Ulmus davidiana var. japonica Nakai Upregulates Eosinophils and Suppresses Th1 and Th17 Cells in the Small Intestine

PLoS ONE

Volumn 8, Issue 10, 2013, Pages

  Lee, Han Sung ^a,b   Jang, Min Seong ^a   Kim, Jung Hwan ^a   Hong, Chun Pyo ^a   Lee, Eun Jung ^a   Jeun, Eun Ji ^a   Kim, Chan ^a   Kim, Eun Kyung ^b   Ahn, Kwang Seong ^b   Yang, Bo Gie ^a   Ahn, Kwang Seok ^b   Jang, Young Pyo ^b   Ahn, Kyoo Seok ^b   Kim, You Me ^a   Jang, Myoung Ho ^a,c  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Kyung Hee University   (South Korea)

^c Institute for Basic Science   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD8ALPHA ANTIGEN; GLYCOPROTEIN P 15095; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G1; INTERLEUKIN 10; INTERLEUKIN 4; PHOSPHATE BUFFERED SALINE; PLANT EXTRACT; TRANSCRIPTION FACTOR FOXP3; ULMUS JAPONICA EXTRACT; UNCLASSIFIED DRUG; WATER;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; BARK; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL COUNT; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; DOWN REGULATION; DRUG SYNTHESIS; EOSINOPHIL; FEMALE; HERB; HOMEOSTASIS; IMMUNOCOMPETENT CELL; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOMODULATION; INTESTINAL HOMEOSTASIS; LAMINA PROPRIA; LYMPHOCYTE DIFFERENTIATION; MACROPHAGE; MESENTERY LYMPH NODE; MOUSE; NONHUMAN; REGULATORY T LYMPHOCYTE; SMALL INTESTINE; SPLEEN; SUPPRESSOR CELL; TH1 CELL; TH17 CELL; ULMACEAE; ULMUS DAVIDIANA; ULMUS JAPONICA; UPREGULATION;

ADMINISTRATION, ORAL; ANIMALS; ANTIGEN-PRESENTING CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; HOMEOSTASIS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INTERLEUKIN-4; INTESTINAL MUCOSA; INTESTINE, SMALL; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; PLANT BARK; PLANT EXTRACTS; TH1 CELLS; TH17 CELLS; ULMUS; UP-REGULATION;

EID: 84885063633     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076716     Document Type: Article

References (30)

1. Uematsu S, Fujimoto K, Jang MH, Yang B-G, Jung Y-J, et al. (2008) Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5. Nat Immunol 9: 769-776. doi:10.1038/ni.1622. PubMed: 18516037.
2. Coombes JL, Powrie F, (2008) Dendritic cells in intestinal immune regulation. Nat Rev Immunol 8: 435-446. doi:10.1038/nri2335. PubMed: 18500229.
3. Chirdo FG, Millington OR, Beacock-Sharp H, Mowat AM, (2005) Immunomodulatory dendritic cells in intestinal lamina propria. Eur J Immunol 35: 1831-1840. doi:10.1002/eji.200425882. PubMed: 16010704.
4. Denning TL, Wang Y-c, Patel SR, Williams IR, Pulendran B, (2007) Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8: 1086-1094. doi:10.1038/ni1511. PubMed: 17873879.
5. Rankin SM, Conroy DM, Williams TJ, (2000) Eotaxin and eosinophil recruitment: implications for human disease. Mol Med Today 6: 20-27. doi:10.1016/S1357-4310(99)01635-4. PubMed: 10637571.
6. Mishra A, Hogan SP, Lee JJ, Foster PS, Rothenberg ME, (1999) Fundamental signals that regulate eosinophil homing to the gastrointestinal tract. J Clin Invest 103: 1719-1727. doi:10.1172/JCI6560. PubMed: 10377178.
7. Lee S-J, Lim K-T, (2007) Glycoprotein isolated from Ulmus davidiana Nakai regulates expression of iNOS and COX-2 in vivo and in vitro. Food Chem Toxicol 45: 990-1000. doi:10.1016/j.fct.2006.12.006. PubMed: 17240506.
8. Park J-W, Bu Y, Bae J, Lee B, Ko S, et al. (2011) Protective effects of Ulmus macrocarpa on experimental colitis mice models. Orient Pharm. J Exp Med 11: 107-112.
9. Mohrs M, Shinkai K, Mohrs K, Locksley RM, (2001) Analysis of type 2 immunity in vivo with a bicistronic IL-4 reporter. Immunity 15: 303-311. doi:10.1016/S1074-7613(01)00186-8. PubMed: 11520464.
10. Yu CN, Cantor AB, Yang H, Browne C, Wells RA, et al. (2002) Targeted deletion of a high-affinity GATA-binding site in the GATA-1 promoter leads to selective loss of the eosinophil lineage in vivo. J Exp Med 195: 1387-1395. doi:10.1084/jem.20020656. PubMed: 12045237.
11. Jang MH, Sougawa N, Tanaka T, Hirata T, Hiroi T, et al. (2006) CCR7 is critically important in intestinal lamina propria for migration of dendritic cells to mesenteric lymph nodes. J Immunol 176: 803-810. PubMed: 16393963.
12. Guo Z, Jang MH, Otani K, Bai Z, Umemoto E, et al. (2008) CD4+CD25+ regulatory T cells in the small intestinal lamina propria show an effector/memory phenotype. Int Immunol 20: 307-315. doi:10.1093/intimm/dxm143. PubMed: 18184698.
13. Stumhofer JS, Silver J, Hunter CA, (2007) Negative regulation of Th17 responses. Semin Immunol 19: 394-399. doi:10.1016/j.smim.2007.11.006. PubMed: 18221887.
14. Strober W, Fuss IJ, (2011) Proinflammatory Cytokines in the Pathogenesis of Inflammatory Bowel Diseases. Gastroenterologist 1401756-1767.e1751 PubMed: 21530742.
15. Zhang Z, Zheng M, Bindas J, Schwarzenberger P, Kolls JK, (2006) Critical role of IL-17 receptor signaling in acute TNBS-induced colitis. Inflamm Bowel Dis 12: 382-388. doi:10.1097/01.MIB.0000218764.06959.91. PubMed: 16670527.
16. Strober W, Fuss I, Mannon P, (2007) The fundamental basis of inflammatory bowel disease. J Clin Invest 117: 514-521. doi:10.1172/JCI30587. PubMed: 17332878.
17. Korn T, Bettelli E, Oukka M, Kuchroo VK, (2009) IL-17 and Th17 Cells. Annu Rev Immunol 27: 485-517. doi:10.1146/annurev.immunol.021908.132710. PubMed: 19132915.
18. Maul J, Loddenkemper C, Mundt P, Berg E, Giese T, et al. (2005) Peripheral and intestinal regulatory CD4+ CD25(high) T cells in inflammatory bowel disease. Gastroenterologist 128: 1868-1878. doi:10.1053/j.gastro.2005.03.043. PubMed: 15940622.
19. Schreiber S, Heinig T, Thiele HG, Raedler A, (1995) Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease. Gastroenterologist 108: 1434-1444. doi:10.1016/0016-5085(95)90692-4. PubMed: 7729636.
20. Sun CM, Hall JA, Blank RB, Bouladoux N, Oukka M, et al. (2007) Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204: 1775-1785. doi:10.1084/jem.20070602. PubMed: 17620362.
21. Rothenberg ME, Mishra A, Brandt EB, Hogan SP, (2001) Gastrointestinal eosinophils. Immunol Rev 179: 139-155. doi:10.1034/j.1600-065X.2001.790114.x. PubMed: 11292017.
22. Svensson-Frej M, (2011) Immunobiology of Intestinal Eosinophils - A Dogma in the Changing? J Innate Immun 3: 565-576. doi:10.1159/000328799. PubMed: 21860213.
23. Wen T, Mingler MK, Blanchard C, Wahl B, Pabst O, et al. (2012) The pan-B cell marker CD22 is expressed on gastrointestinal eosinophils and negatively regulates tissue eosinophilia. J Immunol 188: 1075-1082. doi:10.4049/jimmunol.1102222. PubMed: 22190185.
24. Carlens J, Wahl B, Ballmaier M, Bulfone-Paus S, Förster R, et al. (2009) Common gamma-chain-dependent signals confer selective survival of eosinophils in the murine small intestine. J Immunol 183: 5600-5607. doi:10.4049/jimmunol.0801581. PubMed: 19843944.
25. Straumann A, Simon HU, (2004) The physiological and pathophysiological roles of eosinophils in the gastrointestinal tract. Allergy 59: 15-25. doi:10.1046/j.1398-9995.2003.00382.x. PubMed: 14674928.
26. Choi SY, Lee S, Choi WH, Lee Y, Jo YO, et al. (2010) Isolation and anti-inflammatory activity of Bakuchiol from Ulmus davidiana var. japonica. J Med Food 13: 1019-1023. doi:10.1089/jmf.2009.1207. PubMed: 20553183.
27. Song IK, Kim KS, Suh SJ, Kim MS, Kwon DY, et al. (2007) Anti-inflammatory effect of Ulmus davidiana Planch (Ulmaceae) on collagen-induced inflammation in rats. Environ Toxicol Pharmacol 23: 102-110. doi:10.1016/j.etap.2006.07.013. PubMed: 21783743.
28. Kim YC, Lee MK, Sung SH, Kim SH, (2007) Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production. Fitoterapia 78: 196-199. doi:10.1016/j.fitote.2006.11.013. PubMed: 17343992.
29. Lee EH, Park CW, Jung YJ, (2013) Anti-inflammatory and immune-modulating effect of Ulmus davidiana var. japonica Nakai extract on a macrophage cell line and immune cells in the mouse small intestine. J Ethnopharmacol 146: 608-613. doi:10.1016/j.jep.2013.01.035. PubMed: 23384785.
30. Jacobsen EA, Taranova AG, Lee NA, Lee JJ, (2007) Eosinophils: Singularly destructive effector cells or purveyors of immunoregulation? J Allergy Clin Immunol 119: 1313-1320. doi:10.1016/j.jaci.2007.03.043. PubMed: 17481717.