Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker

Bioorganic and Medicinal Chemistry

Volumn 21, Issue 21, 2013, Pages 6642-6649

  Richard, David J ^a   Lena, Ryan ^a   Bannister, Thomas ^b   Blake, Noel ^a   Pierceall, William E ^a   Carlson, Nicole E ^a   Keller, Christina Eberhart ^b   Koenig, Marcel ^b   He, Yuanjun ^b   Minond, Dmitriy ^b   Mishra, Jitendra ^b   Cameron, Michael ^b   Spicer, Timothy ^b   Hodder, Peter ^b   Cardone, Michael H ^a  

^a Eutropics Pharmaceuticals   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Apoptosis; Biomarkers; Cell based activity; Mcl 1; Oncology

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN INHIBITOR; PROTEIN MCL 1; PROTEIN MCL 1 INHIBITOR; QUINOLINOL DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL LEVEL; CELL SURVIVAL; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PERSONALIZED MEDICINE; PROTEIN TARGETING;

APOPTOSIS; BIOMARKERS; CELL-BASED ACTIVITY; MCL-1; ONCOLOGY;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; BINDING SITES; BIOLOGICAL MARKERS; CELL LINE, TUMOR; CYTOCHROMES C; HIGH-THROUGHPUT SCREENING ASSAYS; HL-60 CELLS; HUMANS; HYDROXYQUINOLINES; MICE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PIPERAZINES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84885189198     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.08.017     Document Type: Article

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