Isolation and anti-inflammatory activity of bakuchiol from ulmus davidiana var. japonica

Journal of Medicinal Food

Volumn 13, Issue 4, 2010, Pages 1019-1023

  Choi, Sang Yoon ^a   Lee, Sanghyun ^b   Choi, Won Hee ^a   Lee, Yeonmi ^a   Jo, Youn Ock ^a   Ha, Tae Youl ^a  

^a Korea Food Research Institute   (South Korea)

^b Chung Ang University   (South Korea)

Author keywords

bakuchiol; nitric oxide; Ulmus davidiana var. japonica

Indexed keywords

ANTIINFLAMMATORY AGENT; BAKUCHIOL; LIPOPOLYSACCHARIDE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN E2;

ANIMAL CELL; ANIMAL CELL CULTURE; ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CELL VIABILITY; CLINICAL EVALUATION; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG ISOLATION; DRUG STRUCTURE; ELM; FLUORESCENCE CORRELATION SPECTROSCOPY; FOURIER TRANSFORMATION; HETERONUCLEAR MULTIPLE BOND CORRELATION; HETERONUCLEAR SINGLE QUANTUM COHERENCE; KOREAN MEDICINE; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PLANT ROOT; PLANT STEM; POLARIZATION; PRIORITY JOURNAL; SPECTROSCOPY; TREATMENT OUTCOME; ULMUS DAVIDIANA;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; DINOPROSTONE; INFLAMMATION; MICE; NITRIC OXIDE; PHENOLS; PLANT BARK; PLANT EXTRACTS; PLANT ROOTS; PLANT STEMS; ULMUS;

JAPONICA; ULMUS DAVIDIANA;

EID: 77955208792     PISSN: 1096620X     EISSN: None     Source Type: Journal    
DOI: 10.1089/jmf.2009.1207     Document Type: Article

References (26)

1. Lee SJ: Korean Folk Medicine, Monographs Series No. 3. Publishing Center of Seoul National University, Seoul, 1996.
2. Jun CD, Pae HO, Kim YC, Jeong SJ, Yoo JC, Lee EJ, Choi BM, Chae SW, Park RK, Chung HT: Inhibition of nitric oxide synthesis by buthanol fraction of the methanol extract of Ulmus davidiana in murine macropahages. J Ethnopharmacol 1998; 62:129-135.
3. Lee GY, Jang DS, Kim J, Kim CS, Kim YS, Kim JH, Kim JS: Flavan-3-ols from Ulmus davidiana var. japonica with inhibitory activity on protein glycation. Planta Med 2008;74:1800-1802.
4. Kim JP, Kim WG, Koshino H, Jung J, Yoo ID: Sesquiterpene O-naphthoquinones from the root bark of Ulmus davidiana. Phytochemistry 1996;43:425-430. (Pubitemid 27065562)
5. Lee MK, Sung SH, Lee HS, Cho JH, Kim YC: Lignan and neolignan glycosides from Ulmus davidiana var. japonica. Arch Pharm Res 2001;24:198-201.
6. Kim YC, Lee MK, Sung SH, Kim SH: Sesquiterpenes from Ulmus davidiana var. japonica with the inhibitory effects on lipopolysaccharide-induced nitric oxide production. Fitoterapia 2007;78:196-199.
7. Kim KS, Lee SD, Kim KH, Kil SY, Chung KH, Kim CH: Suppressive effects of a water extract of Ulmus davidiana Planch (Ulmaceae) on collagen-induced arthritis in mice. J Ethno-pharmacol 2005;97:65-71.
8. Jung HJ, Jeon HJ, Lim EJ, Ahn EK, Song YS, Lee S, Shin KH, Lim CJ, Park EH: Anti-angiogenic activity of the methanol extract and its fraction of Ulmus davidiana var. japonica. J Ethnopharmacol 2007;112:406-409.
9. Lee Y, Park H, Ryu HS, Chun M, Kang S, Kim HS: Effects of elm bark (Ulmus davidiana var. japonica) extracts on the modulation of immunocompetence in mice. J Med Food 2007;10:118-125.
10. Krenisky JM, Luo J, Reed MJ, Carney JR: Isolation and anti-hyperglycemic activity of bakuchiol from Otholobium pub-escens, a Peruvian medicinal plant used for the treatment of diabetes. Biol Pharm Bull 1999;22:1137-1140.
11. Backhouse CN, Delporte CL, Negrete RE, Erazo S, Zuniga A, Pinto A, Cassels BK: Active constituents isolated from Psoralea glandulosa L. with anti-inflammatory and antipyretic activities. J Ethnopharmacol 2001;78:27-31.
12. Haraguchi H, Inoue J, Tamura Y, Mizutani K: Antioxidative components of Psoralea corylifolia. Phytother Res 2002;16:539-544.
13. Katsura H, Tsukiyama R, Suzuki A, Kobayashi M: In vitro antimicrobial activities of bakuchiol against oral microorganisms. Antimicrob Agents Chemother 2001;45:3009-3013.
14. Pae HO, Cho H, Oh G.S, Kim NT, Song EK, Kim YC, Yun YG., Kang CL, Kim JD, Kim JM, Chung HT: Bakuchiol from Psor-alea corylifolia inhibits the expression of inducible nitric oxide synthase gene via the inactivation of nuclear transcription factor-kB in RAW 264.7 macrophages. Int Immunopharmacol 2001; 1:1849-1855.
15. Adhikari S, Joshi R, Patro BS, Ghanty TK, Chintalwar GJ, Sharma A, Chattopadhyay S, Mukherjee T: Antioxidant activity of bakuchiol: experimental evidences and theoretical treatments on the possible involvement of the terpenoid chain. Chem Res Toxicol 2003;16:1062-1069.
16. Wu CZ, Hong SS, Cai XF, Dat NT, Nan JX, Hwang BY, Lee JJ, Lee D: Hypoxia-inducible factor-1 and nuclear factor-kB inhibitory meroterpene analogues of bakuchiol, a constituent of the seeds of Psoralea corylifolia. Bioorg Med Chem Lett 2008; 18:2619-2623.
17. Kim JM, Lee P, Son D, Kim H, Kim SY: Falcarindiol inhibits nitric oxide-mediated neuronal death in lipopolysaccharide-treated organotypic hippocampal cultures. Neuroreport 2003; 14:1941-1944.
18. Kim JB, Han AR, Park EY, Kim JY, Cho W, Lee J, Seo EK, Lee KT: Inhibition of LPS-induced iNOS, COX-2 and cyto-kines expression by poncirin through the NF-kB inactivation in RAW 264.7 macrophage cells. Biol Pharm Bull 2007;30: 2345-2351.
19. Patel R, Attur MG, Dave M, Abramson SB, Amin AR: Regulation of cytosolic COX-2 and prostaglandin E2 production by nitric oxide in activated murine macrophages. J Immunol 1999; 162:4191-4197.
20. Huang H, Hauck C, Yum MY, Rizshsky L, Widrlechner MP, Mccoy JA, Murphy PA, Dixon PM, Nikolau BJ, Birt DF: Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages. J Agric Food Chem 2009; 57:10579-10589.
21. Felts PA, Woolston AM, Fernando HB, Asquith S, Gregson NA, Mizzi OJ, Smith KJ: Inflammation and primary demyelination induced by the intraspinal injection of lipopolysaccharide. Brain 2005;128:1649-1666.
22. Maniscalco M, Sofia M, Pelaia G: Nitric oxide in upper airways inflammatory diseases. Inflamm Res 2007;56:58-69.
23. Needleman P, Isakson PC: The discovery and function of COX-2. J Rheumatol Suppl 1997;49:6-8.
24. Seybold VS, Jia YP, Abrahams LG: Cyclo-oxygenase-2 contributes to central sensitization in rats with peripheral inflammation. Pain 2003;105:47-55.
25. Backhouse CN, Delporte CL, Negrete RE, Erazo S, Zuniga A, Pinto A, Cassels BK: Active constituents isolated from Psoralea glandulosa L. with anti-inflammatory and antipyetic activities. J Ethnopharmacol 2001;78:27-31.
26. Ferrandiz ML, Gil B, Sanz MJ, Ubeda A, Erazo S, Gonzaiez E, Negrete R, Pacheco S, Paya M, Alcaraz MJ: Effect of bakuchiol on leukocyte function and some inflammatory responses in mice. J Pharm Pharmacol 1996;48:975-980.