Endurance Exercise Diverts the Balance between Th17 Cells and Regulatory T Cells

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Perry, Chava ^a   Pick, Marjorie ^b   Bdolach, Nir ^c   Hazan Halevi, Inbal ^a   Kay, Sigi ^a   Berr, Idit ^a   Reches, Adi ^c   Harishanu, Yair ^a   Grisaru, Dan ^c  

^a TEL AVIV SOURASKY MEDICAL CENTER   (Israel)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c LIS MATERNITY HOSPITAL   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CD4 LYMPHOCYTE COUNT; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; EFFECTOR CELL; ENDURANCE TRAINING; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; LEUKOCYTE COUNT; LYMPHOCYTE COUNT; MALE; MARATHON RUNNER; NEUTROPHIL COUNT; NORMAL HUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; REGULATORY T LYMPHOCYTE; TH17 CELL; TRIATHLON;

ADULT; CD4-POSITIVE T-LYMPHOCYTES; CYTOKINES; EXERCISE; FEMALE; HUMANS; INTERLEUKIN-2; INTERLEUKIN-6; MALE; MIDDLE AGED; T-LYMPHOCYTES, REGULATORY; TH17 CELLS;

EID: 84885132475     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0074722     Document Type: Article

References (37)

1. Das UN, (2006) Exercise and inflammation. Eur Heart J 27: 1385; author reply 1385-1386.
2. Matthews CE, Ockene IS, Freedson PS, Rosal MC, Merriam PA, et al. (2002) Moderate to vigorous physical activity and risk of upper-respiratory tract infection. Med Sci Sports Exerc 34: 1242-1248.
3. Nieman DC, Johanssen LM, Lee JW, Arabatzis K, (1990) Infectious episodes in runners before and after the Los Angeles Marathon. J Sports Med Phys Fitness 30: 316-328.
4. Nieman DC, Pedersen BK, (1999) Exercise and immune function. Recent developments. Sports Med 27: 73-80.
5. Alaranta A, Alaranta H, Palmu P, Alha P, Pietila K, et al. (2004) Asthma medication in Finnish olympic athletes: no signs of inhaled beta2-agonist overuse. Med Sci Sports Exerc 36: 919-924.
6. Nystad W, Harris J, Borgen JS, (2000) Asthma and wheezing among Norwegian elite athletes. Med Sci Sports Exerc 32: 266-270.
7. Robson-Ansley P, Howatson G, Tallent J, Mitcheson K, Walshe I, et al. (2012) Prevalence of Allergy and Upper Respiratory Tract Symptoms in Runners of the London Marathon. Med Sci Sports Exerc 44: 999-1004.
8. Helenius I, Rytila P, Sarna S, Lumme A, Helenius M, et al. (2002) Effect of continuing or finishing high-level sports on airway inflammation, bronchial hyperresponsiveness, and asthma: a 5-year prospective follow-up study of 42 highly trained swimmers. J Allergy Clin Immunol 109: 962-968.
9. Annunziato F, Cosmi L, Santarlasci V, Maggi L, Liotta F, et al. (2007) Phenotypic and functional features of human Th17 cells. J Exp Med 204: 1849-1861.
10. Cheung PF, Wong CK, Lam CW, (2008) Molecular mechanisms of cytokine and chemokine release from eosinophils activated by IL-17A, IL-17F, and IL-23: implication for Th17 lymphocytes-mediated allergic inflammation. J Immunol 180: 5625-5635.
11. Chatila TA, (2005) Role of regulatory T cells in human diseases. J Allergy Clin Immunol 116: 949-959; quiz 960.
12. Wang RF, (2006) Functional control of regulatory T cells and cancer immunotherapy. Semin Cancer Biol 16: 106-114.
13. Chen W, Jin W, Hardegen N, Lei KJ, Li L, et al. (2003) Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 198: 1875-1886.
14. Fu S, Zhang N, Yopp AC, Chen D, Mao M, et al. (2004) TGF-beta induces Foxp3 + T-regulatory cells from CD4 + CD25 - precursors. Am J Transplant 4: 1614-1627.
15. Samanta A, Li B, Song X, Bembas K, Zhang G, et al. (2008) TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc Natl Acad Sci U S A 105: 14023-14027.
16. Bettelli E, Carrier Y, Gao W, Korn T, Strom TB, et al. (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441: 235-238.
17. Lochner M, Peduto L, Cherrier M, Sawa S, Langa F, et al. (2008) In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J Exp Med 205: 1381-1393.
18. Balen S, Vukelic-Damijani N, Persic V, Ruzic A, Miletic B, et al. (2008) Anti-inflammatory effects of exercise training in the early period after myocardial infarction. Coll Antropol 32: 285-291.
19. Kasapis C, Thompson PD, (2005) The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review. J Am Coll Cardiol 45: 1563-1569.
20. Nicklas BJ, Hsu FC, Brinkley TJ, Church T, Goodpaster BH, et al. (2008) Exercise training and plasma C-reactive protein and interleukin-6 in elderly people. J Am Geriatr Soc 56: 2045-2052.
21. Haahtela T, Malmberg P, Moreira A, (2008) Mechanisms of asthma in Olympic athletes-practical implications. Allergy 63: 685-694.
22. Walsh NP, Gleeson M, Shephard RJ, Woods JA, Bishop NC, et al. (2011) Position statement. Part one: Immune function and exercise. Exerc Immunol Rev 17: 6-63.
23. Crome SQ, Wang AY, Levings MK, (2010) Translational mini-review series on Th17 cells: function and regulation of human T helper 17 cells in health and disease. Clin Exp Immunol 159: 109-119.
24. Borsellino G, Kleinewietfeld M, Di Mitri D, Sternjak A, Diamantini A, et al. (2007) Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232.
25. Yegutkin GG, Samburski SS, Mortensen SP, Jalkanen S, Gonzalez-Alonso J, (2007) Intravascular ADP and soluble nucleotidases contribute to acute prothrombotic state during vigorous exercise in humans. J Physiol 579: 553-564.
26. Das UN, (2004) Anti-inflammatory nature of exercise. Nutrition 20: 323-326.
27. Neubauer O, Konig D, Wagner KH, (2008) Recovery after an Ironman triathlon: sustained inflammatory responses and muscular stress. Eur J Appl Physiol 104: 417-426.
28. Suzuki K, Nakaji S, Yamada M, Totsuka M, Sato K, et al. (2002) Systemic inflammatory response to exhaustive exercise. Cytokine kinetics. Exerc Immunol Rev 8: 6-48.
29. Veldhoen M, Hocking RJ, Atkins CJ, Locksley RM, Stockinger B, (2006) TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189.
30. Beriou G, Costantino CM, Ashley CW, Yang L, Kuchroo VK, et al. (2009) IL-17-producing human peripheral regulatory T cells retain suppressive function. Blood 113: 4240-4249.
31. Xu Q, Lee J, Jankowska-Gan E, Schultz J, Roenneburg DA, et al. (2007) Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. J Immunol 178: 3983-3995.
32. Zhu J, Paul WE, (2008) CD4 T cells: fates, functions, and faults. Blood 112: 1557-1569.
33. Volpe E, Servant N, Zollinger R, Bogiatzi SI, Hupe P, et al. (2008) A critical function for transforming growth factor-beta, interleukin 23 and proinflammatory cytokines in driving and modulating human T(H)-17 responses. Nat Immunol 9: 650-657.
34. Gleeson M, (2007) Immune function in sport and exercise. J Appl Physiol 103: 693-699.
35. Yeh SH, Chuang H, Lin LW, Hsiao CY, Eng HL, (2006) Regular tai chi chuan exercise enhances functional mobility and CD4CD25 regulatory T cells. Br J Sports Med 40: 239-243.
36. Wang J, Song H, Tang X, Yang Y, Vieira VJ, et al. (2011) Effect of exercise training intensity on murine T-regulatory cells and vaccination response. Scand J Med Sci Sports.
37. Gleeson M, Bishop NC, Stensel DJ, Lindley MR, Mastana SS, et al. (2011) The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease. Nat Rev Immunol 11: 607-615.