Association of FKBP5, COMT and CHRNA5 polymorphisms with PTSD among outpatients at risk for PTSD

Psychiatry Research

Volumn 188, Issue 1, 2011, Pages 173-174

  Boscarino, Joseph A ^a,b,c   Erlich, Porat M ^a,c   Hoffman, Stuart N ^a   Rukstalis, Margaret ^a   Stewart, Walter F ^a,d  

^a GEISINGER MEDICAL CENTER   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE; CHOLINERGIC RECEPTOR NICOTINIC ALPHA5; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 5; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ADULT; CHRNA5 GENE; COMT GENE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL FACTOR; FKBP5 GENE; GENE CLUSTER; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MARKER; GENOTYPE; HUMAN; LETTER; MAJOR CLINICAL STUDY; OUTPATIENT; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; CATECHOL O-METHYLTRANSFERASE; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; OUTPATIENTS; POLYMORPHISM, GENETIC; RECEPTORS, NICOTINIC; RISK FACTORS; STRESS DISORDERS, POST-TRAUMATIC; TACROLIMUS BINDING PROTEINS;

EID: 79955994712     PISSN: 01651781     EISSN: 01651781     Source Type: Journal    
DOI: 10.1016/j.psychres.2011.03.002     Document Type: Letter

References (13)

1. Binder E.B. The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 2009, 34(Suppl 1):S186-S195.
2. Boscarino J.A., Rukstalis M., Hoffman S.N., Han J.J., Erlich P.M., Gerhard G.S., Stewart W.F. Risk factors for drug dependence among outpatients on opioid therapy in a large US healthcare system. Addiction 2010, 105(10):1776-1782.
3. Boscarino J.A., Adams R.E., Galea S. Alcohol use in New York after the terrorist attacks: a study of the effects of psychological trauma on drinking behavior. Addictive Behaviors 2006, 31:606-621.
4. Broekman B.F., Olff M., Boer F. The genetic background to PTSD. Neuroscience and Biobehavioral Reviews 2007, 31(3):348-362.
5. Craddock N., Owen M.J., O'Donovan M.C. The catechol-O-methyltransferase (COMT) gene as a candidate for psychiatric phenotypes: evidence and lessons. Molecular Psychiatry 2006, 11(5):446-458.
6. Erlich P.M., Hoffman S.N., Rukstalis M., Han J.J., Chu X., Kao L.W.H., Gerhard G.S., Stewart W.F., Boscarino J.A. Nicotinic acetylcholine receptor genes on chromosome 15q25.1 are associated with nicotine and opioid dependence severity. Human Genetics 2010, 128(5):491-499.
7. Fu S.S., McFall M., Saxon A.J., Beckham J.C., Carmody T.P., Baker D.G., Joseph A.M. Post-traumatic stress disorder and smoking: a systematic review. Nicotine & Tobacco Research 2007, 9(11):1071-1084.
8. Gillespie C.F., Phifer J., Bradley B., Ressler K.J. Risk and resilience: genetic and environmental influences on development of the stress response. Depression and Anxiety 2009, 26(11):984-992.
9. Koenen K.C. Genetics of posttraumatic stress disorder: review and recommendations for future studies. Journal of Traumatic Stress 2007, 20(5):737-750.
10. Kolassa I.T., Kolassa S., Ertl V., Papassotiropoulos A., De Quervain D.J. The risk of posttraumatic stress disorder after trauma depends on traumatic load and the catechol-o-methyltransferase Val(158)Met polymorphism. Biological Psychiatry 2010, 67(4):304-308.
11. McFarlane A.C. The long-term costs of traumatic stress: intertwined physical and psychological consequences. World Psychiatry 2010, 9(1):3-10.
12. Montag C., Buckholtz J.W., Hartmann P., Merz M., Burk C., Hennig J., Reuter M. COMT genetic variation affects fear processing: psychophysiological evidence. Behavioral Neuroscience 2008, 122(4):901-909.
13. Rauch S.L., Drevets W.C. Neuroimaging and neuroanatomy of stress-induced and fear circuitry disorders. Stress-Induced and Fear Circuitry Disorders: Refining the Research Agenda for DSM-V 2009, 215-254. American Psychiatric Association, Washington, DC. G. Andrews, D.S. Charney, P.J. Sirovatka, D.A. Regier (Eds.).