. PLoS Med., 4, e76.
80. Racette, S.B. et al. (2006) One year of caloric restriction in humans: feasibility and effects on body composition and abdominal adipose tissue. J. Gerontol. A Biol. Sci. Med. Sci., 61, 943-950.
81. Williamson, D.A. et al. (2007) Measurement of dietary restraint: Validity tests of four questionnaires. Appetite, 48, 183-192.
82. Williamson, D.A. et al. (2008) Is caloric restriction associated with development of eating disorder syndrome? An ancillary study of the CALERIE trial. Health Psychol., 27 (1 Suppl): S32-42.
83. Weiss, E.P. et al. (2007) Lower extremity muscle size and strength and aerobic capacity decrease with caloric restriction but not with exercise-induced weight loss. J. Appl. Physiol., 102, 634-640.
84. Weiss, E.P. et al. (2006) Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial. Am. J. Clin. Nutr., 84, 1033-1042.
85. Fontana, L. et al. (2007) Calorie restriction or exercise: effects on coronary heart disease risk factors. A Randomized Controlled Trial. Am. J. Physiol. Endocrinol. Metab., 293, E197-E202.
86. Das, S.K. et al. (2007) Long-term effects of 2 energy-restricted diets differing in glycemic load on dietary adherence, body composition, and metabolism in CALERIE: a 1-y randomized controlled trial. Am. J. Clin. Nutr., 85, 1023-1030.
87. Martin, C.K. et al. (2007) Examination of cognitive function during six-months calorie restriction: results of a randomized controlled trial. Rejuvenation Res., 10, 179-190.
88. Lefevre, M. et al. (2009) Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals. Atherosclerosis, 203 (1), 206-213.
89. Wilson, P.W. et al. (1998) Prediction of coronary heart disease using risk factor categories. Circulation, 97, 1837-1847.
90. Merry, B.J. (2000) Calorie restriction and age-related oxidative stress. Ann. NYAcad. Sci., 908, 180-198.
91. Ingram, D.K. et al. (2006) Calorie restriction mimetics: an emerging research field. Aging Cell., 5, 97-108.
92. Roth, G.S. (2005) Caloric restriction and caloric restriction mimetics: current status and promise for the future. J. Am. Geriatr. Soc., 53 (9 Suppl.), S280-S283.
93. Wood, J.G. et al. (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature, 430 (7000), 686-689.
94. Valenzano, D.R. et al. (2006) Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Curr. Biol., 16, 296-300.
95. Baur, J.A. et al. (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature, 444, 337-342.
96. Lagouge, M. et al. (2006) Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PCG-1a. Cell, 127, 1-14.