Multiple genetic origins of histidine-rich protein 2 gene deletion in Plasmodium falciparum parasites from Peru

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Akinyi, Sheila ^a   Hayden, Tonya ^a   Gamboa, Dionicia ^b,c   Torres, Katherine ^b   Bendezu, Jorge ^b   Abdallah, Joseph F ^a   Griffing, Sean M ^a   Quezada, Wilmer Marquiño ^d   Arrospide, Nancy ^d   De Oliveira, Alexandre MacEdo ^a   Lucas, Carmen ^e   Magill, Alan J ^e   Bacon, David J ^e   Barnwell, John W ^a   Udhayakumar, Venkatachalam ^a  

^a CENTERS FOR DISEASE CONTROL AND PREVENTION   (United States)

^b INSTITUTO DE MEDICINA TROPICAL ALEXANDER VON HUMBOLDT   (Peru)

^c UNIVERSIDAD PERUANA CAYETANO HEREDIA   (Peru)

^d INSTITUTO NACIONAL DE SALUD   (Peru)

^e California   (Peru)

Author keywords

[No Author keywords available]

Indexed keywords

HRP 2 ANTIGEN, PLASMODIUM FALCIPARUM; HRP-2 ANTIGEN, PLASMODIUM FALCIPARUM; MICROSATELLITE DNA; PARASITE ANTIGEN; PROTOZOAL PROTEIN;

ANIMAL; ARTICLE; BAYES THEOREM; CLUSTER ANALYSIS; GENE DELETION; GENETICS; HAPLOTYPE; HUMAN; PARASITE; PERU; PHENOTYPE; PLASMODIUM FALCIPARUM; PREVALENCE;

ANIMALS; ANTIGENS, PROTOZOAN; BAYES THEOREM; CLUSTER ANALYSIS; GENE DELETION; HAPLOTYPES; HUMANS; MICROSATELLITE REPEATS; PARASITES; PERU; PHENOTYPE; PLASMODIUM FALCIPARUM; PREVALENCE; PROTOZOAN PROTEINS;

EID: 84885092153     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02797     Document Type: Article

References (27)

1. Moody, A. Rapid diagnostic tests for malaria parasites. Clin Microbiol Rev 15, 66-78 (2002). (Pubitemid 34052582)
2. Rock, E. P. et al. Comparative analysis of the Plasmodium falciparum histidinerich proteins HRP-I, HRP-II and HRP-III in malaria parasites of diverse origin. Parasitology 95 (Pt 2), 209-227 (1987). (Pubitemid 17144874)
3. Scherf, A. &Mattei, D. Cloning and characterization of chromosome breakpoints of Plasmodium falciparum: breakage and new telomere formation occurs frequently and randomly in subtelomeric genes. Nucleic Acids Res 20, 1491-1496 (1992).
4. Wellems, T. E. & Howard, R. J. Homologous genes encode two distinct histidinerich proteins in a cloned isolate of Plasmodium falciparum. Proc Natl Acad Sci USA 83, 6065-6069 (1986). (Pubitemid 16000654)
5. Kemp,D. J., Thompson, J. K., Walliker, D.&Corcoran, L. M. Molecular karyotype of Plasmodium falciparum: conserved linkage groups and expendable histidinerich protein genes. Proc Natl Acad Sci USA 84, 7672-7676 (1987).
6. Pologe, L. G. & Ravetch, J. V. Large deletions result from breakage and healing of P. falciparum chromosomes. Cell 55, 869-874 (1988).
7. Gamboa, D. et al. A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3: implications for malaria rapid diagnostic tests. PLoS One 5, e8091 (2010).
8. Houze, S., Hubert, V., Le Pessec, G., Le Bras, J. & Clain, J. Combined deletions of pfhrp2 and pfhrp3 genes result in Plasmodium falciparum malaria false-negative rapid diagnostic test. J Clin Microbiol 49, 2694-2696 (2011).
9. Koita, O. A. et al. False-Negative Rapid Diagnostic Tests for Malaria and Deletion of the Histidine-Rich Repeat Region of the hrp2 Gene{dagger}. Am J Trop Med Hyg 86, 194-198 (2012).
10. Wurtz, N. et al. Pfhrp2 and pfhrp3 polymorphisms in Plasmodium falciparum isolates from Dakar, Senegal: impact on rapid malaria diagnostic tests. Malar J 12, 34 (2013).
11. Kumar, N. et al. Genetic deletion of HRP2 and HRP3 in Indian Plasmodium falciparum population and false negative malaria rapid diagnostic test. Acta tropica (2012).
12. Dharia, N. V. et al. Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Res 20, 1534-1544 (2010).
13. Branch, O. H. et al. Plasmodium falciparum genetic diversity maintained and amplified over 5 years of a low transmission endemic in the Peruvian Amazon. Mol Biol Evol 28, 1973-1986 (2011).
14. Griffing, S. M. et al. South American Plasmodium falciparum after the Malaria Eradication Era: Clonal Population Expansion and Survival of the Fittest Hybrids. PLoS One 6, e23486 (2011).
15. Bacon, D. J. et al. Dynamics of malaria drug resistance patterns in the Amazon basin region following changes in Peruvian national treatment policy for uncomplicated malaria. Antimicrob Agents Chemother 53, 2042-2051 (2009).
16. Zhou, Z. et al.Decline in sulfadoxine-pyrimethamine-resistant alleles after change in drug policy in the Amazon region of Peru. Antimicrob Agents Chemother 52, 739-741 (2008). (Pubitemid 351170855)
17. Singh, B. et al. A genus-and species-specific nested polymerase chain reaction malaria detection assay for epidemiologic studies. Am J Trop Med Hyg 60, 687-692 (1999). (Pubitemid 29233131)
18. Anderson, T. J. C. et al. Microsatellite markers reveal a spectrum of population structures in the malaria parasite Plasmodium falciparum. Molecular Biology and Evolution 17, 1467-1482 (2000).
19. Anderson, T. J. C., Su, X. Z., Bockarie, M., Lagog, M. & Day, K. P. Twelve microsatellite markers for characterization of Plasmodium falciparum from finger-prick blood samples. Parasitology 119, 113-125 (1999). (Pubitemid 29381128)
20. dalla Martha, R. C., Tada, M. S., Ferreira, R. G., da Silva, L. H. & Wunderlich, G. Microsatellite characterization of Plasmodium falciparum from symptomatic and non-symptomatic infections from the Western Amazon reveals the existence of non-symptomatic infection-associated genotypes. Mem Inst Oswaldo Cruz 102, 293-298 (2007). (Pubitemid 46869325)
21. Hoffmann, E. H., Ribolla, P. E. & Ferreira, M. U. Genetic relatedness of Plasmodium falciparum isolates and the origin of allelic diversity at the merozoite surface protein-1 (MSP-1) locus in Brazil and Vietnam. Malar J 2, 24 (2003).
22. Machado, R. L. et al. Genetic structure of Plasmodium falciparum populations in the Brazilian Amazon region. J Infect Dis 190, 1547-1555 (2004).
23. McCollum, A. M., Mueller, K., Villegas, L., Udhayakumar, V. & Escalante, A. A. Common origin and fixation of Plasmodium falciparum dhfr and dhpsmutations associated with sulfadoxine-pyrimethamine resistance in a low-transmission area in South America. Antimicrob Agents Chemother 51, 2085-2091 (2007). (Pubitemid 46903098)
24. Pritchard, J. K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000). (Pubitemid 30397141)
25. Falush, D., Stephens, M. & Pritchard, J. K. Inference of population structure using multilocus genotype data: linked loci and correlated allele frequencies. Genetics 164, 1567-1587 (2003). (Pubitemid 37102217)
26. Evanno, G., Regnaut, S. & Goudet, J. Detecting the number of clusters of individuals using the software STRUCTURE: a simulation study. Mol Ecol 14, 2611-2620 (2005). (Pubitemid 40886055)
27. Bandelt, H. J., Forster, P. & Rohl, A. Median-joining networks for inferring intraspecific phylogenies. Mol Biol Evol 16, 37-48 (1999). (Pubitemid 29024937)