ER stress suppresses DNA double-strand break repair and sensitizes tumor cells to ionizing radiation by stimulating proteasomal degradation of Rad51

FEBS Letters

Volumn 587, Issue 20, 2013, Pages 3348-3353

  Yamamori, Tohru ^a   Meike, Shunsuke ^a   Nagane, Masaki ^a   Yasui, Hironobu ^a   Inanami, Osamu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

Author keywords

DNA double strand break repair; ER stress; Rad51; Radiosensitivity; Unfolded protein response

Indexed keywords

DOUBLE STRANDED DNA; PROTEASOME; RAD51 PROTEIN; TUNICAMYCIN;

ARTICLE; CONTROLLED STUDY; DNA REPAIR; DNA STRAND BREAKAGE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IONIZING RADIATION; LUNG CARCINOMA; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RADIOSENSITIVITY; SIGNAL TRANSDUCTION; TUMOR CELL; TUMOR MICROENVIRONMENT; UPREGULATION;

DNA DOUBLE-STRAND BREAK REPAIR; DOUBLE-STRAND BREAK; DSB; ENDOPLASMIC RETICULUM; ER; ER STRESS; ER-ASSOCIATED DEGRADATION; ERAD; HOMOLOGOUS RECOMBINATION; HR; IONIZING RADIATION; IR; NHEJ; NON-HOMOLOGOUS END JOINING; RAD51; RADIOSENSITIVITY; REVERSE TRANSCRIPTION-PCR; RT-PCR; UNFOLDED PROTEIN RESPONSE; UPR;

BLOTTING, WESTERN; CELL LINE, TUMOR; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOPLASMIC RETICULUM STRESS; HUMANS; PROTEASOME ENDOPEPTIDASE COMPLEX; RAD51 RECOMBINASE; RADIATION, IONIZING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84884903293     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2013.08.030     Document Type: Article

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