-
1
-
-
0026659195
-
Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen
-
Perey L., Hayes D.F., Maimonis P., Abe M., O'Hara C., Kufe D.W. Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen. Cancer Res. 1992, 52:2563-2568.
-
(1992)
Cancer Res.
, vol.52
, pp. 2563-2568
-
-
Perey, L.1
Hayes, D.F.2
Maimonis, P.3
Abe, M.4
O'Hara, C.5
Kufe, D.W.6
-
2
-
-
30044448792
-
Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin
-
Macao B., Johansson D.G., Hansson G.C., Hard T. Autoproteolysis coupled to protein folding in the SEA domain of the membrane-bound MUC1 mucin. Nat. Struct. Mol. Biol. 2006, 13:71-76.
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 71-76
-
-
Macao, B.1
Johansson, D.G.2
Hansson, G.C.3
Hard, T.4
-
3
-
-
84874743726
-
MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches
-
Kufe D.W. MUC1-C oncoprotein as a target in breast cancer: activation of signaling pathways and therapeutic approaches. Oncogene 2013, 32:1073-1081.
-
(2013)
Oncogene
, vol.32
, pp. 1073-1081
-
-
Kufe, D.W.1
-
4
-
-
0023741252
-
A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats
-
Gendler S., Taylor-Papadimitriou J., Duhig T., Rothbard J., Burchell J. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem. 1988, 263:12820-12823.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 12820-12823
-
-
Gendler, S.1
Taylor-Papadimitriou, J.2
Duhig, T.3
Rothbard, J.4
Burchell, J.5
-
5
-
-
68149182606
-
Functional targeting of the MUC1 oncogene in human cancers
-
Kufe D.W. Functional targeting of the MUC1 oncogene in human cancers. Cancer Biol. Ther. 2009, 8:1197-1203.
-
(2009)
Cancer Biol. Ther.
, vol.8
, pp. 1197-1203
-
-
Kufe, D.W.1
-
6
-
-
34548214630
-
MUC1: a target molecule for cancer therapy
-
Singh R., Bandyopadhyay D. MUC1: a target molecule for cancer therapy. Cancer Biol. Ther. 2007, 6:481-486.
-
(2007)
Cancer Biol. Ther.
, vol.6
, pp. 481-486
-
-
Singh, R.1
Bandyopadhyay, D.2
-
7
-
-
2442693937
-
The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts
-
Raina D., Kharbanda S., Kufe D. The MUC1 oncoprotein activates the anti-apoptotic phosphoinositide 3-kinase/Akt and Bcl-xL pathways in rat 3Y1 fibroblasts. J. Biol. Chem. 2004, 279:20607-20612.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 20607-20612
-
-
Raina, D.1
Kharbanda, S.2
Kufe, D.3
-
8
-
-
10744220453
-
Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents
-
Ren J., Agata N., Chen D., Li Y., Yu W.H., Huang L., Raina D., Chen W., Kharbanda S., Kufe D. Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. Cancer Cell 2004, 5:163-175.
-
(2004)
Cancer Cell
, vol.5
, pp. 163-175
-
-
Ren, J.1
Agata, N.2
Chen, D.3
Li, Y.4
Yu, W.H.5
Huang, L.6
Raina, D.7
Chen, W.8
Kharbanda, S.9
Kufe, D.10
-
9
-
-
33748055445
-
MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage
-
Raina D., Ahmad R., Kumar S., Ren J., Yoshida K., Kharbanda S., Kufe D. MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage. EMBO J. 2006, 25:3774-3783.
-
(2006)
EMBO J.
, vol.25
, pp. 3774-3783
-
-
Raina, D.1
Ahmad, R.2
Kumar, S.3
Ren, J.4
Yoshida, K.5
Kharbanda, S.6
Kufe, D.7
-
10
-
-
0041850346
-
Human DF3/MUC1 carcinoma-associated protein functions as an oncogene
-
Li Y., Liu D., Chen D., Kharbanda S., Kufe D. Human DF3/MUC1 carcinoma-associated protein functions as an oncogene. Oncogene 2003, 22:6107-6110.
-
(2003)
Oncogene
, vol.22
, pp. 6107-6110
-
-
Li, Y.1
Liu, D.2
Chen, D.3
Kharbanda, S.4
Kufe, D.5
-
11
-
-
0036223297
-
Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor
-
Dunn C., Wiltshire C., MacLaren A., Gillespie D.A. Molecular mechanism and biological functions of c-Jun N-terminal kinase signalling via the c-Jun transcription factor. Cell Signal. 2002, 14:585-593.
-
(2002)
Cell Signal.
, vol.14
, pp. 585-593
-
-
Dunn, C.1
Wiltshire, C.2
MacLaren, A.3
Gillespie, D.A.4
-
12
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
13
-
-
0029885419
-
Selective interaction of JNK protein kinase isoforms with transcription factors
-
Gupta S., Barrett T., Whitmarsh A.J., Cavanagh J., Sluss H.K., Derijard B., Davis R.J. Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J. 1996, 15:2760-2770.
-
(1996)
EMBO J.
, vol.15
, pp. 2760-2770
-
-
Gupta, S.1
Barrett, T.2
Whitmarsh, A.J.3
Cavanagh, J.4
Sluss, H.K.5
Derijard, B.6
Davis, R.J.7
-
14
-
-
77952682040
-
DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death
-
Ho C.Y., Li H.Y. DNA damage during mitosis invokes a JNK-mediated stress response that leads to cell death. J. Cell. Biochem. 2010, 110:725-731.
-
(2010)
J. Cell. Biochem.
, vol.110
, pp. 725-731
-
-
Ho, C.Y.1
Li, H.Y.2
-
15
-
-
84864417986
-
Activation level of JNK and Akt/ERK signaling pathways determinates extent of DNA damage in the liver of diabetic rats
-
Martinovic V., Grigorov I., Bogojevic D., Petrovic A., Jovanovic S., Ilic M., Ivanovic Matic S. Activation level of JNK and Akt/ERK signaling pathways determinates extent of DNA damage in the liver of diabetic rats. Cell. Physiol. Biochem. 2012, 30:723-734.
-
(2012)
Cell. Physiol. Biochem.
, vol.30
, pp. 723-734
-
-
Martinovic, V.1
Grigorov, I.2
Bogojevic, D.3
Petrovic, A.4
Jovanovic, S.5
Ilic, M.6
Ivanovic Matic, S.7
-
16
-
-
77952765908
-
Differential response of heat-shock-induced p38 MAPK and JNK activity in PC12 mutant and PC12 parental cells for differentiation and apoptosis
-
Murai H., Hiragami F., Kawamura K., Motoda H., Koike Y., Inoue S., Kumagishi K., Ohtsuka A., Kano Y. Differential response of heat-shock-induced p38 MAPK and JNK activity in PC12 mutant and PC12 parental cells for differentiation and apoptosis. Acta Med. Okayama 2010, 64:55-62.
-
(2010)
Acta Med. Okayama
, vol.64
, pp. 55-62
-
-
Murai, H.1
Hiragami, F.2
Kawamura, K.3
Motoda, H.4
Koike, Y.5
Inoue, S.6
Kumagishi, K.7
Ohtsuka, A.8
Kano, Y.9
-
17
-
-
84857253295
-
Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFalpha-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein
-
Scudiero I., Zotti T., Ferravante A., Vessichelli M., Reale C., Masone M.C., Leonardi A., Vito P., Stilo R. Tumor necrosis factor (TNF) receptor-associated factor 7 is required for TNFalpha-induced Jun NH2-terminal kinase activation and promotes cell death by regulating polyubiquitination and lysosomal degradation of c-FLIP protein. J. Biol. Chem. 2012, 287:6053-6061.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 6053-6061
-
-
Scudiero, I.1
Zotti, T.2
Ferravante, A.3
Vessichelli, M.4
Reale, C.5
Masone, M.C.6
Leonardi, A.7
Vito, P.8
Stilo, R.9
-
18
-
-
45549094532
-
Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway
-
Hoffmann E., Ashouri J., Wolter S., Doerrie A., Dittrich-Breiholz O., Schneider H., Wagner E.F., Troppmair J., Mackman N., Kracht M. Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway. J. Biol. Chem. 2008, 283:12120-12128.
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 12120-12128
-
-
Hoffmann, E.1
Ashouri, J.2
Wolter, S.3
Doerrie, A.4
Dittrich-Breiholz, O.5
Schneider, H.6
Wagner, E.F.7
Troppmair, J.8
Mackman, N.9
Kracht, M.10
-
19
-
-
17344362761
-
Signaling by dual specificity kinases
-
Dhanasekaran N., Premkumar Reddy E. Signaling by dual specificity kinases. Oncogene 1998, 17:1447-1455.
-
(1998)
Oncogene
, vol.17
, pp. 1447-1455
-
-
Dhanasekaran, N.1
Premkumar Reddy, E.2
-
20
-
-
4444341881
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
-
Sabapathy K., Hochedlinger K., Nam S.Y., Bauer A., Karin M., Wagner E.F. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell 2004, 15:713-725.
-
(2004)
Mol. Cell
, vol.15
, pp. 713-725
-
-
Sabapathy, K.1
Hochedlinger, K.2
Nam, S.Y.3
Bauer, A.4
Karin, M.5
Wagner, E.F.6
-
21
-
-
84870474925
-
The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death
-
Suzuki H., Matsuoka M. The JNK/c-Jun signaling axis contributes to the TDP-43-induced cell death. Mol. Cell. Biochem. 2013, 372:241-248.
-
(2013)
Mol. Cell. Biochem.
, vol.372
, pp. 241-248
-
-
Suzuki, H.1
Matsuoka, M.2
-
22
-
-
0032980723
-
The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells
-
Bost F., McKay R., Bost M., Potapova O., Dean N.M., Mercola D. The Jun kinase 2 isoform is preferentially required for epidermal growth factor-induced transformation of human A549 lung carcinoma cells. Mol. Cell. Biol. 1999, 19:1938-1949.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1938-1949
-
-
Bost, F.1
McKay, R.2
Bost, M.3
Potapova, O.4
Dean, N.M.5
Mercola, D.6
-
23
-
-
12844271380
-
Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes
-
Lee Y.J., Shukla S.D. Pro- and anti-apoptotic roles of c-Jun N-terminal kinase (JNK) in ethanol and acetaldehyde exposed rat hepatocytes. Eur. J. Pharmacol. 2005, 508:31-45.
-
(2005)
Eur. J. Pharmacol.
, vol.508
, pp. 31-45
-
-
Lee, Y.J.1
Shukla, S.D.2
-
24
-
-
84861422747
-
Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells
-
Ma J., Zhang L., Han W., Shen T., Ma C., Liu Y., Nie X., Liu M., Ran Y., Zhu D. Activation of JNK/c-Jun is required for the proliferation, survival, and angiogenesis induced by EET in pulmonary artery endothelial cells. J. Lipid Res. 2012, 53:1093-1105.
-
(2012)
J. Lipid Res.
, vol.53
, pp. 1093-1105
-
-
Ma, J.1
Zhang, L.2
Han, W.3
Shen, T.4
Ma, C.5
Liu, Y.6
Nie, X.7
Liu, M.8
Ran, Y.9
Zhu, D.10
-
25
-
-
0037124099
-
Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling
-
Ren J., Li Y., Kufe D. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J. Biol. Chem. 2002, 277:17616-17622.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 17616-17622
-
-
Ren, J.1
Li, Y.2
Kufe, D.3
-
26
-
-
11144241617
-
The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth
-
Sdek P., Ying H., Zheng H., Margulis A., Tang X., Tian K., Xiao Z.X. The central acidic domain of MDM2 is critical in inhibition of retinoblastoma-mediated suppression of E2F and cell growth. J. Biol. Chem. 2004, 279:53317-53322.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53317-53322
-
-
Sdek, P.1
Ying, H.2
Zheng, H.3
Margulis, A.4
Tang, X.5
Tian, K.6
Xiao, Z.X.7
-
27
-
-
0035794215
-
The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin
-
Li Y., Kuwahara H., Ren J., Wen G., Kufe D. The c-Src tyrosine kinase regulates signaling of the human DF3/MUC1 carcinoma-associated antigen with GSK3 beta and beta-catenin. J. Biol. Chem. 2001, 276:6061-6064.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6061-6064
-
-
Li, Y.1
Kuwahara, H.2
Ren, J.3
Wen, G.4
Kufe, D.5
-
28
-
-
28544448610
-
MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin
-
Huang L., Chen D., Liu D., Yin L., Kharbanda S., Kufe D. MUC1 oncoprotein blocks glycogen synthase kinase 3beta-mediated phosphorylation and degradation of beta-catenin. Cancer Res. 2005, 65:10413-10422.
-
(2005)
Cancer Res.
, vol.65
, pp. 10413-10422
-
-
Huang, L.1
Chen, D.2
Liu, D.3
Yin, L.4
Kharbanda, S.5
Kufe, D.6
-
29
-
-
0031723707
-
Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin
-
Li Y., Bharti A., Chen D., Gong J., Kufe D. Interaction of glycogen synthase kinase 3beta with the DF3/MUC1 carcinoma-associated antigen and beta-catenin. Mol. Cell. Biol. 1998, 18:7216-7224.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 7216-7224
-
-
Li, Y.1
Bharti, A.2
Chen, D.3
Gong, J.4
Kufe, D.5
-
30
-
-
2242473920
-
Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage
-
Yoshida K., Miki Y., Kufe D. Activation of SAPK/JNK signaling by protein kinase Cdelta in response to DNA damage. J. Biol. Chem. 2002, 277:48372-48378.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48372-48378
-
-
Yoshida, K.1
Miki, Y.2
Kufe, D.3
-
31
-
-
0025788098
-
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
-
Smeal T., Binetruy B., Mercola D.A., Birrer M., Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 1991, 354:494-496.
-
(1991)
Nature
, vol.354
, pp. 494-496
-
-
Smeal, T.1
Binetruy, B.2
Mercola, D.A.3
Birrer, M.4
Karin, M.5
-
32
-
-
0041524094
-
A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun
-
Morton S., Davis R.J., McLaren A., Cohen P. A reinvestigation of the multisite phosphorylation of the transcription factor c-Jun. EMBO J. 2003, 22:3876-3886.
-
(2003)
EMBO J.
, vol.22
, pp. 3876-3886
-
-
Morton, S.1
Davis, R.J.2
McLaren, A.3
Cohen, P.4
-
33
-
-
0032054723
-
Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development
-
Ip Y.T., Davis R.J. Signal transduction by the c-Jun N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol. 1998, 10:205-219.
-
(1998)
Curr. Opin. Cell Biol.
, vol.10
, pp. 205-219
-
-
Ip, Y.T.1
Davis, R.J.2
-
34
-
-
23044453047
-
Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest
-
Kuntzen C., Sonuc N., De Toni E.N., Opelz C., Mucha S.R., Gerbes A.L., Eichhorst S.T. Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest. Cancer Res. 2005, 65:6780-6788.
-
(2005)
Cancer Res.
, vol.65
, pp. 6780-6788
-
-
Kuntzen, C.1
Sonuc, N.2
De Toni, E.N.3
Opelz, C.4
Mucha, S.R.5
Gerbes, A.L.6
Eichhorst, S.T.7
-
35
-
-
0035525733
-
Cellular stress response and apoptosis in cancer therapy
-
Herr I., Debatin K.M. Cellular stress response and apoptosis in cancer therapy. Blood 2001, 98:2603-2614.
-
(2001)
Blood
, vol.98
, pp. 2603-2614
-
-
Herr, I.1
Debatin, K.M.2
-
36
-
-
0034068601
-
Mitochondrial control of cell death
-
Kroemer G., Reed J.C. Mitochondrial control of cell death. Nat Med. 2000, 6:513-519.
-
(2000)
Nat Med.
, vol.6
, pp. 513-519
-
-
Kroemer, G.1
Reed, J.C.2
-
37
-
-
0037230304
-
Activation of the JNK signaling pathway: breaking the brake on apoptosis
-
Lin A. Activation of the JNK signaling pathway: breaking the brake on apoptosis. Bioessays 2003, 25:17-24.
-
(2003)
Bioessays
, vol.25
, pp. 17-24
-
-
Lin, A.1
-
38
-
-
16844387124
-
Role of JNK activation in apoptosis: a double-edged sword
-
Liu J., Lin A. Role of JNK activation in apoptosis: a double-edged sword. Cell Res. 2005, 15:36-42.
-
(2005)
Cell Res.
, vol.15
, pp. 36-42
-
-
Liu, J.1
Lin, A.2
-
39
-
-
84862304215
-
The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function
-
Ahmad R., Alam M., Rajabi H., Kufe D. The MUC1-C oncoprotein binds to the BH3 domain of the pro-apoptotic BAX protein and blocks BAX function. J. Biol. Chem. 2012, 287:20866-20875.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 20866-20875
-
-
Ahmad, R.1
Alam, M.2
Rajabi, H.3
Kufe, D.4
|