In human pseudouridine synthase 1 (hPus1), a C-terminal helical insert blocks tRNA from binding in the same orientation as in the Pus1 bacterial homologue TruA, consistent with their different target selectivities

Journal of Molecular Biology

Volumn 425, Issue 20, 2013, Pages 3875-3887

  Czudnochowski, Nadine ^a   Wang, Amy Liya ^a   Finer Moore, Janet ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

isomerase; pseudouridine; RNA modifying enzyme; tRNA; X ray crystallography

Indexed keywords

HUMAN PSEUDOURIDINE SYNTHASE 1; PSEUDOURIDINE; TRANSFER RNA; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ESCHERICHIA COLI; GEL PERMEATION CHROMATOGRAPHY; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MIMICRY; MOLECULE; PRIORITY JOURNAL; RNA ANALYSIS; RNA BINDING; RNA CONFORMATION; RNA FOLDING; STATIC ELECTRICITY; STRUCTURE ANALYSIS; SURFACE PROPERTY;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA;

EID: 84885181433     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2013.05.014     Document Type: Article

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