Combined deletions of pfhrp2 and pfhrp3 genes result in plasmodium falciparum malaria false-negative rapid diagnostic test

Journal of Clinical Microbiology

Volumn 49, Issue 7, 2011, Pages 2694-2696

  Houzé, Sandrine ^a,b,c   Hubert, Véronique ^a,b,c   Le Pessec, Gaëlle ^a   Le Bras, Jacques ^a,b,c   Clain, Jérôme ^b,c  

^a BICHAT HOSPITAL   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c INSTITUT DE RECHERCHE POUR LE DÉVELOPPEMENT   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROQUINE; PLASMODIUM FALCIPARUM HISTIDINE RICH PROTEIN 2; PLASMODIUM FALCIPARUM HISTIDINE RICH PROTEIN 3; PROTOZOAL PROTEIN; UNCLASSIFIED DRUG;

ADULT; AMPLICON; ARTICLE; BRAZIL; CASE REPORT; CONTROLLED STUDY; DIAGNOSTIC ERROR; DIAGNOSTIC TEST; EXON; GENE; GENE DELETION; GENETIC ANALYSIS; HUMAN; INTRON; LABORATORY DIAGNOSIS; MALARIA FALCIPARUM; MALE; NONHUMAN; PARASITEMIA; PFHRP2 GENE; PFHRP3 GENE; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX MALARIA; PRIORITY JOURNAL;

ADULT; ANTIGENS, PROTOZOAN; BRAZIL; DIAGNOSTIC TESTS, ROUTINE; FALSE NEGATIVE REACTIONS; HUMANS; MALARIA, FALCIPARUM; MALE; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SEQUENCE DELETION;

PLASMODIUM FALCIPARUM;

EID: 79959830035     PISSN: 00951137     EISSN: 1098660X     Source Type: Journal    
DOI: 10.1128/JCM.00281-11     Document Type: Article

References (12)

1. Baker, J., et al. 2010. Global sequences variation in the histidine-rich proteins 2 and 3 of Plasmodium falciparum; implications for the performance of malaria rapid diagnostic tests. Malar. J. 9:129.
2. Baker, J., et al. 2005. Genetic diversity of Plasmodium falciparum histidine-rich protein 2 (PfHRP2) and its effect on the performance of PfHRP2-based rapid diagnostic tests. J. Infect. Dis. 192:870-877.
3. Douglas, N. M., N. M. Anstey, B. J. Angus, F. Nosten, and R. N. Price. 2010. Artemisinin combination therapy for vivax malaria. Lancet Infect. Dis. 10: 405-416.
4. Gamboa, D., et al. 2010. A large proportion of P. falciparum isolates in the Amazon region of Peru lack pfhrp2 and pfhrp3; implications for malaria rapid diagnostic tests. PLoS One 5:e8091.
5. Lee, N., et al. 2006. Effect of sequence variation in Plasmodium falciparum histidine-rich protein 2 on binding of specific monoclonal antibodies: implications for rapid diagnostic tests for malaria. J. Clin. Microbiol. 44:2773-2778.
6. Lee, N., J. Baker, D. Bell, J. McCarthy, and Q. Cheng. 2006. Assessing the genetic diversity of the aldolase genes of Plasmodium falciparum and Plasmodium vivax and its potential effect on performance of aldolase-detecting rapid diagnostic tests. J. Clin. Microbiol. 44:4547-4549.
7. Marx, A., et al. 2005. Meta-analysis: accuracy of rapid tests for malaria in travellers returning from endemic areas. Ann. Intern. Med. 142:836-846.
8. Moody, A. 2002. Rapid diagnostic tests for malaria parasites. Clin. Microbiol. Rev. 15:66-78.
9. Snounou, G. 1996. Detection and identification of the four malaria parasite species infecting humans by PCR amplification. Methods Mol. Biol. 50:263-291.
10. Stauffer, W. M., et al. 2009. Diagnostic performance of rapid diagnostic tests versus blood smears for malaria in US clinical practice. Clin. Infect. Dis. 49:908-913.
11. Sullivan, D. J., Y. M. Ayala, and D. E. Goldberg. 1996. An unexpected 5′ untranslated intron in the P. falciparum genes for histidine-rich proteins II and III. Mol. Biochem. Parasitol. 83:247-251.
12. Talman, A. M., et al. 2007. Evaluation of the intra- and inter-specific genetic variability of Plasmodium lactate dehydrogenase. Malar. J. 6:140.