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Volumn 335, Issue 3, 2010, Pages 830-840

Down-regulation of Rad51 expression overcomes drug resistance to gemcitabine in human non-small-cell lung cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; COMPLEMENTARY DNA; CYCLOHEXIMIDE; DACTINOMYCIN; ERLOTINIB; GEMCITABINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; RAD51 PROTEIN; SMALL INTERFERING RNA;

EID: 78649550749     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.110.173146     Document Type: Article
Times cited : (67)

References (45)
  • 1
    • 0038621384 scopus 로고    scopus 로고
    • Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death
    • Arlt A, Gehrz A, Müerköster S, Vorndamm J, Kruse ML, Fölsch UR, and Schäfer H (2003) Role of NF-kappaB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death. Oncogene 22:3243-3251.
    • (2003) Oncogene , vol.22 , pp. 3243-3251
    • Arlt, A.1    Gehrz, A.2    Müerköster, S.3    Vorndamm, J.4    Kruse, M.L.5    Fölsch, U.R.6    Schäfer, H.7
  • 2
    • 0033603537 scopus 로고    scopus 로고
    • The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells
    • Arnaudeau C, Helleday T, and Jenssen D (1999) The RAD51 protein supports homologous recombination by an exchange mechanism in mammalian cells. J Mol Biol 289:1231-1238.
    • (1999) J Mol Biol , vol.289 , pp. 1231-1238
    • Arnaudeau, C.1    Helleday, T.2    Jenssen, D.3
  • 4
    • 0036570311 scopus 로고    scopus 로고
    • Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia
    • Bello VE, Aloyz RS, Christodoulopoulos G, and Panasci LC (2002) Homologous recombinational repair vis-à-vis chlorambucil resistance in chronic lymphocytic leukemia. Biochem Pharmacol 63:1585-1588.
    • (2002) Biochem Pharmacol , vol.63 , pp. 1585-1588
    • Bello, V.E.1    Aloyz, R.S.2    Christodoulopoulos, G.3    Panasci, L.C.4
  • 5
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability
    • Bristow RG and Hill RP (2008) Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 8:180-192.
    • (2008) Nat Rev Cancer , vol.8 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 6
    • 0035872199 scopus 로고    scopus 로고
    • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard J, Clark AS, Ni Y, and Dennis PA (2001) Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61:3986-3997.
    • (2001) Cancer Res , vol.61 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3    Dennis, P.A.4
  • 7
    • 0033081066 scopus 로고    scopus 로고
    • Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry
    • Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, and Pouysségur J (1999) Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry. EMBO J 18:664-674.
    • (1999) EMBO J , vol.18 , pp. 664-674
    • Brunet, A.1    Roux, D.2    Lenormand, P.3    Dowd, S.4    Keyse, S.5    Pouysségur, J.6
  • 10
    • 58149490629 scopus 로고    scopus 로고
    • Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity
    • Choudhury A, Zhao H, Jalali F, Al Rashid S, Ran J, Supiot S, Kiltie AE, and Bristow RG (2009) Targeting homologous recombination using imatinib results in enhanced tumor cell chemosensitivity and radiosensitivity. Mol Cancer Ther 8:203-213.
    • (2009) Mol Cancer Ther , vol.8 , pp. 203-213
    • Choudhury, A.1    Zhao, H.2    Jalali, F.3    Al Rashid, S.4    Ran, J.5    Supiot, S.6    Kiltie, A.E.7    Bristow, R.G.8
  • 11
    • 0034068319 scopus 로고    scopus 로고
    • Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
    • Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, Bianco AR, and Tortora G (2000) Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 6:2053-2063.
    • (2000) Clin Cancer Res , vol.6 , pp. 2053-2063
    • Ciardiello, F.1    Caputo, R.2    Bianco, R.3    Damiano, V.4    Pomatico, G.5    De Placido, S.6    Bianco, A.R.7    Tortora, G.8
  • 12
    • 6044230919 scopus 로고    scopus 로고
    • Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage
    • DOI 10.1158/1078-0432.CCR-04-0174
    • David O, Jett J, LeBeau H, Dy G, Hughes J, Friedman M, and Brody AR (2004) Phospho-Akt overexpression in non-small cell lung cancer confers significant stage-independent survival disadvantage. Clin Cancer Res 10:6865-6871. (Pubitemid 39383035)
    • (2004) Clinical Cancer Research , vol.10 , Issue.20 , pp. 6865-6871
    • David, O.1    Jett, J.2    LeBeau, H.3    Dy, G.4    Hughes, J.5    Friedman, M.6    Brody, A.R.7
  • 13
    • 23344453535 scopus 로고    scopus 로고
    • Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin
    • Ito M, Yamamoto S, Nimura K, Hiraoka K, Tamai K, and Kaneda Y (2005) Rad51 siRNA delivered by HVJ envelope vector enhances the anti-cancer effect of cisplatin. J Gene Med 7:1044-1052.
    • (2005) J Gene Med , vol.7 , pp. 1044-1052
    • Ito, M.1    Yamamoto, S.2    Nimura, K.3    Hiraoka, K.4    Tamai, K.5    Kaneda, Y.6
  • 14
    • 0037499945 scopus 로고    scopus 로고
    • Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: Limited anti-proliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways
    • Janmaat ML, Kruyt FA, Rodriguez JA, and Giaccone G (2003) Response to epidermal growth factor receptor inhibitors in non-small cell lung cancer cells: limited anti-proliferative effects and absence of apoptosis associated with persistent activity of extracellular signal-regulated kinase or Akt kinase pathways. Clin Cancer Res 9:2316-2326.
    • (2003) Clin Cancer Res , vol.9 , pp. 2316-2326
    • Janmaat, M.L.1    Kruyt, F.A.2    Rodriguez, J.A.3    Giaccone, G.4
  • 16
    • 69449106495 scopus 로고    scopus 로고
    • Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells
    • Ko JC, Ciou SC, Jhan JY, Cheng CM, Su YJ, Chuang SM, Lin ST, Chang CC, and Lin YW (2009) Roles of MKK1/2-ERK1/2 and phosphoinositide 3-kinase-AKT signaling pathways in erlotinib-induced Rad51 suppression and cytotoxicity in human non-small cell lung cancer cells. Mol Cancer Res 7:1378-1389.
    • (2009) Mol Cancer Res , vol.7 , pp. 1378-1389
    • Ko, J.C.1    Ciou, S.C.2    Jhan, J.Y.3    Cheng, C.M.4    Su, Y.J.5    Chuang, S.M.6    Lin, S.T.7    Chang, C.C.8    Lin, Y.W.9
  • 17
    • 23344435003 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase is necessary for gemcitabine-induced cytotoxicity in human pancreatic cancer cells
    • Koizumi K, Tanno S, Nakano Y, Habiro A, Izawa T, Mizukami Y, Okumura T, and Kohgo Y (2005) Activation of p38 mitogen-activated protein kinase is necessary for gemcitabine-induced cytotoxicity in human pancreatic cancer cells. Anticancer Res 25:3347-3353.
    • (2005) Anticancer Res , vol.25 , pp. 3347-3353
    • Koizumi, K.1    Tanno, S.2    Nakano, Y.3    Habiro, A.4    Izawa, T.5    Mizukami, Y.6    Okumura, T.7    Kohgo, Y.8
  • 18
    • 19944389532 scopus 로고    scopus 로고
    • Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA)
    • Kokubo Y, Gemma A, Noro R, Seike M, Kataoka K, Matsuda K, Okano T, Minegishi Y, Yoshimura A, Shibuya M, et al. (2005) Reduction of PTEN protein and loss of epidermal growth factor receptor gene mutation in lung cancer with natural resistance to gefitinib (IRESSA). Br J Cancer 92:1711-1719.
    • (2005) Br J Cancer , vol.92 , pp. 1711-1719
    • Kokubo, Y.1    Gemma, A.2    Noro, R.3    Seike, M.4    Kataoka, K.5    Matsuda, K.6    Okano, T.7    Minegishi, Y.8    Yoshimura, A.9    Shibuya, M.10
  • 19
    • 19944413630 scopus 로고    scopus 로고
    • Multicentre randomised phase III study comparing the same dose and schedule of cisplatin plus the same schedule of vinorelbine or gemcitabine in advanced non-small cell lung cancer
    • Martoni A, Marino A, Sperandi F, Giaquinta S, Di Fabio F, Melotti B, Guaraldi M, Palomba G, Preti P, Petralia A, et al. (2005) Multicentre randomised phase III study comparing the same dose and schedule of cisplatin plus the same schedule of vinorelbine or gemcitabine in advanced non-small cell lung cancer. Eur J Cancer 41:81-92.
    • (2005) Eur J Cancer , vol.41 , pp. 81-92
    • Martoni, A.1    Marino, A.2    Sperandi, F.3    Giaquinta, S.4    Di Fabio, F.5    Melotti, B.6    Guaraldi, M.7    Palomba, G.8    Preti, P.9    Petralia, A.10
  • 20
    • 54949105392 scopus 로고    scopus 로고
    • The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases
    • Matsumoto K, Nagahara T, Okano J, and Murawaki Y (2008) The growth inhibition of hepatocellular and cholangiocellular carcinoma cells by gemcitabine and the roles of extracellular signal-regulated and checkpoint kinases. Oncol Rep 20:863-872.
    • (2008) Oncol Rep , vol.20 , pp. 863-872
    • Matsumoto, K.1    Nagahara, T.2    Okano, J.3    Murawaki, Y.4
  • 21
    • 0034988184 scopus 로고    scopus 로고
    • The epidermal growth factor receptor as a target for cancer therapy
    • Mendelsohn J (2001) The epidermal growth factor receptor as a target for cancer therapy. Endocr Relat Cancer 8:3-9.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 3-9
    • Mendelsohn, J.1
  • 22
    • 34249933404 scopus 로고    scopus 로고
    • Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: A phase III trial of the National Cancer Institute of Canada Clinical Trials Group
    • Moore MJ, Goldstein D, Hamm J, Figer A, Hecht JR, Gallinger S, Au HJ, Murawa P, Walde D, Wolff RA, et al. (2007) Erlotinib plus gemcitabine compared with gemcitabine alone in patients with advanced pancreatic cancer: a phase III trial of the National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 25:1960-1966.
    • (2007) J Clin Oncol , vol.25 , pp. 1960-1966
    • Moore, M.J.1    Goldstein, D.2    Hamm, J.3    Figer, A.4    Hecht, J.R.5    Gallinger, S.6    Au, H.J.7    Murawa, P.8    Walde, D.9    Wolff, R.A.10
  • 23
    • 52649108603 scopus 로고    scopus 로고
    • The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer
    • Morgan MA, Parsels LA, Kollar LE, Normolle DP, Maybaum J, and Lawrence TS (2008) The combination of epidermal growth factor receptor inhibitors with gemcitabine and radiation in pancreatic cancer. Clin Cancer Res 14:5142-5149.
    • (2008) Clin Cancer Res , vol.14 , pp. 5142-5149
    • Morgan, M.A.1    Parsels, L.A.2    Kollar, L.E.3    Normolle, D.P.4    Maybaum, J.5    Lawrence, T.S.6
  • 25
    • 2642570481 scopus 로고    scopus 로고
    • Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    • Ono M, Hirata A, Kometani T, Miyagawa M, Ueda S, Kinoshita H, Fujii T, and Kuwano M (2004) Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation. Mol Cancer Ther 3:465-472.
    • (2004) Mol Cancer Ther , vol.3 , pp. 465-472
    • Ono, M.1    Hirata, A.2    Kometani, T.3    Miyagawa, M.4    Ueda, S.5    Kinoshita, H.6    Fujii, T.7    Kuwano, M.8
  • 29
    • 0842329805 scopus 로고    scopus 로고
    • Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability
    • Richardson C, Stark JM, Ommundsen M, and Jasin M (2004) Rad51 overexpression promotes alternative double-strand break repair pathways and genome instability. Oncogene 23:546-553.
    • (2004) Oncogene , vol.23 , pp. 546-553
    • Richardson, C.1    Stark, J.M.2    Ommundsen, M.3    Jasin, M.4
  • 30
    • 3042665933 scopus 로고    scopus 로고
    • Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery
    • Rosell R, Felip E, Taron M, Majo J, Mendez P, Sanchez-Ronco M, Queralt C, Sanchez JJ, and Maestre J (2004) Gene expression as a predictive marker of outcome in stage IIB-IIIA-IIIB non-small cell lung cancer after induction gemcitabine-based chemotherapy followed by resectional surgery. Clin Cancer Res 10:4215s-4219s.
    • (2004) Clin Cancer Res , vol.10
    • Rosell, R.1    Felip, E.2    Taron, M.3    Majo, J.4    Mendez, P.5    Sanchez-Ronco, M.6    Queralt, C.7    Sanchez, J.J.8    Maestre, J.9
  • 31
    • 17444402057 scopus 로고    scopus 로고
    • Targeting of Rad51-dependent homologous recombination: Implications for the radiation sensitivity of human lung cancer cell lines
    • Sak A, Stueben G, Groneberg M, Böcker W, and Stuschke M (2005) Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines. Br J Cancer 92:1089-1097.
    • (2005) Br J Cancer , vol.92 , pp. 1089-1097
    • Sak, A.1    Stueben, G.2    Groneberg, M.3    Böcker, W.4    Stuschke, M.5
  • 32
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciardiello F, and Normanno N (1995) Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232.
    • (1995) Crit Rev Oncol Hematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardiello, F.3    Normanno, N.4
  • 33
    • 50649100744 scopus 로고    scopus 로고
    • Mechanism of eukaryotic homologous recombination
    • San Filippo J, Sung P, and Klein H (2008) Mechanism of eukaryotic homologous recombination. Annu Rev Biochem 77:229-257.
    • (2008) Annu Rev Biochem , vol.77 , pp. 229-257
    • San Filippo, J.1    Sung, P.2    Klein, H.3
  • 34
    • 0037050352 scopus 로고    scopus 로고
    • Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
    • and Eastern Cooperative Oncology Group
    • Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, Zhu J, Johnson DH, and Eastern Cooperative Oncology Group (2002) Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 346: 92-98.
    • (2002) N Engl J Med , vol.346 , pp. 92-98
    • Schiller, J.H.1    Harrington, D.2    Belani, C.P.3    Langer, C.4    Sandler, A.5    Krook, J.6    Zhu, J.7    Johnson, D.H.8
  • 35
    • 0037145061 scopus 로고    scopus 로고
    • Ligand-induced, receptor-mediated dimerization and activation of EGF receptor
    • Schlessinger J (2002) Ligand-induced, receptor-mediated dimerization and activation of EGF receptor. Cell 110:669-672.
    • (2002) Cell , vol.110 , pp. 669-672
    • Schlessinger, J.1
  • 36
    • 0029878429 scopus 로고    scopus 로고
    • Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth
    • Shibata T, Kawano T, Nagayasu H, Okumura K, Arisue M, Hamada J, Takeichi N, and Hosokawa M (1996) Enhancing effects of epidermal growth factor on human squamous cell carcinoma motility and matrix degradation but not growth. Tumour Biol 17:168-175.
    • (1996) Tumour Biol , vol.17 , pp. 168-175
    • Shibata, T.1    Kawano, T.2    Nagayasu, H.3    Okumura, K.4    Arisue, M.5    Hamada, J.6    Takeichi, N.7    Hosokawa, M.8
  • 37
    • 30344446398 scopus 로고    scopus 로고
    • Targeted therapy for the treatment of advanced non-small cell lung cancer: A review of the epidermal growth factor receptor antagonists
    • Silvestri GA and Rivera MP (2005) Targeted therapy for the treatment of advanced non-small cell lung cancer: a review of the epidermal growth factor receptor antagonists. Chest 128:3975-3984.
    • (2005) Chest , vol.128 , pp. 3975-3984
    • Silvestri, G.A.1    Rivera, M.P.2
  • 38
    • 33845187527 scopus 로고    scopus 로고
    • Carcinoma of the bronchus 60 years later
    • Silvestri GA and Spiro SG (2006) Carcinoma of the bronchus 60 years later. Thorax 61:1023-1028.
    • (2006) Thorax , vol.61 , pp. 1023-1028
    • Silvestri, G.A.1    Spiro, S.G.2
  • 39
    • 0036261727 scopus 로고    scopus 로고
    • Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis
    • Slupianek A, Hoser G, Majsterek I, Bronisz A, Malecki M, Blasiak J, Fishel R, and Skorski T (2002) Fusion tyrosine kinases induce drug resistance by stimulation of homology-dependent recombination repair, prolongation of G(2)/M phase, and protection from apoptosis. Mol Cell Biol 22:4189-4201.
    • (2002) Mol Cell Biol , vol.22 , pp. 4189-4201
    • Slupianek, A.1    Hoser, G.2    Majsterek, I.3    Bronisz, A.4    Malecki, M.5    Blasiak, J.6    Fishel, R.7    Skorski, T.8
  • 42
    • 0027232422 scopus 로고
    • The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival
    • Veale D, Kerr N, Gibson GJ, Kelly PJ, and Harris AL (1993) The relationship of quantitative epidermal growth factor receptor expression in non-small cell lung cancer to long term survival. Br J Cancer 68:162-165.
    • (1993) Br J Cancer , vol.68 , pp. 162-165
    • Veale, D.1    Kerr, N.2    Gibson, G.J.3    Kelly, P.J.4    Harris, A.L.5
  • 43
    • 0032526320 scopus 로고    scopus 로고
    • Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation
    • Vispé S, Cazaux C, Lesca C, and Defais M (1998) Overexpression of Rad51 protein stimulates homologous recombination and increases resistance of mammalian cells to ionizing radiation. Nucleic Acids Res 26:2859-2864.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2859-2864
    • Vispé, S.1    Cazaux, C.2    Lesca, C.3    Defais, M.4
  • 45
    • 4143079350 scopus 로고    scopus 로고
    • Homologous recombination: Down to the wire
    • Wyman C and Kanaar R (2004) Homologous recombination: down to the wire. Curr Biol 14:R629-R631.
    • (2004) Curr Biol , vol.14
    • Wyman, C.1    Kanaar, R.2


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