Removal of substrate inhibition and increase in maximal velocity in the short chain dehydrogenase/reductase salutaridine reductase involved in morphine biosynthesis

Journal of Biological Chemistry

Volumn 284, Issue 39, 2009, Pages 26758-26767

  Ziegler, Jörg ^a   Brandt, Wolfgang ^b   Geißler, René ^b,c   Facchini, Peter J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SUBSTITUTION; DOUBLE MUTANTS; HOMOLOGY MODELING; HYDROGEN-BOND FORMATION; HYDROPHOBIC INTERACTIONS; MAXIMAL VELOCITY; MORPHINE BIOSYNTHESIS; SITE DIRECTED MUTAGENESIS; STEREOSPECIFIC REDUCTIONS; SUBSTRATE BINDING; SUBSTRATE INHIBITION; WILD TYPES;

AMINATION; AMINES; AMINO ACIDS; BINDING SITES; BIOCHEMISTRY; BIOSYNTHESIS; DEHYDROGENATION; DOCKING; ENZYME ACTIVITY; ENZYME KINETICS; ENZYMES; HYDROGEN; HYDROGEN BONDS; HYDROPHOBICITY; ORGANIC ACIDS; SUBSTRATES;

ENZYME INHIBITION;

MORPHINE; OXIDOREDUCTASE; SALUTARIDINE REDUCTASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME SUBSTRATE; HYDROGEN BOND; MOLECULAR DOCKING; MOLECULAR MODEL; MUTANT; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; WILD TYPE;

BIOSYNTHETIC PATHWAYS; CATALYSIS; CATALYTIC DOMAIN; CIRCULAR DICHROISM; KINETICS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MORPHINANS; MORPHINE; MUTAGENESIS, SITE-DIRECTED; MUTATION; NADP; OXIDOREDUCTASES; PLANT PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SUBSTRATE SPECIFICITY;

EID: 70350366891     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.030957     Document Type: Article

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