Hepatic bile acids and bile acid-related gene expression in pregnant and lactating rats

PeerJ

Volumn 2013, Issue 1, 2013, Pages

  Zhu, Qiong N ^a   Xie, Hong M ^a   Zhang, Dan ^a   Liu, Jie ^a,b   Lu, Yuan F ^a  

^a ZUNYI MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

Author keywords

Cyp7a1; FXR SHP; Liver bile acids; Ntcp and Bsep; Oatps; Pregnant and lactating rats

Indexed keywords

BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTANETRIOL 26 MONOOXYGENASE; CYTOCHROME P450; ESTROGEN RECEPTOR ALPHA; FARNESOID X RECEPTOR; HETERODIMER; LIVER PROTEIN; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; STEROID 12ALPHA MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME REGULATION; GENE EXPRESSION; GESTATION PERIOD; HEPATIC DUCT; LACTATION; LIVER HOMOGENATE; NONHUMAN; POSTNATAL CARE; PREGNANCY; PUERPERIUM; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

EID: 84885146919     PISSN: None     EISSN: 21678359     Source Type: Journal    
DOI: 10.7717/peerj.143     Document Type: Article

References (35)

1. Abu-Hayyeh S,Martinez-Becerra P, Sheikh Abdul Kadir SH, Selden C, Romero MR, Rees M,Marschall H-U,Marin JJG,Williamson C. 2010. Inhibition of NaC-taurocholate Co-transporting polypeptide-mediated bile acid transport by cholestatic sulfated progesterone metabolites. The Journal of Biological Chemistry 285:16504-16512 DOI 10.1074/jbc.M109.072140.
2. Abu-Hayyeh S, Papacleovoulou G,Williamson C. 2013. Nuclear receptors, bile acids and cholesterol homeostasis series-bile acids and pregnancy. Molecular and Cellular Endocrinology 368:120-128 DOI 10.1016/j.mce.2012.10.027.
3. Abu-Hayyeh S, Papacleovoulou G, Lövgren-SandblomA, Tahir M, Oduwole O, Jamaludin NA, Ravat S, Nikolova V, Chambers J, Selden C, Rees M,Marschall HU, Parker MG, Williamson C. 2013. Intrahepatic cholestasis of pregnancy levels of sulfated progesterone metabolites inhibit farnesoid X receptor resulting in a cholestatic phenotype. Hepatology 57:716-726 DOI 10.1002/hep.26055.
4. Aleksunes LM, Yeager RL,Wen X, Cui JY, Klaassen CD. 2012. Repression of hepatobiliary transporters and differential regulation of classic and alternative bile acid pathways in mice during pregnancy. Toxicological Sciences 130:257-268 DOI 10.1093/toxsci/kfs248.
5. Anzivino C, Odoardi MR,Meschiari E, Baldelli E, Facchinetti F, Neri I, Ruggiero G, Zampino R, Bertolotti M, Loria P, Carulli L. 2013. ABCB4 and ABCB11 mutations in intrahepatic cholestasis of pregnancy in an Italian population. Digestive and Liver Disease 45:226-232 DOI 10.1016/j.dld.2012.08.011.
6. Arrese M, Trauner M, Ananthanarayanan M, Pizarro M, Solís N, Accatino L, Soroka C, Boyer JL, Karpen SJ,Miquel JF, Suchy FJ. 2003. Down-regulation of the NaC/taurocholate cotransporting polypeptide during pregnancy in the rat. Journal of Hepatology 38:148-155 DOI 10.1016/S0168-8278(02)00379-3.
7. Arrese M,Macias RI, Briz O, Perez MJ,Marin JJ. 2008. Molecular pathogenesis of intrahepatic cholestasis of pregnancy. Expert Reviews in Molecular Medicine 10:e9 DOI 10.1017/S1462399408000628.
8. Athippozhy A, Huang L,Wooton-Kee CR, Zhao T, Jungsuwadee P, Stromberg AJ, Vore M. 2011. Differential gene expression in liver and small intestine from lactating rats compared to age-matched virgin controls detects increased mRNA of cholesterol biosynthetic genes. BMC Genomics 12(1):95 DOI 10.1186/1471-2164-12-95.
9. Barth A, Rost M, Kindt A, Peiker G. 2005. Serum bile acid profile in women during pregnancy and childbed. Experimental and Clinical Endocrinology & Diabetes 113:372-375 DOI 10.1055/s-2005-865719.
10. Blazquez AG, Briz O, Romero MR, Rosales R,Monte MJ, Vaquero J,Macias RI, Cassio D, Marin JJ. 2012. Characterization of the role of ABCG2 as a bile acid transporter in liver and placenta. Molecular Pharmacology 81:273-283 DOI 10.1124/mol.111.075143.
11. Cao J, Huang L, Liu Y, Hoffman T, Stieger B,Meier PJ, Vore M. 2001. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin. Hepatology 33:140-147 DOI 10.1053/jhep.2001.20895.
12. Cao J, Stieger B,Meier PJ, Vore M. 2002. Expression of rat hepatic multidrug resistance-associated proteins and organic anion transporters in pregnancy. American Journal of Physiology Gastrointestinal and Liver Physiology 283:G757-G766 DOI 10.1152/ajpgi.00126.2002.
13. Carlin A, Alfirevic Z. 2008. Physiological changes of pregnancy and monitoring. Best Practice & research. Clinical Obstetrics & Gynaecology 22:801-823 DOI 10.1016/j.bpobgyn.2008.06.005.
14. Chiang JY. 2009. Bile acids: regulation of synthesis. Journal of Lipid Research 50:1955-1966 DOI 10.1194/jlr.R900010-JLR200
15. Cripps AW,Williams VJ. 1975. The effect of pregnancy and lactation on food intake, gastrointestinal anatomy and the absorptive capacity of the small intestine in the albino rat. The British Journal of Nutrition 33:17-32 DOI 10.1079/BJN19750005.
16. Cui YJ, Aleksunes LM, Tanaka Y, Goedken MJ, Klaassen CD. 2009. Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice. Toxicological Sciences 110:47-60 DOI 10.1093/toxsci/kfp094.
17. Csanaky IL, Lu H, Zhang Y, Ogura K, Choudhuri S, Klaassen CD. 2011. Organic aniontransporting polypeptide 1b2 (Oatp1b2) is important for the hepatic uptake of unconjugated bile acids: studies in Oatp1b2-null mice. Hepatology 53:272-281 DOI 10.1002/hep.23984.
18. Diken Z, Usta IM, Nassar AH. 2013. A clinical approach to intrahepatic cholestasis of pregnancy. American Journal of Perinatology Epub ahead of print Jan 28 2013 DOI 10.1055/s-0033-1333673.
19. Dixon PH,Weerasekera N, Linton KJ, Donaldson O, Chambers J, Egginton E,Weaver J, Nelson-Piercy C, de Swiet M,Warnes G, Elias E, Higgins CF, Johnston DG,McCarthy MI, Williamson C. 2000. Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Human Molecular Genetics 9:1209-1217 DOI 10.1093/hmg/9.8.1209.
20. Dixon PH, vanMil SW, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V, Glantz A,Mattsson LA,Marschall HU,Molokhia M,Moore GE, Linton KJ, Williamson C. 2009. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut 58:537-544 DOI 10.1136/gut.2008.159541.
21. Egan N, Bartels A, Khashan AS, Broadhurst DI, Joyce C, O'Mullane J, O'Donoghue K. 2012. Reference standard for serum bile acids in pregnancy. BJOG 119:493-498 DOI 10.1111/j.1471-0528.2011.03245.x.
22. Floreani A, Caroli D, Lazzari R,Memmo A, Vidali E, Colavito D, D'Arrigo A, Leon A, Romero R, Gervasi M. 2013. Intrahepatic cholestasis of pregnancy: new insights into its pathogenesis. The Journal of Maternal-Fetal & Neonatal Medicine Epub ahead of print Mar 12 2013 DOI 10.3109/14767058.2013.783810.
23. Geenes V,Williamson C. 2009. Intrahepatic cholestasis of pregnancy. World Journal of Gastroenterology 15:2049-2066 DOI 10.3748/wjg.15.2049.
24. Lam P, Soroka CJ, Boyer JL. 2010. The bile salt export pump: clinical and experimental aspects of genetic and acquired cholestatic liver disease. Seminars in Liver Diseases 30:125-133 DOI 10.1055/s-0030-1253222.
25. Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD. 2008. Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicological Sciences 103:35-45 DOI 10.1093/toxsci/kfn038.
26. Milona A, Owen BM, Cobbold JF,Willemsen EC, Cox IJ, Boudjelal M, Cairns W, Schoonjans K, Taylor-Robinson SD, Klomp LW, Parker MG,White R, vanMil SW,Williamson C. 2010. Raised hepatic bile acid concentrations during pregnancy in mice are associated with reduced farnesoid X receptor function. Hepatology 52:1341-1349 DOI 10.1002/hep.23849.
27. Papacleovoulou G, Abu-Hayyeh S,Williamson C. 2011. Nuclear receptor-driven alterations in bile acid and lipid metabolic pathways during gestation. Biochimica et Biophysica Acta 1812:879-887 DOI 10.1016/j.bbadis.2010.11.001.
28. Pascual MJ, Serrano MA, El-Mir MY,Macias RI, Jiménez F,Marin JGJ. 2002. Relationship between asymptomatic hypercholanaemia of pregnancy and progesterone metabolism. Clinical Science 102:587-593 DOI 10.1042/CS20010258.
29. Shuster DL, Bammler TK, Beyer RP,Macdonald JW, Tsai JM, Farin FM, Hebert MF, Thummel KE,Mao Q. 2013. Gestational age-dependent changes in gene expression of metabolic enzymes and transporters in pregnant mice. Drug Metabolism and Disposition 41:332-342 DOI 10.1124/dmd.112.049718.
30. Vallejo M, Briz O, Serrano MA,Monte MJ,Marin JGJ. 2006. Potential role of trans-inhibition of the bile salt export pump by progesterone metabolites in the etiopathogenesis of intrahepatic cholestasis of pregnancy. Journal of Hepatology 44:1150-1157 DOI 10.1016/j.jhep.2005.09.017.
31. vanMil SWC,Milona A, Dixon PH,Mullenbach R, Geenes VL, Chambers J, Shevchuk V, Moore GE, Lammert F, Glantz AG,Mattsson LA,Whittaker J, Parker MG,White R, Williamson C. 2007. Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy. Gastroenterology 133:507-516 DOI 10.1053/j.gastro.2007.05.015.
32. Vernon RG, Denis RG, Sorensen A,Williams G. 2002. Leptin and the adaptations of lactation in rodents and ruminants. Hormone Metabolic Research 34:678-685 DOI 10.1055/s-2002-38258.
33. Wooton-Kee CR, Cohen DE, Vore M. 2008. Increased cholesterol 7alpha-hydroxylase expression and size of the bile acid pool in the lactating rat. American Journal of Physiology Gastrointestinal and Liver Physiology 294:G1009-G1016 DOI 10.1152/ajpgi.00017.2008.
34. Wooton-Kee CR, Coy DJ, Athippozhy AT, Zhao T, Jones BR, Vore M. 2010. Mechanisms for increased expression of cholesterol 7alpha-hydroxylase (Cyp7a1) in lactating rats. Hepatology 51:277-285 DOI 10.1002/hep.23289.
35. Zhang Y, Csanaky IL, Cheng X, Lehman-McKeeman LD, Klaassen CD. 2012. Organic anion transporting polypeptide 1a1 null mice are sensitive to cholestatic liver injury. Toxicological Sciences 127:451-462 DOI 10.1093/toxsci/kfs123.