Role of Abl in airway hyperresponsiveness and airway remodeling

Respiratory Research

Volumn 14, Issue 1, 2013, Pages

  Cleary, Rachel A ^a   Wang, Ruping ^a   Wang, Tao ^a   Tang, Dale D ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

Airway hyperresponsiveness; Airway remodeling; Airway smooth muscle; Tyrosine kinase

Indexed keywords

ABELSON KINASE; CYCLINE; GNF 5; IMATINIB; INTERLEUKIN 13; MONOCYTE CHEMOTACTIC PROTEIN 1; OVALBUMIN; PROTEIN TYROSINE KINASE INHIBITOR; UNCLASSIFIED DRUG; BENZAMIDE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

AIRWAY REMODELING; AIRWAY RESISTANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL PROLIFERATION; CONTROLLED STUDY; GENE INACTIVATION; HUMAN; HUMAN CELL; KNOCKOUT MOUSE; LUNG LAVAGE; MOUSE; MUSCLE MASS; NONHUMAN; PATHOLOGY; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESPIRATORY TRACT ALLERGY; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER; UPREGULATION; ANIMAL; BRONCHUS; BRONCHUS HYPERREACTIVITY; C57BL MOUSE; CELL CULTURE; CHEMICALLY INDUCED DISORDER; DISEASE MODEL; DRUG EFFECT; FEMALE; GENETICS; IN VITRO STUDY; MALE; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

AIRWAY REMODELING; ANIMALS; ASTHMA; BENZAMIDES; BRONCHI; BRONCHIAL HYPERREACTIVITY; CELLS, CULTURED; CHEMOKINE CCL2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INTERLEUKIN-13; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCYTES, SMOOTH MUSCLE; OVALBUMIN; PIPERAZINES; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-ABL; PYRIMIDINES;

EID: 84885342097     PISSN: 14659921     EISSN: 1465993X     Source Type: Journal    
DOI: 10.1186/1465-9921-14-105     Document Type: Article

References (42)

1. Amrani Y, Tliba O, Deshpande DA, Walseth TF, Kannan MS, Panettieri RA. Bronchial hyperresponsiveness: insights into new signaling molecules. Curr Opin Pharmacol 2004, 4:230-234. 10.1016/j.coph.2004.02.004, 15140413.
2. Ma XF, Cheng ZQ, Kong H, Wang Y, Unruh H, Stephens NL, Laviolette M. Changes in biophysical and biochemical properties of single bronchial smooth muscle cells from asthmatic subjects. Am J Physiol Lung Cell Mol Physiol 2002, 283:L1181-L1189.
3. Bjorck T, Gustafsson LE, Dahlen SE. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am Rev Respir Dis 1992, 145:1087-1091. 10.1164/ajrccm/145.5.1087, 1375009.
4. Guedes AG, Paulin J, Rivero-Nava L, Kita H, Lund FE, Kannan MS. CD38-deficient mice have reduced airway hyperresponsiveness following IL-13 challenge. Am J Physiol Lung Cell Mol Physiol 2006, 291:L1286-L1293. 10.1152/ajplung.00187.2006, 16891391.
5. Guedes AG, Jude JA, Paulin J, Kita H, Lund FE, Kannan MS. Role of CD38 in TNF-alpha-induced airway hyperresponsiveness. Am J Physiol Lung Cell Mol Physiol 2008, 294:L290-L299.
6. Bentley JK, Deng H, Linn MJ, Lei J, Dokshin GA, Fingar DC, Bitar KN, Henderson WR, Hershenson MB. Airway smooth muscle hyperplasia and hypertrophy correlate with glycogen synthase kinase-3(beta) phosphorylation in a mouse model of asthma. Am J Physiol Lung Cell Mol Physiol 2009, 296:L176-L184. 2643992, 19011050.
7. Ammit AJ, Panettieri RA. Airway smooth muscle cell hyperplasia: a therapeutic target in airway remodeling in asthma?. ProgCell Cycle Res 2003, 5:49-57.
8. Dekkers BG, Bos IS, Gosens R, Halayko AJ, Zaagsma J, Meurs H. The integrin-blocking peptide RGDS inhibits airway smooth muscle remodeling in a guinea pig model of allergic asthma. Am J Respir Crit Care Med 2010, 181:556-565. 10.1164/rccm.200907-1065OC, 20019343.
9. Hu H, Bliss JM, Wang Y, Colicelli J. RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration. Curr Biol 2005, 15:815-823. 10.1016/j.cub.2005.03.049, 15886098.
10. Wang JY. Controlling Abl: auto-inhibition and co-inhibition?. Nat Cell Biol 2004, 6:3-7. 10.1038/ncb0104-3, 14704671.
11. Jia L, Tang DD. Abl activation regulates the dissociation of CAS from cytoskeletal vimentin by modulating CAS phosphorylation in smooth muscle. AJP - Cell Physiol 2010, 299:C630-C637.
12. Chen S, Wang R, Li QF, Tang DD. Abl knockout differentially affects p130 Crk-associated substrate, vinculin, and paxillin in blood vessels of mice. Am J Physiol Heart Circ Physiol 2009, 297:H533-H539. 10.1152/ajpheart.00237.2009, 2724200, 19542491.
13. Anfinogenova Y, Wang R, Li QF, Spinelli AM, Tang DD. Abl silencing inhibits CAS-Mediated process and constriction in resistance arteries. Circ Res 2007, 101:420-428. 10.1161/CIRCRESAHA.107.156463, 2084484, 17615370.
14. Jia L, Wang R, Tang DD. Abl regulates smooth muscle cell proliferation by modulating actin dynamics and ERK1/2 activation. Am J Physiol Cell Physiol 2012, 302:C1026-C1034. 10.1152/ajpcell.00373.2011, 3330739, 22301057.
15. Wang R, Mercaitis OP, Jia L, Panettieri RA, Tang DD. Raf-1, actin dynamics and Abl in human airway smooth muscle cells. Am J Respir Cell Mol Biol 2013, 48:172-178. 10.1165/rcmb.2012-0315OC, 23087049.
16. Moresco EMY, Donaldson S, Williamson A, Koleske AJ. Integrin-mediated dendrite branch maintenance requires Abelson (Ab1) family kinases. J Neurosci 2005, 25:6105-6118. 10.1523/JNEUROSCI.1432-05.2005, 15987940.
17. Wegmann M, Goggel R, Sel S, Sel S, Erb KJ, Kalkbrenner F, Renz H, Garn H. Effects of a low-molecular-weight CCR-3 antagonist on chronic experimental asthma. Am J Respir Cell Mol Biol 2007, 36:61-67. 10.1165/rcmb.2006-0188OC, 16917075.
18. Li QF, Spinelli AM, Tang DD. Cdc42GAP, reactive oxygen species, and the vimentin network. AJP - Cell Physiol 2009, 297:C299-C309.
19. Li QF, Spinelli AM, Wang R, Anfinogenova Y, Singer HA, Tang DD. Critical role of Vimentin Phosphorylation at Ser-56 by p21-activated Kinase in Vimentin Cytoskeleton signaling. J Biol Chem 2006, 281:34716-34724. 10.1074/jbc.M607715200, 1634890, 16990256.
20. Shardonofsky FR, Moore J, Schwartz RJ, Boriek AM. Airways in smooth muscle alpha-actin null mice experience a compensatory mechanism that modulates their contractile response. J Appl Physiol 2012, 112:898-903. 10.1152/japplphysiol.00417.2011, 22134689.
21. Li L, Miano JM, Cserjesi P, Olson EN. SM22 alpha, a marker of adult smooth muscle, is expressed in multiple myogenic lineages during embryogenesis. Circ Res 1996, 78:188-195. 10.1161/01.RES.78.2.188, 8575061.
22. Camoretti-Mercado B, Forsythe SM, LeBeau MM, Espinosa R, Vieira JE, Halayko AJ, Willadsen S, Kurtz B, Ober C, Evans GA, et al. Expression and cytogenetic localization of the human SM22 gene (TAGLN). Genomics 1998, 49:452-457. 10.1006/geno.1998.5267, 9615232.
23. Daniels CE, Wilkes MC, Edens M, Kottom TJ, Murphy SJ, Limper AH, Leof EB. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. JClinInvest 2004, 114:1308-1316.
24. Zhang J, Adrian FJ, Jahnke W, Cowan-Jacob SW, Li AG, Iacob RE, Sim T, Powers J, Dierks C, Sun F, et al. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature 2010, 463:501-506. 10.1038/nature08675, 2901986, 20072125.
25. Whitehead GS, Wang T, DeGraff LM, Card JW, Lira SA, Graham GJ, Cook DN. The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity. Am J Respir Crit Care Med 2007, 175:243-249. 10.1164/rccm.200606-839OC, 1899265, 17095748.
26. Gueders MM, Paulissen G, Crahay C, Quesada-Calvo F, Hacha J, Van Hove C, Tournoy K, Louis R, Foidart JM, Noel A, Cataldo DD. Mouse models of asthma: a comparison between C57BL/6 and BALB/c strains regarding bronchial responsiveness, inflammation, and cytokine production. Inflamm Res 2009, 58:845-854. 10.1007/s00011-009-0054-2, 19506803.
27. Tormanen KR, Uller L, Persson CG, Erjefalt JS. Allergen exposure of mouse airways evokes remodeling of both bronchi and large pulmonary vessels. Am J Respir Crit Care Med 2005, 171:19-25. 10.1164/rccm.200406-698OC, 15447945.
28. Howarth PH, Knox AJ, Amrani Y, Tliba O, Panettieri RA, Johnson M. Synthetic responses in airway smooth muscle. J Allergy ClinImmunol 2004, 114:S32-S50.
29. Lazaar AL, Panettieri RA. Airway smooth muscle: a modulator of airway remodeling in asthma. J Allergy ClinImmunol 2005, 116:488-495.
30. Wills-Karp M. Interleukin-13 in asthma pathogenesis. ImmunolRev 2004, 202:175-190.
31. Lazaar AL, Panettieri RA. Airway smooth muscle as a regulator of immune responses and bronchomotor tone. ClinChest Med 2006, 27:53-69. vi.
32. Tang DD, Anfinogenova Y. Physiologic properties and regulation of the actin cytoskeleton in vascular smooth muscle. J Cardiovasc Pharmacol Ther 2008, 13:130-140. 10.1177/1074248407313737, 2396785, 18212360.
33. Wang T, Cleary RA, Wang R, Tang DD. Role of the adapter protein Abi1 in actin-associated signaling and smooth muscle contraction. J Biol Chem 2013, 288:20713-20722. 10.1074/jbc.M112.439877, 23740246.
34. Zimmermann N, Hershey GK, Foster PS, Rothenberg ME. Chemokines in asthma: cooperative interaction between chemokines and IL-13. J Allergy ClinImmunol 2003, 111:227-242.
35. Walter DM, McIntire JJ, Berry G, McKenzie AN, Donaldson DD, DeKruyff RH, Umetsu DT. Critical role for IL-13 in the development of allergen-induced airway hyperreactivity. JImmunol 2001, 167:4668-4675.
36. Tliba O, Deshpande D, Chen H, Van BC, Kannan M, Panettieri RA, Amrani Y. IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle. BrJ Pharmacol 2003, 140:1159-1162.
37. Orsini MJ, Krymskaya VP, Eszterhas AJ, Benovic JL, Panettieri RA, Penn RB. MAPK superfamily activation in human airway smooth muscle: mitogenesis requires prolonged p42/p44 activation. Am J Physiol 1999, 277:L479-L488.
38. Brightbill H, Schlissel MS. The effects of c-Abl mutation on developing B cell differentiation and survival. IntImmunol 2009, 21:575-585.
39. Huang Y, Comiskey EO, Dupree RS, Li S, Koleske AJ, Burkhardt JK. The c-Abl tyrosine kinase regulates actin remodeling at the immune synapse. Blood 2008, 112:111-119. 10.1182/blood-2007-10-118232, 2435682, 18305217.
40. Silberman I, Sionov RV, Zuckerman V, Haupt S, Goldberg Z, Strasser A, Ben-Sasson ZS, Baniyash M, Koleske AJ, Haupt Y. T cell survival and function requires the c-Abl tyrosine kinase. Cell Cycle 2008, 7:3847-3857. 10.4161/cc.7.24.7267, 3407662, 19098427.
41. Baruzzi A, Berton G. The tyrosine kinase Abl is a component of macrophage podosomes and is required for podosome formation and function. Eur J Immunol 2012, 42:2720-2726. 10.1002/eji.201142270, 22733220.
42. Penn RB. Embracing emerging paradigms of G protein-coupled receptor agonism and signaling to address airway smooth muscle pathobiology in asthma. Naunyn Schmiedebergs Arch Pharmacol 2008, 378:149-169. 10.1007/s00210-008-0263-1, 18278482.