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Volumn 26, Issue 10, 2013, Pages 675-682
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Stability assessment on a library scale: A rapid method for the evaluation of the commutability and insertion of residues in C-terminal loops of the CH3 domains of IgG1-Fc
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Author keywords
Fcab; IgG1 Fc; library design; loop engineering; therapeutic antibody; thermal denaturation; yeast surface display
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Indexed keywords
FCAB;
IGG1-FC;
LIBRARY DESIGNS;
THERAPEUTIC ANTIBODIES;
THERMAL DENATURATIONS;
YEAST SURFACE DISPLAYS;
ANTIBODIES;
RANDOM PROCESSES;
SYSTEM STABILITY;
YEAST;
LIBRARIES;
HUMAN IMMUNOGLOBULIN;
HUMAN IMMUNOGLOBULIN G CLASS 1 CRYSTALLIZABLE FRAGMENT PROTEIN;
IMMUNOGLOBULIN FC FRAGMENT;
LIGAND;
UNCLASSIFIED DRUG;
AMINO ACID SEQUENCE;
ARTICLE;
CONTROLLED STUDY;
FLOW CYTOMETRY;
MOLECULAR LIBRARY;
MUTANT;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN ANALYSIS;
PROTEIN BINDING;
PROTEIN DENATURATION;
PROTEIN DETERMINATION;
PROTEIN DOMAIN;
PROTEIN ENGINEERING;
PROTEIN STABILITY;
PROTEIN STRUCTURE;
RANDOMIZATION;
SEQUENCE ANALYSIS;
SURFACE PROPERTY;
TEMPERATURE;
YEAST;
FCAB;
IGG1-FC;
LIBRARY DESIGN;
LOOP ENGINEERING;
THERAPEUTIC ANTIBODY;
THERMAL DENATURATION;
YEAST SURFACE DISPLAY;
AMINO ACID SEQUENCE;
FLOW CYTOMETRY;
HUMANS;
IMMUNOGLOBULIN FC FRAGMENTS;
IMMUNOGLOBULIN G;
MODELS, MOLECULAR;
MOLECULAR SEQUENCE DATA;
PEPTIDE LIBRARY;
PROTEIN STABILITY;
PROTEIN STRUCTURE, TERTIARY;
RECOMBINANT FUSION PROTEINS;
REPRODUCIBILITY OF RESULTS;
TEMPERATURE;
TIME FACTORS;
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EID: 84885001319
PISSN: 17410126
EISSN: 17410134
Source Type: Journal
DOI: 10.1093/protein/gzt041 Document Type: Article |
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Times cited : (23)
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References (24)
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