Application of the McMurry coupling reaction in the synthesis of tri- and tetra-arylethylene analogues as potential cancer chemotherapeutic agents

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 19, 2009, Pages 6993-7001

  Tanpure, Rajendra P ^a   Harkrider, Amanda R ^a   Strecker, Tracy E ^a   Hamel, Ernest ^b   Trawick, Mary Lynn ^a   Pinney, Kevin G ^a  

^a BAYLOR UNIVERSITY   (United States)

^b Developmental Therapeutics Program   (United States)

Author keywords

Anti cancer agents; Combretastatin analogues; Inhibition of tubulin assembly; Tamoxifen analogues; Tetraarylethylene analogues; Triarylethylene analogues

Indexed keywords

1 (3' HYDROXY 4' METHOXYPHENYL) 1 PHENYL 2 (3'',4'',5'' TRIMETHOXYPHENYL)BUT 1 ENE; 1 (3' HYDROXY 4' METHOXYPHENYL) 1 PHENYL 2 (3'',4'',5'' TRIMETHOXYPHENYL)PROP 1 ENE; 2 (3' HYDROXY 4' METHOXYPHENYL) 1 PHENYL 1 (3'',4'',5'' TRIMETHOXYPHENYL)BUT 1 ENE; 2 (3' HYDROXY 4' METHOXYPHENYL) 1 PHENYL 1 (3'',4'',5'' TRIMETHOXYPHENYL)PROP 1 ENE; 2 (3' HYDROXY 4' METHOXYPHENYL) 1,2 BIS PHENYL 1 (3'',4'',5'' TRIMETHOXYPHENYL)ETHYLENE; ANTINEOPLASTIC AGENT; BETA TUBULIN; COLCHICINE; COMBRETASTATIN A4; DOXORUBICIN; TAMOXIFEN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL GROWTH; CONTROLLED STUDY; CROSS COUPLING REACTION; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; ISOMER; MALE; MICROTUBULE ASSEMBLY; NUCLEAR OVERHAUSER EFFECT; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COLCHICINE; DRUG DESIGN; ETHYLENES; HUMANS; HYDROCARBONS, AROMATIC; ORGANIC CHEMISTRY PROCESSES; RECEPTORS, ESTROGEN; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN MODULATORS;

TETRA;

EID: 70249141674     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.08.011     Document Type: Article

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