High-level expression of Rad51 is an independent prognostic marker of survival in non-small-cell lung cancer patients

British Journal of Cancer

Volumn 93, Issue 1, 2005, Pages 137-143

  Qiao, G B ^a   Wu, Y L ^a   Yang, X N ^a   Zhong, W Z ^a   Xie, D ^b   Guan, X Y ^b   Fischer, D ^c   Kolberg, H C ^c   Kruger, S ^c   Stuerzbecher, H W ^c  

^a GUANGDONG PROVINCIAL PEOPLE'S HOSPITAL   (China)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

Non small cell lung carcinoma; Prognosis; Rad51; Tissue microarray

Indexed keywords

RAD51 PROTEIN;

ADULT; AGED; APOPTOSIS; ARTICLE; CANCER GRADING; CANCER STAGING; CANCER SURVIVAL; CONTROLLED STUDY; DISEASE MARKER; DRUG SENSITIVITY; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; KAPLAN MEIER METHOD; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG SQUAMOUS CELL CARCINOMA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; RADIOSENSITIVITY; SURVIVAL TIME; TISSUE MICROARRAY; TUMOR DIFFERENTIATION;

CARCINOMA, NON-SMALL-CELL LUNG; DNA-BINDING PROTEINS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROGNOSIS; RAD51 RECOMBINASE; SURVIVAL ANALYSIS;

EID: 23044437224     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6602665     Document Type: Article

References (22)

1. Brundage MD, Davies D, Mackillop WJ (2002) Prognostic factors in non-small cell lung cancer. Chest 122: 1037-1057
2. Buccheri G, Ferrigno D (1994) Prognostic factor in lung cancer: tables and comments. Eur Resp J 7: 1350-1364
3. Buchhop S, Donzelmann B, Nastainczyk W, Stuerzbecher H-W (1996) Isolation and characterisation of six monoclonal antibodies raised against human RAD51 recombination protein. Hybridoma 15: 205-210
4. Carney DN (2002) Lung cancer: time to move on from chemotherapy. N Engl Med 346: 126-127
5. Grondin SC, Liptay MJ (2002) Current concepts in the staging of non-small cell lung cancer. Surg Oncol 11: 181-190
6. Han H, Bearss DJ, Browne LW, Calaluce R, Nagle RB, Von Hoff DD (2002) Identification of differentially expressed genes in pancreatic cancer cells using cDNA microarray. Cancer Res 62: 2890-2896
7. Henning W, Stuerzbecher H-W (2003) Homologous recombination and cell cycle checkpoints: Rad51 in tumour progression and therapy resistance. Toxicology 193: 91-109
8. Kronqvist P, Kuppio T, Collan Y (1998) Morphometric grading of invasive ductal breast cancer. Br J Cancer 78: 800-805
9. Maacke H, Jost K, Opitz S, Miska S, Yuan Y, Hasselbach L, Lüttges J, Kalthoff H, Stuerzbecher H-W (2000a) DNA repair and recombination factor Rad51 is over-expressed in human pancreatic adenocarcinoma. Oncogene 19: 2791-2795
10. Maacke H, Opitz S, Jost K, Hamdorf W, Henning W, Krueger S, Feller AC, Lopens A, Diedrich K, Schwinger E, Stuerzbecher H-W (2000b) Overexpression of wild-type Rad51 correlates with histological grading of invasive ductal breast cancer. Int J Cancer 88: 907-913
11. Mountain CF (1997) Revisions in the International System for staging lung cancer. Chest 111: 1710-1717
12. Ohnishi T, Taki T, Hiraga S, Arita N, Morita T (1998) In vitro and in vivo potentiation of radiosensitivity of malignant gliomas by antisense inhibition of the RAD51 gene. Biochem Biophys Res Commun 245: 319-324
13. Raderschall E, Stout K, Freier S, Suckow V, Schweiger S, Haaf T (2002) Elevated levels of Rad51 recombination protein in tumor cells. Cancer Res 62: 219-225
14. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM (1997) Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88: 265-275
15. Sharan SK, Morimatsu M, Albrecht U, Lim DS, Regel E, Dinh C, Sands A, Eichele G, Hasty P, Bradley A (1997) Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386: 804-810
16. Sobin LH (1982) The World Health Organization's histological classification of lung tumors: a comparison of the first and second editions. Cancer Detect Prev 5: 391-406
17. Sonoda E, Sasaki MS, Buerstedde JM, Bezzubova O, Shinohara A, Ogawa H, Takata M, Yamaguchi-Iwal Y, Takeda S (1998) Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell death. EMBO J 17: 598-608
18. Stuerzbecher H-W, Donzelmann B, Henning W, Knippschild U, Buchhop S (1996) p53 is linked directly to homologous recombination processes via Rad51/RecA protein interaction. EMBO J 15: 1992-2002
19. Tsuzuki T, Fujii Y, Sakumi K, Tominaga Y, Nakao K, Sekiguchi M, Matsushiro A, Yoshimura Y, Morita T (1996) Targeted disruption of the rad51 gene leads to lethality in embryonic mice. Proc Natl Acad Sci USA 93: 6236-6240
20. Vispé S, Cazaux C, Lesca C, Defais M (1998) Overexpression of Rad51 protein stimulates ionizing radiation. Nucleic Acids Res 26: 2859-2864
21. Xia SJ, Shammas MA, Shmookler Reis RJ (1997) Elevated recombination in immortal human cells is mediated by HsRad51 recombinase. Mol Cell Biol 17: 7151-7158
22. Yanagisawa T, Urade M, Yamamoto Y, Furuyama J (1998) Increased expression of human DNA repair genes XRCC1, XRCC3, and cRad51 in radioresistant human KB carcinoma cell line N10. Oral Oncol 34: 524-528