Ethanol-induced neurodegeneration in NRSF/REST neuronal conditional knockout mice

Neuroscience

Volumn 181, Issue , 2011, Pages 196-205

  Cai, L ^a,e   Bian, M ^b   Liu, M ^a,e   Sheng, Z ^c   Suo, H ^b   Wang, Z ^d   Huang, F ^b   Fei, J ^c,d  

^a INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

^b FUDAN UNIVERSITY   (China)

^c TONGJI UNIVERSITY   (China)

^d Shanghai Research Center for Model Organisms   (China)

^e UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Apoptosis; Caspase 3; Ethanol; Fetal alcohol syndrome; Nrsf conditional knockout

Indexed keywords

ALCOHOL; NEURON RESTRICTIVE SILENCER FACTOR; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR 4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN; BRAIN REGION; CONTROLLED STUDY; MOUSE; NERVE DEGENERATION; NEUROPROTECTION; NONHUMAN; PERINATAL PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ALCOHOL-INDUCED DISORDERS, NERVOUS SYSTEM; ANIMALS; DISEASE MODELS, ANIMAL; ETHANOL; FEMALE; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NERVE DEGENERATION; PREGNANCY; REPRESSOR PROTEINS;

EID: 79953702787     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.02.059     Document Type: Article

References (41)

1. Ballas N., Grunseich C., Lu D.D., Speh J.C., Mandel G. REST and its corepressors mediate plasticity of neuronal gene chromatin throughout neurogenesis. Cell 2005, 121:645-657.
2. Bauer-Moffett C., Altman J. The effect of ethanol chronically administered to preweanling rats on cerebellar development: a morphological study. Brain Res 1977, 119:249-268.
3. Bian M., Yu M., Yang S., Gao H., Huang Y., Deng C., Gao Y., Sun F., Huang F. Expression of Cbl-interacting protein of 85 kDa in MPTP mouse model of Parkinson's disease and 1-methyl-4-phenyl-pyridinium ion-treated dopaminergic SH-SY5Y cells. Acta Biochim Biophys Sin (Shanghai) 2008, 40:505-512.
4. Bonthius D.J., Tzouras G., Karacay B., Mahoney J., Hutton A., McKim R., Pantazis N.J. Deficiency of neuronal nitric oxide synthase (nNOS) worsens alcohol-induced microencephaly and neuronal loss in developing mice. Brain Res Dev Brain Res 2002, 138:45-59.
5. Cai Y.Q., Cai G.Q., Liu G.X., Cai Q., Shi J.H., Shi J., Ma S.K., Sun X., Sheng Z.J., Mei Z.T., et al. Mice with genetically altered GABA transporter subtype I (GAT1) expression show altered behavioral responses to ethanol. J Neurosci Res 2006, 84:255-267.
6. Calderone A., Jover T., Noh K.M., Tanaka H., Yokota H., Lin Y., Grooms S.Y., Regis R., Bennett M.V., Zukin R.S. Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci 2003, 23:2112-2121.
7. Chen Z.F., Paquette A.J., Anderson D.J. NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis. Nat Genet 1998, 20:136-142.
8. Chong J.A., Tapia-Ramirez J., Kim S., Toledo-Aral J.J., Zheng Y., Boutros M.C., Altshuller Y.M., Frohman M.A., Kraner S.D., Mandel G. REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons. Cell 1995, 80:949-957.
9. Dobbing J., Sands J. Comparative aspects of the brain growth spurt. Early Hum Dev 1979, 3:79-83.
10. Formisano L., Noh K.M., Miyawaki T., Mashiko T., Bennett M.V., Zukin R.S. Ischemic insults promote epigenetic reprogramming of mu opioid receptor expression in hippocampal neurons. Proc Natl Acad Sci U S A 2007, 104:4170-4175.
11. Forss-Petter S., Danielson P.E., Catsicas S., Battenberg E., Price J., Nerenberg M., Sutcliffe J.G. Transgenic mice expressing beta-galactosidase in mature neurons under neuron-specific enolase promoter control. Neuron 1990, 5:187-197.
12. Garthwaite J., Charles S.L., Chess-Williams R. Endothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 1988, 336:385-388.
13. Goodlett C.R., Marcussen B.L., West J.R. A single day of alcohol exposure during the brain growth spurt induces brain weight restriction and cerebellar Purkinje cell loss. Alcohol 1990, 7:107-114.
14. Hamre K.M., West J.R. The effects of the timing of ethanol exposure during the brain growth spurt on the number of cerebellar Purkinje and granule cell nuclear profiles. Alcohol Clin Exp Res 1993, 17:610-622.
15. Ieraci A., Herrera D.G. Nicotinamide protects against ethanol-induced apoptotic neurodegeneration in the developing mouse brain. PLoS Med 2006, 3:e101.
16. Ikonomidou C., Bittigau P., Ishimaru M.J., Wozniak D.F., Koch C., Genz K., Price M.T., Stefovska V., Horster F., Tenkova T., et al. Ethanol-induced apoptotic neurodegeneration and fetal alcohol syndrome. Science 2000, 287:1056-1060.
17. Ikonomidou C., Bosch F., Miksa M., Bittigau P., Vockler J., Dikranian K., Tenkova T.I., Stefovska V., Turski L., Olney J.W. Blockade of NMDA receptors and apoptotic neurodegeneration in the developing brain. Science 1999, 283:70-74.
18. Jones K.L., Smith D.W. Recognition of the fetal alcohol syndrome in early infancy. Lancet 1973, 2:999-1001.
19. Jurgensmeier J.M., Xie Z., Deveraux Q., Ellerby L., Bredesen D., Reed J.C. Bax directly induces release of cytochrome c from isolated mitochondria. Proc Natl Acad Sci U S A 1998, 95:4997-5002.
20. Lepagnol-Bestel A.M., Zvara A., Maussion G., Quignon F., Ngimbous B., Ramoz N., Imbeaud S., Loe-Mie Y., Benihoud K., Agier N., et al. DYRK1A interacts with the REST/NRSF-SWI/SNF chromatin remodelling complex to deregulate gene clusters involved in the neuronal phenotypic traits of Down syndrome. Hum Mol Genet 2009, 18:1405-1414.
21. Naruse Y., Aoki T., Kojima T., Mori N. Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. Proc Natl Acad Sci U S A 1999, 96:13691-13696.
22. Olney J.W., Tenkova T., Dikranian K., Muglia L.J., Jermakowicz W.J., D'Sa C., Roth K.A. Ethanol-induced caspase-3 activation in the in vivo developing mouse brain. Neurobiol Dis 2002, 9:205-219.
23. Olney J.W., Tenkova T., Dikranian K., Qin Y.Q., Labruyere J., Ikonomidou C. Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain. Brain Res Dev Brain Res 2002, 133:115-126.
24. Palm K., Belluardo N., Metsis M., Timmusk T. Neuronal expression of zinc finger transcription factor REST/NRSF/XBR gene. J Neurosci 1998, 18:1280-1296.
25. Pantazis N.J., West J.R., Dai D. The nitric oxide-cyclic GMP pathway plays an essential role in both promoting cell survival of cerebellar granule cells in culture and protecting the cells against ethanol neurotoxicity. J Neurochem 1998, 70:1826-1838.
26. Ruiz-Vela A., Opferman J.T., Cheng E.H., Korsmeyer S.J. Proapoptotic BAX and BAK control multiple initiator caspases. EMBO Rep 2005, 6:379-385.
27. Ryabinin A.E., Cole M., Bloom F.E., Wilson M.C. Exposure of neonatal rats to alcohol by vapor inhalation demonstrates specificity of microcephaly and Purkinje cell loss but not astrogliosis. Alcohol Clin Exp Res 1995, 19:784-791.
28. Schoenherr C.J., Anderson D.J. The neuron-restrictive silencer factor (NRSF): a coordinate repressor of multiple neuron-specific genes. Science 1995, 267:1360-1363.
29. Shimojo M., Paquette A.J., Anderson D.J., Hersh L.B. Protein kinase A regulates cholinergic gene expression in PC12 cells: REST4 silences the silencing activity of neuron-restrictive silencer factor/REST. Mol Cell Biol 1999, 19:6788-6795.
30. Soriano P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat Genet 1999, 21:70-71.
31. Spencer E.M., Chandler K.E., Haddley K., Howard M.R., Hughes D., Belyaev N.D., Coulson J.M., Stewart J.P., Buckley N.J., Kipar A., et al. Regulation and role of REST and REST4 variants in modulation of gene expression in in vivo and in vitro in epilepsy models. Neurobiol Dis 2006, 24:41-52.
32. Tabuchi A., Yamada T., Sasagawa S., Naruse Y., Mori N., Tsuda M. REST4-mediated modulation of REST/NRSF-silencing function during BDNF gene promoter activation. Biochem Biophys Res Commun 2002, 290:415-420.
33. Tateno M., Ukai W., Hashimoto E., Ikeda H., Saito T. Implication of increased NRSF/REST binding activity in the mechanism of ethanol inhibition of neuronal differentiation. J Neural Transm 2006, 113:283-293.
34. Wei M.C., Zong W.X., Cheng E.H., Lindsten T., Panoutsakopoulou V., Ross A.J., Roth K.A., MacGregor G.R., Thompson C.B., Korsmeyer S.J. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 2001, 292:727-730.
35. Weiss D.J., Liggitt D., Clark J.G. Histochemical discrimination of endogenous mammalian beta-galactosidase activity from that resulting from lac-Z gene expression. Histochem J 1999, 31:231-236.
36. West J.R., Hamre K.M., Cassell M.D. Effects of ethanol exposure during the third trimester equivalent on neuron number in rat hippocampus and dentate gyrus. Alcohol Clin Exp Res 1986, 10:190-197.
37. Wozniak D.F., Hartman R.E., Boyle M.P., Vogt S.K., Brooks A.R., Tenkova T., Young C., Olney J.W., Muglia L.J. Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults. Neurobiol Dis 2004, 17:403-414.
38. Young C., Klocke B.J., Tenkova T., Choi J., Labruyere J., Qin Y.Q., Holtzman D.M., Roth K.A., Olney J.W. Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain. Cell Death Differ 2003, 10:1148-1155.
39. Zuccato C., Belyaev N., Conforti P., Ooi L., Tartari M., Papadimou E., MacDonald M., Fossale E., Zeitlin S., Buckley N., et al. Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. J Neurosci 2007, 27:6972-6983.
40. Zuccato C., Tartari M., Crotti A., Goffredo D., Valenza M., Conti L., Cataudella T., Leavitt B.R., Hayden M.R., Timmusk T., et al. Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes. Nat Genet 2003, 35:76-83.
41. Zukin R.S. Eradicating the mediators of neuronal death with a fine-tooth comb. Sci Signal 2010, 3:pe20.