Synthesis of a 2-aryl-3-aroyl indole salt (OXi8007) resembling combretastatin A-4 with application as a vascular disrupting agent

Journal of Natural Products

Volumn 76, Issue 9, 2013, Pages 1668-1678

  Hadimani, Mallinath B ^a   MacDonough, Matthew T ^a   Ghatak, Anjan ^a   Strecker, Tracy E ^a   Lopez, Ramona ^b   Sriram, Madhavi ^a   Nguyen, Benson L ^a   Hall, John J ^a   Kessler, Raymond J ^a   Shirali, Anupama R ^a   Liu, Li ^b   Garner, Charles M ^a   Pettit, George R ^c   Hamel, Ernest ^d   Chaplin, David J ^e   Mason, Ralph P ^b   Trawick, Mary Lynn ^a   Pinney, Kevin G ^a  

^a BAYLOR UNIVERSITY   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^c ARIZONA STATE UNIVERSITY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e OXiGENE Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (3' DISODIUM PHOSPHATE 4' METHOXYPHENYL) 3 (3'',4'',5'' TRIMETHOXYBENZOYL) 6 METHOXYINDOLE; 2 (3' DISODIUM PHOSPHATE 4' METHOXYPHENYL) 3 (3'',4'',5'' TRIMETHOXYBENZOYL) N METHYL 6 METHOXYINDOLE; 2 (3' HYDROXY 4' METHOXYPHENYL) 3 (3'',4'',5'' TRIMETHOXYBENZOYL) 6 METHOXYINDOLE; 2 (3' HYDROXY 4' METHOXYPHENYL) 3 (3'',4'',5'' TRIMETHOXYBENZOYL) N METHYL 6 METHOXYINDOLE; ANTINEOPLASTIC AGENT; COMBRETASTATIN A4; OXI 8006; OXI 8007; UNCLASSIFIED DRUG; VASCULAR TARGETING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; COLOR ULTRASOUND FLOWMETRY; CYTOTOXICITY; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MALE; MICROTUBULE ASSEMBLY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR VASCULARIZATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BIBENZYLS; COLCHICINE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MALE; MICE; MOLECULAR STRUCTURE; ORGANOPHOSPHATES; PRODRUGS; PROSTATIC NEOPLASMS; STILBENES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 84885030356     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/np400374w     Document Type: Article

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