메뉴 건너뛰기




Volumn 133, Issue 11, 2013, Pages 2551-2562

P14ARF induces apoptosis via an entirely caspase-3-dependent mitochondrial amplification loop

Author keywords

apoptosis; caspase 3; mitochondria; p14ARF

Indexed keywords

CASPASE 3; CYTOCHROME C; PROTEIN P14; PROTEIN P14 ARF; PROTEIN P53; UNCLASSIFIED DRUG; CYCLIN DEPENDENT KINASE INHIBITOR 2A;

EID: 84884909671     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.28279     Document Type: Article
Times cited : (7)

References (47)
  • 1
    • 0028980262 scopus 로고
    • A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies
    • Duro D, Bernard O, Della Valle V, et al. A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies. Oncogene 1995; 11: 21-9.
    • (1995) Oncogene , vol.11 , pp. 21-29
    • Duro, D.1    Bernard, O.2    Della Valle, V.3
  • 2
    • 0028982932 scopus 로고
    • A novel p16INK4A transcript
    • Mao L, Merlo A, Bedi G, et al. A novel p16INK4A transcript. Cancer Res 1995; 55: 2995-7.
    • (1995) Cancer Res , vol.55 , pp. 2995-2997
    • Mao, L.1    Merlo, A.2    Bedi, G.3
  • 3
    • 0029060657 scopus 로고
    • Complex structure and regulation of the P16 (MTS1) locus
    • Stone S, Jiang P, Dayananth P, et al. Complex structure and regulation of the P16 (MTS1) locus. Cancer Res 1995; 55: 2988-94.
    • (1995) Cancer Res , vol.55 , pp. 2988-2994
    • Stone, S.1    Jiang, P.2    Dayananth, P.3
  • 4
    • 0031030325 scopus 로고    scopus 로고
    • Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF
    • Quelle DE, Cheng M, Ashmun RA, et al. Cancer-associated mutations at the INK4a locus cancel cell cycle arrest by p16INK4a but not by the alternative reading frame protein p19ARF. Proc Natl Acad Sci USA 1997; 94: 669-73.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 669-673
    • Quelle, D.E.1    Cheng, M.2    Ashmun, R.A.3
  • 5
    • 0032146795 scopus 로고    scopus 로고
    • E1A signaling to p53 involves the p19(ARF) tumor suppressor
    • de Stanchina E, McCurrach ME, Zindy F, et al. E1A signaling to p53 involves the p19(ARF) tumor suppressor. Genes Dev 1998; 12: 2434-42.
    • (1998) Genes Dev , vol.12 , pp. 2434-2442
    • De Stanchina, E.1    McCurrach, M.E.2    Zindy, F.3
  • 6
    • 0032573088 scopus 로고    scopus 로고
    • P19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation
    • Radfar A, Unnikrishnan I, Lee HW, et al. p19(Arf) induces p53-dependent apoptosis during abelson virus-mediated pre-B cell transformation. Proc Natl Acad Sci USA 1998; 95: 13194-9.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 13194-13199
    • Radfar, A.1    Unnikrishnan, I.2    Lee, H.W.3
  • 7
    • 0032145569 scopus 로고    scopus 로고
    • Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization
    • Zindy F, Eischen CM, Randle DH, et al. Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev 1998; 12: 2424-33.
    • (1998) Genes Dev , vol.12 , pp. 2424-2433
    • Zindy, F.1    Eischen, C.M.2    Randle, D.H.3
  • 8
    • 0842346437 scopus 로고    scopus 로고
    • Principles of tumor suppression
    • Sherr CJ,. Principles of tumor suppression. Cell 2004; 116: 235-46.
    • (2004) Cell , vol.116 , pp. 235-246
    • Sherr, C.J.1
  • 9
    • 0036133108 scopus 로고    scopus 로고
    • ARF function does not require p53 stabilization or Mdm2 relocalization
    • Korgaonkar C, Zhao L, Modestou M, et al. ARF function does not require p53 stabilization or Mdm2 relocalization. Mol Cell Biol 2002; 22: 196-206.
    • (2002) Mol Cell Biol , vol.22 , pp. 196-206
    • Korgaonkar, C.1    Zhao, L.2    Modestou, M.3
  • 10
    • 0036172197 scopus 로고    scopus 로고
    • Human tumor suppressor ARF impedes S-phase progression independent of p53
    • Yarbrough WG, Bessho M, Zanation A, et al. Human tumor suppressor ARF impedes S-phase progression independent of p53. Cancer Res 2002; 62: 1171-7.
    • (2002) Cancer Res , vol.62 , pp. 1171-1177
    • Yarbrough, W.G.1    Bessho, M.2    Zanation, A.3
  • 11
    • 0037468575 scopus 로고    scopus 로고
    • P14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
    • Eymin B, Leduc C, Coll JL, et al. p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice. Oncogene 2003; 22: 1822-35.
    • (2003) Oncogene , vol.22 , pp. 1822-1835
    • Eymin, B.1    Leduc, C.2    Coll, J.L.3
  • 12
    • 6044254972 scopus 로고    scopus 로고
    • P19ARF directly and differentially controls the functions of c-Myc independently of p53
    • Qi Y, Gregory MA, Li Z, et al. p19ARF directly and differentially controls the functions of c-Myc independently of p53. Nature 2004; 431: 712-17.
    • (2004) Nature , vol.431 , pp. 712-717
    • Qi, Y.1    Gregory, M.A.2    Li, Z.3
  • 13
    • 85047698445 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis
    • Hemmati PG, Gillissen B, von, Haefen C, et al. Adenovirus-mediated overexpression of p14(ARF) induces p53 and Bax-independent apoptosis. Oncogene 2002; 21: 3149-61.
    • (2002) Oncogene , vol.21 , pp. 3149-3161
    • Hemmati, P.G.1    Gillissen, B.2    Haefen, C.3
  • 14
    • 56249110099 scopus 로고    scopus 로고
    • Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF
    • Hemmati PG, Normand G, Gillissen B, et al. Cooperative effect of p21Cip1/WAF-1 and 14-3-3sigma on cell cycle arrest and apoptosis induction by p14ARF. Oncogene 2008; 27: 6707-19.
    • (2008) Oncogene , vol.27 , pp. 6707-6719
    • Hemmati, P.G.1    Normand, G.2    Gillissen, B.3
  • 15
    • 21244502525 scopus 로고    scopus 로고
    • Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells
    • Hemmati PG, Normand G, Verdoodt B, et al. Loss of p21 disrupts p14 ARF-induced G1 cell cycle arrest but augments p14 ARF-induced apoptosis in human carcinoma cells. Oncogene 2005; 24: 4114-28.
    • (2005) Oncogene , vol.24 , pp. 4114-4128
    • Hemmati, P.G.1    Normand, G.2    Verdoodt, B.3
  • 16
    • 0043172452 scopus 로고    scopus 로고
    • P53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor
    • Rocha S, Campbell KJ, Perkins ND,. p53- and Mdm2-independent repression of NF-kappa B transactivation by the ARF tumor suppressor. Mol Cell 2003; 12: 15-25.
    • (2003) Mol Cell , vol.12 , pp. 15-25
    • Rocha, S.1    Campbell, K.J.2    Perkins, N.D.3
  • 17
    • 33645716061 scopus 로고    scopus 로고
    • P14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation
    • Eymin B, Claverie P, Salon C, et al. p14ARF triggers G2 arrest through ERK-mediated Cdc25C phosphorylation, ubiquitination and proteasomal degradation. Cell Cycle 2006; 5: 759-65.
    • (2006) Cell Cycle , vol.5 , pp. 759-765
    • Eymin, B.1    Claverie, P.2    Salon, C.3
  • 18
    • 33747819484 scopus 로고    scopus 로고
    • Divorcing ARF and p53: An unsettled case
    • Sherr CJ,. Divorcing ARF and p53: an unsettled case. Nat Rev Cancer 2006; 6: 663-73.
    • (2006) Nat Rev Cancer , vol.6 , pp. 663-673
    • Sherr, C.J.1
  • 19
    • 14844303695 scopus 로고    scopus 로고
    • P14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity
    • Normand G, Hemmati PG, Verdoodt B, et al. p14ARF induces G2 cell cycle arrest in p53- and p21-deficient cells by down-regulating p34cdc2 kinase activity. J Biol Chem 2005; 280: 7118-30.
    • (2005) J Biol Chem , vol.280 , pp. 7118-7130
    • Normand, G.1    Hemmati, P.G.2    Verdoodt, B.3
  • 20
    • 30544446125 scopus 로고    scopus 로고
    • Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth
    • Bhonde MR, Hanski ML, Notter M, et al. Equivalent effect of DNA damage-induced apoptotic cell death or long-term cell cycle arrest on colon carcinoma cell proliferation and tumour growth. Oncogene 2006; 25: 165-75.
    • (2006) Oncogene , vol.25 , pp. 165-175
    • Bhonde, M.R.1    Hanski, M.L.2    Notter, M.3
  • 21
    • 0142058036 scopus 로고    scopus 로고
    • Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy
    • Rau B, Sturm I, Lage H, et al. Dynamic expression profile of p21WAF1/CIP1 and Ki-67 predicts survival in rectal carcinoma treated with preoperative radiochemotherapy. J Clin Oncol 2003; 21: 3391-401.
    • (2003) J Clin Oncol , vol.21 , pp. 3391-3401
    • Rau, B.1    Sturm, I.2    Lage, H.3
  • 22
    • 0042815099 scopus 로고    scopus 로고
    • Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway
    • Gillissen B, Essmann F, Graupner V, et al. Induction of cell death by the BH3-only Bcl-2 homolog Nbk/Bik is mediated by an entirely Bax-dependent mitochondrial pathway. EMBO J 2003; 22: 3580-90.
    • (2003) EMBO J , vol.22 , pp. 3580-3590
    • Gillissen, B.1    Essmann, F.2    Graupner, V.3
  • 23
    • 8844245663 scopus 로고    scopus 로고
    • Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway
    • von Haefen C, Gillissen B, Hemmati PG, et al. Multidomain Bcl-2 homolog Bax but not Bak mediates synergistic induction of apoptosis by TRAIL and 5-FU through the mitochondrial apoptosis pathway. Oncogene 2004; 23: 8320-32.
    • (2004) Oncogene , vol.23 , pp. 8320-8332
    • Von Haefen, C.1    Gillissen, B.2    Hemmati, P.G.3
  • 24
    • 33646861005 scopus 로고    scopus 로고
    • P14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress
    • Eymin B, Claverie P, Salon C, et al. p14ARF activates a Tip60-dependent and p53-independent ATM/ATR/CHK pathway in response to genotoxic stress. Mol Cell Biol 2006; 26: 4339-50.
    • (2006) Mol Cell Biol , vol.26 , pp. 4339-4350
    • Eymin, B.1    Claverie, P.2    Salon, C.3
  • 25
    • 0040298568 scopus 로고    scopus 로고
    • Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis
    • Jänicke RU, Sprengart ML, Wati MR, et al. Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 1998; 273: 9357-60.
    • (1998) J Biol Chem , vol.273 , pp. 9357-9360
    • Jänicke, R.U.1    Sprengart, M.L.2    Wati, M.R.3
  • 26
    • 0035901938 scopus 로고    scopus 로고
    • Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance
    • Friedrich K, Wieder T, Von Haefen C, et al. Overexpression of caspase-3 restores sensitivity for drug-induced apoptosis in breast cancer cell lines with acquired drug resistance. Oncogene 2001; 20: 2749-60.
    • (2001) Oncogene , vol.20 , pp. 2749-2760
    • Friedrich, K.1    Wieder, T.2    Von Haefen, C.3
  • 27
    • 14444284332 scopus 로고    scopus 로고
    • Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells
    • Craig C, Kim M, Ohri E, et al. Effects of adenovirus-mediated p16INK4A expression on cell cycle arrest are determined by endogenous p16 and Rb status in human cancer cells. Oncogene 1998; 16: 265-72.
    • (1998) Oncogene , vol.16 , pp. 265-272
    • Craig, C.1    Kim, M.2    Ohri, E.3
  • 28
    • 0034662619 scopus 로고    scopus 로고
    • Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells
    • Blanc C, Deveraux QL, Krajewski S, et al. Caspase-3 is essential for procaspase-9 processing and cisplatin-induced apoptosis of MCF-7 breast cancer cells. Cancer Res 2000; 60: 4386-90.
    • (2000) Cancer Res , vol.60 , pp. 4386-4390
    • Blanc, C.1    Deveraux, Q.L.2    Krajewski, S.3
  • 29
    • 77954549639 scopus 로고    scopus 로고
    • Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3
    • Hemmati PG, Müer A, Gillissen B, et al. Systematic genetic dissection of p14ARF-mediated mitochondrial cell death signaling reveals a key role for p21CDKN1 and the BH3-only protein Puma/bbc3. J Mol Med 2010; 88: 609-22.
    • (2010) J Mol Med , vol.88 , pp. 609-622
    • Hemmati, P.G.1    Müer, A.2    Gillissen, B.3
  • 30
    • 33244474612 scopus 로고    scopus 로고
    • Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells
    • Wendt J, Radetzki S, von Haefen C, et al. Induction of p21CIP/WAF-1 and G2 arrest by ionizing irradiation impedes caspase-3-mediated apoptosis in human carcinoma cells. Oncogene 2006; 25: 972-80.
    • (2006) Oncogene , vol.25 , pp. 972-980
    • Wendt, J.1    Radetzki, S.2    Von Haefen, C.3
  • 31
    • 0032546795 scopus 로고    scopus 로고
    • Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis
    • Jänicke RU, Ng P, Sprengart ML, et al. Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 1998; 273: 15540-5.
    • (1998) J Biol Chem , vol.273 , pp. 15540-15545
    • Jänicke, R.U.1    Ng, P.2    Sprengart, M.L.3
  • 32
    • 39849104757 scopus 로고    scopus 로고
    • Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak
    • Neise D, Graupner V, Gillissen BF, et al. Activation of the mitochondrial death pathway is commonly mediated by a preferential engagement of Bak. Oncogene 2008; 27: 1387-96.
    • (2008) Oncogene , vol.27 , pp. 1387-1396
    • Neise, D.1    Graupner, V.2    Gillissen, B.F.3
  • 33
    • 0035279162 scopus 로고    scopus 로고
    • Human ARF binds E2F1 and inhibits its transcriptional activity
    • Eymin B, Karayan L, Seite P, et al. Human ARF binds E2F1 and inhibits its transcriptional activity. Oncogene 2001; 20: 1033-41.
    • (2001) Oncogene , vol.20 , pp. 1033-1041
    • Eymin, B.1    Karayan, L.2    Seite, P.3
  • 34
  • 36
    • 0036653392 scopus 로고    scopus 로고
    • E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest
    • Rowland BD, Denissov SG, Douma S, et al. E2F transcriptional repressor complexes are critical downstream targets of p19(ARF)/p53-induced proliferative arrest. Cancer Cell 2002; 2: 55-65.
    • (2002) Cancer Cell , vol.2 , pp. 55-65
    • Rowland, B.D.1    Denissov, S.G.2    Douma, S.3
  • 37
    • 0032701521 scopus 로고    scopus 로고
    • Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    • Bunz F, Hwang PM, Torrance C, et al. Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest 1999; 104: 263-9.
    • (1999) J Clin Invest , vol.104 , pp. 263-269
    • Bunz, F.1    Hwang, P.M.2    Torrance, C.3
  • 38
    • 0030011128 scopus 로고    scopus 로고
    • Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    • Waldman T, Lengauer C, Kinzler KW, et al. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature 1996; 381: 713-16.
    • (1996) Nature , vol.381 , pp. 713-716
    • Waldman, T.1    Lengauer, C.2    Kinzler, K.W.3
  • 39
    • 0037452759 scopus 로고    scopus 로고
    • PUMA mediates the apoptotic response to p53 in colorectal cancer cells
    • Yu J, Wang Z, Kinzler KW, et al. PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proc Natl Acad Sci USA 2003; 100: 1931-6.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 1931-1936
    • Yu, J.1    Wang, Z.2    Kinzler, K.W.3
  • 40
    • 33750483637 scopus 로고    scopus 로고
    • Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells
    • Hemmati PG, Güner D, Gillissen B, et al. Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells. Oncogene 2006; 25: 6582-94.
    • (2006) Oncogene , vol.25 , pp. 6582-6594
    • Hemmati, P.G.1    Güner, D.2    Gillissen, B.3
  • 41
    • 84861212019 scopus 로고    scopus 로고
    • P14ARF-induced Apoptosis in p53 protein-deficient cells Is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins
    • Muer A, Overkamp T, Gillissen B, et al. p14ARF-induced Apoptosis in p53 protein-deficient cells Is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins. J Biol Chem 2012; 287: 17343-52.
    • (2012) J Biol Chem , vol.287 , pp. 17343-17352
    • Muer, A.1    Overkamp, T.2    Gillissen, B.3
  • 42
    • 9644307904 scopus 로고    scopus 로고
    • Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
    • Enoksson M, Robertson JD, Gogvadze V, et al. Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids. J Biol Chem 2004; 279: 49575-8.
    • (2004) J Biol Chem , vol.279 , pp. 49575-49578
    • Enoksson, M.1    Robertson, J.D.2    Gogvadze, V.3
  • 44
    • 66149103719 scopus 로고    scopus 로고
    • DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
    • Olsson M, Vakifahmetoglu H, Abruzzo PM, et al. DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene 2009; 28: 1949-59.
    • (2009) Oncogene , vol.28 , pp. 1949-1959
    • Olsson, M.1    Vakifahmetoglu, H.2    Abruzzo, P.M.3
  • 45
    • 0033535350 scopus 로고    scopus 로고
    • Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis
    • Desagher S, Osen-Sand A, Nichols A, et al. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol 1999; 144: 891-901.
    • (1999) J Cell Biol , vol.144 , pp. 891-901
    • Desagher, S.1    Osen-Sand, A.2    Nichols, A.3
  • 46
    • 0038382972 scopus 로고    scopus 로고
    • Nonredundant role of Bax and Bak in Bid-mediated apoptosis
    • Cartron PF, Juin P, Oliver L, et al. Nonredundant role of Bax and Bak in Bid-mediated apoptosis. Mol Cell Biol 2003; 23: 4701-12.
    • (2003) Mol Cell Biol , vol.23 , pp. 4701-4712
    • Cartron, P.F.1    Juin, P.2    Oliver, L.3
  • 47
    • 33846964621 scopus 로고    scopus 로고
    • Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
    • Willis SN, Fletcher JI, Kaufmann T, et al. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak. Science 2007; 315: 856-9.
    • (2007) Science , vol.315 , pp. 856-859
    • Willis, S.N.1    Fletcher, J.I.2    Kaufmann, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.