Airways in smooth muscle α-actin null mice experience a compensatory mechanism that modulates their contractile response

Journal of Applied Physiology

Volumn 112, Issue 5, 2012, Pages 898-903

  Shardonofsky, Felix R ^a   Moore, Joan ^b   Schwartz, Robert J ^c   Boriek, Aladin M ^b  

^a SCOTT AND WHITE MEMORIAL HOSPITAL   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c UNIVERSITY OF HOUSTON   (United States)

Author keywords

Airway resistance; Lung elastance; Lung mechanical stress; Mechanical ventilation; SM22

Indexed keywords

ACTIN; ACTIN BINDING PROTEIN; ALPHA SMOOTH MUSCLE ACTIN, MOUSE; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; CONTRACTILE PROTEIN; MESSENGER RNA; METHACHOLINE CHLORIDE; MUSCLE PROTEIN; MYOSIN; TRANSGELIN;

AIRWAY RESISTANCE; ANIMAL; ARTICLE; ARTIFICIAL VENTILATION; C57BL MOUSE; DRUG EFFECT; GENETICS; LUNG; METABOLISM; METHODOLOGY; MOUSE; MOUSE MUTANT; MUSCLE CONTRACTION; PHYSIOLOGY; SKELETAL MUSCLE; SMOOTH MUSCLE; SMOOTH MUSCLE FIBER;

ACTINS; AIRWAY RESISTANCE; ANIMALS; CONTRACTILE PROTEINS; LUNG; METHACHOLINE CHLORIDE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROFILAMENT PROTEINS; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; MUSCLE, SMOOTH; MYOCYTES, SMOOTH MUSCLE; RESPIRATION, ARTIFICIAL; RNA, MESSENGER; SMOOTH MUSCLE MYOSINS;

EID: 84859626351     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00417.2011     Document Type: Article

References (36)

1. Albinsson S, Nordström I, Hellstrand P. Stretch of the vascular wall induces smooth muscle differentiation by promoting actin polymerization. J Biol Chem 279: 34849-34855, 2004. (Pubitemid 39318119)
2. Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Stelmack GL, Halayko AJ, Solway J, Mitchell RW. Latrunculin B increases force fluctuation-induced relengthening of Ach-contracted, isotonically shortened canine tracheal smooth muscle. J Appl Physiol 98: 489-497, 2005. (Pubitemid 40129956)
3. Dong-Chuan G, Papke CL, Tran-Fadulu V, Regalado ES, Avidan N, Johnson RJ, Kim DH, Pannu H, Willing MC, Sparks E, Pyeritz RE, Singh MN, Dalman RL, Grotta JC, Marian AJ, Boerwinkle EA, Frazier LQ, LeMaire SA, Coselli JS, Estrera AL, Safi HJ, Veeraghavan S, Muzny DM, Wheeler DA, Willerson JT, Yu RK, Shete SS, Scherer SE, Raman CS, Buja LM, Milewicz DM. Mutations in smooth muscle alpha actin (ACTA2) cause coronary artery disease, stroke, and Moyamoya disease, along with thoracic aortic disease. Am J Med Genet 84: 617-627, 2009.
4. Dowell ML, Lavoie TL, Lakser OJ, Dulin NO, Fredberg JJ, Gerthoffer WT, Seow CY, Solway J. MEK modulates force-fluctuation-induced relengthening of canine tracheal smooth muscle. Eur Respir J 36: 630-637, 2010.
5. Fatigati V, Murphy RA. Actin and tropomyosin variants in smooth muscles. Dependence on tissue type. J Biol Chem 259: 14383-14888, 1984.
6. Fay FS, Fujiwara K, Rees DD, Fogarty KE. Distribution of α-actin in single isolated smooth muscle cells. J Cell Biol 96: 783-795, 1983. (Pubitemid 13131341)
7. Fu Y, Liu HW, Forsythe SM, Kogut P, McConville JF, Halayko AJ, Camoretti-Mercado B, Solway J. Mutagenesis analysis of human SM22: characterization of acting binding. J Appl Physiol 89: 1985-1990, 2000.
8. Gunst SJ, Zhang W. Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol 295: C576-C587, 2008.
9. Han D, Dong LH, Zheng B, Shi JH, Wen JK, Cheng Y. Smooth muscle 22 α maintains the differentiated phenotype of vascular smooth muscle cells by inducing actin bundling. Life Sci 84: 394-401, 2009.
10. Hantos Z, Daroczy B, Csendes T, Suki B, Nagy S. Modeling of low-frequency pulmonary impedance in dogs. J Appl Physiol 68: 849-860, 1990. (Pubitemid 20136405)
11. Harris DE, Warshaw DM. Smooth and skeletal muscle actin are mechanically indistinguishable in the in vitro motility assay. Circ Res 72: 219-224, 1993.
12. Hodgkinson JL, Newman TM, Marston SB, Severs NJ. The structure of the contractile apparatus in ultrarapidly frozen smooth muscle: freezefracture, deep-etch, and freeze-substitution studies. J Struct Biol 114: 93-104, 1995.
13. Jesudason EC, Smith NP, Connell MG, Spiller DG, White MRH, Fernig DG, Losty PD. Peristalsis of airway smooth muscle is developmentally regulated and uncoupled from hypoplastic lung growth. Am J Physiol Lung Cell Mol Physiol 291: L559-L565, 2006. (Pubitemid 44498464)
14. Kapsali T, Permutt S, Laube B, Scichilone N, Togias A. Potent bronchoprotective effect of deep inspiration and its absence in asthma. J Appl Physiol 89: 711-720, 2000. (Pubitemid 30637122)
15. Kumar A, Crawford K, Close L, Madison M, Lorenz J, Doetschman T, Pawlowski S, Duffy J, Neumann J, Robbins J, Boivin GP, O'Toole BA, Lessard JL. Rescue of cardiac alpha-actin deficient my by enteric smooth muscle gamma-actin. Proc Natl Acad Sci USA 94: 4406-4411, 1997.
16. Kuo KH, Seow CY. Contractile filament architecture and force transmission in swine airway smooth muscle. J Cell Sci 117: 1503-1511, 2004. (Pubitemid 38559825)
17. Lavoie TL, Dowell ML, Lakser OJ, Gerthoffer WT, Fredberg JJ, Seow CY, Mitchell RW, Solway J. Disrupting actin-myosin-actin connectivity in airway smooth muscle as a treatment for asthma? Proc Am Thorac Soc 6: 295-300, 2009.
18. Léguillette R, Laviolette M, Bergeron C, Zitouni N, Kogut P, Solway J, Kachmar L, Hamid Q, Lauzon AM. Myosin, transgrelin, and myosin light chain kinase expression and function in asthma. Am J Respir Crit Care Med 179: 194-204, 2009.
19. Lu W, Liu HW, McNeill KD, Stelmack G, Scott JE, Halayko AJ. Mechanical strain inhibits airway smooth muscle gene transcription via protein kinase C signaling. Am J Respir Cell Mol Biol 31: 54-61, 2004. (Pubitemid 38888039)
20. Milewicz DM, Øestergaard JR, Ala-Kokko LM, Grange DK, Mendoza-Londono R, Bradley TJ, Olney AH, Adés L, Maher JF, Buja LM, Kim D, Hyland JC, Regalado ES. De novo ACTA2 mutation causes a novel syndrome of multisystemic smooth muscle dysfunction. Am J Med Genet 152A: 2437-2443, 2010.
21. Oldmixon EH, Carlsson HK, Khun C III, Butler JP, Hoppin FG Jr. α-Actin: disposition, quantities, and estimated effects on lung recoil and compliance. J Appl Physiol 91: 459-473, 2001. (Pubitemid 32574757)
22. Panettieri RA, Murray RK, Depalo LR, Yadvish PA, Kotlokoff MI. A human airway smooth muscle line that retains physiological responsiveness. Am J Physiol Cell Physiol 255: C329-C335, 1988.
23. Schildmeyer LA, Braun R, Taffet G, Debiasi M, Burns AE, Bradley A, Schwartz RJ. Impaired vascular contractility and blood pressure homeostasis in the smooth muscle α-actin null mouse. FASEB J 14: 2213-2220, 2000.
24. Schuessler TF, Bates JHT. A computer-controlled research ventilator for small animals: design and evaluation. IEEE Trans Biomed Eng 42: 860-866, 1995.
25. Scichilone N, Permutt S, Togias A. The lack of the bronchoprotective and not the bronchodilatory ability of deep inspiration is associated with airway hyperresponsiveness. Am J Respir Crit Care Med 163: 413-419, 2001. (Pubitemid 32158521)
26. Seaborn T, St-Amand J, Cloutier M, Tremblay MG, Maltais F, Dinel S, Moulin V, Khan PA, Piedboeuf B. Identification of cellular processes that are rapidly modulated in response to tracheal occlusion within mice lungs. Pediatr Res 63: 124-130, 2008.
27. Shardonofsky FR, Capetanaki Y, Boriek AM. Desmin modulates lung elastic recoil and airway responsiveness. Am J Physiol Lung Cell Mol Physiol 290: L890-L896, 2006. (Pubitemid 43725051)
28. Shen X, Gunst SJ, Tepper RS. Effects of tidal volume and frequency on airway responsiveness in mechanically ventilated rabbits. J Appl Physiol 83: 1202-1208, 1997. (Pubitemid 27433088)
29. Singh SR, Hall IP. Airway myofibroblasts and their relationship with airway myocytes and fibroblasts. Proc Am Thorac Soc 5: 127-132, 2008.
30. Solway J, Bellam S, Dowell M, et al. Actin dynamics: a potential integrator of small muscle (dys-)function and contractile apparatus gene expression in asthma. Parker B Davis Lecture Chest 123, Suppl 3: 392S-398S. 2003. (Pubitemid 36315433)
31. Takeji M, Moriyama T, Oseto S, Kawada N, Hori M, Imai E, Miwa T. Smooth muscle α-actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis. J Biol Chem 281: 40193-40200, 2006. (Pubitemid 46041824)
32. Tock J, Van Putten V, Stenmark KR, Nemenoff RA. Induction of SM-α-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase. Biochem Biophys Res Commun 301: 1116-1121, 2003. (Pubitemid 36279228)
33. Vanderkerckhove J, Weber K. At least six different actins are expressed in higher mammals: an analysis based on the amino acid sequence of the amino-terminal peptide. J Mol Biol 126: 783-802, 1978.
34. Zeidan A, Nordström I, Albisson S, Malmqvist U, Hellstrand P. Stretch-induced contractile differentiation of vascular smooth muscle: sensitivity to actin polymerization inhibitors. Am J Physiol Cell Physiol 284: C1387-C1396, 2003. (Pubitemid 36583379)
35. Zhang W, Gunst SJ. Interactions of airway smooth muscle cells with their tissue matrix. Implications for contraction. Proc Am Thorac Soc 5: 32-39, 2008.
36. Zimmerman RA, Tomasek JJ, McRae J, Haaksma CJ, Schwartz RJ, Lin HK, Cowan RL, Jones AN, Kropp BP. Decreased expression of smooth muscle α-actin results in decreased contractile function of the mouse bladder. J Urol 172: 1667-1672, 2004. (Pubitemid 39245013)