SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors

Biopolymers

Volumn 101, Issue 1, 2014, Pages 121-128

  Gomez Monterrey, Isabel ^a   Carotenuto, Alfonso ^a   Cipolletta, Ersilia ^a   Sala, Marina ^b   Vernieri, Ermelinda ^b   Limatola, Antonio ^a   Bertamino, Alessia ^b   Musella, Simona ^b   Grieco, Paolo ^a   Trimarco, Bruno ^a   Novellino, Ettore ^a   Iaccarino, Guido ^b,c   Campiglia, Pietro ^b  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF SALERNO   (Italy)

^c IRCCS MULTIMEDICA   (Italy)

Author keywords

cardiovascular system; GRK2 inhibitors; NMR conformational analysis; peptide Ala scan

Indexed keywords

CARDIOVASCULAR SYSTEM; ENZYMES;

CHRONIC HEART FAILURES; CONFORMATIONAL ANALYSIS; DISEASE PROGRESSION; G PROTEIN-COUPLED RECEPTOR KINASE 2; INHIBITION PROPERTY; NOVEL PEPTIDES; PATHOLOGICAL CONDITIONS; THERAPEUTIC SOLUTIONS;

PEPTIDES;

ALANINE; DEXTRO AMINO ACID; G PROTEIN COUPLED RECEPTOR KINASE 2; G PROTEIN COUPLED RECEPTOR KINASE 2 INHIBITOR; PEPTIDOMIMETIC AGENT; PROTEIN KINASE INHIBITOR; UNCLASSIFIED DRUG; PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; BETA SHEET; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; ENZYME INHIBITION; HEART FAILURE; NUCLEAR OVERHAUSER EFFECT; PROTEIN CONFORMATION; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; UPREGULATION; METABOLISM; PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE;

G-PROTEIN-COUPLED RECEPTOR KINASE 2; PEPTIDES; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY;

EID: 84884901999     PISSN: 00063525     EISSN: 10970282     Source Type: Journal    
DOI: 10.1002/bip.22295     Document Type: Article

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