Distortional binding of transition state analogs to human purine nucleoside phosphorylase probed by magic angle spinning solid-state NMR

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 40, 2013, Pages 15991-15996

  Èetticatt, Mathew J ^a   Itin, Boris ^b   Eèans, Gary B ^c   Schramm, Èern L ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^c Carbohydrate Chemistry Team   (New Zealand)

Author keywords

Catalytic site interactions; Ground state destabilization; Optimizing transition state analogs

Indexed keywords

FORODESINE; HYPOXANTHINE; PURINE NUCLEOSIDE PHOSPHORYLASE; STABLE ISOTOPE;

ARTICLE; CONFORMATION; HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; PROTON TRANSPORT; SOLID STATE; SYNTHESIS;

CATALYTIC SITE INTERACTIONS; GROUND STATE DESTABILIZATION; OPTIMIZING TRANSITION STATE ANALOGS;

HUMANS; MAGNETIC RESONANCE IMAGING; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; PURINE-NUCLEOSIDE PHOSPHORYLASE;

EID: 84885075071     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1313657110     Document Type: Article

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