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Volumn 4, Issue SEP, 2013, Pages

Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD

Author keywords

Epigenetics; FK506 binding protein 5; Glucocorticoid receptor; Methylation; Promoter; Psychotherapy; PTSD; Veterans

Indexed keywords

BIOLOGICAL MARKER; CORTICOTROPIN; CYTOSINE; DEXAMETHASONE; DNA; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; LYSOZYME; NEUROPEPTIDE Y;

EID: 84885344455     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2013.00118     Document Type: Article
Times cited : (272)

References (58)
  • 1
    • 77956678376 scopus 로고    scopus 로고
    • Epigenetics and parental effects
    • doi: 10.1002/bies.201000015
    • Kappeler L, Meaney MJ. Epigenetics and parental effects. Bioessays (2010) 32:818-27. doi: 10.1002/bies.201000015.
    • (2010) Bioessays , vol.32 , pp. 818-827
    • Kappeler, L.1    Meaney, M.J.2
  • 2
    • 77449083293 scopus 로고    scopus 로고
    • Epigenetics and the environmental regulation of the genome and its function
    • doi:10.1146/annurev.psych.60.110707.163625
    • Zhang TY, Meaney MJ. Epigenetics and the environmental regulation of the genome and its function. Annu Rev Psychol (2010) 61(439-466):C431-3. doi:10.1146/annurev.psych.60.110707.163625.
    • (2010) Annu Rev Psychol , vol.61 , Issue.439-466
    • Zhang, T.Y.1    Meaney, M.J.2
  • 3
    • 84876140223 scopus 로고    scopus 로고
    • Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders?
    • doi:10.2217/epi.13.11
    • Klengel T, Binder EB. Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders? Epigenomics (2013) 5:109-12. doi:10.2217/epi.13.11.
    • (2013) Epigenomics , vol.5 , pp. 109-112
    • Klengel, T.1    Binder, E.B.2
  • 4
    • 84871832771 scopus 로고    scopus 로고
    • How do environments talk to genes?
    • doi:10.1038/nn.3286
    • Szyf M. How do environments talk to genes? Nat Neurosci (2013) 16:2-4. doi:10.1038/nn.3286.
    • (2013) Nat Neurosci , vol.16 , pp. 2-4
    • Szyf, M.1
  • 6
    • 84872236734 scopus 로고    scopus 로고
    • Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus
    • doi:10.1073/pnas.1121260109
    • Suderman M, McGowan PO, Sasaki A, Huang TC, Hallett MT, Meaney MJ, et al. Conserved epigenetic sensitivity to early life experience in the rat and human hippocampus. Proc Natl Acad Sci U S A (2012) 109(Suppl 2):17266-72. doi:10.1073/pnas.1121260109.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.SUPPL. 2 , pp. 17266-72
    • Suderman, M.1    McGowan, P.O.2    Sasaki, A.3    Huang, T.C.4    Hallett, M.T.5    Meaney, M.J.6
  • 7
    • 15144344289 scopus 로고    scopus 로고
    • Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress
    • doi:10.1126/science.277.5332.1659
    • Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, et al. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic-pituitary-adrenal responses to stress. Science (1997) 277:1659-62. doi:10.1126/science.277.5332.1659.
    • (1997) Science , vol.277 , pp. 1659-1662
    • Liu, D.1    Diorio, J.2    Tannenbaum, B.3    Caldji, C.4    Francis, D.5    Freedman, A.6
  • 8
    • 0034596146 scopus 로고    scopus 로고
    • Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood
    • doi:10.1001/jama.284.5.592
    • Heim C, Newport DJ, Heit S, Graham YP, Wilcox M, Bonsall R, et al. Pituitary-adrenal and autonomic responses to stress in women after sexual and physical abuse in childhood. JAMA (2000) 284:592-7. doi:10.1001/jama.284.5.592.
    • (2000) JAMA , vol.284 , pp. 592-597
    • Heim, C.1    Newport, D.J.2    Heit, S.3    Graham, Y.P.4    Wilcox, M.5    Bonsall, R.6
  • 9
    • 60749105468 scopus 로고    scopus 로고
    • Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse
    • doi:10.1038/nn.2270
    • McGowan PO, Sasaki A, D'Alessio AC, Dymov S, Labonte B, Szyf M, et al. Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse. Nat Neurosci (2009) 12:342-8. doi:10.1038/nn.2270.
    • (2009) Nat Neurosci , vol.12 , pp. 342-348
    • McGowan, P.O.1    Sasaki, A.2    D'Alessio, A.C.3    Dymov, S.4    Labonte, B.5    Szyf, M.6
  • 10
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • doi:10.1210/er.18.3.306
    • Pratt WB, Toft DO. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev (1997) 18:306-60. doi:10.1210/er.18.3.306.
    • (1997) Endocr Rev , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 11
    • 80051667737 scopus 로고    scopus 로고
    • FKBP51-a selective modulator of glucocorticoid and androgen sensitivity
    • doi:10.1016/j.coph.2011.04.012
    • Stechschulte LA, Sanchez ER. FKBP51-a selective modulator of glucocorticoid and androgen sensitivity. Curr Opin Pharmacol (2011) 11:332-7. doi:10.1016/j.coph.2011.04.012.
    • (2011) Curr Opin Pharmacol , vol.11 , pp. 332-337
    • Stechschulte, L.A.1    Sanchez, E.R.2
  • 12
    • 70350731477 scopus 로고    scopus 로고
    • The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders
    • doi:10.1016/j.psyneuen.2009.05.021
    • Binder EB. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology (2009) 34(Suppl 1):S186-95. doi:10.1016/j.psyneuen.2009.05.021.
    • (2009) Psychoneuroendocrinology , vol.34 , Issue.SUPPL. 1
    • Binder, E.B.1
  • 13
    • 40949142290 scopus 로고    scopus 로고
    • Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    • doi:10.1001/jama.299.11.1291
    • Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, Mercer KB, et al. Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA (2008) 299:1291-305. doi:10.1001/jama.299.11.1291.
    • (2008) JAMA , vol.299 , pp. 1291-1305
    • Binder, E.B.1    Bradley, R.G.2    Liu, W.3    Epstein, M.P.4    Deveau, T.C.5    Mercer, K.B.6
  • 14
    • 77953611084 scopus 로고    scopus 로고
    • Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide
    • doi:10.1038/npp.2009.236
    • Roy A, Gorodetsky E, Yuan Q, Goldman D, Enoch MA. Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide. Neuropsychopharmacology (2010) 35:1674-83. doi:10.1038/npp.2009.236.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1674-1683
    • Roy, A.1    Gorodetsky, E.2    Yuan, Q.3    Goldman, D.4    Enoch, M.A.5
  • 15
    • 77953555469 scopus 로고    scopus 로고
    • Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    • doi:10.1038/npp.2010.37
    • Xie P, Kranzler HR, Poling J, Stein MB, Anton RF, Farrer LA, et al. Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder. Neuropsychopharmacology (2010) 35:1684-92. doi:10.1038/npp.2010.37.
    • (2010) Neuropsychopharmacology , vol.35 , pp. 1684-1692
    • Xie, P.1    Kranzler, H.R.2    Poling, J.3    Stein, M.B.4    Anton, R.F.5    Farrer, L.A.6
  • 16
    • 80051791111 scopus 로고    scopus 로고
    • Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population
    • doi:10.1038/npp.2011.81
    • Appel K, Schwahn C, Mahler J, Schulz A, Spitzer C, Fenske K, et al. Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population. Neuropsychopharmacology (2011) 36:1982-91. doi:10.1038/npp.2011.81.
    • (2011) Neuropsychopharmacology , vol.36 , pp. 1982-1991
    • Appel, K.1    Schwahn, C.2    Mahler, J.3    Schulz, A.4    Spitzer, C.5    Fenske, K.6
  • 17
    • 84871717397 scopus 로고    scopus 로고
    • Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions
    • doi:10.1038/nn.3275
    • Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM, et al. Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci (2013) 16:33-41. doi:10.1038/nn.3275.
    • (2013) Nat Neurosci , vol.16 , pp. 33-41
    • Klengel, T.1    Mehta, D.2    Anacker, C.3    Rex-Haffner, M.4    Pruessner, J.C.5    Pariante, C.M.6
  • 19
    • 18444386162 scopus 로고    scopus 로고
    • Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors
    • doi:10.1038/sj.mp.4001676
    • Segman RH, ShefiN, Goltser-Dubner T, Friedman N, Kaminski N, Shalev AY. Peripheral blood mononuclear cell gene expression profiles identify emergent post-traumatic stress disorder among trauma survivors. Mol Psychiatry (2005) 10(500-513):425. doi:10.1038/sj.mp.4001676.
    • (2005) Mol Psychiatry , vol.10 , Issue.500-513 , pp. 425
    • Segman, R.H.1    Shefi, N.2    Goltser-Dubner, T.3    Friedman, N.4    Kaminski, N.5    Shalev, A.Y.6
  • 20
    • 34247540487 scopus 로고    scopus 로고
    • Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder
    • de Kloet CS, Vermetten E, Bikker A, Meulman E, Geuze E, Kavelaars A, et al. Leukocyte glucocorticoid receptor expression and immunoregulation in veterans with and without post-traumatic stress disorder. Mol Psychiatry (2007) 12:443-53.
    • (2007) Mol Psychiatry , vol.12 , pp. 443-453
    • de Kloet, C.S.1    Vermetten, E.2    Bikker, A.3    Meulman, E.4    Geuze, E.5    Kavelaars, A.6
  • 21
    • 69749097818 scopus 로고    scopus 로고
    • Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks
    • doi:10.1016/j.biopsych.2009.02.034
    • Yehuda R, Cai G, Golier JA, Sarapas C, Galea S, Ising M, et al. Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks. Biol Psychiatry (2009) 66:708-11. doi:10.1016/j.biopsych.2009.02.034.
    • (2009) Biol Psychiatry , vol.66 , pp. 708-711
    • Yehuda, R.1    Cai, G.2    Golier, J.A.3    Sarapas, C.4    Galea, S.5    Ising, M.6
  • 22
    • 79955994712 scopus 로고    scopus 로고
    • Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD
    • doi:10.1016/j.psychres.2011.03.002
    • Boscarino JA, Erlich PM, Hoffman SN, Rukstalis M, Stewart WF. Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD. Psychiatry Res (2011) 188:173-4. doi:10.1016/j.psychres.2011.03.002.
    • (2011) Psychiatry Res , vol.188 , pp. 173-174
    • Boscarino, J.A.1    Erlich, P.M.2    Hoffman, S.N.3    Rukstalis, M.4    Stewart, W.F.5
  • 23
    • 80051926419 scopus 로고    scopus 로고
    • Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies
    • doi:10.1001/archgenpsychiatry.2011.50
    • Mehta D, Gonik M, Klengel T, Rex-Haffner M, Menke A, Rubel J, et al. Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studies. Arch Gen Psychiatry (2011) 68:901-10. doi:10.1001/archgenpsychiatry.2011.50.
    • (2011) Arch Gen Psychiatry , vol.68 , pp. 901-910
    • Mehta, D.1    Gonik, M.2    Klengel, T.3    Rex-Haffner, M.4    Menke, A.5    Rubel, J.6
  • 24
    • 79955125328 scopus 로고    scopus 로고
    • Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks
    • doi:10.3233/DMA-2011-0764
    • Sarapas C, Cai G, Bierer LM, Golier JA, Galea S, Ising M, et al. Genetic markers for PTSD risk and resilience among survivors of the World Trade Center attacks. Dis Markers (2011) 30:101-10. doi:10.3233/DMA-2011-0764.
    • (2011) Dis Markers , vol.30 , pp. 101-110
    • Sarapas, C.1    Cai, G.2    Bierer, L.M.3    Golier, J.A.4    Galea, S.5    Ising, M.6
  • 25
    • 78651340668 scopus 로고    scopus 로고
    • Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment
    • doi:10.1176/appi.ajp.2010.10050706
    • van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Heijnen CJ, et al. Pre-existing high glucocorticoid receptor number predicting development of posttraumatic stress symptoms after military deployment. Am J Psychiatry (2011) 168:89-96. doi:10.1176/appi.ajp.2010.10050706.
    • (2011) Am J Psychiatry , vol.168 , pp. 89-96
    • van Zuiden, M.1    Geuze, E.2    Willemen, H.L.3    Vermetten, E.4    Maas, M.5    Heijnen, C.J.6
  • 26
    • 84856005896 scopus 로고    scopus 로고
    • Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study
    • doi:10.1016/j.biopsych.2011.10.026
    • van Zuiden M, Geuze E, Willemen HL, Vermetten E, Maas M, Amarouchi K, et al. Glucocorticoid receptor pathway components predict posttraumatic stress disorder symptom development: a prospective study. Biol Psychiatry (2012) 71:309-16. doi:10.1016/j.biopsych.2011.10.026.
    • (2012) Biol Psychiatry , vol.71 , pp. 309-316
    • van Zuiden, M.1    Geuze, E.2    Willemen, H.L.3    Vermetten, E.4    Maas, M.5    Amarouchi, K.6
  • 27
    • 84873550690 scopus 로고    scopus 로고
    • Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD
    • Matic G, Milutinovic DV, Nestorov J, Elakovic I, Jovanovic SM, Perisic T, et al. Lymphocyte glucocorticoid receptor expression level and hormone-binding properties differ between war trauma-exposed men with and without PTSD. Prog Neuropsychopharmacol Biol Psychiatry (2013) 43C:238-45. doi:10.1016/j.pnpbp.2013.01.005.
    • (2013) Prog Neuropsychopharmacol Biol Psychiatry , vol.43 C , pp. 238-245
    • Matic, G.1    Milutinovic, D.V.2    Nestorov, J.3    Elakovic, I.4    Jovanovic, S.M.5    Perisic, T.6
  • 28
    • 46249091103 scopus 로고    scopus 로고
    • The link between childhood trauma and depression: insights from HPA axis studies in humans
    • doi:10.1016/j.psyneuen.2008.03.008
    • Heim C, Newport DJ, Mletzko T, Miller AH, NemeroffCB. The link between childhood trauma and depression: insights from HPA axis studies in humans. Psychoneuroendocrinology (2008) 33:693-710. doi:10.1016/j.psyneuen.2008.03.008.
    • (2008) Psychoneuroendocrinology , vol.33 , pp. 693-710
    • Heim, C.1    Newport, D.J.2    Mletzko, T.3    Miller, A.H.4    Nemeroff, C.B.5
  • 29
    • 0027450513 scopus 로고
    • Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans
    • Bremner JD, Southwick SM, Johnson DR, Yehuda R, Charney DS. Childhood physical abuse and combat-related posttraumatic stress disorder in Vietnam veterans. Am J Psychiatry (1993) 150:235-9.
    • (1993) Am J Psychiatry , vol.150 , pp. 235-239
    • Bremner, J.D.1    Southwick, S.M.2    Johnson, D.R.3    Yehuda, R.4    Charney, D.S.5
  • 30
    • 0032977287 scopus 로고    scopus 로고
    • Previous exposure to trauma and PTSD effects of subsequent trauma: results from the Detroit Area Survey of Trauma
    • Breslau N, Chilcoat HD, Kessler RC, Davis GC. Previous exposure to trauma and PTSD effects of subsequent trauma: results from the Detroit Area Survey of Trauma. Am J Psychiatry (1999) 156:902-7.
    • (1999) Am J Psychiatry , vol.156 , pp. 902-907
    • Breslau, N.1    Chilcoat, H.D.2    Kessler, R.C.3    Davis, G.C.4
  • 31
    • 0035354561 scopus 로고    scopus 로고
    • Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion
    • doi:10.1017/S0954579401003170
    • Yehuda R, Halligan SL, Grossman R. Childhood trauma and risk for PTSD: relationship to intergenerational effects of trauma, parental PTSD, and cortisol excretion. Dev Psychopathol (2001) 13:733-53. doi:10.1017/S0954579401003170.
    • (2001) Dev Psychopathol , vol.13 , pp. 733-753
    • Yehuda, R.1    Halligan, S.L.2    Grossman, R.3
  • 32
    • 78649316753 scopus 로고    scopus 로고
    • Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD
    • doi:10.1007/s00213-010-1969-6
    • Yehuda R, Flory JD, Pratchett LC, Buxbaum J, Ising M, Holsboer F. Putative biological mechanisms for the association between early life adversity and the subsequent development of PTSD. Psychopharmacology (Berl) (2010) 212:405-17. doi:10.1007/s00213-010-1969-6.
    • (2010) Psychopharmacology (Berl) , vol.212 , pp. 405-417
    • Yehuda, R.1    Flory, J.D.2    Pratchett, L.C.3    Buxbaum, J.4    Ising, M.5    Holsboer, F.6
  • 33
    • 0033007466 scopus 로고    scopus 로고
    • Biological factors associated with susceptibility to posttraumatic stress disorder
    • Yehuda R. Biological factors associated with susceptibility to posttraumatic stress disorder. Can J Psychiatry (1999) 44:34-9.
    • (1999) Can J Psychiatry , vol.44 , pp. 34-39
    • Yehuda, R.1
  • 34
    • 0037050366 scopus 로고    scopus 로고
    • Post-traumatic stress disorder
    • doi:10.1056/NEJMra012941
    • Yehuda R. Post-traumatic stress disorder. N Engl J Med (2002) 346:108-14. doi:10.1056/NEJMra012941.
    • (2002) N Engl J Med , vol.346 , pp. 108-114
    • Yehuda, R.1
  • 35
    • 0442272538 scopus 로고    scopus 로고
    • When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders
    • doi:10.1176/appi.ajp.160.9.1554
    • Raison CL, Miller AH. When not enough is too much: the role of insufficient glucocorticoid signaling in the pathophysiology of stress-related disorders. Am J Psychiatry (2003) 160:1554-65. doi:10.1176/appi.ajp.160.9.1554.
    • (2003) Am J Psychiatry , vol.160 , pp. 1554-1565
    • Raison, C.L.1    Miller, A.H.2
  • 36
    • 70449413781 scopus 로고    scopus 로고
    • Status of glucocorticoid alterations in post-traumatic stress disorder
    • doi:10.1111/j.1749-6632.2009.04979.x
    • Yehuda R. Status of glucocorticoid alterations in post-traumatic stress disorder. Ann N Y Acad Sci (2009) 1179:56-69. doi:10.1111/j.1749-6632.2009.04979.x.
    • (2009) Ann N Y Acad Sci , vol.1179 , pp. 56-69
    • Yehuda, R.1
  • 37
    • 84876867628 scopus 로고    scopus 로고
    • Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions
    • doi:10.1016/j.bbi.2012.08.015
    • van Zuiden M, Kavelaars A, Geuze E, OlffM, Heijnen CJ. Predicting PTSD: pre-existing vulnerabilities in glucocorticoid-signaling and implications for preventive interventions. Brain Behav Immun (2013) 30:12-21. doi:10.1016/j.bbi.2012.08.015.
    • (2013) Brain Behav Immun , vol.30 , pp. 12-21
    • van Zuiden, M.1    Kavelaars, A.2    Geuze, E.3    Olff, M.4    Heijnen, C.J.5
  • 38
    • 79955114682 scopus 로고    scopus 로고
    • Epigenetic aspects of posttraumatic stress disorder
    • doi:10.1155/2011/343616
    • Schmidt U, Holsboer F, Rein T. Epigenetic aspects of posttraumatic stress disorder. Dis Markers (2011) 30:77-87. doi:10.1155/2011/343616.
    • (2011) Dis Markers , vol.30 , pp. 77-87
    • Schmidt, U.1    Holsboer, F.2    Rein, T.3
  • 39
    • 83755180447 scopus 로고    scopus 로고
    • Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma
    • doi:10.1038/tp.2011.60
    • Perroud N, Paoloni-Giacobino A, Prada P, Olie E, Salzmann A, Nicastro R, et al. Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma. Transl Psychiatry (2011) 1:e59. doi:10.1038/tp.2011.60.
    • (2011) Transl Psychiatry , vol.1
    • Perroud, N.1    Paoloni-Giacobino, A.2    Prada, P.3    Olie, E.4    Salzmann, A.5    Nicastro, R.6
  • 40
    • 84856277610 scopus 로고    scopus 로고
    • Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults
    • doi:10.1371/journal.pone.0030148
    • Tyrka AR, Price LH, Marsit C, Walters OC, Carpenter LL. Childhood adversity and epigenetic modulation of the leukocyte glucocorticoid receptor: preliminary findings in healthy adults. PLoS One (2012) 7:e30148. doi:10.1371/journal.pone.0030148.
    • (2012) PLoS One , vol.7
    • Tyrka, A.R.1    Price, L.H.2    Marsit, C.3    Walters, O.C.4    Carpenter, L.L.5
  • 41
    • 0028867185 scopus 로고
    • Posttraumatic stress disorder in the National Comorbidity Survey
    • doi:10.1001/archpsyc.1995.03950240066012
    • Kessler RC, Sonnega A, Bromet E, Hughes M, Nelson CB. Posttraumatic stress disorder in the National Comorbidity Survey. Arch Gen Psychiatry (1995) 52:1048-60. doi:10.1001/archpsyc.1995.03950240066012.
    • (1995) Arch Gen Psychiatry , vol.52 , pp. 1048-1060
    • Kessler, R.C.1    Sonnega, A.2    Bromet, E.3    Hughes, M.4    Nelson, C.B.5
  • 42
    • 78149259186 scopus 로고    scopus 로고
    • Using biological markers to inform a clinically meaningful treatment response
    • doi:10.1111/j.1749-6632.2010.05698.x
    • Yehuda R, Bierer LM, Pratchett LC, Pelcovitz M. Using biological markers to inform a clinically meaningful treatment response. Ann N Y Acad Sci (2010) 1208:158-63. doi:10.1111/j.1749-6632.2010.05698.x.
    • (2010) Ann N Y Acad Sci , vol.1208 , pp. 158-163
    • Yehuda, R.1    Bierer, L.M.2    Pratchett, L.C.3    Pelcovitz, M.4
  • 45
    • 0027894189 scopus 로고
    • Reliability and validity of a brief instrument for assessing post-traumatic stress disorder
    • doi:10.1002/jts.2490060405
    • Foa EB, Riggs DS, Dancu CV, Rothbaum BO. Reliability and validity of a brief instrument for assessing post-traumatic stress disorder. J Trauma Stress (1993) 6:459-73. doi:10.1002/jts.2490060405.
    • (1993) J Trauma Stress , vol.6 , pp. 459-473
    • Foa, E.B.1    Riggs, D.S.2    Dancu, C.V.3    Rothbaum, B.O.4
  • 46
    • 0037293191 scopus 로고    scopus 로고
    • Development and validation of a brief screening version of the Childhood Trauma Questionnaire
    • doi:10.1016/S0145-2134(02)00541-0
    • Bernstein DP, Stein JA, Newcomb MD, Walker E, Pogge D, Ahluvalia T, et al. Development and validation of a brief screening version of the Childhood Trauma Questionnaire. Child Abuse Negl (2003) 27:169-90. doi:10.1016/S0145-2134(02)00541-0.
    • (2003) Child Abuse Negl , vol.27 , pp. 169-190
    • Bernstein, D.P.1    Stein, J.A.2    Newcomb, M.D.3    Walker, E.4    Pogge, D.5    Ahluvalia, T.6
  • 47
    • 33748577997 scopus 로고    scopus 로고
    • Deployment Risk and Resilience Inventory: a collection of measures for studying deployment-related experiences of military personnel and veterans
    • doi:10.1207/s15327876mp1802_1
    • King LA, King DW, Vogt DS, Knight J, Samper RE. Deployment Risk and Resilience Inventory: a collection of measures for studying deployment-related experiences of military personnel and veterans. Mil Psychol (2006) 18:89-120. doi:10.1207/s15327876mp1802_1.
    • (2006) Mil Psychol , vol.18 , pp. 89-120
    • King, L.A.1    King, D.W.2    Vogt, D.S.3    Knight, J.4    Samper, R.E.5
  • 48
    • 33751231429 scopus 로고    scopus 로고
    • Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment
    • doi:10.1016/j.psyneuen.2006.08.005
    • Golier JA, Schmeidler J, Legge J, Yehuda R. Enhanced cortisol suppression to dexamethasone associated with Gulf War deployment. Psychoneuroendocrinology (2006) 31:1181-9. doi:10.1016/j.psyneuen.2006.08.005.
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 1181-1189
    • Golier, J.A.1    Schmeidler, J.2    Legge, J.3    Yehuda, R.4
  • 49
    • 67349099508 scopus 로고    scopus 로고
    • Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors
    • doi:10.1016/j.jpsychires.2008.12.003
    • Yehuda R, Bierer LM, Andrew R, Schmeidler J, Seckl JR. Enduring effects of severe developmental adversity, including nutritional deprivation, on cortisol metabolism in aging Holocaust survivors. J Psychiatr Res (2009) 43:877-83. doi:10.1016/j.jpsychires.2008.12.003.
    • (2009) J Psychiatr Res , vol.43 , pp. 877-883
    • Yehuda, R.1    Bierer, L.M.2    Andrew, R.3    Schmeidler, J.4    Seckl, J.R.5
  • 50
    • 33644817491 scopus 로고    scopus 로고
    • Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping
    • doi:10.1016/j.biopsych.2005.08.027
    • Yehuda R, Brand S, Yang RK. Plasma neuropeptide Y concentrations in combat exposed veterans: relationship to trauma exposure, recovery from PTSD, and coping. Biol Psychiatry (2006) 59:660-3. doi:10.1016/j.biopsych.2005.08.027.
    • (2006) Biol Psychiatry , vol.59 , pp. 660-663
    • Yehuda, R.1    Brand, S.2    Yang, R.K.3
  • 51
    • 2542423960 scopus 로고    scopus 로고
    • Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder
    • doi:10.1016/j.biopsych.2004.02.010
    • Yehuda R, Golier JA, Yang RK, Tischler L. Enhanced sensitivity to glucocorticoids in peripheral mononuclear leukocytes in posttraumatic stress disorder. Biol Psychiatry (2004) 55:1110-6. doi:10.1016/j.biopsych.2004.02.010.
    • (2004) Biol Psychiatry , vol.55 , pp. 1110-1116
    • Yehuda, R.1    Golier, J.A.2    Yang, R.K.3    Tischler, L.4
  • 52
    • 77956053977 scopus 로고    scopus 로고
    • Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice
    • doi:10.1210/en.2010-0225
    • Lee RS, Tamashiro KL, Yang X, Purcell RH, Harvey A, Willour VL, et al. Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice. Endocrinology (2010) 151:4332-43. doi:10.1210/en.2010-0225.
    • (2010) Endocrinology , vol.151 , pp. 4332-4343
    • Lee, R.S.1    Tamashiro, K.L.2    Yang, X.3    Purcell, R.H.4    Harvey, A.5    Willour, V.L.6
  • 53
    • 85027949076 scopus 로고    scopus 로고
    • A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice
    • doi:10.1007/s00213-011-2307-3
    • Lee RS, Tamashiro KL, Yang X, Purcell RH, Huo Y, Rongione M, et al. A measure of glucocorticoid load provided by DNA methylation of Fkbp5 in mice. Psychopharmacology (Berl) (2011) 218:303-12. doi:10.1007/s00213-011-2307-3.
    • (2011) Psychopharmacology (Berl) , vol.218 , pp. 303-312
    • Lee, R.S.1    Tamashiro, K.L.2    Yang, X.3    Purcell, R.H.4    Huo, Y.5    Rongione, M.6
  • 54
    • 77958526499 scopus 로고    scopus 로고
    • Epigenetic regulation of the neural transcriptome: the meaning of the marks
    • doi:10.1038/nn1110-1313
    • Meaney MJ, Ferguson-Smith AC. Epigenetic regulation of the neural transcriptome: the meaning of the marks. Nat Neurosci (2010) 13:1313-8. doi:10.1038/nn1110-1313.
    • (2010) Nat Neurosci , vol.13 , pp. 1313-1318
    • Meaney, M.J.1    Ferguson-Smith, A.C.2
  • 55
    • 84869090771 scopus 로고    scopus 로고
    • Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans
    • doi:10.1038/npp.2012.149
    • Zhang TY, Labonte B, Wen XL, Turecki G, Meaney MJ. Epigenetic mechanisms for the early environmental regulation of hippocampal glucocorticoid receptor gene expression in rodents and humans. Neuropsychopharmacology (2013) 38:111-23. doi:10.1038/npp.2012.149.
    • (2013) Neuropsychopharmacology , vol.38 , pp. 111-123
    • Zhang, T.Y.1    Labonte, B.2    Wen, X.L.3    Turecki, G.4    Meaney, M.J.5
  • 56
    • 28044436691 scopus 로고    scopus 로고
    • Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life
    • doi:10.1523/JNEUROSCI.3652-05.2005
    • Weaver IC, Champagne FA, Brown SE, Dymov S, Sharma S, Meaney MJ, et al. Reversal of maternal programming of stress responses in adult offspring through methyl supplementation: altering epigenetic marking later in life. J Neurosci (2005) 25:11045-54. doi:10.1523/JNEUROSCI.3652-05.2005.
    • (2005) J Neurosci , vol.25 , pp. 11045-54
    • Weaver, I.C.1    Champagne, F.A.2    Brown, S.E.3    Dymov, S.4    Sharma, S.5    Meaney, M.J.6
  • 57
    • 84864208883 scopus 로고    scopus 로고
    • Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade
    • doi:10.1098/rstb.2012.0223
    • Hellstrom IC, Dhir SK, Diorio JC, Meaney MJ. Maternal licking regulates hippocampal glucocorticoid receptor transcription through a thyroid hormone-serotonin-NGFI-A signalling cascade. Philos Trans R Soc Lond B Biol Sci (2012) 367:2495-510. doi:10.1098/rstb.2012.0223.
    • (2012) Philos Trans R Soc Lond B Biol Sci , vol.367 , pp. 2495-2510
    • Hellstrom, I.C.1    Dhir, S.K.2    Diorio, J.C.3    Meaney, M.J.4
  • 58
    • 84874133001 scopus 로고    scopus 로고
    • Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress
    • doi:10.1038/tp.2012.77
    • Unternaehrer E, Luers P, Mill J, Dempster E, Meyer AH, Staehli S, et al. Dynamic changes in DNA methylation of stress-associated genes (OXTR, BDNF) after acute psychosocial stress. Transl Psychiatry (2012) 2:e150. doi:10.1038/tp.2012.77.
    • (2012) Transl Psychiatry , vol.2
    • Unternaehrer, E.1    Luers, P.2    Mill, J.3    Dempster, E.4    Meyer, A.H.5    Staehli, S.6


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