Predictors of vitamin B6 and folate concentrations in older persons: The InCHIANTI study

Clinical Chemistry

Volumn 52, Issue 7, 2006, Pages 1318-1324

  Gori, Anna Maria ^a   Sofi, Francesco ^a   Corsi, Anna Maria ^a,c   Gazzini, Alessandra ^a   Sestini, Ilaria ^a   Lauretani, Fulvio ^c   Bandinelli, Stepania ^d   Gensini, Gian Franco ^a,b   Ferrucci, Luigi ^e   Abbate, Rosanna ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^c Tuscany Regional Health Agency   (Italy)

^d Azienda Sanitaria di Firenze   (Italy)

^e NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); ALBUMIN; ANTIOXIDANT; ASCORBIC ACID; C REACTIVE PROTEIN; CREATININE; CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; INTERLEUKIN 6 RECEPTOR; PYRIDOXINE; RETINOL; IL1RN PROTEIN, HUMAN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 6; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); SIALOGLYCOPROTEIN;

ADULT; AGED; ALBUMIN BLOOD LEVEL; ARTICLE; CALORIC INTAKE; CARDIOVASCULAR DISEASE; CREATININE BLOOD LEVEL; DIETARY INTAKE; FEMALE; FOLIC ACID BLOOD LEVEL; GENOTYPE; HUMAN; INFLAMMATION; MALE; NORMAL HUMAN; SMOKING; VASCULAR DISEASE; VITAMIN BLOOD LEVEL; VITAMIN INTAKE; BLOOD; GENETIC VARIABILITY; GENETICS; LEUKOCYTE COUNT; MIDDLE AGED; STATISTICAL MODEL;

ADULT; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; FEMALE; FOLIC ACID; HUMANS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-6; LEUKOCYTE COUNT; LINEAR MODELS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MIDDLE AGED; SIALOGLYCOPROTEINS; VARIATION (GENETICS); VITAMIN B 6;

EID: 33745460378     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2005.066217     Document Type: Article

References (36)

1. Voutilainen S, Lakka TA, Porkkala-Sarataho E, Rissanen T, Kaplan GA, Salonen JT. Low serum folate concentrations are associated with an excess incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Eur J Clin Nutr 2000;54:424-8.
2. Booth GL, Wang EEL. Preventive health care, 2000 update: screening and management of hyperhomocysteinemia for the prevention of coronary artery disease events. The Canadian Task Force on Preventive Health Care. CMAJ 2000;163:21-9.
3. Voutilainen S, Rissanen TH, Virtanen J, Lakka TA, Salonen JT. Kuopio Ischemic Heart Disease Risk Factor Study: low dietary folate intake is associated with an excess incidence of acute coronary events: The Kuopio Ischemic Heart Disease Risk Factor Study. Circulation 2001;103:2674-80.
4. Hu FB, Willett WC. Diet and coronary heart disease: findings from the Nurses' Health Study and Health Professionals' Follow-up Study. J Nutr Health Aging 2001;5:132-8.
5. Bazzano LA, He J, Ogden LG, Loria C, Vupputuri S, Myers L, et al. Dietary intake of folate and risk of stroke in US men and women: NHANES I Epidemiologic Follow-up Study. National Health and Nutrition Examination Survey. Stroke 2002;33:1183-8.
6. Voutilainen S, Virtanen JK, Rissanen TH, Alfthan G, Laukkanen J, Nyyssonen K, et al. Serum folate and homocysteine and the incidence of acute coronary events: the Kuopio Ischaemic Heart Disease Risk Factor Study. Am J Clin Nutr 2004;80:317-23.
7. Friso S, Girelli D, Martinelli N, Olivieri O, Lotto V, Bozzini C, et al. Low plasma vitamin B-6 concentrations and modulation of coronary artery disease risk. Am J Clin Nutr 2004;79:992-8.
8. Blake GJ, Ridker PM. Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med 2002;252:283-94.
9. Libby P, Ridker PM. Inflammation and atherosclerosis: role of C-reactive protein in risk assessment. Am J Med 2004;111:9S-16S.
10. Ridker PM. High-sensitivity C-reactive protein and cardiovascular risk: rationale for screening and primary prevention. Am J Cardiol 2003;92:17K-22K.
11. Blake GJ, Ridker PM. C-reactive protein and other inflammatory risk markers in acute coronary syndromes. J Am Coll Cardiol 2003;41:37S-42S.
12. Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation 2004;109:2-10.
13. Biasucci LM, Liuzzo G, Fantuzzi G, Caligiuri G, Rebuzzi AG, Ginnetti F, et al. Increasing concentrations of interleukin (IL)-1Ra and IL-6 during the first 2 days of hospitalization in unstable angina are associated with increased risk of in-hospital coronary events. Circulation 1999;99:2079-84.
14. Ridker PM, Rifai N, Stampfer MJ, Hennekens CH. Plasma concentration of interleukin-6 and the risk of future myocardial infarction among apparently healthy men. Circulation 2000;101:1767-72.
15. Lindmark E, Diderholm E, Wallentin L, Siegbahn A. Relationship between interleukin 6 and mortality in patients with unstable coronary artery disease: effects of an early invasive or non-invasive strategy. JAMA 2001;286:2107-13.
16. Cesari M, Penninx BW, Newman AB, Kritchevsky SB, Nicklas BJ, Sutton-Tyrrell K, et al. Inflammatory markers and onset of cardiovascular events: results from the Health ABC study. Circulation 2003;108:2317-22.
17. Friso S, Jacques PF, Wilson PW, Rosenberg IH, Selhub J. Low circulating vitamin B(6) is associated with elevation of the inflammation marker C-reactive protein independently of plasma homocysteine concentrations. Circulation 2001;103:2788-91.
18. Turk MJ, Breur GJ, Widmer WR, Paulos CM, Xu LC, Grote LA, et al. Folate-targeted imaging of activated macrophages in rats with adjuvant-induced arthritis. Arthritis Rheum 2002;46:1947-55.
19. Chiang EP, Bagley PJ, Selhub J, Nadeau M, Roubenoff R. Abnormal vitamin B(6) status is associated with severity of symptoms in patients with rheumatoid arthritis. Am J Med 2003;114:283-7.
20. Ferrucci L, Bandinelli S, Benvenuti E, Di Iorio A, Macchi C, Harris TB, et al. Subsystems contributing to the decline in ability to walk: bridging the gap between epidemiology and geriatric practice in the InCHIANTI study. J Am Geriatr Soc 2000;48:1618-25.
21. Third report of the National Cholesterol Education Program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adult (Adult Treatment Panel III): final report. Circulation 2002;106:3143-421.
22. Gori AM, Corsi AM, Fedi S, Gazzini A, Sofi F, Bartali B, et al. A proinflammatory state is associated with hyperhomocysteinemia in the elderly population. Am J Clin Nutr 2005;82:335-41.
23. Frusconi S, Giusti B, Rossi L, Bernabini S, Poggi F, Giotti I, et al. Improvement of low-density microelectronic array technology to characterize 14 mutations/single-nucleotide polymorphisms from several human genes on a large scale. Clin Chem 2004;50:775-7.
24. Pisani P, Faggiano F, Krogh V, Palli D, Vineis P, Berrino F. Relative validity and reproducibility of a food frequency dietary questionnaire for use in the Italian EPIC centres. Int J Epidemiol 1997;26: S152-60.
25. Salvini S. A food composition database for epidemiological studies in Italy. Cancer Lett 1997;114:299-300.
26. Saibeni S, Cattaneo M, Vecchi M, Zighetti ML, Lecchi A, Lombardi R, et al. Low vitamin B(6) plasma levels, a risk factor for thrombosis, in inflammatory bowel disease: role of inflammation and correlation with acute phase reactants. Am J Gastroenterol 2003;98:112-7.
27. Kelly PJ, Kistler JP, Shih VE, Mandell R, Atassi N, Barron M, et al. Inflammation, homocysteine, and vitamin B6 status after ischemic stroke. Stroke 2004;35:12-5.
28. Folsom AR, Desvarieux M, Nieto FJ, Boland LL, Ballantyne CM, Chambless LE. B vitamin status and inflammatory markers. Atherosclerosis 2003;169:169-74.
29. Jones SA, Horiuchi S, Topley N, Yamamoto N, Fuller GM. The soluble interleukin 6 receptor: mechanisms of production and implications in disease. FASEB J 2001;15:43-8.
30. Anderson TW. Large-scale trials of vitamin C. Ann N Y Acad Sci 1975;258:498-504.
31. Cafolla A, Dragoni F, Girelli G, Tosti ME, Costante A, De Luca AM, et al. Effect of folic acid and vitamin C supplementation on folate status and homocysteine level: a randomized controlled trial in Italian smoker-blood donors. Atherosclerosis 2002;163:105-11.
32. Girelli D, Friso S, Trabetti E, Olivieri O, Russo C, Pessotto R, et al. Methylenetetrahydrofolate reductase C677T mutation, plasma homocysteine, and folate in subjects from northern Italy with or without angiographically documented severe coronary atherosclerotic disease: evidence for an important genetic-environmental interaction. Blood 1998;91:4158-63.
33. Friso S, Choi SW, Girelli D, Mason JB, Dolnikowski GG, Bagley PJ, et al. A common mutation in the 5,10-methylenetetrahydrofolate reductase gene affects genomic DNA methylation through an interaction with folate status. Proc Natl Acad Sci U S A 2002;99:5606-11.
34. de Bree A, Verschuren WM, Bjorke-Monsen AL, van der Put NM, Heil SG, Trijbels FJ, et al. Effect of the methylenetetrahydrofolate reductase 677C→T mutation on the relations among folate intake and plasma folate and homocysteine concentrations in a general population sample. Am J Clin Nutr 2003;77:687-93.
35. Lonn E, Yusuf S, Arnold MJ, Sheridan P, Pogue J, Micks M, et al.; Heart Outcomes Prevention Evaluation (HOPE) 2 Investigators. Homocysteine lowering with folic acid and B vitamins in vascular disease. N Engl J Med 2006;354:1567-77.
36. Bonaa KH, Njolstad I, Ueland PM, Schirmer H, Tverdal A, Steigen T, et al; NORVIT Trial investigators. Homocysteine lowering and cardiovascular events after acute myocardial infarction. N Engl J Med 2006;354:1626-32.