Metabolite profiling and identification of triptolide in rats

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 939, Issue , 2013, Pages 51-58

  Liu, Jia ^a   Li, Liang ^a   Zhou, Xin ^a   Chen, Xiaoyan ^a   Huang, Haihua ^a   Zhao, Shunbo ^a   Li, Xiuli ^a   Zhong, Dafang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

High performance liquid chromatography online radiodetector; Metabolite profiling; Triptolide; Ultra performance liquid chromatography quadrupole time of flight mass spectrometry

Indexed keywords

BIOMOLECULES; BODY FLUIDS; CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; RATS;

CUNNINGHAMELLA BLAKESLEANA; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ONLINE RADIODETECTOR; LIQUID CHROMATOGRAPHY-QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRIES; METABOLITE PROFILES; METABOLITE PROFILING; MICROBIAL TRANSFORMATION; RAT LIVER MICROSOMES; TRIPTOLIDE;

METABOLITES;

15 HYDROXYTRIPTOLIDE; 16 HYDROXYTRIPTOLIDE; 17 HYDROXYTRIPTOLIDE; DRUG METABOLITE; GLUTATHIONE; SULFATE; TRIPDIOLID; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BILE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; CUNNINGHAMELLA BLAKESLEEANA; DRUG BLOOD LEVEL; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG TRANSFORMATION; DRUG URINE LEVEL; FECES; FEMALE; HETERONUCLEAR MULTIPLE BOND CORRELATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; QUADRUPOLE MASS SPECTROMETRY; RADIATION DETECTION; RAT; SEPARATION TECHNIQUE; SINGLE DRUG DOSE; TIME OF FLIGHT MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CUNNINGHAMELLA; RATTUS;

HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-ONLINE RADIODETECTOR; METABOLITE PROFILING; TRIPTOLIDE; ULTRA-PERFORMANCE LIQUID CHROMATOGRAPHY-QUADRUPOLE TIME-OF-FLIGHT MASS SPECTROMETRY;

ANIMALS; BILE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DITERPENES; EPOXY COMPOUNDS; FECES; FEMALE; LIMIT OF DETECTION; MALE; MASS SPECTROMETRY; METABOLOME; PHENANTHRENES; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS;

EID: 84885080056     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2013.08.015     Document Type: Article

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