Characterization of a flavoprotein oxidase from opium poppy catalyzing the final steps in sanguinarine and papaverine biosynthesis

Journal of Biological Chemistry

Volumn 287, Issue 51, 2012, Pages 42972-42983

  Hagel, Jillian M ^a   Beaudoin, Guillaume A W ^a   Fossati, Elena ^b   Ekins, Andrew ^b   Martin, Vincent J J ^b   Facchini, Peter J ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b Dept of Electrical and Computer Engineering   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CANDIDATE GENES; CDNA ENCODING; DIHYDROSANGUINARINE; FUNCTIONAL CHARACTERIZATION; HETEROLOGOUS EXPRESSION; HIGH CONCENTRATION; OPIUM POPPY; OXIDATIVE ENZYMES; PAPAVER SOMNIFERUM; PICHIA PASTORIS; PROTOBERBERINE ALKALOIDS; RECOMBINANT ENZYMES; RING SYSTEMS; SANGUINARINE; TRANSCRIPT LEVEL; TRANSCRIPTOMES; TWO-ELECTRON OXIDATION; VIRUS-INDUCED GENE SILENCING;

BIOCHEMISTRY; BIOSYNTHESIS; CATALYSIS; ENZYMES; GENE EXPRESSION; GENETIC ENGINEERING; METABOLITES; NITROGEN COMPOUNDS; VIRUSES;

OXIDATION;

ALKALOID; BENZOPHENANTHRIDINE; BERBERINE; BERBERINE BRIDGE ENZYME 1; BERBERINE BRIDGE ENZYME 2; CANADINE; COMPLEMENTARY DNA; DIHYDROBENZOPHENANTHRIDINE OXIDASE; DIHYDROPAPAVERINE; DIHYDROSANGUINARINE; OXIDOREDUCTASE; PAPAVERINE; PROTOBERBERINE; RETICULINE; SANGUINARINE; SCOULERINE; TETRAHYDROPAPAVERINE; TETRAHYDROPROTOBERBERINE OXIDASE; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ARTICLE; BIOACCUMULATION; BIOSYNTHESIS; CATALYSIS; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRON OXIDATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ISOLATION; ENZYME METABOLISM; GENE EXPRESSION; GENE SILENCING; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PAPAVER SOMNIFERUM; PHYLOGENETIC TREE; PICHIA PASTORIS; PLANT ROOT; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

BENZOPHENANTHRIDINES; BIOCATALYSIS; ENZYME ASSAYS; FLAVOPROTEINS; GENE EXPRESSION REGULATION, PLANT; GENE SILENCING; GENES, PLANT; GENETIC ASSOCIATION STUDIES; ISOQUINOLINES; OPIUM; OXIDOREDUCTASES; PAPAVER; PAPAVERINE; PHYLOGENY; PLANT VIRUSES; RNA, MESSENGER; SUBSTRATE SPECIFICITY;

PAPAVER SOMNIFERUM; PICHIA PASTORIS;

EID: 84871165564     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.420414     Document Type: Article

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